STANDARD_NAME GSE40068_CXCR5NEG_BCL6NEG_CD4_TCELL_VS_CXCR5POS_BCL6NEG_TFH_DN SYSTEMATIC_NAME M9263 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE40068_CXCR5NEG_BCL6NEG_CD4_TCELL_VS_CXCR5POS_BCL6NEG_TFH_DN NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes down-regulated in CXCR5- BCL6- CD4+ [GeneID=643;604;920] T cells versus CXCR5+ BCL6- [GeneID=643;604] follicular helper T cells. DESCRIPTION_FULL T follicular helper (Tfh) cells play a pivotal role in germinal center reactions, which requires Bcl6 transcription factor. To analyze their relationships with other effector T cell lineages and their stability in vivo, we developed and analyzed a new Bcl6 reporter mouse alone or together with other lineage reporter systems. Assisted with genome-wide transcriptome analysis, we show substantial plasticity of T cell differentiation in the early phase of immune response. At this stage, CXCR5 appears to be expressed in a Bcl6-independent manner. Once Bcl6 is highly expressed, Tfh cells can persist in vivo and some of them develop into memory cells. Together, our results indicate Bcl6 as a bona fide marker for Tfh polarized program. PMID 22987803 GEOID GSE40068 AUTHORS Liu X,Yan X,Zhong B,Nurieva RI,Wang A,Wang X,Martin-Orozco N,Wang Y,Chang SH,Esplugues E,Flavell RA,Tian Q,Dong C CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE40068_2481_200_DN FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ABCA2,ACOT7,ACSBG1,ADAM8,AFG3L2,AHNAK,AKR1B10,ANXA1,ANXA2,APOBEC3B,APOBR,APRT,ARHGAP18,ARHGAP26,ATF6,ATP8B4,B3GNT5,B4GALNT4,BAG3,BAIAP3,BCL2A1,BTBD11,C17orf28,C2orf56,C3orf14,CAPN2,CAPSL,CARHSP1,CCR5,CD44,CDC25B,CDC42EP3,CDH1,CERCAM,CHSY1,CORO2A,CRIP1,CRMP1,CSDA,CST7,CTNNA1,CTSW,CXCR6,CYB5R4,CYSLTR2,DBNDD2,DHDH,DKKL1,DNAJC15,DNASE1L1,DOCK5,DYM,EFHD2,EHBP1L1,ENDOD1,ENTPD1,EPSTI1,ERN1,ERRFI1,FAM129A,FAM19A3,FAM71B,FAM82A1,FCGR2B,FHL2,FLOT1,GAB3,GALM,GALNT3,GARS,GBP4,GLUD1,GNG2,GOLM1,GPC1,GPR155,GPRIN3,GRAMD3,GZMM,HGSNAT,HIC1,HIGD1C,HOPX,HSD11B1,ID2,IFI27,IFNGR1,IGSF8,IL12RB2,IL18R1,IL18RAP,IL2RB,ITGB1,ITGB2,KCNK5,KDELC1,KDELC2,KIF5C,KLRC1,KLRD1,LAIR1,LAX1,LGALS1,LGALS3,LSS,LYSMD2,LYST,MAF,MAP2K3,MCART6,MCOLN2,MDFIC,METTL7A,MICAL1,MNS1,MOGS,MTHFS,NAT10,NEK7,NFIL3,NOD1,NQO2,NRARP,NUCB1,OSTF1,PADI2,PARP16,PCGF2,PCTP,PDE2A,PILRB,PION,PKP4,PLAC8,PLEKHM3,PLSCR1,POGK,POU6F1,PPP3CC,PRKAR2A,PRR13,PTGER2,PTGER4,PTPN13,PTPN22,PTPN4,PVT1,RAB19,RAB23,RALGDS,RAP1GAP2,RAPH1,RBL2,RBM47,RCN1,RECK,RHOC,RNF157,ROM1,RORA,RRAS,S100A11,SEMA4F,SIDT1,SLAMF7,SLC25A24,SLC26A11,SLC2A1,SLC2A8,SMAD3,SNAI3,SORL1,ST14,ST3GAL6,STAT4,STX11,SYTL3,TBL2,THTPA,TMBIM1,TMEM109,TMEM159,TMEM2,TMEM37,TNFRSF18,TPI1,TPST2,TRAF1,TRMT112,TRPS1,TSPAN31,TTC39C,TXN,USP20,USP48,VIM,WWP1,YES1,ZBTB42,ZDHHC2 GENE_SYMBOLS ABCA2,ACOT7,ACSBG1,ADAM8,AFG3L2,AHNAK,AKR1B10,ANXA1,ANXA2,APOBEC3B,APOBR,APRT,ARHGAP18,ARHGAP26,ATF6,ATP8B4,B3GNT5,B4GALNT4,BAG3,BAIAP3,BCL2A1,ABTB3,HID1,NDUFAF7,C3orf14,CAPN2,CAPSL,CARHSP1,CCR5,CD44,CDC25B,CDC42EP3,CDH1,CERCAM,CHSY1,CORO2A,CRIP1,CRMP1,YBX3,CST7,CTNNA1,CTSW,CXCR6,CYB5R4,CYSLTR2,DBNDD2,DHDH,DKKL1,DNAJC15,DNASE1L1,DOCK5,DYM,EFHD2,EHBP1L1,ENDOD1,ENTPD1,EPSTI1,ERN1,ERRFI1,NIBAN1,TAFA3,GARIN3,RMDN2,FCGR2B,FHL2,FLOT1,GAB3,GALM,GALNT3,GARS1,GBP4,GLUD1,GNG2,GOLM1,GPC1,GPR155,GPRIN3,GRAMD2B,GZMM,HGSNAT,HIC1,HIGD1C,HOPX,HSD11B1,ID2,IFI27,IFNGR1,IGSF8,IL12RB2,IL18R1,IL18RAP,IL2RB,ITGB1,ITGB2,KCNK5,POGLUT2,POGLUT3,KIF5C,KLRC1,KLRD1,LAIR1,LAX1,LGALS1,LGALS3,LSS,LYSMD2,LYST,MAF,MAP2K3,SLC25A53,MCOLN2,MDFIC,METTL7A,MICAL1,MNS1,MOGS,MTHFS,NAT10,NEK7,NFIL3,NOD1,NQO2,NRARP,NUCB1,OSTF1,PADI2,PARP16,PCGF2,PCTP,PDE2A,PILRB,GSAP,PKP4,PLAC8,PLEKHM3,PLSCR1,POGK,POU6F1,PPP3CC,PRKAR2A,PRR13,PTGER2,PTGER4,PTPN13,PTPN22,PTPN4,PVT1,RAB19,RAB23,RALGDS,RAP1GAP2,RAPH1,RBL2,RBM47,RCN1,RECK,RHOC,RNF157,ROM1,RORA,RRAS,S100A11,SEMA4F,SIDT1,SLAMF7,SLC25A24,SLC26A11,SLC2A1,SLC2A8,SMAD3,SNAI3,SORL1,ST14,ST3GAL6,STAT4,STX11,SYTL3,TBL2,THTPA,TMBIM1,TMEM109,LDAF1,CEMIP2,TMEM37,TNFRSF18,TPI1,TPST2,TRAF1,TRMT112,TRPS1,TSPAN31,TTC39C,TXN,USP20,USP48,VIM,WWP1,YES1,ZBTB42,ZDHHC2 FOUNDER_NAMES