STANDARD_NAME GSE3920_UNTREATED_VS_IFNG_TREATED_ENDOTHELIAL_CELL_DN SYSTEMATIC_NAME M6696 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE3920_UNTREATED_VS_IFNG_TREATED_ENDOTHELIAL_CELL_DN NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes down-regulated in endothelial cells: untreated versus IFNG [GeneID=3458]. DESCRIPTION_FULL IFNs are highly pleiotropic cytokines also endowed with marked anti-angiogenic activity. In this study, the mRNA expression profiles of endothelial cells (EC) exposed in vitro to IFN-alpha, IFN-beta, or IFN-gamma were determined. We found that in HUVEC as well as in other EC types 175 genes were upregulated (>2-fold increase) by IFNs, including genes involved in the host response to RNA viruses, inflammation, and apoptosis. Interestingly, 41 genes showed a >5-fold higher induction by IFN-alpha in EC compared to human fibroblasts; among them, the gene encoding the angiostatic chemokine CXCL11 was selectively induced by IFN-alpha in EC along with other genes associated with angiogenesis regulation, including CXCL10, TRAIL, and guanylate binding protein 1 (GBP-1). These transcriptional changes were confirmed and extended by quantitative PCR analysis and ELISA; whereas IFN-alpha and IFN-beta exerted virtually identical effects on transcriptome modulation, a differential gene regulation by type I and type II IFN emerged, especially as far as quantitative aspects were concerned. In vivo, IFN-alpha-producing tumors over-expressed murine CXCL10-11, GBP-1 and TRAIL, with evidence of CXCL11 production by tumor-associated EC. Overall, these findings improve our understanding of the anti-angiogenic effects of IFNs by showing that these cytokines trigger an anti-angiogenic transcriptional program in EC. Moreover, we suggest that quantitative differences in the magnitude of the transcriptional activation of IFNresponsive genes could form the basis for cell-specific transcriptional signatures. PMID 17202376 GEOID GSE3920 AUTHORS Indraccolo S,Pfeffer U,Minuzzo S,Esposito G,Roni V,Mandruzzato S,Ferrari N,Anfosso L,Dell'Eva R,Noonan DM,Chieco-Bianchi L,Albini A,Amadori A CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE3920_3483_200_DN FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS 