<?xml version="1.0" encoding="UTF-8" standalone="yes"?>

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     See license terms at www.gsea-msigdb.org/gsea/license_terms_list. Please note that certain gene sets have special access terms.
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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="GSE3920_UNTREATED_VS_IFNA_TREATED_FIBROBLAST_UP" SYSTEMATIC_NAME="M6704" HISTORICAL_NAMES="" PMID="17202376" AUTHORS="Indraccolo S,Pfeffer U,Minuzzo S,Esposito G,Roni V,Mandruzzato S,Ferrari N,Anfosso L,Dell'Eva R,Noonan DM,Chieco-Bianchi L,Albini A,Amadori A" GEOID="GSE3920" EXACT_SOURCE="GSE3920_3487_200_UP" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="" CHIP="HUMAN_GENE_SYMBOL" CONTRIBUTOR="Jernej Godec" CONTRIBUTOR_ORG="Dana-Farber Cancer Institute" DESCRIPTION_BRIEF="Genes up-regulated fibroblasts: untreated versus interferon alpha." DESCRIPTION_FULL="IFNs are highly pleiotropic cytokines also endowed with marked anti-angiogenic activity. In this study, the mRNA expression profiles of endothelial cells (EC) exposed in vitro to IFN-alpha, IFN-beta, or IFN-gamma were determined. We found that in HUVEC as well as in other EC types 175 genes were upregulated (&gt;2-fold increase) by IFNs, including genes involved in the host response to RNA viruses, inflammation, and apoptosis. Interestingly, 41 genes showed a &gt;5-fold higher induction by IFN-alpha in EC compared to human fibroblasts; among them, the gene encoding the angiostatic chemokine CXCL11 was selectively induced by IFN-alpha in EC along with other genes associated with angiogenesis regulation, including CXCL10, TRAIL, and guanylate binding protein 1 (GBP-1). These transcriptional changes were confirmed and extended by quantitative PCR analysis and ELISA; whereas IFN-alpha and IFN-beta exerted virtually identical effects on transcriptome modulation, a differential gene regulation by type I and type II IFN emerged, especially as far as quantitative aspects were concerned. In vivo, IFN-alpha-producing tumors over-expressed murine CXCL10-11, GBP-1 and TRAIL, with evidence of CXCL11 production by tumor-associated EC. Overall, these findings improve our understanding of the anti-angiogenic effects of IFNs by showing that these cytokines trigger an anti-angiogenic transcriptional program in EC. Moreover, we suggest that quantitative differences in the magnitude of the transcriptional activation of