STANDARD_NAME GSE39152_BRAIN_VS_SPLEEN_CD103_NEG_MEMORY_CD8_TCELL_UP SYSTEMATIC_NAME M9075 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE39152_BRAIN_VS_SPLEEN_CD103_NEG_MEMORY_CD8_TCELL_UP NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes up-regulated in memory CD8 T cells, ITGAE- [GeneID=3682] population: brain versus spleen sources. DESCRIPTION_FULL Tissue resident memory (Trm) represent a newly described memory T cell population. We have previously characterized a population of Trm that persists within the brain following acute virus infection. Although capable of providing marked protection against a subsequent local challenge, brain Trm do not undergo recall expansion following dissociation from the tissue. Furthermore, these Trm do not depend on the same survival factors as the circulating memory T cell pool as assessed either in vivo or in vitro. To gain greater insight into this population of cells we compared the gene-expression profiles of Trm isolated from the brain to circulating memory T cells isolated from the spleen following an acute virus infection. Trm displayed altered expression of genes involved in chemotaxis, expressed a distinct set of transcription factors and overexpressed several inhibitory receptors. Cumulatively, these data indicates that Trm are a distinct memory T cell population disconnected from the circulating memory T cell pool and displaying a unique molecular signature which likely results in optimal survival and function within their local environment. PMID 22922816 GEOID GSE39152 AUTHORS Wakim LM,Woodward-Davis A,Liu R,Hu Y,Villadangos J,Smyth G,Bevan MJ CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE39152_2714_200_UP FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ACADL,ACTG1,ACTN4,ACYP2,ADK,ADSSL1,AGFG1,ANKH,ANKRD13C,ANKRD17,ANXA4,AP1AR,ARPC2,ATAD3A,ATF1,ATF3,ATP13A3,ATP1B3,ATP6AP2,AZI2,BAG1,BCL2A1,BCL2L1,BCL6,BRIX1,BTG3,CAPN2,CASP3,CCT5,CD164,CD83,CDH5,CDK8,CENPV,CHTOP,CHUK,CLIC4,CLK4,CSF1,CTBP1,CWC15,CXCL10,CYP2C19,DAG1,DAP3,DCK,DEGS1,DNAJA2,DOK2,DPPA5,DRG1,DSTN,E2F8,EEA1,EIF5,EML5,EMP1,ETFB,FABP3,FAM120A,FARS2,FAS,FGFR1OP2,FMR1,FNBP4,FXN,FYN,GBP4,GBP7,GCFC1,GCH1,GKAP1,GNB2L1,GPX3,H3F3C,HDAC2,HIVEP1,HLA-B,HNRNPA1,HNRNPK,HPRT1,HSP90AB1,HSPC159,IFI35,IGF1,IKBKG,IL15,IQGAP1,IRF9,IRG1,IRGM,ISOC1,JAK2,KALRN,KIT,KITLG,KLF2,KLHL7,LASP1,LPCAT1,LPL,LRPPRC,LSP1,LYRM2,M6PR,MAP4K3,MARCH5,MAX,MBD2,MBNL1,MDM2,MINPP1,MMP13,MT2A,MTDH,NAMPT,NAV2,NCR1,NDUFA2,NOC4L,NONO,NRAS,NVL,OAS1,ODC1,OTUD4,PDHB,PDK3,PEBP1,PFKP,PLA2G4A,PLAA,PLAC9,PLEC,PLSCR1,PLXND1,PPAP2A,PPP1R15B,PRKD3,PSMB4,PSMD6,PTGS2,PTPN2,PTRF,QDPR,RAD17,RALA,RAP1GDS1,RARS,RASA4,RBM3,RBMS1,RELL1,RFC2,RFC3,RNASEH1,RNF19B,RNF34,RTN4,RUFY1,SAP30,SF3A3,SGCA,SH3BGRL,SLC25A28,SLC39A6,SLC6A12,SNX10,SNX12,SPRED2,SQSTM1,STAT1,STMN1,SUN2,TANK,TAP1,TBCA,TCP1,TEC,THUMPD1,TINAGL1,TOR1AIP2,TRAF1,TRIM27,TSNAX,TTC27,TTR,TUBB2A,TXNRD1,U2SURP,UBL3,UHRF1BP1,USO1,USP18,VCL,ZFPM1,ZNF281,ZNF398,ZNF639,ZNHIT3 GENE_SYMBOLS ACADL,ACTG1,ACTN4,ACYP2,ADK,ADSS1,AGFG1,ANKH,ANKRD13C,ANKRD17,ANXA4,AP1AR,ARPC2,ATAD3A,ATF1,ATF3,ATP13A3,ATP1B3,ATP6AP2,AZI2,BAG1,BCL2A1,BCL2L1,BCL6,BRIX1,BTG3,CAPN2,CASP3,CCT5,CD164,CD83,CDH5,CDK8,CENPV,CHTOP,CHUK,CLIC4,CLK4,CSF1,CTBP1,CWC15,CXCL10,CYP2C19,DAG1,DAP3,DCK,DEGS1,DNAJA2,DOK2,DPPA5,DRG1,DSTN,E2F8,EEA1,EIF5,EML5,EMP1,ETFB,FABP3,FAM120A,FARS2,FAS,FGFR1OP2,FMR1,FNBP4,FXN,FYN,GBP4,GBP7,PAXBP1,GCH1,GKAP1,RACK1,GPX3,H3-5,HDAC2,HIVEP1,HLA-B,HNRNPA1,HNRNPK,HPRT1,HSP90AB1,LGALSL,IFI35,IGF1,IKBKG,IL15,IQGAP1,IRF9,ACOD1,IRGM,ISOC1,JAK2,KALRN,KIT,KITLG,KLF2,KLHL7,LASP1,LPCAT1,LPL,LRPPRC,LSP1,LYRM2,M6PR,MAP4K3,MARCHF5,MAX,MBD2,MBNL1,MDM2,MINPP1,MMP13,MT2A,MTDH,NAMPT,NAV2,NCR1,NDUFA2,NOC4L,NONO,NRAS,NVL,OAS1,ODC1,OTUD4,PDHB,PDK3,PEBP1,PFKP,PLA2G4A,PLAA,PLAC9,PLEC,PLSCR1,PLXND1,PLPP1,PPP1R15B,PRKD3,PSMB4,PSMD6,PTGS2,PTPN2,CAVIN1,QDPR,RAD17,RALA,RAP1GDS1,RARS1,RASA4,RBM3,RBMS1,RELL1,RFC2,RFC3,RNASEH1,RNF19B,RNF34,RTN4,RUFY1,SAP30,SF3A3,SGCA,SH3BGRL,SLC25A28,SLC39A6,SLC6A12,SNX10,SNX12,SPRED2,SQSTM1,STAT1,STMN1,SUN2,TANK,TAP1,TBCA,TCP1,TEC,THUMPD1,TINAGL1,TOR1AIP2,TRAF1,TRIM27,TSNAX,TTC27,TTR,TUBB2A,TXNRD1,U2SURP,UBL3,BLTP3A,USO1,USP18,VCL,ZFPM1,ZNF281,ZNF398,ZNF639,ZNHIT3 FOUNDER_NAMES