<?xml version="1.0" encoding="UTF-8" standalone="yes"?>

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     See license terms at www.gsea-msigdb.org/gsea/license_terms_list. Please note that certain gene sets have special access terms.
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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="GSE42021_CD24HI_VS_CD24LOW_TCONV_THYMUS_DN" SYSTEMATIC_NAME="M9595" HISTORICAL_NAMES="" PMID="23420886" AUTHORS="Toker A,Engelbert D,Garg G,Polansky JK,Floess S,Miyao T,Baron U,Düber S,Geffers R,Giehr P,Schallenberg S,Kretschmer K,Olek S,Walter J,Weiss S,Hori S,Hamann A,Huehn J" GEOID="GSE42021" EXACT_SOURCE="GSE42021_3791_200_DN" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="" CHIP="HUMAN_GENE_SYMBOL" CONTRIBUTOR="Jernej Godec" CONTRIBUTOR_ORG="Dana-Farber Cancer Institute" DESCRIPTION_BRIEF="Genes down-regulated in thymic T conv: CD24 high [GeneID=100133941] versus CD24 low [GeneID=100133941]." DESCRIPTION_FULL="We investigated at which stage of maturation commitment to a stable Foxp3-expressing phenotype takes place. We assessed stability of Foxp3 expression in thymic Foxp3+ Treg subsets of different maturity, defined by CD24 expression. Next we compared gene expression profiles of Foxp3+ Treg subsets (+) of different maturity (24lo, 24int, 24hi) and could identify a set of genes that were specifically up or downregulated in Foxp3+ Tregs, but not in Foxp3- conventional T cells, in a maturation-dependent manner." TAGS="" MEMBERS="ACSL3,ACTN2,ADAP1,ADPGK,AK2,AK4,APOL1,APOL2,APOL3,APOL6,ARNTL2,ASPM,ATP10D,BACH1,BATF3,BCL2L13,BCMO1,BST2,BTN3A1,BTN3A2,BTN3A3,C1R,C1S,C3,C5orf15,CALCOCO2,CASP1,CASP7,CCDC68,CCL5,CCRL1,CD38,CD40,CD47,CD74,CDK18,CEACAM1,CFB,CFH,CLEC2B,COQ10B,CREM,CTSS,CXCL10,CXCL11,CXCL2,CYLD,DDX58,DENND5A,DOCK4,DOPEY1,DPYD,DRAM1,DUSP5,E2F5,ERLIN1,ERV3-2,FAM111A,FAS,FLT3LG,FST,GBP1,GBP2,GGCX,GLRX,GOLGA1,GSTK1,GUK1,HCP5,HEG1,HIF1A,HK1,HK2,HLA-A,HLA-C,HLA-E,HLA-F,HLA-G,HLA-K,IDO1,IFI30,IFI35,IFI44L,IFIH1,IFIT2,IFIT3,IFNGR1,IGFBP3,IGFLR1,IL15,IL15RA,IL32,IL4R,IRF1,IRF8,ISG20,ITM2B,JAK2,KIAA0226,KIAA0664L3,KIF2A,KLF6,LAMP3,LAP3,LARS2,LEPROTL1,LPIN2,LTBR,LXN,MAFF,MAX,MCL1,METTL3,MREG,MTMR14,MX2,NAMPT,NBN,NDUFA9,NECAP1,NFE2L3,NMI,NUP107,OAS2,OASL,OPTN,PAR5,PARP3,PCLO,PION,PLAUR,PLEKHF2,PLSCR4,PMAIP1,POLI,POU5F1B,PSMA4,PSMA6,PSMB10,PSMB8,PSMB9,PSME1,RARRES3,RASGRP3,RBCK1,RBM7,RBMS1,RHBDF2,RMI1,RNF114,RNF19B,RTP4,SAMHD1,SECTM1,SEMA3F,SEPP1,SEPX1,SERPING1,SLC15A3,SLC25A22,SLC25A28,SLC7A2,SOCS1,SOD2,SP110,SP140L,SPATS2L,SQRDL,ST8SIA4,STAT2,STAT3,STS,TAP1,TAP2,TAPBPL,TDP2,TFG,TGM2,TLR3,TMEM140,TMEM59,TNFAIP3,TNFRSF1B,TNFSF10,TOP1,TRAFD1,TRIM21,TRIM22,TRIM31,TRIM38,UBA7,UBE2L6,USO1,USP15,WARS,WDR25,XPO6,ZFP36,ZNF22,ZNF302" MEMBERS_SYMBOLIZED="ACKR4,ACSL3,ACTN2,ADAP1,ADPGK,AK2,AK4,APOL1,APOL2,APOL3,APOL6,ASPM,ATP10D,BACH1,BATF3,BCL2L13,BCO1,BMAL2,BST2,BTN3A1,BTN3A2,BTN3A3,C1R,C1S,C3,C5orf15,CALCOCO2,CASP1,CASP7,CCDC68,CCL5,CD38,CD40,CD47,CD74,CDK18,CEACAM1,CFB,CFH,CLEC2B,CLUHP3,COQ10B,CREM,CTSS,CXCL10,CXCL11,CXCL2,CYLD,DENND5A,DOCK4,DOP1A,DPYD,DRAM1,DUSP5,E2F5,ERLIN1,FAM111A,FAS,FLT3LG,FST,GBP1,GBP2,GGCX,GLRX,GOLGA1,GSAP,GSTK1,GUK1,HCP5,HEG1,HIF1A,HK1,HK2,HLA-A,HLA-C,HLA-E,HLA-F,HLA-G,HLA-K,IDO1,IFI30,IFI35,IFI44L,IFIH1,IFIT2,IFIT3,IFNGR1,IGFBP3,IGFLR1,IL15,IL15RA,IL32,IL4R,IRF1,IRF8,ISG20,ITM2B,JAK2,KIF2A,KLF6,LAMP3,LAP3,LARS2,LEPROTL1,LPIN2,LTBR,LXN,MAFF,MAX,MCL1,METTL3,MREG,MSRB1,MTMR14,MX2,NAMPT,NBN,NDUFA9,NECAP1,NFE2L3,NMI,NUP107,OAS2,OASL,OPTN,PARP3,PCLO,PLAAT4,PLAUR,PLEKHF2,PLSCR4,PMAIP1,POLI,POU5F1B,PSMA4,PSMA6,PSMB10,PSMB8,PSMB9,PSME1,PWAR5,RASGRP3,RBCK1,RBM7,RBMS1,RHBDF2,RIGI,RMI1,RNF114,RNF19B,RTP4,RUBCN,SAMHD1,SECTM1,SELENOP,SEMA3F,SERPING1,SLC15A3,SLC25A22,SLC25A28,SLC7A2,SOCS1,SOD2,SP110,SP140L,SPATS2L,SQOR,ST8SIA4,STAT2,STAT3,STS,TAP1,TAP2,TAPBPL,TDP2,TFG,TGM2,TLR3,TMEM140,TMEM59,TNFAIP3,TNFRSF1B,TNFSF10,TOP1,TRAFD1,TRIM21,TRIM22,TRIM31,TRIM38,UBA7,UBE2L6,USO1,USP15,WARS1,WDR25,XPO6,ZFP36,ZNF22,ZNF302" MEMBERS_EZID="100132341,10039,10133,10135,10179,10241,10342,10346,10384,10437,10468,10475,10613,10616,10866,10906,10964,11033,11074,11118,11119,11201,127544,1316,1390,1520,1540,1806,1847,1875,204,205,2181,23033,23214,2323,23258,23395,23484,23586,23764,23780,23786,25780,259266,25939,25977,26010,2633,2634,2677,27074,27445,2745,2800,2920,2987,3075,3091,3098,3099,3105,3107,3133,3134