STANDARD_NAME	GSE42021_CD24HI_VS_CD24LOW_TCONV_THYMUS_DN
SYSTEMATIC_NAME	M9595
COLLECTION	C7:IMMUNESIGDB
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE42021_CD24HI_VS_CD24LOW_TCONV_THYMUS_DN
NAMESPACE	HUMAN_GENE_SYMBOL
DESCRIPTION_BRIEF	Genes down-regulated in thymic T conv: CD24 high [GeneID=100133941] versus CD24 low [GeneID=100133941].
DESCRIPTION_FULL	We investigated at which stage of maturation commitment to a stable Foxp3-expressing phenotype takes place. We assessed stability of Foxp3 expression in thymic Foxp3+ Treg subsets of different maturity, defined by CD24 expression. Next we compared gene expression profiles of Foxp3+ Treg subsets (+) of different maturity (24lo, 24int, 24hi) and could identify a set of genes that were specifically up or downregulated in Foxp3+ Tregs, but not in Foxp3- conventional T cells, in a maturation-dependent manner.
PMID	23420886
GEOID	GSE42021
AUTHORS	Toker A,Engelbert D,Garg G,Polansky JK,Floess S,Miyao T,Baron U,Düber S,Geffers R,Giehr P,Schallenberg S,Kretschmer K,Olek S,Walter J,Weiss S,Hori S,Hamann A,Huehn J
CONTRIBUTOR	Jernej Godec
CONTRIBUTOR_ORG	Dana-Farber Cancer Institute
EXACT_SOURCE	GSE42021_3791_200_DN
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	ACSL3,ACTN2,ADAP1,ADPGK,AK2,AK4,APOL1,APOL2,APOL3,APOL6,ARNTL2,ASPM,ATP10D,BACH1,BATF3,BCL2L13,BCMO1,BST2,BTN3A1,BTN3A2,BTN3A3,C1R,C1S,C3,C5orf15,CALCOCO2,CASP1,CASP7,CCDC68,CCL5,CCRL1,CD38,CD40,CD47,CD74,CDK18,CEACAM1,CFB,CFH,CLEC2B,COQ10B,CREM,CTSS,CXCL10,CXCL11,CXCL2,CYLD,DDX58,DENND5A,DOCK4,DOPEY1,DPYD,DRAM1,DUSP5,E2F5,ERLIN1,ERV3-2,FAM111A,FAS,FLT3LG,FST,GBP1,GBP2,GGCX,GLRX,GOLGA1,GSTK1,GUK1,HCP5,HEG1,HIF1A,HK1,HK2,HLA-A,HLA-C,HLA-E,HLA-F,HLA-G,HLA-K,IDO1,IFI30,IFI35,IFI44L,IFIH1,IFIT2,IFIT3,IFNGR1,IGFBP3,IGFLR1,IL15,IL15RA,IL32,IL4R,IRF1,IRF8,ISG20,ITM2B,JAK2,KIAA0226,KIAA0664L3,KIF2A,KLF6,LAMP3,LAP3,LARS2,LEPROTL1,LPIN2,LTBR,LXN,MAFF,MAX,MCL1,METTL3,MREG,MTMR14,MX2,NAMPT,NBN,NDUFA9,NECAP1,NFE2L3,NMI,NUP107,OAS2,OASL,OPTN,PAR5,PARP3,PCLO,PION,PLAUR,PLEKHF2,PLSCR4,PMAIP1,POLI,POU5F1B,PSMA4,PSMA6,PSMB10,PSMB8,PSMB9,PSME1,RARRES3,RASGRP3,RBCK1,RBM7,RBMS1,RHBDF2,RMI1,RNF114,RNF19B,RTP4,SAMHD1,SECTM1,SEMA3F,SEPP1,SEPX1,SERPING1,SLC15A3,SLC25A22,SLC25A28,SLC7A2,SOCS1,SOD2,SP110,SP140L,SPATS2L,SQRDL,ST8SIA4,STAT2,STAT3,STS,TAP1,TAP2,TAPBPL,TDP2,TFG,TGM2,TLR3,TMEM140,TMEM59,TNFAIP3,TNFRSF1B,TNFSF10,TOP1,TRAFD1,TRIM21,TRIM22,TRIM31,TRIM38,UBA7,UBE2L6,USO1,USP15,WARS,WDR25,XPO6,ZFP36,ZNF22,ZNF302
GENE_SYMBOLS	ACSL3,ACTN2,ADAP1,ADPGK,AK2,AK4,APOL1,APOL2,APOL3,APOL6,BMAL2,ASPM,ATP10D,BACH1,BATF3,BCL2L13,BCO1,BST2,BTN3A1,BTN3A2,BTN3A3,C1R,C1S,C3,C5orf15,CALCOCO2,CASP1,CASP7,CCDC68,CCL5,ACKR4,CD38,CD40,CD47,CD74,CDK18,CEACAM1,CFB,CFH,CLEC2B,COQ10B,CREM,CTSS,CXCL10,CXCL11,CXCL2,CYLD,RIGI,DENND5A,DOCK4,DOP1A,DPYD,DRAM1,DUSP5,E2F5,ERLIN1,,FAM111A,FAS,FLT3LG,FST,GBP1,GBP2,GGCX,GLRX,GOLGA1,GSTK1,GUK1,HCP5,HEG1,HIF1A,HK1,HK2,HLA-A,HLA-C,HLA-E,HLA-F,HLA-G,HLA-K,IDO1,IFI30,IFI35,IFI44L,IFIH1,IFIT2,IFIT3,IFNGR1,IGFBP3,IGFLR1,IL15,IL15RA,IL32,IL4R,IRF1,IRF8,ISG20,ITM2B,JAK2,RUBCN,CLUHP3,KIF2A,KLF6,LAMP3,LAP3,LARS2,LEPROTL1,LPIN2,LTBR,LXN,MAFF,MAX,MCL1,METTL3,MREG,MTMR14,MX2,NAMPT,NBN,NDUFA9,NECAP1,NFE2L3,NMI,NUP107,OAS2,OASL,OPTN,PWAR5,PARP3,PCLO,GSAP,PLAUR,PLEKHF2,PLSCR4,PMAIP1,POLI,POU5F1B,PSMA4,PSMA6,PSMB10,PSMB8,PSMB9,PSME1,PLAAT4,RASGRP3,RBCK1,RBM7,RBMS1,RHBDF2,RMI1,RNF114,RNF19B,RTP4,SAMHD1,SECTM1,SEMA3F,SELENOP,MSRB1,SERPING1,SLC15A3,SLC25A22,SLC25A28,SLC7A2,SOCS1,SOD2,SP110,SP140L,SPATS2L,SQOR,ST8SIA4,STAT2,STAT3,STS,TAP1,TAP2,TAPBPL,TDP2,TFG,TGM2,TLR3,TMEM140,TMEM59,TNFAIP3,TNFRSF1B,TNFSF10,TOP1,TRAFD1,TRIM21,TRIM22,TRIM31,TRIM38,UBA7,UBE2L6,USO1,USP15,WARS1,WDR25,XPO6,ZFP36,ZNF22,ZNF302
FOUNDER_NAMES