STANDARD_NAME GSE41867_DAY6_VS_DAY15_LCMV_ARMSTRONG_EFFECTOR_CD8_TCELL_DN SYSTEMATIC_NAME M9515 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE41867_DAY6_VS_DAY15_LCMV_ARMSTRONG_EFFECTOR_CD8_TCELL_DN NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes down-regulated in CD8 T effectors at acute infection with LCMV-Armstrong: day 6 versus day 15. DESCRIPTION_FULL During acute viral infections, naïve CD8+ T cells differentiate into effector CD8+ T cells and, after viral control, into memory CD8+ T cells. Memory CD8+ T cells are highly functional, proliferate rapidly upon reinfection and persist long-term without antigen. In contrast, during chronic infections, CD8+ T cells become “exhausted” and have poor effector function, express multiple inhibitory receptors, possess low proliferative capacity, and cannot persist without antigen. To compare the development of functional memory T cells with poorly functional exhausted T cells, we generated longitudinal transcriptional profiles for each. PMID 23159438 GEOID GSE41867 AUTHORS Doering TA,Crawford A,Angelosanto JM,Paley MA,Ziegler CG,Wherry EJ CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE41867_1599_200_DN FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS AAK1,AFF3,AHNAK,AKR7A2,AMPD1,ANKLE2,ATF7IP2,BABAM1,BACH2,BTBD10,BTN3A2,C10orf76,C11orf24,C14orf159,C16orf53,C7orf55,CACYBP,CADM1,CAPNS2,CCDC125,CCDC132,CCDC22,CCDC92,CCL21,CCT4,CD69,CDC37L1,CDK4,CLDN12,CNPY3,CTDSPL2,CTR9,CUEDC2,CXCR5,CYP51A1,DCTN6,DDX56,DEAF1,DGCR14,DNAJA2,DSCR3,ENOSF1,FAM118B,FAM18B1,FBP2,FBXO28,FKBP4,FSHB,GNA15,GNG5,GOPC,GPR183,HPCA,HRAS,HSP90B1,IDI1,IDO2,IQGAP2,IWS1,KCTD20,KIAA0907,KIAA1143,KLK13,KRT77,KRT80,LARP1B,LCK,LOC100128822,LOC100132167,LOC400027,LOC400622,LOC440149,LOC646509,LOC728264,LOC729839,LOC92659,LSM14A,MAB21L1,MAP2K1,MAP4,MAP7D1,MARCH8,MARCO,MBD1,MBD2,MCF2,MED1,METRNL,MFAP3,MFSD3,MPV17,MRPS30,MT1P2,MUDENG,MYLPF,N6AMT2,NAP1L4,NCRNA00294,NDUFB5,NOB1,NPEPPS,NR1H2,NRF1,NUDCD3,NUP210L,NXT1,OBFC2B,OPA3,PAFAH1B3,PALM,PAQR7,PAQR8,PARP2,PCID2,PEPD,PINK1,PKNOX1,PLA2G2A,PLCB2,PLEK,PMS2P1,PNMA3,POU4F2,PPIG,PPM1B,PPP6R3,PRKAB1,PRPF3,PSMC3,PSMD14,PTTG1,PUM2,RAB27A,RAB5B,RAB8A,RAGE,RAP2B,RASL10B,RCE1,RDH5,RIPK3,RNASE6,RNF181,RPL36AL,RSPH9,RTN3,SART3,SC5DL,SCAF4,SCAF8,SCML2,SDCCAG3,SEL1L3,SEPT1,SFXN1,SGCD,SLC15A4,SLC25A1,SLC2A1,SLC33A1,SLC45A3,SMCR7L,SOX1,STAG1,STX2,TM2D3,TMEM147,TMEM212,TMEM68,TMEM9B,TNRC18,TOPBP1,TRAPPC10,TRIP6,TRPT1,TSN,TWF1,UBA5,UBA7,UBE2I,UNC5CL,UTP3,VPS37A,VPS4B,WIPF2,WNK1,WRNIP1,XBP1,XIST,ZBED3,ZBTB7B,ZCCHC7,ZFPM1,ZGPAT,ZMYND8,ZNF22,ZNF548,ZNF668,ZNF791,ZRSR1 GENE_SYMBOLS AAK1,AFF3,AHNAK,AKR7A2,AMPD1,ANKLE2,ATF7IP2,BABAM1,BACH2,BTBD10,BTN3A2,ARMH3,C11orf24,DGLUCY,PAGR1,FMC1,CACYBP,CADM1,CAPNS2,CCDC125,VPS50,CCDC22,CCDC92,CCL21,CCT4,CD69,CDC37L1,CDK4,CLDN12,CNPY3,CTDSPL2,CTR9,CUEDC2,CXCR5,CYP51A1,DCTN6,DDX56,DEAF1,ESS2,DNAJA2,VPS26C,ENOSF1,FAM118B,TVP23B,FBP2,FBXO28,FKBP4,FSHB,GNA15,GNG5,GOPC,GPR183,HPCA,HRAS,HSP90B1,IDI1,IDO2,IQGAP2,IWS1,KCTD20,KHDC4,KIAA1143,KLK13,KRT77,KRT80,LARP1B,LCK,LINC01003,,LINC00938,ENSG00000267665,,,CARMN,,MILIP,LSM14A,MAB21L1,MAP2K1,MAP4,MAP7D1,MARCHF8,MARCO,MBD1,MBD2,MCF2,MED1,METRNL,MFAP3,MFSD3,MPV17,MRPS30,MT1HL1,AP5M1,MYL11,EEF1AKMT1,NAP1L4,LINC00294,NDUFB5,NOB1,NPEPPS,NR1H2,NRF1,NUDCD3,NUP210L,NXT1,NABP2,OPA3,PAFAH1B3,PALM,PAQR7,PAQR8,PARP2,PCID2,PEPD,PINK1,PKNOX1,PLA2G2A,PLCB2,PLEK,PMS2P1,PNMA3,POU4F2,PPIG,PPM1B,PPP6R3,PRKAB1,PRPF3,PSMC3,PSMD14,PTTG1,PUM2,RAB27A,RAB5B,RAB8A,MOK,RAP2B,RASL10B,RCE1,RDH5,RIPK3,RNASE6,RNF181,RPL36AL,RSPH9,RTN3,SART3,SC5D,SCAF4,SCAF8,SCML2,ENTR1,SEL1L3,SEPTIN1,SFXN1,SGCD,SLC15A4,SLC25A1,SLC2A1,SLC33A1,SLC45A3,MIEF1,SOX1,STAG1,STX2,TM2D3,TMEM147,TMEM212,TMEM68,TMEM9B,TNRC18,TOPBP1,TRAPPC10,TRIP6,TRPT1,TSN,TWF1,UBA5,UBA7,UBE2I,UNC5CL,UTP3,VPS37A,VPS4B,WIPF2,WNK1,WRNIP1,XBP1,XIST,ZBED3,ZBTB7B,ZCCHC7,ZFPM1,ZGPAT,ZMYND8,ZNF22,ZNF548,ZNF668,ZNF791,ZRSR2P1 FOUNDER_NAMES