STANDARD_NAME GSE39556_UNTREATED_VS_3H_POLYIC_INJ_MOUSE_NK_CELL_DN SYSTEMATIC_NAME M9411 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE39556_UNTREATED_VS_3H_POLYIC_INJ_MOUSE_NK_CELL_DN NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes down-regulated in NK cells: untreated versus poly(IC). DESCRIPTION_FULL The injection of the pathogen-associated molecular pattern Polyinosinic-polycytidylic acid (poly(I:C)) leads to the activation of various immune cells, including dendritic cells (DCs) and Natural Killer (NK) cells. This activation is due to different innate cytokines produced early after injection, in particular IFN-I. The objective of the study was to compare the pattern of expression of IFN-I stimulated genes between DC and NK cells. The project focused on a specific subset of conventional DC, CD8a DC, which responsiveness to IFN-I determines the capacity to activate CD8 T cells by cross-presentation of exogenous antigens. To identify the responses to IFN-I selectively induced in CD8a+ DC, we compared their gene expression profile to that of NK cells, using gene chips, before and after poly(I:C) stimulation. PMID 23084923 GEOID GSE39556 AUTHORS Baranek T,Manh TP,Alexandre Y,Maqbool MA,Cabeza JZ,Tomasello E,Crozat K,Bessou G,Zucchini N,Robbins SH,Vivier E,Kalinke U,Ferrier P,Dalod M CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE39556_3194_200_DN FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ABLIM1,ACSL1,ACTN1,ACVR1,ADA,AFF1,AIF1,AK1,AKAP12,AKT3,ANKRD17,AP3S1,ARHGEF17,ASB9,ATP2B4,BAZ2B,BCL11A,BMI1,BRD1,BRWD1,C10orf10,C11orf9,C1orf38,C3orf37,CACNB3,CALCOCO2,CCND2,CD27,CD34,CD9,CD99,CDS2,CEP68,CHD1,CHST15,CKMT2,COBL,CRIM1,CSDA,CSNK1A1,CSNK1E,CTBS,CTGF,DENND5A,DMXL2,DPYD,EDEM1,EIF1,ENG,ERG,FAM134B,FAM179B,FBLN5,FHIT,FOXJ3,FOXO3,FPR1,GAB2,GABPB1,GADD45A,GLS,GNAQ,GNG11,GNS,GUCY1A3,HCP5,HERC4,HIF1A,HIST1H1C,HIST1H2AC,HIST1H2BD,HIST1H3H,HIST2H2BE,HLX,HOXA10,HOXA9,IQGAP2,ITGA5,ITPR1,KCNS3,KHNYN,KIAA0125,KIAA1033,KIAA1539,KIF3C,KLF10,KLF7,KRT12,LCP2,LIG4,LILRA2,LILRB2,LMO2,LRIG1,LST1,MAN1A1,MAPK8IP3,MAU2,MDK,MED13L,MEF2C,MLXIP,MME,MMRN1,MPP1,MPPED2,MRC2,MRPS14,MTMR3,MXI1,MYB,MYLK,N4BP2L2,NDRG1,NEDD4,NFYA,NPAS3,NR3C1,NRIP1,OAS2,OR7A5,P2RY14,PDE4B,PDLIM7,PECAM1,PFN2,PGLYRP1,PLSCR1,PLXNB2,PPP3CC,PRMT2,PSD3,PTPN12,PTPRE,PXDN,RAB11FIP5,RABAC1,RAG1,RANBP6,RAPGEF2,RDH11,RECK,RFX5,RGL1,RIMS3,RNASE2,RNF103,ROCK1,RYBP,S1PR4,SATB1,SCARF1,SCHIP1,SEC63,SECISBP2L,SENP6,SERPINB6,SERPING1,SERPINI1,SIAH2,SLC2A5,SMAD1,SNPH,SOCS2,SORL1,SPIN2A,SPINK1,SRSF5,ST3GAL6,STAM,STARD3,STAT5A,STK38,STX4,SUN2,SV2A,SYNGR1,TIA1,TKT,TLE1,TMCC1,TMEM87A,TNFAIP1,TNFAIP3,TNFSF4,TRANK1,TSPAN7,TSPAN9,TTBK2,UBL3,VGLL4,WDFY3,WFS1,WSB1,WWP1,ZFYVE16,ZMIZ1,ZMYM2,ZNF135,ZNF32 GENE_SYMBOLS ABLIM1,ACSL1,ACTN1,ACVR1,ADA,AFF1,AIF1,AK1,AKAP12,AKT3,ANKRD17,AP3S1,ARHGEF17,ASB9,ATP2B4,BAZ2B,BCL11A,BMI1,BRD1,BRWD1,DEPP1,MYRF,THEMIS2,HMCES,CACNB3,CALCOCO2,CCND2,CD27,CD34,CD9,CD99,CDS2,CEP68,CHD1,CHST15,CKMT2,COBL,CRIM1,YBX3,CSNK1A1,CSNK1E,CTBS,CCN2,DENND5A,DMXL2,DPYD,EDEM1,EIF1,ENG,ERG,RETREG1,TOGARAM1,FBLN5,FHIT,FOXJ3,FOXO3,FPR1,GAB2,GABPB1,GADD45A,GLS,GNAQ,GNG11,GNS,GUCY1A1,HCP5,HERC4,HIF1A,H1-2,H2AC6,H2BC5,H3C10,H2BC21,HLX,HOXA10,HOXA9,IQGAP2,ITGA5,ITPR1,KCNS3,KHNYN,FAM30A,WASHC4,ATOSB,KIF3C,KLF10,KLF7,KRT12,LCP2,LIG4,LILRA2,LILRB2,LMO2,LRIG1,LST1,MAN1A1,MAPK8IP3,MAU2,MDK,MED13L,MEF2C,MLXIP,MME,MMRN1,MPP1,MPPED2,MRC2,MRPS14,MTMR3,MXI1,MYB,MYLK,N4BP2L2,NDRG1,NEDD4,NFYA,NPAS3,NR3C1,NRIP1,OAS2,OR7A5,P2RY14,PDE4B,PDLIM7,PECAM1,PFN2,PGLYRP1,PLSCR1,PLXNB2,PPP3CC,PRMT2,PSD3,PTPN12,PTPRE,PXDN,RAB11FIP5,RABAC1,RAG1,RANBP6,RAPGEF2,RDH11,RECK,RFX5,RGL1,RIMS3,RNASE2,RNF103,ROCK1,RYBP,S1PR4,SATB1,SCARF1,SCHIP1,SEC63,SECISBP2L,SENP6,SERPINB6,SERPING1,SERPINI1,SIAH2,SLC2A5,SMAD1,SNPH,SOCS2,SORL1,SPIN2A,SPINK1,SRSF5,ST3GAL6,STAM,STARD3,STAT5A,STK38,STX4,SUN2,SV2A,SYNGR1,TIA1,TKT,TLE1,TMCC1,TMEM87A,TNFAIP1,TNFAIP3,TNFSF4,TRANK1,TSPAN7,TSPAN9,TTBK2,UBL3,VGLL4,WDFY3,WFS1,WSB1,WWP1,ZFYVE16,ZMIZ1,ZMYM2,ZNF135,ZNF32 FOUNDER_NAMES