STANDARD_NAME	GSE40274_EOS_VS_FOXP3_AND_EOS_TRANSDUCED_ACTIVATED_CD4_TCELL_DN
SYSTEMATIC_NAME	M9153
COLLECTION	C7:IMMUNESIGDB
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE40274_EOS_VS_FOXP3_AND_EOS_TRANSDUCED_ACTIVATED_CD4_TCELL_DN
NAMESPACE	HUMAN_GENE_SYMBOL
DESCRIPTION_BRIEF	Genes down-regulated in CD4 T conv over-expressing: IKZF4 [GeneID=64375] versus IKZF4 and FOXP3 [GeneID=64375;50943].
DESCRIPTION_FULL	The transcription factor FoxP3 partakes dominantly in the specification and function of FoxP3+ CD4+ T regulatory cells (Tregs), but is neither strictly necessary nor sufficient to determine the characteristic Treg transcriptional signature. Computational network inference and experimental testing assessed the contribution of several other transcription factors (TFs). Enforced expression of Helios or Xbp1 elicited specific signatures, but Eos, Irf4, Satb1, Lef1 and Gata1 elicited exactly the same outcome, synergizing with FoxP3 to activate most of the Treg signature, including key TFs, and enhancing FoxP3 occupancy at its genomic targets. Conversely, the Treg signature was robust to inactivation of any single cofactor. A redundant genetic switch thus locks-in the Treg phenotype, a model which accounts for several aspects of Treg physiology, differentiation and stability.
PMID	22961053
GEOID	GSE40274
AUTHORS	Fu W,Ergun A,Lu T,Hill JA,Haxhinasto S,Fassett MS,Gazit R,Adoro S,Glimcher L,Chan S,Kastner P,Rossi D,Collins JJ,Mathis D,Benoist C
CONTRIBUTOR	Jernej Godec
CONTRIBUTOR_ORG	Dana-Farber Cancer Institute
EXACT_SOURCE	GSE40274_1482_200_DN
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	0610008F07Rik,1110006G14Rik,1110015M06Rik,1700007I08Rik,1700010D01Rik,1700010H22Rik,1700010M22Rik,1700017B05Rik,1700080G18Rik,1700128F08Rik,1810011O10Rik,2010204K13Rik,2310003L06Rik,2310067E19Rik,2900041M22Rik,4921517D21Rik,4930407I10Rik,4930505O20Rik,4933427E13Rik,4933427I04Rik,5730528L13Rik,8430432A02Rik,9230110K08Rik,A630023P12Rik,A830019P07Rik,ACTL6B,ADARB2,AKR1D1,ALDH3A1,ALPPL2,ANO1,AQP6,ARVCF,AU042651,AURKA,B3GALNT1,BATF2,BC002189,C130021I20Rik,CAR11,CASKIN1,CC2D2A,CC2D2B,CER1,CES7,CHMP4C,CNIH2,CSNK1G1,CSPG5,CYP11B1,CYP2D10,CYP7B1,D630023F18Rik,DRD1A,DUSP3,DYSFIP1,EFCAB4A,ENAH,F830212C03Rik,FAM115C,FAM117A,FAM170A,FBLL1,FRMD7,FRMPD4,FUT4,GABRR2,GDF15,GH,GLI1,GLRA3,GM10007,GM10484,GM10672,GM10748,GM1082,GM11977,GM11992,GM16503,GM5793,GM6578,GM7348,GM7457,GM962,GM9871,GM9895,GM9921,GNG3,GRHL2,GRP,HCRTR2,HIST2H2BE,HSPB3,IGF2BP3,IL17D,IL28A,IQCA,ITIH2,KCNA1,KCNK18,KDM5C,KIRREL2,KLHL32,LHFPL5,LHX6,LRRC52,LRRC8B,LTK,MAFG,MAPK7,MASTL,MCTP1,MFAP3L,MIR125B-2,MIR329,MIR374,MIR377,MIR379,MIR421,MS4A1,MUC16,NFIB,NICN1,NKX2-6,NOSTRIN,NR2E3,NRAS,NRXN2,NUDT12,OBP1A,OLFR1122,OLFR1130,OLFR1248,OLFR1290,OLFR1329,OLFR1449,OLFR1480,OLFR1487,OLFR568,OLFR641,OLFR677,OLFR705,OLFR731,OLFR786,OLFR815,OLFR872,OLFR916,PAMR1,PAX2,PCDH8,PDYN,PELI2,PHXR2,PHYHD1,PILRA,PLXNA4,PON1,PON3,PPFIBP2,PRSS32,PRUNE2,PSG22,RAG2,RASSF9,RBMS3,RESP18,SGPP2,SLC16A10,SLC7A2,SLCO1C1,SMR3A,SOHLH1,SOX21,SPAG16,SPAG17,SPOCD1,SPRR2K,SPTLC3,STK35,STXBP1,SUPT3H,SYT8,TAAR3,TAS2R120,TAS2R139,TBC1D2,TCF7L1,TCTN2,TDO2,TMEM201,TRPD52L3,TRPV3,TTC36,TYMS-PS,VMN1R203,VMN2R18,VSX2,XIST,ZCCHC12,ZIK1
GENE_SYMBOLS	,,,,,,,,,,,,,,,,,,,,,,,,,ACTL6B,ADARB2,AKR1D1,ALDH3A1,ALPG,ANO1,AQP6,ARVCF,SLC25A48,AURKA,B3GALNT1,BATF2,,,,CASKIN1,CC2D2A,CC2D2B,CER1,CES5A,CHMP4C,CNIH2,CSNK1G1,CSPG5,CYP11B1,,CYP7B1,,,DUSP3,PPP1R27,CRACR2B,ENAH,,TCAF2,FAM117A,FAM170A,FBLL1,FRMD7,FRMPD4,FUT4,GABRR2,GDF15,GH1,GLI1,GLRA3,,,,,,,,,,,,,,,,,GNG3,GRHL2,GRP,HCRTR2,H2BC21,HSPB3,IGF2BP3,IL17D,IFNL2,IQCA1,ITIH2,KCNA1,KCNK18,KDM5C,KIRREL2,KLHL32,LHFPL5,LHX6,LRRC52,LRRC8B,LTK,MAFG,MAPK7,MASTL,MCTP1,MFAP3L,,,,MIR377,MIR379,MIR421,MS4A1,MUC16,NFIB,NICN1,NKX2-6,NOSTRIN,NR2E3,NRAS,NRXN2,NUDT12,,,,,,,,,,,,,,,,,,,PAMR1,PAX2,PCDH8,PDYN,PELI2,,PHYHD1,PILRA,PLXNA4,PON1,PON3,PPFIBP2,,PRUNE2,,RAG2,RASSF9,RBMS3,RESP18,SGPP2,SLC16A10,SLC7A2,SLCO1C1,SMR3A,SOHLH1,SOX21,SPAG16,SPAG17,SPOCD1,,SPTLC3,STK35,STXBP1,SUPT3H,SYT8,TAAR3P,,,TBC1D2,TCF7L1,TCTN2,TDO2,TMEM201,,TRPV3,TTC36,,,,VSX2,XIST,ZCCHC12,ZIK1
FOUNDER_NAMES