IFNresponsive genes could form the basis for cell-specific transcriptional signatures." TAGS="" MEMBERS="0610010O12Rik,1190002H23Rik,2010002N04Rik,2310079F23Rik,3300002A11Rik,4632411B12Rik,4732471D19Rik,4930590J08Rik,4933407C03Rik,6530418L21Rik,9330154K18Rik,A430090L17Rik,ABL2,ABTB2,ACR,ADAM9,ADARB1,ADORA1,ADORA2A,ADORA2B,AEN,AHI1,AI848100,AKAP13,ANKRD17,ARL5B,ATF4,ATG16L2,ATXN7,BAIAP2,BC016423,BCL2L1,BCL2L11,BIRC3,BLCAP,BRWD1,BTG1,C030046E11Rik,C1QTNF3,C530030P08Rik,CASC1,CCL3,CCNK,CCNL1,CCNL2,CCR8,CD274,CD69,CD83,CHD2,CISH,CLDND2,CLIP2,CLK1,CLK4,CPD,CSRNP1,CXADR,DCAF12L1,DGAT1,DHX40,DNAJB2,DUSP14,DUSP2,DUSP4,DUSP8,ELAVL3,ELL2,EPC1,ETV3,F830045P16Rik,FAP,FBXW9,FEM1C,FGD3,FNIP1,FOXO1,FXYD7,GABARAPL1,GADD45B,GM10030,GM10099,GM10589,GM10673,GM14005,GM5486,GM9883,GM9948,GNPTAB,GPR133,H1FNT,HERPUD1,HIVEP1,HSN2,ICAM1,IL3,ITGAV,ITK,JMJD1C,JMY,KBTBD7,KDM2B,KRTAP5-3,LANCL3,MAFG,MAP3K7,MAPK8IP3,MBTD1,MIR155,MIR23B,MNT,MST1R,MT2,MTAP1B,MTAP9,MXD1,MXI1,NAB2,NDRG1,NFAT5,NFKB1,NFKBID,NFKBIZ,NINJ1,NMD3,NNAT,NR3C1,NR4A3,ODC1,OLFR1215,OLFR370,OLFR472,OLFR633,ORAI1,PAN3,PDCD1LG2,PHLDA1,PHLDA3,PHXR4,PIM1,PLK3,PPP1R16B,PPP2R2A,PTGER2,RABGEF1,RARA,RASA2,RELA,RELB,RHBDD1,RNF149,RNF157,RORA,RRAD,SAFB2,SDCBP2,SESN2,SH2B3,SH2D2A,SIAH2,SIDT2,SIK3,SIPA1L2,SLC15A3,SLC17A6,SLC25A19,SLC7A1,SMOX,SPAG9,SPATA2,SV2C,TGIF2,TINF2,TMEM44,TMEM66,TMEM67,TNFAIP3,TNFRSF10B,TNKS,TOM1,TRAF1,TRAF3,TRIM42,TRP53INP2,TTC19,TUT1,UPB1,USP31,USP53,USPL1,VPS37B,ZBTB43,ZBTB46,ZC3H12A,ZCCHC6,ZFAND2A,ZFP295,ZSCAN18,ZSWIM4,ZSWIM6" MEMBERS_SYMBOLIZED="ABL2,ABTB2,ACR,ADAM9,ADARB1,ADGRD1,ADORA1,ADORA2A,ADORA2B,AEN,AHI1,AKAP13,ANKRD17,ARL5B,ATF4,ATG16L2,ATXN7,BAIAP2,BCL2L1,BCL2L11,BIRC3,BLCAP,BRWD1,BTG1,C1QTNF3,CCL3,CCNK,CCNL1,CCNL2,CCR8,CD274,CD69,CD83,CHD2,CISH,CLDND2,CLIP2,CLK1,CLK4,CPD,CSRNP1,CXADR,DCAF12L1,DGAT1,DHX40,DNAI7,DNAJB2,DUSP14,DUSP2,DUSP4,DUSP8,ELAVL3,ELL2,EPC1,ETV3,FAP,FBXW9,FEM1C,FGD3,FNIP1,FOXO1,FXYD7,GABARAPL1,GADD45B,GNPTAB,H1-7,HERPUD1,HIVEP1,ICAM1,IL3,ITGAV,ITK,JMJD1C,JMY,KBTBD7,KDM2B,KRTAP5-3,LANCL3,MAFG,MAP3K7,MAPK8IP3,MBTD1,MIR155,MIR23B,MNT,MST1R,MT2A,MXD1,MXI1,NAB2,NDRG1,NFAT5,NFKB1,NFKBID,NFKBIZ,NINJ1,NMD3,NNAT,NR3C1,NR4A3,ODC1,ORAI1,PAN3,PDCD1LG2,PHLDA1,PHLDA3,PIM1,PLK3,PPP1R16B,PPP2R2A,PTGER2,RABGEF1,RARA,RASA2,RELA,RELB,RHBDD1,RNF149,RNF157,RORA,RRAD,SAFB2,SARAF,SDCBP2,SESN2,SH2B3,SH2D2A,SIAH2,SIDT2,SIK3,SIPA1L2,SLC15A3,SLC17A6,SLC25A19,SLC7A1,SMOX,SPAG9,SPATA2,SUCO,SV2C,TASOR2,TGIF2,TINF2,TMEM44,TMEM67,TNFAIP3,TNFRSF10B,TNKS,TOM1,TRAF1,TRAF3,TRIM42,TTC19,TUT1,TUT7,UPB1,USP31,USP53,USPL1,VPS37B,WNK1,ZBTB43,ZBTB46,ZC3H12A,ZFAND2A,ZSCAN18,ZSWIM4,ZSWIM6" MEMBERS_EZID="10018,10019,10043,10208,10397,104,10458,10725,10904,1106,11072,11214,114804,114899,1154,1195,1237,125875,1263,133746,134,135,136,1362,139170,140685,1525,1844,1846,1850,1995,2117,2191,221037,221079,22822,22936,22987,2308,23099,23162,23387,23612,23710,255967,25841,26051,26057,26277,27,27111,27342,283383,284996,287015,2908,29126,3096,330,3300,3383,341567,347404,3562,3685,3702,387266,406947,407011,4084,4097,4335,4486,4502,4601,4616,4665,468,4790,4814,4826,49,4953,51068,51092,51296,51430,51669,51733,5292,53822,54014,54498,54532,54799,54806,54902,54906,5520,55259,56929,57018,57084,5732,57396,57478,57568,57688,5914,5922,5970,5971,598,60386,60436,6095,6236,6314,6348,64332,64651,6478,64782,64852,65125,65249,6541,65982,6885,694,7128,7185,7187,7461,79158,79665,79670,79720,8013,80149,80314,80380,81669,83667,84078,84236,84261,84678,84807,84876,8658,8694,8754,8795,8812,89846,89849,9043,9047,90637,91147,9308,93109,96459,9667,969,9709,9825" MEMBERS_MAPPING="0610010O12Rik,null,null|1190002H23Rik,null,null|2010002N04Rik,null,null|2310079F23Rik,null,null|3300002A11Rik,null,null|4632411B12Rik,null,null|4732471D19Rik,null,null|4930590J08Rik,null,null|4933407C03Rik,null,null|6530418L21Rik,null,null|9330154K18Rik,null,null|A430090L17Rik,null,null|ABL2,ABL2,27|ABTB2,ABTB2,25841|ACR,ACR,49|ADAM9,ADAM9,8754|ADARB1,ADARB1,104|ADORA1,ADORA1,134|ADORA2A,ADORA2A,135|ADORA2B,ADORA2B,136|AEN,AEN,64782|AHI1,AHI1,54806|AI848100,SUCO,51430|AKAP13,AKAP13,11214|ANKRD17,ANKRD17,26057|ARL5B,ARL5B,221079|ATF4,ATF4,468|ATG16L2,ATG16L2,89849|ATXN7,ATXN7,6314|BAIAP2,BAIAP2,10458|BC016423,TASOR2,54906|BCL2L1,BCL2L1,598|BCL2L11,BCL2L11,10018|BIRC3,BIRC3,330|BLCAP,BLCAP,10904|BRWD1,BRWD1,54014|BTG1,BTG1,694|C030046E11Rik,null,null|C1QTNF3,C1QTNF3,114899|C530030P08Rik,null,null|CASC1,DNAI7,55259|CCL3,CCL3,6348|CCNK,CCNK,8812|CCNL1,CCNL1,57018|CCNL2,CCNL2,81669|CCR8,CCR8,1237|CD274,CD274,29126|CD69,CD69,969|CD83,CD83,9308|CHD2,CHD2,1106|CISH,CISH,1154|CLDND2,CLDND2,125875|CLIP2,CLIP2,7461|CLK1,CLK1,1195|CLK4,CLK4,57396|CPD,CPD,1362|CSRNP1,CSRNP1,64651|CXADR,CXADR,1525|DCAF12L1,DCAF12L1,139170|DGAT1,DGAT1,8694|DHX40,DHX40,79665|DNAJB2,DNAJB2,3300|DUSP14,DUSP14,11072|DUSP2,DUSP2,1844|DUSP4,DUSP4,1846|DUSP8,DUSP8,1850|ELAVL3,ELAVL3,1995|ELL2,ELL2,22936|EPC1,EPC1,80314|ETV3,ETV3,2117|F830045P16Rik,null,null|FAP,FAP,2191|FBXW9,FBXW9,84261|FEM