STANDARD_NAME GSE36888_UNTREATED_VS_IL2_TREATED_TCELL_6H_DN SYSTEMATIC_NAME M8741 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE36888_UNTREATED_VS_IL2_TREATED_TCELL_6H_DN NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes down-regulated in T cells: control versus IL2 [GeneID=3558] stimulation for 6h. DESCRIPTION_FULL Cytokine-activated STAT proteins dimerize and bind to high-affinity motifs, and N-terminal domain-mediated oligomerization of dimers allows tetramer formation and binding to low-affinity tandem motifs, but the functions of dimers versus tetramers are unknown. We generated Stat5a and Stat5b double knock-in (DKI) N-domain mutant mice that form dimers but not tetramers, identified cytokine-regulated genes whose expression required STAT5 tetramers, and defined consensus motifs for dimers versus tetramers. Whereas Stat5- deficient mice exhibited perinatal lethality, DKI mice were viable, indicating that STAT5 dimers were sufficient for survival. Nevertheless, STAT5 DKI mice had fewer CD4+CD25+ T cells, NK cells, and CD8+ T cells, with impaired cytokine-induced proliferation and homeostatic proliferation of CD8+ T cells. DKI CD8+ T cell proliferation following viral infection was diminished and DKI Treg cells did not efficiently control colitis. Thus, tetramerization of STAT5 is dispensable for survival but is critical for cytokine responses and normal immune function. PMID 22520852 GEOID GSE36888 AUTHORS Lin JX,Li P,Liu D,Jin HT,He J,Ata Ur Rasheed M,Rochman Y,Wang L,Cui K,Liu C,Kelsall BL,Ahmed R,Leonard WJ CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE36888_2357_200_DN FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS A2M,AASDHPPT,ACADM,ACVR2A,ADCK1,ADK,ADORA2B,AGPS,AKAP11,ALG2,ALG5,ARMC10,ARMCX5,ARRDC3,ASB13,ATP5A1,ATP6V1G1,AVPI1,B3GALT1,B7H6,BLOC1S2,BPNT1,BRCC3,C11orf45,C11orf74,C14orf147,C15orf61,C1orf109,C1orf131,C2CD2,C6orf203,C7orf69,CAMK1,CANX,CCT5,CD163L1,CD1B,CD1E,CD84,CDC23,CFDP1,CHCHD4,CHML,CLEC12B,CMTM7,CNBP,COG2,COMMD10,COX18,COX7B,CRLS1,CTSA,CUTC,DAK,DDX28,DNAJB11,DPCD,DUSP19,E2F6,EEF2K,ELOVL6,ENC1,EPS8,ERLIN2,FABP4,FABP5,FAM195A,FAM82A2,FASTKD1,FBXO4,FECH,FKBP14,FN1,FRMD4A,FUCA2,GAL3ST4,GCLC,GEMIN6,GFM1,GLUD1,GMFB,GML,GRSF1,GTF2E1,GTF3C2,HEATR3,HMG20B,HNRNPA3,HNRNPR,HTATSF1,HYLS1,IGFL2,IKBKAP,IMPAD1,IQGAP2,ITGB5,KIAA1826,KIF1C,KLF11,KRT40,LARP4,LCTL,LGALS9,LGMN,LIG3,LOC100506325,LOC284385,LOC645638,LRRK1,MBNL3,MDH1,MEX3B,MORF4L2,MRPL15,MRPS14,MYO1E,MYOF,NANP,NARS,NCAPD3,NCBP2,NDUFV3,NELF,NETO2,NEUROD1,NMB,NOL8,NUDCD2,NUDT15,NUDT4,NUP35,OSBPL1A,OTUD4,PACRGL,PCBD1,PCNA,PDCD6,PEMT,PGBD2,PIGW,PNN,PNPO,POLE3,PON2,POP4,PPARGC1B,PPT1,PRDX1,PRKDC,PRPS2,PSMA5,PTCD3,PTRH2,RAB42,RAB7B,RABGGTB,RAP1GDS1,RAPH1,RBBP9,RBM28,RHOBTB1,RIOK1,RIOK2,SCO1,SDCCAG3,SEC63,SETD7,SIP1,SLC16A1,SLC25A13,SLC4A7,SRSF7,TAF9,TANC2,TFAM,THBS3,THEM5,TIMM13,TMEM119,TMEM138,TMEM48,TMEM70,TMTC2,TMTC4,TNS1,TREM2,TREML1,TRIM47,TSGA14,TSSK4,TTF2,UCHL3,UTP18,UTP3,VSIG4,XPO1,ZC3HAV1L,ZNF614,ZNF664,ZZZ3 GENE_SYMBOLS A2M,AASDHPPT,ACADM,ACVR2A,ADCK1,ADK,ADORA2B,AGPS,AKAP11,ALG2,ALG5,ARMC10,ARMCX5,ARRDC3,ASB13,ATP5F1A,ATP6V1G1,AVPI1,B3GALT1,,BLOC1S2,BPNT1,BRCC3,KCNJ5-AS1,IFTAP,SPTSSA,C15orf61,C1orf109,C1orf131,C2CD2,MTRES1,PKD1L1-AS1,CAMK1,CANX,CCT5,CD163L1,CD1B,CD1E,CD84,CDC23,CFDP1,CHCHD4,CHML,CLEC12B,CMTM7,CNBP,COG2,COMMD10,COX18,COX7B,CRLS1,CTSA,CUTC,TKFC,DDX28,DNAJB11,DPCD,DUSP19,E2F6,EEF2K,ELOVL6,ENC1,EPS8,ERLIN2,FABP4,FABP5,MCRIP2,RMDN3,FASTKD1,FBXO4,FECH,FKBP14,FN1,FRMD4A,FUCA2,GAL3ST4,GCLC,GEMIN6,GFM1,GLUD1,GMFB,GML,GRSF1,GTF2E1,GTF3C2,HEATR3,HMG20B,HNRNPA3,HNRNPR,HTATSF1,HYLS1,IGFL2,ELP1,BPNT2,IQGAP2,ITGB5,MSANTD4,KIF1C,KLF11,KRT40,LARP4,LCTL,LGALS9,LGMN,LIG3,SP2-AS1,ZNF561-AS1,WFDC21P,LRRK1,MBNL3,MDH1,MEX3B,MORF4L2,MRPL15,MRPS14,MYO1E,MYOF,NANP,NARS1,NCAPD3,NCBP2,NDUFV3,NSMF,NETO2,NEUROD1,NMB,NOL8,NUDCD2,NUDT15,NUDT4,NUP35,OSBPL1A,OTUD4,PACRGL,PCBD1,PCNA,PDCD6,PEMT,PGBD2,PIGW,PNN,PNPO,POLE3,PON2,POP4,PPARGC1B,PPT1,PRDX1,PRKDC,PRPS2,PSMA5,PTCD3,PTRH2,RAB42,RAB7B,RABGGTB,RAP1GDS1,RAPH1,RBBP9,RBM28,RHOBTB1,RIOK1,RIOK2,SCO1,ENTR1,SEC63,SETD7,GEMIN2,SLC16A1,SLC25A13,SLC4A7,SRSF7,TAF9,TANC2,TFAM,THBS3,THEM5,TIMM13,TMEM119,TMEM138,NDC1,TMEM70,TMTC2,TMTC4,TNS1,TREM2,TREML1,TRIM47,CEP41,TSSK4,TTF2,UCHL3,UTP18,UTP3,VSIG4,XPO1,ZC3HAV1L,ZNF614,ZNF664,ZZZ3 FOUNDER_NAMES