STANDARD_NAME GSE41867_LCMV_ARMSTRONG_VS_CLONE13_DAY6_EFFECTOR_CD8_TCELL_UP SYSTEMATIC_NAME M9493 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE41867_LCMV_ARMSTRONG_VS_CLONE13_DAY6_EFFECTOR_CD8_TCELL_UP NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes up-regulated in CD8 T effector cells at day 6 of chronic infection: LCMV-Armstrong versus LCMV-Clone 13. DESCRIPTION_FULL During acute viral infections, naïve CD8+ T cells differentiate into effector CD8+ T cells and, after viral control, into memory CD8+ T cells. Memory CD8+ T cells are highly functional, proliferate rapidly upon reinfection and persist long-term without antigen. In contrast, during chronic infections, CD8+ T cells become “exhausted” and have poor effector function, express multiple inhibitory receptors, possess low proliferative capacity, and cannot persist without antigen. To compare the development of functional memory T cells with poorly functional exhausted T cells, we generated longitudinal transcriptional profiles for each. PMID 23159438 GEOID GSE41867 AUTHORS Doering TA,Crawford A,Angelosanto JM,Paley MA,Ziegler CG,Wherry EJ CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE41867_1596_200_UP FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ABCF1,ACAT1,ACTN1,AFTPH,AGRN,AHCYL2,AHNAK,AIFM1,ARRB1,ATP5J,ATP5L,B3GNT2,BATF3,BOLA1,BRP44,C14orf21,C17orf48,C1orf114,C1orf55,C4orf32,C9orf86,CABP4,CD3D,CD5L,CDK1,CDK10,CDYL2,CENPV,COX6A1,COX6B1,CRIP1,CTSL2,DCTN3,DCTPP1,DDX24,DDX55,DHX29,DOPEY2,DUSP12,ECE1,EEF1E1,EIF2B1,EIF2B3,EIF4A3,EIF4G1,EIF5A,EIF6,ENTPD1,ESYT1,ETFB,EXOG,EZH2,FADD,FAM129C,FAM49A,FAM53A,FBLIM1,FBXO42,G6PD,GCSH,GFI1,GLE1,GNPNAT1,GPN3,GSG2,GTF3C5,H2AFJ,H2AFZ,HADHB,HIVEP2,HMOX2,HRAS,HSPE1,HTRA2,IFRD2,IL6R,INPP5B,IQGAP2,IRF7,ITGB1,KATNA1,KDELC1,KDM6B,KIAA0232,KIAA0664,KIT,KPNA3,LHPP,LOC388564,LPHN2,LYAR,MAD2L1,MAF,MAGOHB,MAN2C1,MANF,MED17,MED9,MFSD2A,MINA,MLKL,MPHOSPH6,MRPL1,MRPL21,MRPL40,MRPL42,MRPS12,MRPS22,MRPS6,MT1E,MTHFD1,N6AMT2,NADK,NAPSA,NFKBIB,NLE1,NOC3L,NOP10,NUDCD3,NUP210,ORAI1,ORC1,ORMDL3,PCBP1,PDCD1,PDCD11,PDSS2,PELP1,PFDN2,PHRF1,PLAC8,PML,PPIA,PREPL,PROS1,PRPF18,PSMA4,PSMB2,PSMB4,PSMB6,PSMC2,PSMD8,PSMG3,PTPN12,PTPRJ,PTTG1,PUS10,RABGGTB,RAN,RBM19,RCC2,RPL7L1,RRAS2,RUNX3,RUVBL1,SEC11A,SEC13,SFI1,SHMT1,SKA1,SLAMF9,SLC19A1,SLC29A1,SLC9A5,SPC24,SPCS2,SPINT1,SSX2IP,STOML2,SUB1,SUMO3,SUPT6H,SUV39H1,TBC1D10B,TBC1D16,TFRC,TGFB3,TIMM10,TIMM8B,TMED10,TMEM97,TRAFD1,TRAPPC2P1,TREX1,TRIM28,TUBA1B,TXN,TYMS,UMPS,UQCR10,USP47,VCL,VDAC2,VGLL4,WDR83,WISP3,WWP1,YBX1,YIF1B,ZNF428 GENE_SYMBOLS ABCF1,ACAT1,ACTN1,AFTPH,AGRN,AHCYL2,AHNAK,AIFM1,ARRB1,ATP5PF,ATP5MG,B3GNT2,BATF3,BOLA1,MPC2,NOP9,ADPRM,CCDC181,SDE2,FAM241A,RABL6,CABP4,CD3D,CD5L,CDK1,CDK10,CDYL2,CENPV,COX6A1,COX6B1,CRIP1,CTSV,DCTN3,DCTPP1,DDX24,DDX55,DHX29,DOP1B,DUSP12,ECE1,EEF1E1,EIF2B1,EIF2B3,EIF4A3,EIF4G1,EIF5A,EIF6,ENTPD1,ESYT1,ETFB,EXOG,EZH2,FADD,NIBAN3,CYRIA,FAM53A,FBLIM1,FBXO42,G6PD,GCSH,GFI1,GLE1,GNPNAT1,GPN3,HASPIN,GTF3C5,H2AJ,H2AZ1,HADHB,HIVEP2,HMOX2,HRAS,HSPE1,HTRA2,IFRD2,IL6R,INPP5B,IQGAP2,IRF7,ITGB1,KATNA1,POGLUT2,KDM6B,KIAA0232,CLUH,KIT,KPNA3,LHPP,TMEM238,ADGRL2,LYAR,MAD2L1,MAF,MAGOHB,MAN2C1,MANF,MED17,MED9,MFSD2A,RIOX2,MLKL,MPHOSPH6,MRPL1,MRPL21,MRPL40,MRPL42,MRPS12,MRPS22,MRPS6,MT1E,MTHFD1,EEF1AKMT1,NADK,NAPSA,NFKBIB,NLE1,NOC3L,NOP10,NUDCD3,NUP210,ORAI1,ORC1,ORMDL3,PCBP1,PDCD1,PDCD11,PDSS2,PELP1,PFDN2,PHRF1,PLAC8,PML,PPIA,PREPL,PROS1,PRPF18,PSMA4,PSMB2,PSMB4,PSMB6,PSMC2,PSMD8,PSMG3,PTPN12,PTPRJ,PTTG1,PUS10,RABGGTB,RAN,RBM19,RCC2,RPL7L1,RRAS2,RUNX3,RUVBL1,SEC11A,SEC13,SFI1,SHMT1,SKA1,SLAMF9,SLC19A1,SLC29A1,SLC9A5,SPC24,SPCS2,SPINT1,SSX2IP,STOML2,SUB1,SUMO3,SUPT6H,SUV39H1,TBC1D10B,TBC1D16,TFRC,TGFB3,TIMM10,TIMM8B,TMED10,TMEM97,TRAFD1,TRAPPC2B,TREX1,TRIM28,TUBA1B,TXN,TYMS,UMPS,UQCR10,USP47,VCL,VDAC2,VGLL4,WDR83,CCN6,WWP1,YBX1,YIF1B,ZNF428 FOUNDER_NAMES