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     See license terms at www.gsea-msigdb.org/gsea/license_terms_list. Please note that certain gene sets have special access terms.
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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="GSE40274_EOS_VS_FOXP3_AND_EOS_TRANSDUCED_ACTIVATED_CD4_TCELL_DN" SYSTEMATIC_NAME="M9153" HISTORICAL_NAMES="" PMID="22961053" AUTHORS="Fu W,Ergun A,Lu T,Hill JA,Haxhinasto S,Fassett MS,Gazit R,Adoro S,Glimcher L,Chan S,Kastner P,Rossi D,Collins JJ,Mathis D,Benoist C" GEOID="GSE40274" EXACT_SOURCE="GSE40274_1482_200_DN" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="" CHIP="HUMAN_GENE_SYMBOL" CONTRIBUTOR="Jernej Godec" CONTRIBUTOR_ORG="Dana-Farber Cancer Institute" DESCRIPTION_BRIEF="Genes down-regulated in CD4 T conv over-expressing: IKZF4 [GeneID=64375] versus IKZF4 and FOXP3 [GeneID=64375;50943]." DESCRIPTION_FULL="The transcription factor FoxP3 partakes dominantly in the specification and function of FoxP3+ CD4+ T regulatory cells (Tregs), but is neither strictly necessary nor sufficient to determine the characteristic Treg transcriptional signature. Computational network inference and experimental testing assessed the contribution of several other transcription factors (TFs). Enforced expression of Helios or Xbp1 elicited specific signatures, but Eos, Irf4, Satb1, Lef1 and Gata1 elicited exactly the same outcome, synergizing with FoxP3 to activate most of the Treg signature, including key TFs, and enhancing FoxP3 occupancy at its genomic targets. Conversely, the Treg signature was robust to inactivation of any single cofactor. A redundant genetic switch thus locks-in the Treg phenotype, a model which accounts for several aspects of Treg physiology, differentiation and stability." TAGS="" MEMBERS="0610008F07Rik,1110006G14Rik,1110015M06Rik,1700007I08Rik,1700010D01Rik,1700010H22Rik,1700010M22Rik,1700017B05Rik,1700080G18Rik,1700128F08Rik,1810011O10Rik,2010204K13Rik,2310003L06Rik,2310067E19Rik,2900041M22Rik,4921517D21Rik,4930407I10Rik,4930505O20Rik,4933427E13Rik,4933427I04Rik,5730528L13Rik,8430432A02Rik,9230110K08Rik,A630023P12Rik,A830019P07Rik,ACTL6B,ADARB2,AKR1D1,ALDH3A1,ALPPL2,ANO1,AQP6,ARVCF,AU042651,AURKA,B3GALNT1,BATF2,BC002189,C130021I20Rik,CAR11,CASKIN1,CC2D2A,CC2D2B,CER1,CES7,CHMP4C,CNIH2,CSNK1G1,CSPG5,CYP11B1,CYP2D10,CYP7B1,D630023F18Rik,DRD1A,DUSP3,DYSFIP1,EFCAB4A,ENAH,F830212C03Rik,FAM115C,FAM117A,FAM170A,FBLL1,FRMD7,FRMPD4,FUT4,GABRR2,GDF15,GH,GLI1,GLRA3,GM10007,GM10484,GM10672,GM10748,GM1082,GM11977,GM11992,GM16503,GM5793,GM6578,GM7348,GM7457,GM962,GM9871,GM9895,GM9921,GNG3,GRHL2,GRP,HCRTR2,HIST2H2BE,HSPB3,IGF2BP3,IL17D,IL28A,IQCA,ITIH2,KCNA1,KCNK18,KDM5C,KIRREL2,KLHL32,LHFPL5,LHX6,LRRC52,LRRC8B,LTK,MAFG,MAPK7,MASTL,MCTP1,MFAP3L,MIR125B-2,MIR329,MIR374,MIR377,MIR379,MIR421,MS4A1,MUC16,NFIB,NICN1,NKX2-6,NOSTRIN,NR2E3,NRAS,NRXN2,NUDT12,OBP1A,OLFR1122,OLFR1130,OLFR1248,OLFR1290,OLFR1329,OLFR1449,OLFR1480,OLFR1487,OLFR568,OLFR641,OLFR677,OLFR705,OLFR731,OLFR786,OLFR815,OLFR872,OLFR916,PAMR1,PAX2,PCDH8,PDYN,PELI2,PHXR2,PHYHD1,PILRA,PLXNA4,PON1,PON3,PPFIBP2,PRSS32,PRUNE2,PSG22,RAG2,RASSF9,RBMS3,RESP18,SGPP2,SLC16A10,SLC7A2,SLCO1C1,SMR3A,SOHLH1,SOX21,SPAG16,SPAG17,SPOCD1,SPRR2K,SPTLC3,STK35,STXBP1,SUPT3H,SYT8,TAAR3,TAS2R120,TAS2R139,TBC1D2,TCF7L1,TCTN2,TDO2,TMEM201,TRPD52L3,TRPV3,TTC36,TYMS-PS,VMN1R203,VMN2R18,VSX2,XIST,ZCCHC12,ZIK1" MEMBERS_SYMBOLIZED="ACTL6B,ADARB2,AKR1D1,ALDH3A1,ALPG,ANO1,AQP6,ARVCF,AURKA,B3GALNT1,BATF2,CASKIN1,CC2D2A,CC2D2B,CER1,CES5A,CHMP4C,CNIH2,CRACR2B,CSNK1G1,CSPG5,CYP11B1,CYP7B1,DUSP3,ENAH,FAM117A,FAM170A,FBLL1,FRMD7,FRMPD4,FUT4,GABRR2,GDF15,GH1,GLI1,GLRA3,GNG3,GRHL2,GRP,H2BC21,HCRTR2,HSPB3,IFNL2,IGF2BP3,IL17D,IQCA1,ITIH2,KCNA1,KCNK18,KDM5C,KIRREL2,KLHL32,LHFPL5,LHX6,LRRC52,LRRC8B,LTK,MAFG,MAPK7,MASTL,MCTP1,MFAP3L,MIR377,MIR379,MIR421,MS4A1,MUC16,NFIB,NICN1,NKX2-6,NOSTRIN,NR2E3,NRAS,NRXN2,NUDT12,PAMR1,PAX2,PCDH8,PDYN,PELI2,PHYHD1,PILRA,PLXNA4,PON1,PON3,PPFIBP2,PPP1R27,PRUNE2,RAG2,RASSF9,RBMS3,RESP18,SGPP2,SLC16A10,SLC25A48,SLC7A2,SLCO1C1,SMR3A,SOHLH1,SOX21,SPAG16,SPAG17,SPOCD1,SPTLC3,STK35,STXBP1,SUPT3H,SYT8,TAAR3P,TBC1D2,TCAF2,TCF7L1,TCTN2,TDO2,TMEM201,TRPV3,TTC36,VSX2,XIST,ZCCHC12,ZIK1" MEMBERS_EZID="10002,105,10643,10675,11166,114792,115677,116071,116729,117247,130367,137814,140901,143941,153328,1584,158471,162514,170261,1845,199953,200162,218,221223,222662,23507,251,2526,254263,254295,2570,25891,26468,2688,26952,27303,2735,2785,282616,283229,284307,285966,2922,29992,3062,338567,338917,340069,345630,363,3698,3736,387707,389075,402381,4058,4097,421,440699,4781,4893,494326,494328,5076,5100,51412,5173,53342,53919,53944,5444,5446,55107,55304,55357,55740,5598,57161,57524,57545,5897,6542,6718,6790,6812,693122,6999,7503,79582,79772,79781,79867,79977,8001,81558,8242,83439,8349,83594,84063,84276,8464,84930,8495,8706,8988,90019,90167,90853,91584,9182,92421,9288,931,9350,9379,94025,9420,9518,9758,9848" MEMBERS_MAPPING="0610008F07Rik,null,null|1110006G14Rik,null,null|1110015M06Rik,null,null|1700007I08Rik,null,null|1700010D01Rik,null,null|1700010H22Rik,null,null|1700010M22Rik,null,null|1700017B05Rik,null,null|1700080G18Rik,null,null|1700128F08Rik,null,null|1810011O10Rik,null,null|2010204K13Rik,null,null|2310003L06Rik,null,null|2310067E19Rik,null,null|2900041M22Rik,null,null|4921517D21Rik,null,null|4930407I10Rik,null,null|4930505O20Rik,null,null|4933427E13Rik,null,null|4933427I04Rik,null,null|5730528L13Rik,null,null|8430432A02Rik,null,null|9230110K08Rik,null,null|A630023P12Rik,null,null|A830019P07Rik,null,null|ACTL6B,ACTL6B,51412|ADARB2,ADARB2,105|AKR1D1,AKR1D1,6718|ALDH3A1,ALDH3A1,218|ALPPL2,ALPG,251|ANO1,ANO1,55107|AQP6,AQP6,363|ARVCF,ARVCF,421|AU042651,SLC25A48,153328|AURKA,AURKA,6790|B3GALNT1,B3GALNT1,8706|BATF2,BATF2,116071|BC002189,null,null|C130021I20Rik,null,null|CAR11,null,null|CASKIN1,CASKIN1,57524|CC2D2A,CC2D2A,57545|CC2D2B,CC2D2B,387707|CER1,CER1,9350|CES7,CES5A,221223|CHMP4C,CHMP4C,92421|CNIH2,CNIH2,254263|CSNK1G1,CSNK1G1,53944|CSPG5,CSPG5,10675|CYP11B1,CYP11B1,1584|CYP2D10,null,null|CYP7B1,CYP7B1,9420|D630023F18Rik,null,null|DRD1A,null,null|DUSP3,DUSP3,1845|DYSFIP1,PPP1R27,116729|EFCAB4A,CRACR2B,283229|ENAH,ENAH,55740|F830212C03Rik,null,null|FAM115C,TCAF2,285966|FAM117A,FAM117A,81558|FAM170A,FAM170A,340069|FBLL1,FBLL1,345630|FRMD7,FRMD7,90167|FRMPD4,FRMPD4,9758|FUT4,FUT4,2526|GABRR2,GABRR2,2570|GDF15,GDF15,9518|GH,GH1,2688|GLI1,GLI1,2735|GLRA3,GLRA3,8001|GM10007,null,null|GM10484,null,null|GM10672,null,null|GM10748,null,null|GM1082,null,null|GM11977,null,null|GM11992,null,null|GM16503,null,null|GM5793,null,null|GM6578,null,null|GM7348,null,null|GM7457,null,null|GM962,null,null|GM9871,null,null|GM9895,null,null|GM9921,null,null|GNG3,GNG3,2785|GRHL2,GRHL2,79977|GRP,GRP,2922|HCRTR2,HCRTR2,3062|HIST2H2BE,H2BC21,8349|HSPB3,HSPB3,8988|IGF2BP3,IGF2BP3,10643|IL17D,IL17D,53342|IL28A,IFNL2,282616|IQCA,IQCA1,79781|ITIH2,ITIH2,3698|KCNA1,KCNA1,3736|KCNK18,KCNK18,338567|KDM5C,KDM5C,8242|KIRREL2,KIRREL2,84063|KLHL32,KLHL32,114792|LHFPL5,LHFPL5,222662|LHX6,LHX6,26468|LRRC52,LRRC52,440699|LRRC8B,LRRC8B,23507|LTK,LTK,4058|MAFG,MAFG,4097|MAPK7,MAPK7,5598|MASTL,MASTL,84930|MCTP1,MCTP1,79772|MFAP3L,MFAP3L,9848|MIR125B-2,null,null|MIR329,null,null|MIR374,null,null|MIR377,MIR377,494326|MIR379,MIR379,494328|MIR421,MIR421,693122|MS4A1,MS4A1,931|MUC16,MUC16,94025|NFIB,NFIB,4781|NICN1,NICN1,84276|NKX2-6,NKX2-6,137814|NOSTRIN,NOSTRIN,115677|NR2E3,NR2E3,10002|NRAS,NRAS,4893|NRXN2,NRXN2,9379|NUDT12,NUDT12,83594|OBP1A,null,null|OLFR1122,null,null|OLFR1130,null,null|OLFR1248,null,null|OLFR1290,null,null|OLFR1329,null,null|OLFR1449,null,null|OLFR1480,null,null|OLFR1487,null,null|OLFR568,null,null|OLFR641,null,null|OLFR677,null,null|OLFR705,null,null|OLFR731,null,null|OLFR786,null,null|OLFR815,null,null|OLFR872,null,null|OLFR916,null,null|PAMR1,PAMR1,25891|PAX2,PAX2,5076|PCDH8,PCDH8,5100|PDYN,PDYN,5173|PELI2,PELI2,57161|PHXR2,null,null|PHYHD1,PHYHD1,254295|PILRA,PILRA,29992|PLXNA4,PLXNA4,91584|PON1,PON1,5444|PON3,PON3,5446|PPFIBP2,PPFIBP2,8495|PRSS32,null,null|PRUNE2,PRUNE2,158471|PSG22,null,null|RAG2,RAG2,5897|RASSF9,RASSF9,9182|RBMS3,RBMS3,27303|RESP18,RESP18,389075|SGPP2,SGPP2,130367|SLC16A10,SLC16A10,117247|SLC7A2,SLC7A2,6542|SLCO1C1,SLCO1C1,53919|SMR3A,SMR3A,26952|SOHLH1,SOHLH1,402381|SOX21,SOX21,11166|SPAG16,SPAG16,79582|SPAG17,SPAG17,200162|SPOCD1,SPOCD1,90853|SPRR2K,null,null|SPTLC3,SPTLC3,55304|STK35,STK35,140901|STXBP1,STXBP1,6812|SUPT3H,SUPT3H,8464|SYT8,SYT8,90019|TAAR3,TAAR3P,9288|TAS2R120,null,null|TAS2R139,null,null|TBC1D2,TBC1D2,55357|TCF7L1,TCF7L1,83439|TCTN2,TCTN2,79867|TDO2,TDO2,6999|TMEM201,TMEM201,199953|TRPD52L3,null,null|TRPV3,TRPV3,162514|TTC36,TTC36,143941|TYMS-PS,null,null|VMN1R203,null,null|VMN2R18,null,null|VSX2,VSX2,338917|XIST,XIST,7503|ZCCHC12,ZCCHC12,170261|ZIK1,ZIK1,284307" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="C7" ORGANISM="Mus musculus" SUB_CATEGORY_CODE="IMMUNESIGDB"/>
</MSIGDB>
