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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="GSE43863_NAIVE_VS_MEMORY_TFH_CD4_TCELL_D150_LCMV_DN" SYSTEMATIC_NAME="M9738" HISTORICAL_NAMES="" PMID="23583644" AUTHORS="Hale JS,Youngblood B,Latner DR,Mohammed AU,Ye L,Akondy RS,Wu T,Iyer SS,Ahmed R" GEOID="GSE43863" EXACT_SOURCE="GSE43863_3731_200_DN" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="" CHIP="HUMAN_GENE_SYMBOL" CONTRIBUTOR="Jernej Godec" CONTRIBUTOR_ORG="Dana-Farber Cancer Institute" DESCRIPTION_BRIEF="Genes down-regulated in CD4 [GeneID=920] SMARTA T cells: naïve versus memory follicular helper (Tfh)." DESCRIPTION_FULL="CD4 T follicular helper (Tfh) cells provide the required signals to B cells for germinal center reactions that are necessary for longlived antibody responses. However, it remains unclear whether there are CD4+ memory T cells committed to the Tfh lineage after antigen clearance. Using adoptive transfer of antigen-specific memory CD4+ subpopulations (based on CXCR5 and Ly6c expression)in the LCMV infection model, we found that there are distinct memory CD4+ T cell populations with commitment to the Tfh and Th1 lineages. Our conclusions are based on gene expression profiles, epigenetic studies and phenotypic and functional analysis. The gene expression profiles of virus-specific CD4 T cell subets at effector and memory stages is presented here." TAGS="" MEMBERS="ABT1,ACTN1,ADM,AGFG1,AGPAT5,AIMP2,ALG2,ALOX15B,AMZ1,ANKRD13B,APOO,ARFRP1,ARL4C,ATF3,B4GALT5,BAG2,BATF,BEX1,BTG3,C14orf1,C14orf169,C14orf21,C17orf96,C1orf51,C3orf21,C4orf43,C7orf50,C7orf68,C9orf114,CACYBP,CCDC137,CCDC41,CCNB1IP1,CD44,CFLAR,CHCHD4,CHRNA2,CHST11,CIRH1A,CITED2,CLEC12B,CST7,CTPS,DDX18,DDX31,DDX56,DNMT3B,DUSP4,EGR2,EIF2B3,EIF2S2,EIF4A1,EIF4E,ENTPD6,EPT1,ERH,ERO1L,ETF1,EXOSC2,FABP5,FASN,FASTKD3,FOSL1,FOXRED2,FRAS1,FTSJ3,GFI1,GJC3,GLA,GRHL1,GRWD1,GSPT1,GTPBP4,HIC1,HMGA1,HNF1B,HOMER1,HOXB1,HPRT1,HSPD1,IDH3A,IFRD2,IL15RA,IL28RA,IL2RA,IL6,IRF8,KCTD13,KLF16,KTI12,LAG3,LAP3,LARS,LIPG,LMO4,LYAR,MAFG,MAK16,MAN1A2,MAT2A,MIOS,MRPL50,MRTO4,MTRR,MYO1E,NAA50,NAF1,NBN,NFKBIB,NLE1,NOC3L,NOL11,NOP16,NUDT5,NUP205,NUS1,ODC1,ORC2,PCGF6,PDCD1LG2,PDGFC,PELP1,PITRM1,PLK3,PLXND1,PMP22,POLR3D,PPAT,PPP5C,PRDM4,PREP,PRPS1,PSMD8,PTAR1,PUS10,RAB20,RAB34,RAP1B,RAPGEF5,RBM15B,RBPMS2,RCC1,RCL1,RCN1,RHBDL3,RPS6KA2,RRP9,RSL24D1,RUVBL1,RUVBL2,RWDD4,SCN1A,SEMA7A,SERPINB9,SH2D2A,SLC15A3,SLC16A