STANDARD_NAME GSE41867_DAY15_EFFECTOR_VS_DAY30_MEMORY_CD8_TCELL_LCMV_ARMSTRONG_DN SYSTEMATIC_NAME M9521 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE41867_DAY15_EFFECTOR_VS_DAY30_MEMORY_CD8_TCELL_LCMV_ARMSTRONG_DN NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes down-regulated in CD5 T cells at acute infection with LCMV-Armstrong: effectors at day 15 versus memory at day 30. DESCRIPTION_FULL During acute viral infections, naïve CD8+ T cells differentiate into effector CD8+ T cells and, after viral control, into memory CD8+ T cells. Memory CD8+ T cells are highly functional, proliferate rapidly upon reinfection and persist long-term without antigen. In contrast, during chronic infections, CD8+ T cells become “exhausted” and have poor effector function, express multiple inhibitory receptors, possess low proliferative capacity, and cannot persist without antigen. To compare the development of functional memory T cells with poorly functional exhausted T cells, we generated longitudinal transcriptional profiles for each. PMID 23159438 GEOID GSE41867 AUTHORS Doering TA,Crawford A,Angelosanto JM,Paley MA,Ziegler CG,Wherry EJ CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE41867_1601_200_DN FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ABCA17P,ABCC2,ABCD4,ACCS,AGGF1,AK7,AKAP17A,AKAP5,ANKRD26,AP1G2,AP4E1,ATG2B,ATP1A1OS,C11orf72,C15orf32,C15orf50,C1orf96,C20orf12,C2orf44,C5orf53,C8orf22,CABP7,CACNA1E,CAMSAP1,CCDC14,CCDC144B,CCDC77,CCR2,CDK8,CEMP1,CENPL,CEP76,CEP97,COG1,COG6,CPSF2,CSNK1G3,CTRC,CYP17A1,DAB2,DCDC2,DFFB,DGKD,DHFRL1,DIRC3,DOCK7,DPY19L3,DUSP18,DYDC1,EDC4,EEPD1,EID2B,ELAC2,ERCC5,EXOSC2,FAM102B,FAM126A,FAM78A,FBXL6,FBXO45,FIGF,FOXE3,FSTL3,GAS2L3,GCC2,GLCE,GMNN,GPR20,GRM2,GSG1L,GSTA4,HAUS6,HCRP1,HERC2,HES2,HIST1H3A,HMHA1,HRASLS,IL1F10,IMPG1,INE1,IQCF3,ISLR,KBTBD8,KCNE3,KCTD2,KIAA0355,KIAA1875,KLF3,KRT80,LBR,LEFTY1,LOC100127940,LOC100134017,LOC100134713,LOC100288673,LOC100506392,LOC100507362,LOC100507410,LOC253264,LOC283357,LOC284009,LOC286052,LOC375295,LOC401442,LOC727818,LOC728353,LOC731139,LOC731656,LOH12CR2,MIS18BP1,MTM1,NAIP,NINL,NIPBL,NLRC4,NMUR2,NPAT,NPY1R,NR2F6,NRXN3,NUDT12,OBSCN,OXR1,PBX3,PCA3,PCM1,PHYHIP,PLB1,POTED,PPIP5K2,PRAM1,PRO2964,PTPN22,PWWP2B,RANBP2,REN,RGS14,RHOT1,RNF168,RUNX1,SCGB2A1,SDSL,SEC24D,SEPHS2,SERPINH1,SERTAD2,SETDB2,SHARPIN,SIX3,SLC23A1,SLC26A11,SNORA71A,SNX21,SNX30,SPATA3,SPOPL,ST6GALNAC5,STAMBPL1,STARD13,STC2,STX6,SUN1,SUV420H1,TAS1R1,TAS2R10,TBC1D15,TEC,TLR1,TMEM132B,TMEM185A,TMEM223,TNFRSF12A,TRAPPC8,TRIM32,TSNARE1,TTI1,UBAP2,UHRF1BP1L,ULK3,USP32,USP38,USP4,WT1,YLPM1,ZBTB34,ZC3H14,ZCCHC14,ZFP30,ZFYVE16,ZMYM2,ZMYND17,ZNF18,ZNF225,ZNF514,ZNF638,ZNF782,ZNF804A,ZNF808,ZNF828 GENE_SYMBOLS ABCA17P,ABCC2,ABCD4,ACCS,AGGF1,AK7,AKAP17A,AKAP5,ANKRD26,AP1G2,AP4E1,ATG2B,ATP1A1-AS1,NDUFV1-DT,C15orf32,,CCSAP,DZANK1,WDCP,IGIP,PPDPFL,CABP7,CACNA1E,CAMSAP1,CCDC14,CCDC144BP,CCDC77,CCR2,CDK8,CEMP1,CENPL,CEP76,CEP97,COG1,COG6,CPSF2,CSNK1G3,CTRC,CYP17A1,DAB2,DCDC2,DFFB,DGKD,DHFR2,DIRC3,DOCK7,DPY19L3,DUSP18,DYDC1,EDC4,EEPD1,EID2B,ELAC2,ERCC5,EXOSC2,EEIG2,HYCC1,FAM78A,FBXL6,FBXO45,VEGFD,FOXE3,FSTL3,GAS2L3,GCC2,GLCE,GMNN,GPR20,GRM2,GSG1L,GSTA4,HAUS6,VPS37A,HERC2,HES2,H3C1,ARHGAP45,PLAAT1,IL1F10,IMPG1,INE1,IQCF3,ISLR,KBTBD8,KCNE3,KCTD2,GARRE1,WDR97,KLF3,KRT80,LBR,LEFTY1,,,NDUFB2-AS1,,SLC16A1-AS1,LINC01015,C1QTNF1-AS1,ZNF503-AS1,,,TMEM65,LINC01116,LOC401442,,,,LINC01348,LOH12CR2,MIS18BP1,MTM1,NAIP,NINL,NIPBL,NLRC4,NMUR2,NPAT,NPY1R,NR2F6,NRXN3,NUDT12,OBSCN,OXR1,PBX3,PCA3,PCM1,PHYHIP,PLB1,POTED,PPIP5K2,PRAM1,,PTPN22,PWWP2B,RANBP2,REN,RGS14,RHOT1,RNF168,RUNX1,SCGB2A1,SDSL,SEC24D,SEPHS2,SERPINH1,SERTAD2,SETDB2,SHARPIN,SIX3,SLC23A1,SLC26A11,SNORA71A,SNX21,SNX30,SPATA3,SPOPL,ST6GALNAC5,STAMBPL1,STARD13,STC2,STX6,SUN1,KMT5B,TAS1R1,TAS2R10,TBC1D15,TEC,TLR1,TMEM132B,TMEM185A,TMEM223,TNFRSF12A,TRAPPC8,TRIM32,TSNARE1,TTI1,UBAP2,BLTP3B,ULK3,USP32,USP38,USP4,WT1,YLPM1,ZBTB34,ZC3H14,ZCCHC14,ZFP30,ZFYVE16,ZMYM2,MSS51,ZNF18,ZNF225,ZNF514,ZNF638,ZNF782,ZNF804A,ZNF808,CHAMP1 FOUNDER_NAMES