STANDARD_NAME GSE40666_UNTREATED_VS_IFNA_STIM_STAT4_KO_EFFECTOR_CD8_TCELL_90MIN_UP SYSTEMATIC_NAME M9237 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE40666_UNTREATED_VS_IFNA_STIM_STAT4_KO_EFFECTOR_CD8_TCELL_90MIN_UP NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes up-regulated in CD8 T cells with STAT4 [GeneID=6775]: untreated versus interferon alpha. DESCRIPTION_FULL Type 1 IFNs can conditionally activate all of the signal transducers and activators of transcription molecules (STATs), including STAT4. The best-characterized signaling pathways use STAT1, however, and type 1 IFN inhibition of cell proliferation is STAT1 dependent. We report that type 1 IFNs can basally stimulate STAT1- and STAT4- dependent effects in CD8 T cells, but that CD8 T cells responding to infections of mice with lymphocytic choriomenigitis virus have elevated STAT4 and lower STAT1 expression with significant consequences for modifying the effects of type 1 IFN exposure. The phenotype was associated with preferential type 1 IFN activation of STAT4 as compared to STAT1. Stimulation through the TCR induced elevated STAT4 expression, and STAT4 was required for peak expansion of antigen-specific CD8 T cells, low STAT1 levels, and resistance to type 1 IFN-mediated inhibition of proliferation. Thus, a mechanism is discovered for regulating the consequences of type 1 IFN exposure in CD8 T cells, with STAT4 acting as a key molecule in driving optimal antigen-specific responses and overcoming STAT1-dependent inhibition of proliferation. PMID 22968462 GEOID GSE40666 AUTHORS Gil MP,Ploquin MJ,Watford WT,Lee SH,Kim K,Wang X,Kanno Y,O'Shea JJ,Biron CA CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE40666_3509_200_UP FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ACOT4,ACP5,ACTG1,ADAT1,AGPS,AHR,AK8,ANXA4,AP2S1,APOBEC3B,ARF1,ARHGAP44,ARHGDIA,ARID5A,ARL3,ASNA1,ASPM,AZIN1,BAIAP3,BAK1,BHLHE40,BMF,BUB1,C10orf54,C12orf74,C12orf75,C16orf54,C19orf22,C1orf85,C21orf7,C6orf105,C8orf80,CAMKK2,CAPG,CAPZB,CASP10,CCDC24,CCNE1,CD151,CD226,CDC34,CDYL2,CECR1,CENPE,CHAD,CHN2,CMTM7,CORO7,CPPED1,CUTA,CYFIP1,DAXX,DCPS,DNAH8,DPYSL2,DUSP2,EBI3,ECE1,EHD1,EZH2,FAM102A,GPR77,GPRC5D,GPRIN3,GRAMD1B,GSTK1,GTDC1,GUSB,HCK,HIPK2,HIST1H2BM,HJURP,HK1,HMOX1,HMOX2,HN1,HPGD,HYOU1,IER2,IL6R,ILDR1,INPP4A,IRF5,ITGA3,ITGAM,ITGAX,ITPK1,ITPRIPL2,KCNA2,KCNH2,KCNQ5,KEAP1,KIAA0240,KIAA1539,KLF8,KPNA2,LDLR,LGALSL,LILRB4,LPXN,LTK,MAPKAPK3,MARCKS,MCM6,MGLL,MLKL,MOB3A,MRPL4,MSC,MT2A,MTMR14,MYO1F,NANS,NAPSA,NCF2,NCOA4,NDC80,NDST1,NLRC5,OAS1,OGDH,PFN1,PI4K2A,PITPNC1,PLCG2,PLEKHA7,PLIN2,PLK4,PRDM1,PRR11,PSEN2,PTAFR,PTPN1,QPCTL,RANBP3,RASGRF1,RASGRP1,RASSF2,RASSF6,RHOF,RHOG,RNFT2,RSU1,RUNX3,S100A11,SAMD13,SCAMP5,SCFD1,SDF4,SEC14L1,SEC24D,SEC61B,SETD8,SFXN1,SH3BGRL3,SHMT2,SLAMF7,SLC16A10,SLC1A5,SLC43A3,SLC5A3,SLC7A5,SLCO3A1,SND1,SPATS2,SRM,STK38,STK38L,SUOX,TAGLN2,TAP1,TBC1D27,TCIRG1,TET2,TFDP1,TFEB,TIAM2,TNFRSF17,TRAM2,TRERF1,TRIB1,TRIM47,TUFT1,UBE2G1,UBE2L3,UBE2N,USP28,USP46,VDR,VOPP1,XBP1,YKT6,YPEL3,YWHAH,ZBP1,ZBTB32,ZBTB7A,ZDHHC16,ZYG11A,ZYX GENE_SYMBOLS ACOT4,ACP5,ACTG1,ADAT1,AGPS,AHR,AK8,ANXA4,AP2S1,APOBEC3B,ARF1,ARHGAP44,ARHGDIA,ARID5A,ARL3,GET3,ASPM,AZIN1,BAIAP3,BAK1,BHLHE40,BMF,BUB1,VSIR,PLEKHG7,C12orf75,C16orf54,R3HDM4,GLMP,MAP3K7CL,ADTRP,NUGGC,CAMKK2,CAPG,CAPZB,CASP10,CCDC24,CCNE1,CD151,CD226,CDC34,CDYL2,ADA2,CENPE,CHAD,CHN2,CMTM7,CORO7,CPPED1,CUTA,CYFIP1,DAXX,DCPS,DNAH8,DPYSL2,DUSP2,EBI3,ECE1,EHD1,EZH2,EEIG1,C5AR2,GPRC5D,GPRIN3,GRAMD1B,GSTK1,GTDC1,GUSB,HCK,HIPK2,H2BC14,HJURP,HK1,HMOX1,HMOX2,JPT1,HPGD,HYOU1,IER2,IL6R,ILDR1,INPP4A,IRF5,ITGA3,ITGAM,ITGAX,ITPK1,ITPRIPL2,KCNA2,KCNH2,KCNQ5,KEAP1,BICRAL,ATOSB,KLF8,KPNA2,LDLR,LGALSL,LILRB4,LPXN,LTK,MAPKAPK3,MARCKS,MCM6,MGLL,MLKL,MOB3A,MRPL4,MSC,MT2A,MTMR14,MYO1F,NANS,NAPSA,NCF2,NCOA4,NDC80,NDST1,NLRC5,OAS1,OGDH,PFN1,PI4K2A,PITPNC1,PLCG2,PLEKHA7,PLIN2,PLK4,PRDM1,PRR11,PSEN2,PTAFR,PTPN1,QPCTL,RANBP3,RASGRF1,RASGRP1,RASSF2,RASSF6,RHOF,RHOG,RNFT2,RSU1,RUNX3,S100A11,SAMD13,SCAMP5,SCFD1,SDF4,SEC14L1,SEC24D,SEC61B,KMT5A,SFXN1,SH3BGRL3,SHMT2,SLAMF7,SLC16A10,SLC1A5,SLC43A3,SLC5A3,SLC7A5,SLCO3A1,SND1,SPATS2,SRM,STK38,STK38L,SUOX,TAGLN2,TAP1,TBC1D27P,TCIRG1,TET2,TFDP1,TFEB,TIAM2,TNFRSF17,TRAM2,TRERF1,TRIB1,TRIM47,TUFT1,UBE2G1,UBE2L3,UBE2N,USP28,USP46,VDR,VOPP1,XBP1,YKT6,YPEL3,YWHAH,ZBP1,ZBTB32,ZBTB7A,ZDHHC16,ZYG11A,ZYX FOUNDER_NAMES