STANDARD_NAME GSE40666_WT_VS_STAT1_KO_CD8_TCELL_WITH_IFNA_STIM_90MIN_DN SYSTEMATIC_NAME M9215 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE40666_WT_VS_STAT1_KO_CD8_TCELL_WITH_IFNA_STIM_90MIN_DN NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes down-regulated in CD8 T cells treated by interferon alpha: STAT1 [GeneID=6772] knockout versus STAT4 [GeneID=6775]. DESCRIPTION_FULL Type 1 IFNs can conditionally activate all of the signal transducers and activators of transcription molecules (STATs), including STAT4. The best-characterized signaling pathways use STAT1, however, and type 1 IFN inhibition of cell proliferation is STAT1 dependent. We report that type 1 IFNs can basally stimulate STAT1- and STAT4- dependent effects in CD8 T cells, but that CD8 T cells responding to infections of mice with lymphocytic choriomenigitis virus have elevated STAT4 and lower STAT1 expression with significant consequences for modifying the effects of type 1 IFN exposure. The phenotype was associated with preferential type 1 IFN activation of STAT4 as compared to STAT1. Stimulation through the TCR induced elevated STAT4 expression, and STAT4 was required for peak expansion of antigen-specific CD8 T cells, low STAT1 levels, and resistance to type 1 IFN-mediated inhibition of proliferation. Thus, a mechanism is discovered for regulating the consequences of type 1 IFN exposure in CD8 T cells, with STAT4 acting as a key molecule in driving optimal antigen-specific responses and overcoming STAT1-dependent inhibition of proliferation. PMID 22968462 GEOID GSE40666 AUTHORS Gil MP,Ploquin MJ,Watford WT,Lee SH,Kim K,Wang X,Kanno Y,O'Shea JJ,Biron CA CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE40666_3514_200_DN FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ABI2,ADCY6,AKAP1,AKR1C3,ALDH2,ALMS1,APITD1,ARMCX1,ARMCX6,ASF1B,ATAD5,ATP9A,BASP1,BCL3,BIRC5,BLM,BRCA2,BZRAP1,C13orf15,C1orf130,C20orf27,C2orf29,C9orf3,CA2,CACNG4,CAPG,CBFB,CCR9,CD7,CDC6,CDCA5,CDCA8,CDK1,CDK2,CENPK,CENPM,CENPP,CENPW,CHEK1,CHL1,CKAP2L,CKB,CKS1B,CKS2,CLSPN,CTSW,CUX1,DCLRE1A,DHFR,DHX58,DMRT1,DNMT3A,DNTT,DSCC1,E2F1,E2F3,ECT2,EGR2,EIF2AK2,EIF4E3,ENTPD7,EPHB6,EXO1,EZH2,FABP5,FAM110B,FAM168A,FAP,FAR1,GMNN,GNB4,GPR171,GPR97,GPRASP2,GSK3B,GTF2IRD1,GTF3C1,H2AFZ,HELLS,HNRNPD,HSPA4L,IFI27L2,IFI44,IFI44L,IFIH1,IFIT1B,IL21,ISG20,JAZF1,KHDRBS3,KIAA0101,KLC3,KLF12,KNTC1,LHX2,LIG1,LITAF,LMF1,LMNA,LRR1,LXN,MAD2L1,MAP2,MCM10,MCM4,MCM5,MCM8,MELK,MFSD10,MMS22L,MSN,MX1,MX2,MXD1,N4BP2,NCAPG2,NCOA7,NDC80,NDRG1,NETO2,NIM1,NR4A1,OAS2,OIP5,PAK1,PARD6G,PARP9,PCNA,PLEKHO1,PLOD2,PLXND1,PML,POLE,POP1,PPM1B,PRR11,PSTPIP2,PTGFRN,PTGIR,PTPRS,PURG,PUS10,RAB10,RAD54L,RAPH1,RASL11B,RDBP,RFC2,RFC3,RFC4,RNF213,RRAGD,RRM2,RSAD2,RTN3,RTP4,RUNDC3A,RWDD4,SALL2,SHCBP1,SLC25A38,SLC2A9,SMC2,SMOX,SMPD4,SOX4,SPC25,SPSB1,ST3GAL1,STAT5A,SYCE2,TACC2,TBC1D19,TCF19,TFRC,THOC4,TK1,TLE3,TMEM64,TMIE,TOP2A,TOR1AIP2,TP53BP1,TRAF4,TRAFD1,TRIM25,TRIP13,TSC22D1,TUBA4A,TUBB,TUBB3,UBE4B,VIM,WDR78,WEE1,YPEL2,ZCCHC12,ZNF821,ZUFSP,ZWILCH GENE_SYMBOLS ABI2,ADCY6,AKAP1,AKR1C3,ALDH2,ALMS1,CENPS,ARMCX1,ARMCX6,ASF1B,ATAD5,ATP9A,BASP1,BCL3,BIRC5,BLM,BRCA2,TSPOAP1,RGCC,NCMAP,ADISSP,CNOT11,AOPEP,CA2,CACNG4,CAPG,CBFB,CCR9,CD7,CDC6,CDCA5,CDCA8,CDK1,CDK2,CENPK,CENPM,CENPP,CENPW,CHEK1,CHL1,CKAP2L,CKB,CKS1B,CKS2,CLSPN,CTSW,CUX1,DCLRE1A,DHFR,DHX58,DMRT1,DNMT3A,DNTT,DSCC1,E2F1,E2F3,ECT2,EGR2,EIF2AK2,EIF4E3,ENTPD7,EPHB6,EXO1,EZH2,FABP5,FAM110B,FAM168A,FAP,FAR1,GMNN,GNB4,GPR171,ADGRG3,GPRASP2,GSK3B,GTF2IRD1,GTF3C1,H2AZ1,HELLS,HNRNPD,HSPA4L,IFI27L2,IFI44,IFI44L,IFIH1,IFIT1B,IL21,ISG20,JAZF1,KHDRBS3,PCLAF,KLC3,KLF12,KNTC1,LHX2,LIG1,LITAF,LMF1,LMNA,LRR1,LXN,MAD2L1,MAP2,MCM10,MCM4,MCM5,MCM8,MELK,MFSD10,MMS22L,MSN,MX1,MX2,MXD1,N4BP2,NCAPG2,NCOA7,NDC80,NDRG1,NETO2,NIM1K,NR4A1,OAS2,OIP5,PAK1,PARD6G,PARP9,PCNA,PLEKHO1,PLOD2,PLXND1,PML,POLE,POP1,PPM1B,PRR11,PSTPIP2,PTGFRN,PTGIR,PTPRS,PURG,PUS10,RAB10,RAD54L,RAPH1,RASL11B,NELFE,RFC2,RFC3,RFC4,RNF213,RRAGD,RRM2,RSAD2,RTN3,RTP4,RUNDC3A,RWDD4,SALL2,SHCBP1,SLC25A38,SLC2A9,SMC2,SMOX,SMPD4,SOX4,SPC25,SPSB1,ST3GAL1,STAT5A,SYCE2,TACC2,TBC1D19,TCF19,TFRC,ALYREF,TK1,TLE3,TMEM64,TMIE,TOP2A,TOR1AIP2,TP53BP1,TRAF4,TRAFD1,TRIM25,TRIP13,TSC22D1,TUBA4A,TUBB,TUBB3,UBE4B,VIM,DNAI4,WEE1,YPEL2,ZCCHC12,ZNF821,ZUP1,ZWILCH FOUNDER_NAMES