STANDARD_NAME GSE40274_HELIOS_VS_FOXP3_AND_HELIOS_TRANSDUCED_ACTIVATED_CD4_TCELL_DN SYSTEMATIC_NAME M9168 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE40274_HELIOS_VS_FOXP3_AND_HELIOS_TRANSDUCED_ACTIVATED_CD4_TCELL_DN NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes down-regulated in CD4 T conv over-expressing IKZF2 [GeneID=22807] versus IKZF2 and FOX3P [GeneID=22807;50943]. DESCRIPTION_FULL The transcription factor FoxP3 partakes dominantly in the specification and function of FoxP3+ CD4+ T regulatory cells (Tregs), but is neither strictly necessary nor sufficient to determine the characteristic Treg transcriptional signature. Computational network inference and experimental testing assessed the contribution of several other transcription factors (TFs). Enforced expression of Helios or Xbp1 elicited specific signatures, but Eos, Irf4, Satb1, Lef1 and Gata1 elicited exactly the same outcome, synergizing with FoxP3 to activate most of the Treg signature, including key TFs, and enhancing FoxP3 occupancy at its genomic targets. Conversely, the Treg signature was robust to inactivation of any single cofactor. A redundant genetic switch thus locks-in the Treg phenotype, a model which accounts for several aspects of Treg physiology, differentiation and stability. PMID 22961053 GEOID GSE40274 AUTHORS Fu W,Ergun A,Lu T,Hill JA,Haxhinasto S,Fassett MS,Gazit R,Adoro S,Glimcher L,Chan S,Kastner P,Rossi D,Collins JJ,Mathis D,Benoist C CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE40274_1488_200_DN FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ABI3,ACAT1,ACOT7,ACP5,ACPL2,ACTR2,AFP,AGFG2,AGK,ANTXR2,ARHGAP29,ARHGEF6,ARMC7,ATP6V0A2,ATPBD4,BACE1,BACH2,BPGM,C14orf159,C16orf61,C1orf55,CACNG4,CCR9,CD247,CD84,CDYL,CENPJ,CEP78,CHMP6,CIRH1A,CKB,CLIC1,CLTB,CNGA1,COL1A2,COL23A1,COL6A2,CORO1C,CPM,CRTAM,CSNK1G2,CTPS,DET1,DNTTIP1,DTX2,DUSP12,DZIP1,EFNA4,EMILIN1,ENDOU,ENG,ENTPD5,EPHB6,EPHX4,EXOC5,EXTL3,F2R,FAM188A,FLOT2,FXYD5,GBP2,GPATCH4,H19,HAUS4,HDAC5,HIVEP3,HSDL1,HSPA1B,ID2,IFT57,IGFBP4,IKZF1,IL1RAPL1,IL1RL2,IL21,INPP1,IPO11,IPP,IQCG,ITGA8,ITGB3,ITPR1,KBTBD7,KHDRBS3,KIAA0247,KIAA1147,KIAA1715,KIAA1967,KLK8,LAT,LEF1,LOC100129269,LPAR6,LXN,LYPD6B,MBOAT1,MCTP2,METTL2B,MORF4L2,MPDU1,MPHOSPH6,MRPL19,MSL2,MTAP,MYL10,MYLPF,NAA16,NCBP1,NRGN,OXCT1,PACS2,PACSIN1,PAG1,PDE3B,PDLIM5,PDXK,PGGT1B,PGLYRP2,PHF20,PITRM1,PJA1,PLCB2,PLCE1,PLXND1,POP1,PPM1F,PPRC1,PTGFRN,PXMP4,QPCT,QRICH1,RAB35,RAP1A,RBM15B,RCBTB1,RCBTB2,REPIN1,RNF113A,ROBO1,RPH3AL,RUNX3,SAG,SALL2,SATB1,SCML4,SCOC,SEMA4A,SEPSECS,SEPT9,SGK223,SGPL1,SHC1,SLC12A5,SLC16A10,SLC39A11,SLC39A14,SLC9A9,SMAD1,SNX30,SPPL2A,SPRYD4,SPSB1,SSBP4,SSNA1,SSR1,ST3GAL6,TBL1X,TCF20,TDRKH,TET1,TGFBR3,TM6SF1,TMCC3,TMEM164,TMEM185A,TMEM48,TMEM53,TMEM59L,TMIE,TSEN2,TSGA14,TSNAX,TSPYL4,USP12,USP36,VOPP1,WBSCR22,WDR45L,XPO1,XRCC6BP1,ZBED4,ZNF22,ZNF330,ZNF467,ZNF597,ZNF623,ZNF629,ZNF770,ZNF799,ZRSR2 GENE_SYMBOLS ABI3,ACAT1,ACOT7,ACP5,PXYLP1,ACTR2,AFP,AGFG2,AGK,ANTXR2,ARHGAP29,ARHGEF6,ARMC7,ATP6V0A2,DPH6,BACE1,BACH2,BPGM,DGLUCY,CMC2,SDE2,CACNG4,CCR9,CD247,CD84,CDYL,CENPJ,CEP78,CHMP6,UTP4,CKB,CLIC1,CLTB,CNGA1,COL1A2,COL23A1,COL6A2,CORO1C,CPM,CRTAM,CSNK1G2,CTPS1,DET1,DNTTIP1,DTX2,DUSP12,DZIP1,EFNA4,EMILIN1,ENDOU,ENG,ENTPD5,EPHB6,EPHX4,EXOC5,EXTL3,F2R,MINDY3,FLOT2,FXYD5,GBP2,GPATCH4,H19,HAUS4,HDAC5,HIVEP3,HSDL1,HSPA1B,ID2,IFT57,IGFBP4,IKZF1,IL1RAPL1,IL1RL2,IL21,INPP1,IPO11,IPP,IQCG,ITGA8,ITGB3,ITPR1,KBTBD7,KHDRBS3,SUSD6,DENND11,LNPK,CCAR2,KLK8,LAT,LEF1,LINC01160,LPAR6,LXN,LYPD6B,MBOAT1,MCTP2,METTL2B,MORF4L2,MPDU1,MPHOSPH6,MRPL19,MSL2,MTAP,MYL10,MYL11,NAA16,NCBP1,NRGN,OXCT1,PACS2,PACSIN1,PAG1,PDE3B,PDLIM5,PDXK,PGGT1B,PGLYRP2,PHF20,PITRM1,PJA1,PLCB2,PLCE1,PLXND1,POP1,PPM1F,PPRC1,PTGFRN,PXMP4,QPCT,QRICH1,RAB35,RAP1A,RBM15B,RCBTB1,RCBTB2,REPIN1,RNF113A,ROBO1,RPH3AL,RUNX3,SAG,SALL2,SATB1,SCML4,SCOC,SEMA4A,SEPSECS,SEPTIN9,,SGPL1,SHC1,SLC12A5,SLC16A10,SLC39A11,SLC39A14,SLC9A9,SMAD1,SNX30,SPPL2A,SPRYD4,SPSB1,SSBP4,SSNA1,SSR1,ST3GAL6,TBL1X,TCF20,TDRKH,TET1,TGFBR3,TM6SF1,TMCC3,TMEM164,TMEM185A,NDC1,TMEM53,TMEM59L,TMIE,TSEN2,CEP41,TSNAX,TSPYL4,USP12,USP36,VOPP1,BUD23,WDR45B,XPO1,ATP23,ZBED4,ZNF22,ZNF330,ZNF467,ZNF597,ZNF623,ZNF629,ZNF770,ZNF799,ZRSR2 FOUNDER_NAMES