,3135,3138,3394,3430,3431,3433,3437,3459,3486,355,3566,3600,3601,3620,3627,3659,3669,3717,373156,3796,4055,412,4149,4170,4600,4683,4704,4939,51056,5129,51296,51554,51567,51734,5329,53630,5366,54103,5462,55080,55281,55332,55509,55686,55900,55905,56339,5685,5687,56925,56938,56951,5696,5698,5699,57088,571,57122,5720,57205,57493,58472,5920,5937,629,634,6352,6373,63901,6398,6405,64108,64135,6414,64419,6542,6648,6737,6773,6774,684,6890,6891,7052,7098,710,7128,7133,715,7150,716,718,7318,7453,7538,7570,7903,79446,79651,79666,79713,79751,80010,80219,80323,80830,80833,8123,81894,834,83440,840,8542,8615,8638,8651,8743,88,9111,9235,9246,93349,9445,952,9528,958,9603,961,9663,9711,972,9732,9958,9976" MEMBERS_MAPPING="ACSL3,ACSL3,2181|ACTN2,ACTN2,88|ADAP1,ADAP1,11033|ADPGK,ADPGK,83440|AK2,AK2,204|AK4,AK4,205|APOL1,APOL1,8542|APOL2,APOL2,23780|APOL3,APOL3,80833|APOL6,APOL6,80830|ARNTL2,BMAL2,56938|ASPM,ASPM,259266|ATP10D,ATP10D,57205|BACH1,BACH1,571|BATF3,BATF3,55509|BCL2L13,BCL2L13,23786|BCMO1,BCO1,53630|BST2,BST2,684|BTN3A1,BTN3A1,11119|BTN3A2,BTN3A2,11118|BTN3A3,BTN3A3,10384|C1R,C1R,715|C1S,C1S,716|C3,C3,718|C5orf15,C5orf15,56951|CALCOCO2,CALCOCO2,10241|CASP1,CASP1,834|CASP7,CASP7,840|CCDC68,CCDC68,80323|CCL5,CCL5,6352|CCRL1,ACKR4,51554|CD38,CD38,952|CD40,CD40,958|CD47,CD47,961|CD74,CD74,972|CDK18,CDK18,5129|CEACAM1,CEACAM1,634|CFB,CFB,629|CFH,CFH,3075|CLEC2B,CLEC2B,9976|COQ10B,COQ10B,80219|CREM,CREM,1390|CTSS,CTSS,1520|CXCL10,CXCL10,3627|CXCL11,CXCL11,6373|CXCL2,CXCL2,2920|CYLD,CYLD,1540|DDX58,RIGI,23586|DENND5A,DENND5A,23258|DOCK4,DOCK4,9732|DOPEY1,DOP1A,23033|DPYD,DPYD,1806|DRAM1,DRAM1,55332|DUSP5,DUSP5,1847|E2F5,E2F5,1875|ERLIN1,ERLIN1,10613|ERV3-2,null,null|FAM111A,FAM111A,63901|FAS,FAS,355|FLT3LG,FLT3LG,2323|FST,FST,10468|GBP1,GBP1,2633|GBP2,GBP2,2634|GGCX,GGCX,2677|GLRX,GLRX,2745|GOLGA1,GOLGA1,2800|GSTK1,GSTK1,373156|GUK1,GUK1,2987|HCP5,HCP5,10866|HEG1,HEG1,57493|HIF1A,HIF1A,3091|HK1,HK1,3098|HK2,HK2,3099|HLA-A,HLA-A,3105|HLA-C,HLA-C,3107|HLA-E,HLA-E,3133|HLA-F,HLA-F,3134|HLA-G,HLA-G,3135|HLA-K,HLA-K,3138|IDO1,IDO1,3620|IFI30,IFI30,10437|IFI35,IFI35,3430|IFI44L,IFI44L,10964|IFIH1,IFIH1,64135|IFIT2,IFIT2,3433|IFIT3,IFIT3,3437|IFNGR1,IFNGR1,3459|IGFBP3,IGFBP3,3486|IGFLR1,IGFLR1,79713|IL15,IL15,3600|IL15RA,IL15RA,3601|IL32,IL32,9235|IL4R,IL4R,3566|IRF1,IRF1,3659|IRF8,IRF8,3394|ISG20,ISG20,3669|ITM2B,ITM2B,9445|JAK2,JAK2,3717|KIAA0226,RUBCN,9711|KIAA0664L3,CLUHP3,100132341|KIF2A,KIF2A,3796|KLF6,KLF6,1316|LAMP3,LAMP3,27074|LAP3,LAP3,51056|LARS2,LARS2,23395|LEPROTL1,LEPROTL1,23484|LPIN2,LPIN2,9663|LTBR,LTBR,4055|LXN,LXN,56925|MAFF,MAFF,23764|MAX,MAX,4149|MCL1,MCL1,4170|METTL3,METTL3,56339|MREG,MREG,55686|MTMR14,MTMR14,64419|MX2,MX2,4600|NAMPT,NAMPT,10135|NBN,NBN,4683|NDUFA9,NDUFA9,4704|NECAP1,NECAP1,25977|NFE2L3,NFE2L3,9603|NMI,NMI,9111|NUP107,NUP107,57122|OAS2,OAS2,4939|OASL,OASL,8638|OPTN,OPTN,10133|PAR5,PWAR5,8123|PARP3,PARP3,10039|PCLO,PCLO,27445|PION,GSAP,54103|PLAUR,PLAUR,5329|PLEKHF2,PLEKHF2,79666|PLSCR4,PLSCR4,57088|PMAIP1,PMAIP1,5366|POLI,POLI,11201|POU5F1B,POU5F1B,5462|PSMA4,PSMA4,5685|PSMA6,PSMA6,5687|PSMB10,PSMB10,5699|PSMB8,PSMB8,5696|PSMB9,PSMB9,5698|PSME1,PSME1,5720|RARRES3,PLAAT4,5920|RASGRP3,RASGRP3,25780|RBCK1,RBCK1,10616|RBM7,RBM7,10179|RBMS1,RBMS1,5937|RHBDF2,RHBDF2,79651|RMI1,RMI1,80010|RNF114,RNF114,55905|RNF19B,RNF19B,127544|RTP4,RTP4,64108|SAMHD1,SAMHD1,25939|SECTM1,SECTM1,6398|SEMA3F,SEMA3F,6405|SEPP1,SELENOP,6414|SEPX1,MSRB1,51734|SERPING1,SERPING1,710|SLC15A3,SLC15A3,51296|SLC25A22,SLC25A22,79751|SLC25A28,SLC25A28,81894|SLC7A2,SLC7A2,6542|SOCS1,SOCS1,8651|SOD2,SOD2,6648|SP110,SP110,3431|SP140L,SP140L,93349|SPATS2L,SPATS2L,26010|SQRDL,SQOR,58472|ST8SIA4,ST8SIA4,7903|STAT2,STAT2,6773|STAT3,STAT3,6774|STS,STS,412|TAP1,TAP1,6890|TAP2,TAP2,6891|TAPBPL,TAPBPL,55080|TDP2,TDP2,51567|TFG,TFG,10342|TGM2,TGM2,7052|TLR3,TLR3,7098|TMEM140,TMEM140,55281|TMEM59,TMEM59,9528|TNFAIP3,TNFAIP3,7128|TNFRSF1B,TNFRSF1B,7133|TNFSF10,TNFSF10,8743|TOP1,TOP1,7150|TRAFD1,TRAFD1,10906|TRIM21,TRIM21,6737|TRIM22,TRIM22,10346|TRIM31,TRIM31,11074|TRIM38,TRIM38,10475|UBA7,UBA7,7318|UBE2L6,UBE2L6,9246|USO1,USO1,8615|USP15,USP15,9958|WARS,WARS1,7453|WDR25,WDR25,79446|XPO6,XPO6,23214|ZFP36,ZFP36,7538|ZNF22,ZNF22,7570|ZNF302,ZNF302,55900" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="C7" ORGANISM="Mus musculus" SUB_CATEGORY_CODE="IMMUNESIGDB"/>
</MSIGDB>
