STANDARD_NAME	GSE37416_CTRL_VS_6H_F_TULARENSIS_LVS_NEUTROPHIL_UP
SYSTEMATIC_NAME	M5332
COLLECTION	C7:IMMUNESIGDB
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE37416_CTRL_VS_6H_F_TULARENSIS_LVS_NEUTROPHIL_UP
NAMESPACE	HUMAN_GENE_SYMBOL
DESCRIPTION_BRIEF	Genes up-regulated in comparison of control polymorphonuclear leukocytes (PMN) at 6 h versus PMN treated with F. tularensis vaccine at 6 h.
DESCRIPTION_FULL	We demonstrated recently that both constitutive and FAS-triggered apoptosis of human neutrophils are profoundly impaired by Francisella tularensis, but how this is achieved is largely unknown. To test the hypothesis that changes in neutrophil gene expression contribute to this phenotype, we used human oligonucleotide microarrays to identify differentially regulated genes in cells infected with F. tularensis strain LVS compared with uninfected controls. In order to examine the effect of F. tularensis on the neutrophil transcriptome, we performed microarray expression analysis on human neutrophils treated with F. tularensis subsp. holarctica live vaccine strain (LVS).
PMID	22986450
GEOID	GSE37416
AUTHORS	Schwartz JT,Bandyopadhyay S,Kobayashi SD,McCracken J,Whitney AR,Deleo FR,Allen LA
CONTRIBUTOR	Jernej Godec
CONTRIBUTOR_ORG	Dana-Farber Cancer Institute
EXACT_SOURCE	GSE37416_2052_200_UP
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	ABCC5,ABHD2,ABHD3,AIDA,AMN1,ANKRD32,APPL2,ARHGAP19,ATG2B,ATP6AP2,ATP6V0B,BCAP31,BICD2,BRI3BP,BRP44,C12orf35,C14orf129,C1orf55,C20orf197,C7orf23,C7orf41,CARD6,CASP2,CASP3,CCNY,CD46,CEBPD,CEP44,CHMP1B,CHST14,CHUK,CMTM4,CNOT6,CTBS,CUL4B,DDX28,DEF8,DGCR2,DHRS9,DHTKD1,DKFZP586I1420,DPEP2,DPY30,DSTYK,DUS2L,EED,EMR2,EVI2A,EXTL3,FAM101B,FAM13B,FAM174A,FAM26F,FAM43A,FAM53B,FAM78A,FAM91A1,FDFT1,FGFR1OP,FIG4,FKRP,FLJ10038,FLJ39051,FLJ39653,FUNDC1,G6PD,GALNT1,GLRX2,GNB4,GPR27,GPR77,GRAMD1C,GSK3B,GTF3C1,HDAC1,HEATR5A,HERC1,HHEX,HIST1H2BI,HNRNPUL1,HSPA8,HVCN1,ICAM3,ICT1,IDH1,IKBKAP,IMPA2,INPP5B,ISL2,ITGAE,JPX,KCNE3,KCTD12,KIAA0040,KIAA0146,KIAA0232,KIAA0930,KIF21B,KLHDC2,KLHL7,LAMP2,LCLAT1,LIMD2,LIX1L,LNX2,LOC100130837,LOC100505702,LOC152217,LOC153546,LOC645158,LRP10,MAP3K3,MAP7,MAVS,MBIP,ME2,MED25,MIR21,MLXIP,MPPE1,MPZL1,MSL3,MSRB2,MTM1,MTMR12,NAA10,NCK1,NCKAP1L,NDC80,NDUFA2,NDUFB1,NFATC3,NLRP12,NSFL1C,NT5C,NUDT3,PDE3B,PDLIM2,PGD,PKN2,PRDX3,PRPF38B,PTRH2,QARS,RAB37,RABAC1,RABIF,RASGEF1A,RASSF1,RFC2,RFC3,RFK,RGS18,RNF114,RPGRIP1,RPS16P5,RPS6KB2,SDC2,SERINC5,SGPP1,SLC16A5,SLC19A1,SLC22A15,SLC25A20,SLC25A3,SLC25A44,SLC38A2,SLC40A1,SLMAP,ST3GAL6,STK4,SUCNR1,TACC1,TAX1BP3,TBC1D14,TCHP,TCP11L2,TGFBR2,TIGD1,TIGD3,TLR1,TLR6,TMEM219,TMEM55A,TOP3A,TSPYL4,TWF2,UBE4B,UBN1,UGGT1,VPS54,XPO7,XYLT1,ZC3H13,ZMAT2,ZMPSTE24,ZNF516,ZNF518B,ZNF688,ZNF75D
GENE_SYMBOLS	ABCC5,ABHD2,ABHD3,AIDA,AMN1,SLF1,APPL2,ARHGAP19,ATG2B,ATP6AP2,ATP6V0B,BCAP31,BICD2,BRI3BP,MPC2,RESF1,GSKIP,SDE2,MIR646HG,TMEM243,MTURN,CARD6,CASP2,CASP3,CCNY,CD46,CEBPD,CEP44,CHMP1B,CHST14,CHUK,CMTM4,CNOT6,CTBS,CUL4B,DDX28,DEF8,DGCR2,DHRS9,DHTKD1,,DPEP2,DPY30,DSTYK,DUS2,EED,ADGRE2,EVI2A,EXTL3,RFLNB,FAM13B,FAM174A,CALHM6,FAM43A,FAM53B,FAM78A,FAM91A1,FDFT1,CEP43,FIG4,FKRP,GABPB1-IT1,GSEC,TAPT1-AS1,FUNDC1,G6PD,GALNT1,GLRX2,GNB4,GPR27,C5AR2,GRAMD1C,GSK3B,GTF3C1,HDAC1,HEATR5A,HERC1,HHEX,H2BC10,HNRNPUL1,HSPA8,HVCN1,ICAM3,MRPL58,IDH1,ELP1,IMPA2,INPP5B,ISL2,ITGAE,JPX,KCNE3,KCTD12,KIAA0040,SPIDR,KIAA0232,KIAA0930,KIF21B,KLHDC2,KLHL7,LAMP2,LCLAT1,LIMD2,LIX1L,LNX2,,,NCBP2AS2,,CBX3P2,LRP10,MAP3K3,MAP7,MAVS,MBIP,ME2,MED25,MIR21,MLXIP,MPPE1,MPZL1,MSL3,MSRB2,MTM1,MTMR12,NAA10,NCK1,NCKAP1L,NDC80,NDUFA2,NDUFB1,NFATC3,NLRP12,NSFL1C,NT5C,NUDT3,PDE3B,PDLIM2,PGD,PKN2,PRDX3,PRPF38B,PTRH2,EPRS1,RAB37,RABAC1,RABIF,RASGEF1A,RASSF1,RFC2,RFC3,RFK,RGS18,RNF114,RPGRIP1,RPS16P5,RPS6KB2,SDC2,SERINC5,SGPP1,SLC16A5,SLC19A1,SLC22A15,SLC25A20,SLC25A3,SLC25A44,SLC38A2,SLC40A1,SLMAP,ST3GAL6,STK4,SUCNR1,TACC1,TAX1BP3,TBC1D14,TCHP,TCP11L2,TGFBR2,TIGD1,TIGD3,TLR1,TLR6,TMEM219,PIP4P2,TOP3A,TSPYL4,TWF2,UBE4B,UBN1,UGGT1,VPS54,XPO7,XYLT1,ZC3H13,ZMAT2,ZMPSTE24,ZNF516,ZNF518B,ZNF688,ZNF75D
FOUNDER_NAMES