1C,FEM1C,56929|FGD3,FGD3,89846|FNIP1,FNIP1,96459|FOXO1,FOXO1,2308|FXYD7,FXYD7,53822|GABARAPL1,GABARAPL1,23710|GADD45B,GADD45B,4616|GM10030,null,null|GM10099,null,null|GM10589,null,null|GM10673,null,null|GM14005,null,null|GM5486,null,null|GM9883,null,null|GM9948,null,null|GNPTAB,GNPTAB,79158|GPR133,ADGRD1,283383|H1FNT,H1-7,341567|HERPUD1,HERPUD1,9709|HIVEP1,HIVEP1,3096|HSN2,WNK1,65125|ICAM1,ICAM1,3383|IL3,IL3,3562|ITGAV,ITGAV,3685|ITK,ITK,3702|JMJD1C,JMJD1C,221037|JMY,JMY,133746|KBTBD7,KBTBD7,84078|KDM2B,KDM2B,84678|KRTAP5-3,KRTAP5-3,387266|LANCL3,LANCL3,347404|MAFG,MAFG,4097|MAP3K7,MAP3K7,6885|MAPK8IP3,MAPK8IP3,23162|MBTD1,MBTD1,54799|MIR155,MIR155,406947|MIR23B,MIR23B,407011|MNT,MNT,4335|MST1R,MST1R,4486|MT2,MT2A,4502|MTAP1B,null,null|MTAP9,null,null|MXD1,MXD1,4084|MXI1,MXI1,4601|NAB2,NAB2,4665|NDRG1,NDRG1,10397|NFAT5,NFAT5,10725|NFKB1,NFKB1,4790|NFKBID,NFKBID,84807|NFKBIZ,NFKBIZ,64332|NINJ1,NINJ1,4814|NMD3,NMD3,51068|NNAT,NNAT,4826|NR3C1,NR3C1,2908|NR4A3,NR4A3,8013|ODC1,ODC1,4953|OLFR1215,null,null|OLFR370,null,null|OLFR472,null,null|OLFR633,null,null|ORAI1,ORAI1,84876|PAN3,PAN3,255967|PDCD1LG2,PDCD1LG2,80380|PHLDA1,PHLDA1,22822|PHLDA3,PHLDA3,23612|PHXR4,null,null|PIM1,PIM1,5292|PLK3,PLK3,1263|PPP1R16B,PPP1R16B,26051|PPP2R2A,PPP2R2A,5520|PTGER2,PTGER2,5732|RABGEF1,RABGEF1,27342|RARA,RARA,5914|RASA2,RASA2,5922|RELA,RELA,5970|RELB,RELB,5971|RHBDD1,RHBDD1,84236|RNF149,RNF149,284996|RNF157,RNF157,114804|RORA,RORA,6095|RRAD,RRAD,6236|SAFB2,SAFB2,9667|SDCBP2,SDCBP2,27111|SESN2,SESN2,83667|SH2B3,SH2B3,10019|SH2D2A,SH2D2A,9047|SIAH2,SIAH2,6478|SIDT2,SIDT2,51092|SIK3,SIK3,23387|SIPA1L2,SIPA1L2,57568|SLC15A3,SLC15A3,51296|SLC17A6,SLC17A6,57084|SLC25A19,SLC25A19,60386|SLC7A1,SLC7A1,6541|SMOX,SMOX,54498|SPAG9,SPAG9,9043|SPATA2,SPATA2,9825|SV2C,SV2C,22987|TGIF2,TGIF2,60436|TINF2,TINF2,26277|TMEM44,TMEM44,93109|TMEM66,SARAF,51669|TMEM67,TMEM67,91147|TNFAIP3,TNFAIP3,7128|TNFRSF10B,TNFRSF10B,8795|TNKS,TNKS,8658|TOM1,TOM1,10043|TRAF1,TRAF1,7185|TRAF3,TRAF3,7187|TRIM42,TRIM42,287015|TRP53INP2,null,null|TTC19,TTC19,54902|TUT1,TUT1,64852|UPB1,UPB1,51733|USP31,USP31,57478|USP53,USP53,54532|USPL1,USPL1,10208|VPS37B,VPS37B,79720|ZBTB43,ZBTB43,23099|ZBTB46,ZBTB46,140685|ZC3H12A,ZC3H12A,80149|ZCCHC6,TUT7,79670|ZFAND2A,ZFAND2A,90637|ZFP295,null,null|ZSCAN18,ZSCAN18,65982|ZSWIM4,ZSWIM4,65249|ZSWIM6,ZSWIM6,57688" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="C7" ORGANISM="Homo sapiens" SUB_CATEGORY_CODE="IMMUNESIGDB"/>
</MSIGDB>
