STANDARD_NAME GSE41867_DAY8_EFFECTOR_VS_DAY30_EXHAUSTED_CD8_TCELL_LCMV_CLONE13_DN SYSTEMATIC_NAME M9492 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE41867_DAY8_EFFECTOR_VS_DAY30_EXHAUSTED_CD8_TCELL_LCMV_CLONE13_DN NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes down-regulated in CD8 T cells during chronic infection with LCMV-Clone 13: effectors at day 8 versus exhausted at day 30. DESCRIPTION_FULL During acute viral infections, naïve CD8+ T cells differentiate into effector CD8+ T cells and, after viral control, into memory CD8+ T cells. Memory CD8+ T cells are highly functional, proliferate rapidly upon reinfection and persist long-term without antigen. In contrast, during chronic infections, CD8+ T cells become “exhausted” and have poor effector function, express multiple inhibitory receptors, possess low proliferative capacity, and cannot persist without antigen. To compare the development of functional memory T cells with poorly functional exhausted T cells, we generated longitudinal transcriptional profiles for each. PMID 23159438 GEOID GSE41867 AUTHORS Doering TA,Crawford A,Angelosanto JM,Paley MA,Ziegler CG,Wherry EJ CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE41867_1595_200_DN FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ABHD2,ACACA,ADD3,AFP,AHR,AIG1,ALDH16A1,ANAPC13,ANKRA2,ANKRD10,ANKRD44,AP1S3,AP4S1,ARID5B,ARMCX4,ASNSD1,BIN1,C14orf43,C22orf28,C2CD3,C2orf76,C9orf80,CABLES1,CAPZB,CCM2,CD180,CDK19,CEP63,CHST7,CHSY1,CISD2,CNOT2,CNST,COMMD6,CORO1A,COTL1,CPSF3,CSF1,CSF2RA,CSTF2T,CTDP1,CTSA,DDX4,DENND2D,DFFB,DNASE1L3,DSC2,DZIP3,EED,EFTUD1,EIF3K,ENPP6,ERP44,EYA1,FAM101A,FAM134B,FAM167A,FANCL,FBXW2,FCRL1,FGF13,FHIT,FLJ27352,GABPB2,GADD45A,GAMT,GLIPR1,GLTSCR2,GLYCTK,GNA12,GPSM3,GRASP,GRIPAP1,GRM1,HACE1,HDAC11,HERC2,HIATL1,HIVEP3,HPGDS,HRH2,HSCB,HSPBAP1,IFI27,IFI30,IFT122,IL1R2,INPP5D,INTS9,JAK2,KCTD1,KCTD14,KHDRBS1,LAMP1,LCLAT1,LPCAT1,LRRC2,LRRK1,LRWD1,LTBP3,MAP4K1,MAPRE2,MBD4,MCM9,MGA,MICAL1,MKNK2,MLLT10,MRPL41,MYBL1,MYH9,MYLPF,NAT1,NCF2,NCOA3,NTPCR,NUBP1,NUDT19,OSGEP,PACRGL,PARM1,PARP1,PCMTD1,PDCD1LG2,PDGFA,PIK3IP1,PL-5283,PLCD3,PLDN,POLR3C,PPDPF,PPIL2,PPTC7,PQBP1,PREX1,PTGS1,PTP4A3,PUM1,PURB,RAD17,RAPGEF4,RBMS1,RFESD,RFX7,RMI2,RNF145,RPL26,RPL36,S1PR3,SDHAF2,SEMA4D,SESN1,SFT2D1,SH2D3C,SH3BP5,SLC30A4,SLC35F5,SNX10,SNX30,SPAG9,SPATA5L1,SRF,STAMBPL1,STARD4,STK17B,SUMF1,SWAP70,SYS1,TAF10,TAF15,TAGAP,TANC2,TANK,TBC1D4,TBCE,TCF12,TESK1,TFEB,TMEM108,TMEM17,TMEM53,TMEM57,TRAF3IP3,TTC33,TUBG2,UBLCP1,UCKL1,UNC13D,USP14,USP2,VAMP4,VASP,VPS37B,WDR44,XRCC1,ZAK,ZBED4,ZBTB25,ZDHHC13,ZNF521 GENE_SYMBOLS ABHD2,ACACA,ADD3,AFP,AHR,AIG1,ALDH16A1,ANAPC13,ANKRA2,ANKRD10,ANKRD44,AP1S3,AP4S1,ARID5B,ARMCX4,ASNSD1,BIN1,MIDEAS,RTCB,C2CD3,C2orf76,INIP,CABLES1,CAPZB,CCM2,CD180,CDK19,CEP63,CHST7,CHSY1,CISD2,CNOT2,CNST,COMMD6,CORO1A,COTL1,CPSF3,CSF1,CSF2RA,CSTF2T,CTDP1,CTSA,DDX4,DENND2D,DFFB,DNASE1L3,DSC2,DZIP3,EED,EFL1,EIF3K,ENPP6,ERP44,EYA1,RFLNA,RETREG1,FAM167A,FANCL,FBXW2,FCRL1,FGF13,FHIT,PIERCE2,GABPB2,GADD45A,GAMT,GLIPR1,NOP53,GLYCTK,GNA12,GPSM3,TAMALIN,GRIPAP1,GRM1,HACE1,HDAC11,HERC2,MFSD14B,HIVEP3,HPGDS,HRH2,HSCB,HSPBAP1,IFI27,IFI30,IFT122,IL1R2,INPP5D,INTS9,JAK2,KCTD1,KCTD14,KHDRBS1,LAMP1,LCLAT1,LPCAT1,LRRC2,LRRK1,LRWD1,LTBP3,MAP4K1,MAPRE2,MBD4,MCM9,MGA,MICAL1,MKNK2,MLLT10,MRPL41,MYBL1,MYH9,MYL11,NAT1,NCF2,NCOA3,NTPCR,NUBP1,NUDT19,OSGEP,PACRGL,PARM1,PARP1,PCMTD1,PDCD1LG2,PDGFA,PIK3IP1,STMP1,PLCD3,BLOC1S6,POLR3C,PPDPF,PPIL2,PPTC7,PQBP1,PREX1,PTGS1,PTP4A3,PUM1,PURB,RAD17,RAPGEF4,RBMS1,RFESD,RFX7,RMI2,RNF145,RPL26,RPL36,S1PR3,SDHAF2,SEMA4D,SESN1,SFT2D1,SH2D3C,SH3BP5,SLC30A4,SLC35F5,SNX10,SNX30,SPAG9,SPATA5L1,SRF,STAMBPL1,STARD4,STK17B,SUMF1,SWAP70,SYS1,TAF10,TAF15,TAGAP,TANC2,TANK,TBC1D4,TBCE,TCF12,TESK1,TFEB,TMEM108,TMEM17,TMEM53,MACO1,TRAF3IP3,TTC33,TUBG2,UBLCP1,UCKL1,UNC13D,USP14,USP2,VAMP4,VASP,VPS37B,WDR44,XRCC1,MAP3K20,ZBED4,ZBTB25,ZDHHC13,ZNF521 FOUNDER_NAMES