STANDARD_NAME GSE41867_NAIVE_VS_DAY8_LCMV_EFFECTOR_CD8_TCELL_DN SYSTEMATIC_NAME M9469 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE41867_NAIVE_VS_DAY8_LCMV_EFFECTOR_CD8_TCELL_DN NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes down-regulated in CD8 T cells: naïve versus effectors at day 8. DESCRIPTION_FULL During acute viral infections, naïve CD8+ T cells differentiate into effector CD8+ T cells and, after viral control, into memory CD8+ T cells. Memory CD8+ T cells are highly functional, proliferate rapidly upon reinfection and persist long-term without antigen. In contrast, during chronic infections, CD8+ T cells become “exhausted” and have poor effector function, express multiple inhibitory receptors, possess low proliferative capacity, and cannot persist without antigen. To compare the development of functional memory T cells with poorly functional exhausted T cells, we generated longitudinal transcriptional profiles for each. PMID 23159438 GEOID GSE41867 AUTHORS Doering TA,Crawford A,Angelosanto JM,Paley MA,Ziegler CG,Wherry EJ CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE41867_1607_200_DN FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ABCA1,ACCS,ADAM19,ADAMTS10,ADCK4,ADRB2,AFF3,ANGPTL1,ANKRD13D,ARHGEF18,ARPC5,ARPM1,ARSA,ARSK,ASPG,ATP10D,ATP2A3,AVL9,AZI2,BCL10,BHLHA15,BRAP,BSDC1,BTG2,C15orf39,C3orf37,CACNA1H,CC2D1B,CCBP2,CD2,CD28,CD79A,CDS2,CEP57,CEPT1,CHD2,COQ10A,CORO7,CPSF7,CRIP1,CTBP1,CXXC5,CYTH1,DDX26B,DDX50,DERL1,DLGAP4,DNAJB2,DOCK11,DUSP5,DYNLT3,DYRK1A,E4F1,EGR2,EIF1,ELOVL5,ETS1,F2R,FAM108B1,FAM116B,FAM193B,FAM49B,FAM65B,FGD2,FOXP1,GCOM1,GLS,GLTSCR2,GNAQ,GNGT2,GOLGA5,GPCPD1,GRAMD3,GRK6,HECTD1,HERPUD2,HIST3H2A,HIVEP2,HPCAL1,HSD17B11,IFRD1,IKBKG,ING2,INPP5E,INPP5F,INPP5K,ITGB7,ITPKC,KCTD12,KDM5A,KDM5B,KIAA1468,KIAA1539,KIF21B,KLF7,KLHL15,KLRC1,LAT,LEMD3,LENG8,LNPEP,MAFG,MAP1LC3A,MBTD1,MDM1,MKNK1,MXD4,MYL12B,MYO18A,MYO1E,MYO9B,MYSM1,NAPSA,NCOA3,NFAT5,NFE2L2,NR3C1,NSD1,NUB1,NUMB,NXF1,P2RY10,PCNX,PDCD4,PDE2A,PDK2,PECAM1,PHF21A,PHF6,PIKFYVE,POLR3GL,PRKAB2,PRKAG1,PSEN2,RAB11FIP2,RAB33B,RAB4B,RANBP9,RASA3,RASGRP2,RBM33,RCSD1,RDH10,RHOQ,RLIM,RMND5A,RNF167,RPL17,RPS21,SAMD4B,SCAI,SELT,SERINC3,SESN3,SETD7,SFT2D1,SFT2D2,SIAH2,SKI,SLC37A4,SLC44A2,SLC50A1,SLC9A8,SLK,SMC6,SMG6,SPATA13,SRSF11,SRSF6,STK4,STX16,SUB1,SYNRG,TAF13,TGFBRAP1,TMEM121,TMEM66,TOB1,TOP2B,TPRG1L,TRPS1,TSSK4,TUBA1A,TXNDC16,UAP1,UBAC2,UBL3,UNKL,USP3,VAMP2,VAT1,WBP1,WDR45,WIPI2,ZC3H11A,ZDHHC18,ZFP91,ZMYND11,ZNF148,ZNF692 GENE_SYMBOLS ABCA1,ACCS,ADAM19,ADAMTS10,COQ8B,ADRB2,AFF3,ANGPTL1,ANKRD13D,ARHGEF18,ARPC5,ACTRT3,ARSA,ARSK,ASPG,ATP10D,ATP2A3,AVL9,AZI2,BCL10,BHLHA15,BRAP,BSDC1,BTG2,C15orf39,HMCES,CACNA1H,CC2D1B,ACKR2,CD2,CD28,CD79A,CDS2,CEP57,CEPT1,CHD2,COQ10A,CORO7,CPSF7,CRIP1,CTBP1,CXXC5,CYTH1,INTS6L,DDX50,DERL1,DLGAP4,DNAJB2,DOCK11,DUSP5,DYNLT3,DYRK1A,E4F1,EGR2,EIF1,ELOVL5,ETS1,F2R,ABHD17B,DENND6B,FAM193B,CYRIB,RIPOR2,FGD2,FOXP1,GCOM1,GLS,NOP53,GNAQ,GNGT2,GOLGA5,GPCPD1,GRAMD2B,GRK6,HECTD1,HERPUD2,H2AC25,HIVEP2,HPCAL1,HSD17B11,IFRD1,IKBKG,ING2,INPP5E,INPP5F,INPP5K,ITGB7,ITPKC,KCTD12,KDM5A,KDM5B,RELCH,ATOSB,KIF21B,KLF7,KLHL15,KLRC1,LAT,LEMD3,LENG8,LNPEP,MAFG,MAP1LC3A,MBTD1,MDM1,MKNK1,MXD4,MYL12B,MYO18A,MYO1E,MYO9B,MYSM1,NAPSA,NCOA3,NFAT5,NFE2L2,NR3C1,NSD1,NUB1,NUMB,NXF1,P2RY10,PCNX1,PDCD4,PDE2A,PDK2,PECAM1,PHF21A,PHF6,PIKFYVE,POLR3GL,PRKAB2,PRKAG1,PSEN2,RAB11FIP2,RAB33B,RAB4B,RANBP9,RASA3,RASGRP2,RBM33,RCSD1,RDH10,RHOQ,RLIM,RMND5A,RNF167,RPL17,RPS21,SAMD4B,SCAI,SELENOT,SERINC3,SESN3,SETD7,SFT2D1,SFT2D2,SIAH2,SKI,SLC37A4,SLC44A2,SLC50A1,SLC9A8,SLK,SMC6,SMG6,SPATA13,SRSF11,SRSF6,STK4,STX16,SUB1,SYNRG,TAF13,TGFBRAP1,TMEM121,SARAF,TOB1,TOP2B,TPRG1L,TRPS1,TSSK4,TUBA1A,TXNDC16,UAP1,UBAC2,UBL3,UNKL,USP3,VAMP2,VAT1,WBP1,WDR45,WIPI2,ZC3H11A,ZDHHC18,ZFP91,ZMYND11,ZNF148,ZNF692 FOUNDER_NAMES