STANDARD_NAME GSE40184_HEALTHY_VS_HCV_INFECTED_DONOR_PBMC_UP SYSTEMATIC_NAME M9405 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE40184_HEALTHY_VS_HCV_INFECTED_DONOR_PBMC_UP NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes up-regulated in peripheral blood monocytes (PBMC): healthy donors versus patients with HCV infection. DESCRIPTION_FULL This study characterizes the effects of chronic Hepatitis C virus (HCV) infection on gene expression by analyzing blood samples from 10 treatment-naive HCV patients and 6 healthy volunteers. Differential expression analysis of microarray data from peripheral blood mononuclear cells (PBMCs) identified a 136 gene signature, including 66 genes elevated in infected individuals. Most of the up-regulated genes were associated with interferon (IFN) activity (including members of the OAS and MX families, ISG15 and IRF7), suggesting an ongoing immune response. This HCV signature was also found to be consistently enriched in many other viral infection and vaccination datasets. Validation of these genes was carried out using a second cohort composed of 5 HCV patients and 5 healthy volunteers, confirming the up-regulation of the IFN signature. In summary, this is the first study to directly compare blood transcriptional profiles from HCV patients with healthy controls. The results show that chronic HCV infection has a pronounced effect on gene expression in PBMCs of infected individuals, and significantly elevates the expression of a subset of interferon-stimulated genes. PMID 23067362 GEOID GSE40184 AUTHORS Bolen CR,Robek MD,Brodsky L,Schulz V,Lim JK,Taylor MW,Kleinstein SH CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE40184_3228_200_UP FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ABAT,ABL2,ACTG2,ADH4,ADK,AFF3,AHR,AK3,ALOX12,ALOX5,ANKRD39,ARHGAP28,ARL5B,ATF4,BARHL1,BAZ2B,BTBD6,C10orf90,C11orf16,C16orf70,C18orf54,C19orf59,C5AR1,C5orf51,C6orf211,C6orf48,CAPN6,CC2D2A,CCNT1,CCRN4L,CD33,CDC14B,CEP95,CLK2,CLYBL,CMPK2,COL2A1,CPLX2,CTTNBP2,CXCR5,CXXC5,CYB5R3,CYP2C18,DPP4,DVL2,DZIP1L,EGFR,EHHADH,EOMES,EPAS1,EPB42,EPN2,ESM1,F2RL1,FAM108B1,FAM171B,FAM195A,FAM55D,FAM69A,FAM73A,FCRL1,FGF13,FGFRL1,FLCN,FOXN2,GADD45A,GANC,GGA2,GPR137B,GPR155,GPR158,GPR39,GPRC5A,GRHL1,GRM4,HEY1,HMP19,HOXA1,HOXA5,HPCAL1,HSD3B1,HTR1D,IFNGR2,IFT88,IGFBP6,IL10RA,IL5,ILKAP,INTS9,IRF7,KCNA5,KCNC2,KLHDC2,KPNA4,KRAS,KRT80,KRTAP13-2,LACTB,LACTB2,LMBRD1,LOC729810,LRRK2,MAGED2,MAPK8,MARCH7,MAST1,MAT2A,MDN1,MEOX1,MESP2,MOBKL3,MST1R,MTFMT,MTFR1,MTHFD1L,MUTYH,NARS2,NEIL1,NINJ2,NMNAT3,NOBOX,NOP2,NR4A2,NUDT11,ORC4,OVGP1,P2RX4,PDS5B,PFKM,PLCB1,POGK,POLE3,POU6F1,PRF1,PTCH2,PTPLAD1,PTPN12,PURG,RAB3C,RALYL,RASA3,RHBDD2,RNF145,ROGDI,RPL31,RPS6KA6,RRN3,S1PR1,SCPEP1,SERPINA11,SH2D1A,SIGLEC7,SIM1,SLAIN1,SLC17A9,SLC22A4,SLC6A18,SLFN12,SNCA,SNX33,SP6,SRSF1,STEAP1,SVIL,TAF1C,TBC1D12,TBC1D4,TCN2,TMEM102,TMEM116,TMEM191C,TMEM216,TMEM65,TMTC4,TNFAIP6,TNFRSF11A,TOMM20,TPCN2,TPP1,TRIM35,TRPM7,TSC22D3,TSN,TTC13,TUBB2A,USP34,WDR34,WDR46,WEE2,WNT6,XRCC2,ZC4H2,ZCCHC18,ZFP41,ZMYM3,ZNF23,ZNF280B,ZNF354C,ZNF518B,ZNF623 GENE_SYMBOLS ABAT,ABL2,ACTG2,ADH4,ADK,AFF3,AHR,AK3,ALOX12,ALOX5,ANKRD39,ARHGAP28,ARL5B,ATF4,BARHL1,BAZ2B,BTBD6,C10orf90,C11orf16,PHAF1,C18orf54,MCEMP1,C5AR1,RIMOC1,ARMT1,SNHG32,CAPN6,CC2D2A,CCNT1,NOCT,CD33,CDC14B,CEP95,CLK2,CLYBL,CMPK2,COL2A1,CPLX2,CTTNBP2,CXCR5,CXXC5,CYB5R3,CYP2C18,DPP4,DVL2,DZIP1L,EGFR,EHHADH,EOMES,EPAS1,EPB42,EPN2,ESM1,F2RL1,ABHD17B,FAM171B,MCRIP2,NXPE4,DIPK1A,MIGA1,FCRL1,FGF13,FGFRL1,FLCN,FOXN2,GADD45A,GANC,GGA2,GPR137B,GPR155,GPR158,GPR39,GPRC5A,GRHL1,GRM4,HEY1,NSG2,HOXA1,HOXA5,HPCAL1,HSD3B1,HTR1D,IFNGR2,IFT88,IGFBP6,IL10RA,IL5,ILKAP,INTS9,IRF7,KCNA5,KCNC2,KLHDC2,KPNA4,KRAS,KRT80,KRTAP13-2,LACTB,LACTB2,LMBRD1,,LRRK2,MAGED2,MAPK8,MARCHF7,MAST1,MAT2A,MDN1,MEOX1,MESP2,MOB4,MST1R,MTFMT,MTFR1,MTHFD1L,MUTYH,NARS2,NEIL1,NINJ2,NMNAT3,NOBOX,NOP2,NR4A2,NUDT11,ORC4,OVGP1,P2RX4,PDS5B,PFKM,PLCB1,POGK,POLE3,POU6F1,PRF1,PTCH2,HACD3,PTPN12,PURG,RAB3C,RALYL,RASA3,RHBDD2,RNF145,ROGDI,RPL31,RPS6KA6,RRN3,S1PR1,SCPEP1,SERPINA11,SH2D1A,SIGLEC7,SIM1,SLAIN1,SLC17A9,SLC22A4,SLC6A18,SLFN12,SNCA,SNX33,SP6,SRSF1,STEAP1,SVIL,TAF1C,TBC1D12,TBC1D4,TCN2,TMEM102,TMEM116,TMEM191C,TMEM216,TMEM65,TMTC4,TNFAIP6,TNFRSF11A,TOMM20,TPCN2,TPP1,TRIM35,TRPM7,TSC22D3,TSN,TTC13,TUBB2A,USP34,DYNC2I2,WDR46,WEE2,WNT6,XRCC2,ZC4H2,ZCCHC18,ZFP41,ZMYM3,ZNF23,ZNF280B,ZNF354C,ZNF518B,ZNF623 FOUNDER_NAMES