1110018G07Rik,2010106G01Rik,2310008H09Rik,2610507B11Rik,5430437P03Rik,8430419L09Rik,AA960436,ABHD8,ADRBK1,AKAP1,ALAD,ALG11,ALOX8,AMFR,ANAPC1,AP1AR,AQP9,ASB8,ATG9B,BC023829,BCKDK,BRP16,CAD,CCDC71,CDCA7,CDK19,CENPV,CHTF8,CINP,CLINT1,CLSTN3,COPA,CSNK2A1,CTSS,CTSZ,CYHR1,DDB1,DEF8,DFFA,DGCR8,DNAJA3,E130309D02Rik,EDEM2,EIF2C1,ELP2,ERMP1,EXTL2,FADS1,FAM134A,FAM20B,FAM54B,FAM73A,FAM82A2,FBXL14,FBXO5,FGFR1OP2,GART,GATAD1,GBF1,GM10397,GM12387,GM5452,GNA12,GPD1L,GRINL1A,GRN,GTF2H4,H6PD,HEXIM2,HIPK3,ISOC1,ITPRIPL1,JAGN1,JTB,KBTBD11,KCTD1,KCTD21,KIF1C,KPNA6,LASP1,LEPROT,LEPROTL1,LGALS3BP,LHPP,LIMD1,LPCAT3,LRRC8C,MAEA,MAPKSP1,MBD3,MCART1,MCM2,MED18,MED23,MEN1,MESDC2,METTL13,METTL8,MEX3D,MFSD1,MLEC,MRPL11,MRPL14,MRPL44,MRPS2,MTMR3,MTMR4,NACC1,NAGPA,NAPEPLD,NDUFAF1,NDUFS7,NOMO1,NPC1,NUDT1,NUDT16,NUP160,OXSM,PATZ1,PBK,PBRM1,PCCB,PCYOX1,PCYT1B,PDDC1,PES1,PFAS,PFKL,PHF2,PHLPP2,PIGC,PIGQ,PIGS,PIK3R4,PLDN,PLIN3,PLRG1,PLXNB2,POLR2B,PREP,PRPF8,PSMB5,PSMD1,PTPN11,RNF113A1,SCARB1,SDC3,SEC23IP,SEC24C,SETD3,SFRS12IP1,SGPP1,SLC25A16,SLC25A44,SLC39A3,SNAP23,SNAPC2,SPCS3,SPTLC2,SRD5A3,SRM,SSX2IP,SUPT7L,TARBP1,TBC1D14,TBL1XR1,TEX261,TGM2,THOC3,TIMELESS,TMCO1,TMED7,TMEM168,TMEM177,TMEM41A,TMEM50B,TMEM9B,TMTC4,TRAM1,TRAPPC10,TRIM32,TRIM7,TSC2,TSFM,TYRO3,UBE4B,UBIAD1,UBQLN4,USP21,WDR18,WDR77,XKR8,XPNPEP1,ZBTB22,ZDHHC3,ZFP106,ZFP280B,ZFP362,ZFP623,ZSWIM1 GENE_SYMBOLS ,,,,,,USB1,ABHD8,GRK2,AKAP1,ALAD,ALG11,,AMFR,ANAPC1,AP1AR,AQP9,ASB8,ATG9B,TMEM185A,BCKDK,,CAD,CCDC71,CDCA7,CDK19,CENPV,CHTF8,CINP,CLINT1,CLSTN3,COPA,CSNK2A1,CTSS,CTSZ,ZFTRAF1,DDB1,DEF8,DFFA,DGCR8,DNAJA3,,EDEM2,AGO1,ELP2,ERMP1,EXTL2,FADS1,RETREG2,FAM20B,MTFR1L,MIGA1,RMDN3,FBXL14,FBXO5,FGFR1OP2,GART,GATAD1,GBF1,,,,GNA12,GPD1L,POLR2M,GRN,GTF2H4,H6PD,HEXIM2,HIPK3,ISOC1,ITPRIPL1,JAGN1,JTB,KBTBD11,KCTD1,KCTD21,KIF1C,KPNA6,LASP1,LEPROT,LEPROTL1,LGALS3BP,LHPP,LIMD1,LPCAT3,LRRC8C,MAEA,LAMTOR3,MBD3,SLC25A51,MCM2,MED18,MED23,MEN1,MESD,METTL13,METTL8,MEX3D,MFSD1,MLEC,MRPL11,MRPL14,MRPL44,MRPS2,MTMR3,MTMR4,NACC1,NAGPA,NAPEPLD,NDUFAF1,NDUFS7,NOMO1,NPC1,NUDT1,NUDT16,NUP160,OXSM,PATZ1,PBK,PBRM1,PCCB,PCYOX1,PCYT1B,GATD1,PES1,PFAS,PFKL,PHF2,PHLPP2,PIGC,PIGQ,PIGS,PIK3R4,BLOC1S6,PLIN3,PLRG1,PLXNB2,POLR2B,PREP,PRPF8,PSMB5,PSMD1,PTPN11,,SCARB1,SDC3,SEC23IP,SEC24C,SETD3,SREK1IP1,SGPP1,SLC25A16,SLC25A44,SLC39A3,SNAP23,SNAPC2,SPCS3,SPTLC2,SRD5A3,SRM,SSX2IP,SUPT7L,TARBP1,TBC1D14,TBL1XR1,TEX261,TGM2,THOC3,TIMELESS,TMCO1,TMED7,TMEM168,TMEM177,TMEM41A,TMEM50B,TMEM9B,TMTC4,TRAM1,TRAPPC10,TRIM32,TRIM7,TSC2,TSFM,TYRO3,UBE4B,UBIAD1,UBQLN4,USP21,WDR18,WDR77,XKR8,XPNPEP1,ZBTB22,ZDHHC3,ZNF106,,,,ZSWIM1 FOUNDER_NAMES