STANDARD_NAME	GSE43863_NAIVE_VS_MEMORY_TFH_CD4_TCELL_D150_LCMV_DN
SYSTEMATIC_NAME	M9738
COLLECTION	C7:IMMUNESIGDB
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE43863_NAIVE_VS_MEMORY_TFH_CD4_TCELL_D150_LCMV_DN
NAMESPACE	HUMAN_GENE_SYMBOL
DESCRIPTION_BRIEF	Genes down-regulated in CD4 [GeneID=920] SMARTA T cells: naïve versus memory follicular helper (Tfh).
DESCRIPTION_FULL	CD4 T follicular helper (Tfh) cells provide the required signals to B cells for germinal center reactions that are necessary for longlived antibody responses. However, it remains unclear whether there are CD4+ memory T cells committed to the Tfh lineage after antigen clearance. Using adoptive transfer of antigen-specific memory CD4+ subpopulations (based on CXCR5 and Ly6c expression)in the LCMV infection model, we found that there are distinct memory CD4+ T cell populations with commitment to the Tfh and Th1 lineages. Our conclusions are based on gene expression profiles, epigenetic studies and phenotypic and functional analysis. The gene expression profiles of virus-specific CD4 T cell subets at effector and memory stages is presented here.
PMID	23583644
GEOID	GSE43863
AUTHORS	Hale JS,Youngblood B,Latner DR,Mohammed AU,Ye L,Akondy RS,Wu T,Iyer SS,Ahmed R
CONTRIBUTOR	Jernej Godec
CONTRIBUTOR_ORG	Dana-Farber Cancer Institute
EXACT_SOURCE	GSE43863_3731_200_DN
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	ABT1,ACTN1,ADM,AGFG1,AGPAT5,AIMP2,ALG2,ALOX15B,AMZ1,ANKRD13B,APOO,ARFRP1,ARL4C,ATF3,B4GALT5,BAG2,BATF,BEX1,BTG3,C14orf1,C14orf169,C14orf21,C17orf96,C1orf51,C3orf21,C4orf43,C7orf50,C7orf68,C9orf114,CACYBP,CCDC137,CCDC41,CCNB1IP1,CD44,CFLAR,CHCHD4,CHRNA2,CHST11,CIRH1A,CITED2,CLEC12B,CST7,CTPS,DDX18,DDX31,DDX56,DNMT3B,DUSP4,EGR2,EIF2B3,EIF2S2,EIF4A1,EIF4E,ENTPD6,EPT1,ERH,ERO1L,ETF1,EXOSC2,FABP5,FASN,FASTKD3,FOSL1,FOXRED2,FRAS1,FTSJ3,GFI1,GJC3,GLA,GRHL1,GRWD1,GSPT1,GTPBP4,HIC1,HMGA1,HNF1B,HOMER1,HOXB1,HPRT1,HSPD1,IDH3A,IFRD2,IL15RA,IL28RA,IL2RA,IL6,IRF8,KCTD13,KLF16,KTI12,LAG3,LAP3,LARS,LIPG,LMO4,LYAR,MAFG,MAK16,MAN1A2,MAT2A,MIOS,MRPL50,MRTO4,MTRR,MYO1E,NAA50,NAF1,NBN,NFKBIB,NLE1,NOC3L,NOL11,NOP16,NUDT5,NUP205,NUS1,ODC1,ORC2,PCGF6,PDCD1LG2,PDGFC,PELP1,PITRM1,PLK3,PLXND1,PMP22,POLR3D,PPAT,PPP5C,PRDM4,PREP,PRPS1,PSMD8,PTAR1,PUS10,RAB20,RAB34,RAP1B,RAPGEF5,RBM15B,RBPMS2,RCC1,RCL1,RCN1,RHBDL3,RPS6KA2,RRP9,RSL24D1,RUVBL1,RUVBL2,RWDD4,SCN1A,SEMA7A,SERPINB9,SH2D2A,SLC15A3,SLC16A1,SLC19A2,SLC25A1,SLC25A32,SLC25A33,SLC39A14,SLC39A6,SLC5A6,SLC7A1,SLC7A6,SLC9A5,SOX12,SOX21,SPRYD7,SRFBP1,SRM,ST6GALNAC4,SYTL3,TBP,THOP1,TIMM44,TIMM8A,TLCD1,TMEM150A,TMEM189,TMEM20,TRIB1,TRMT6,TRNAU1AP,UAP1,UBXN2A,UMPS,URB2,USP36,UTP6,WBSCR16,WDR18,WDR43,WDR55,WDR77,WEE1,XCL1,ZC3H12C,ZMYND19
GENE_SYMBOLS	ABT1,ACTN1,ADM,AGFG1,AGPAT5,AIMP2,ALG2,ALOX15B,AMZ1,ANKRD13B,APOO,ARFRP1,ARL4C,ATF3,B4GALT5,BAG2,BATF,BEX1,BTG3,ERG28,RIOX1,NOP9,EPOP,CIART,XXYLT1,TMA16,CHLSN,HILPDA,SPOUT1,CACYBP,CCDC137,CEP83,CCNB1IP1,CD44,CFLAR,CHCHD4,CHRNA2,CHST11,UTP4,CITED2,CLEC12B,CST7,CTPS1,DDX18,DDX31,DDX56,DNMT3B,DUSP4,EGR2,EIF2B3,EIF2S2,EIF4A1,EIF4E,ENTPD6,SELENOI,ERH,ERO1A,ETF1,EXOSC2,FABP5,FASN,FASTKD3,FOSL1,FOXRED2,FRAS1,FTSJ3,GFI1,GJC3,GLA,GRHL1,GRWD1,GSPT1,GTPBP4,HIC1,HMGA1,HNF1B,HOMER1,HOXB1,HPRT1,HSPD1,IDH3A,IFRD2,IL15RA,IFNLR1,IL2RA,IL6,IRF8,KCTD13,KLF16,KTI12,LAG3,LAP3,LARS1,LIPG,LMO4,LYAR,MAFG,MAK16,MAN1A2,MAT2A,MIOS,MRPL50,MRTO4,MTRR,MYO1E,NAA50,NAF1,NBN,NFKBIB,NLE1,NOC3L,NOL11,NOP16,NUDT5,NUP205,NUS1,ODC1,ORC2,PCGF6,PDCD1LG2,PDGFC,PELP1,PITRM1,PLK3,PLXND1,PMP22,POLR3D,PPAT,PPP5C,PRDM4,PREP,PRPS1,PSMD8,PTAR1,PUS10,RAB20,RAB34,RAP1B,RAPGEF5,RBM15B,RBPMS2,RCC1,RCL1,RCN1,RHBDL3,RPS6KA2,RRP9,RSL24D1,RUVBL1,RUVBL2,RWDD4,SCN1A,SEMA7A,SERPINB9,SH2D2A,SLC15A3,SLC16A1,SLC19A2,SLC25A1,SLC25A32,SLC25A33,SLC39A14,SLC39A6,SLC5A6,SLC7A1,SLC7A6,SLC9A5,SOX12,SOX21,SPRYD7,SRFBP1,SRM,ST6GALNAC4,SYTL3,TBP,THOP1,TIMM44,TIMM8A,TLCD1,TMEM150A,PEDS1,SLC35G1,TRIB1,TRMT6,TRNAU1AP,UAP1,UBXN2A,UMPS,URB2,USP36,UTP6,RCC1L,WDR18,WDR43,WDR55,WDR77,WEE1,XCL1,ZC3H12C,ZMYND19
FOUNDER_NAMES