1,SLC19A2,SLC25A1,SLC25A32,SLC25A33,SLC39A14,SLC39A6,SLC5A6,SLC7A1,SLC7A6,SLC9A5,SOX12,SOX21,SPRYD7,SRFBP1,SRM,ST6GALNAC4,SYTL3,TBP,THOP1,TIMM44,TIMM8A,TLCD1,TMEM150A,TMEM189,TMEM20,TRIB1,TRMT6,TRNAU1AP,UAP1,UBXN2A,UMPS,URB2,USP36,UTP6,WBSCR16,WDR18,WDR43,WDR55,WDR77,WEE1,XCL1,ZC3H12C,ZMYND19" MEMBERS_SYMBOLIZED="ABT1,ACTN1,ADM,AGFG1,AGPAT5,AIMP2,ALG2,ALOX15B,AMZ1,ANKRD13B,APOO,ARFRP1,ARL4C,ATF3,B4GALT5,BAG2,BATF,BEX1,BTG3,CACYBP,CCDC137,CCNB1IP1,CD44,CEP83,CFLAR,CHCHD4,CHLSN,CHRNA2,CHST11,CIART,CITED2,CLEC12B,CST7,CTPS1,DDX18,DDX31,DDX56,DNMT3B,DUSP4,EGR2,EIF2B3,EIF2S2,EIF4A1,EIF4E,ENTPD6,EPOP,ERG28,ERH,ERO1A,ETF1,EXOSC2,FABP5,FASN,FASTKD3,FOSL1,FOXRED2,FRAS1,FTSJ3,GFI1,GJC3,GLA,GRHL1,GRWD1,GSPT1,GTPBP4,HIC1,HILPDA,HMGA1,HNF1B,HOMER1,HOXB1,HPRT1,HSPD1,IDH3A,IFNLR1,IFRD2,IL15RA,IL2RA,IL6,IRF8,KCTD13,KLF16,KTI12,LAG3,LAP3,LARS1,LIPG,LMO4,LYAR,MAFG,MAK16,MAN1A2,MAT2A,MIOS,MRPL50,MRTO4,MTRR,MYO1E,NAA50,NAF1,NBN,NFKBIB,NLE1,NOC3L,NOL11,NOP16,NOP9,NUDT5,NUP205,NUS1,ODC1,ORC2,PCGF6,PDCD1LG2,PDGFC,PEDS1,PELP1,PITRM1,PLK3,PLXND1,PMP22,POLR3D,PPAT,PPP5C,PRDM4,PREP,PRPS1,PSMD8,PTAR1,PUS10,RAB20,RAB34,RAP1B,RAPGEF5,RBM15B,RBPMS2,RCC1,RCC1L,RCL1,RCN1,RHBDL3,RIOX1,RPS6KA2,RRP9,RSL24D1,RUVBL1,RUVBL2,RWDD4,SCN1A,SELENOI,SEMA7A,SERPINB9,SH2D2A,SLC15A3,SLC16A1,SLC19A2,SLC25A1,SLC25A32,SLC25A33,SLC35G1,SLC39A14,SLC39A6,SLC5A6,SLC7A1,SLC7A6,SLC9A5,SOX12,SOX21,SPOUT1,SPRYD7,SRFBP1,SRM,ST6GALNAC4,SYTL3,TBP,THOP1,TIMM44,TIMM8A,TLCD1,TMA16,TMEM150A,TRIB1,TRMT6,TRNAU1AP,UAP1,UBXN2A,UMPS,URB2,USP36,UTP4,UTP6,WDR18,WDR43,WDR55,WDR77,WEE1,XCL1,XXYLT1,ZC3H12C,ZMYND19" MEMBERS_EZID="100170841,10123,10139,10171,10221,10370,10469,10531,10538,10560,10856,10905,10950,1104,11108,11161,11164,11166,112970,1135,116150,116225,116238,117246,124930,1263,129303,131474,133,148523,1503,150962,152002,153443,155185,159371,161424,162494,163702,165324,1678,1789,1846,1959,1973,1977,201965,2079,2107,2171,2194,23129,23160,23165,23404,23516,23560,247,253980,25800,25926,2672,27043,27090,27101,2717,2935,29777,29841,29890,29923,30001,3090,3159,3211,3251,3267,3329,339230,3394,3419,348093,349149,3559,3569,3601,375743,387521,387837,3902,4097,4144,4552,4643,467,4683,4793,4953,4999,50515,51056,51134,51154,51187,51296,51490,51491,51520,51605,5272,5376,54468,54475,54534,54606,5471,54853,54952,55319,55326,5536,5550,55646,55647,55813,55859,56034,5631,5714,57213,57418,57602,57820,5908,5954,6196,6323,6375,64318,64794,6541,6553,6566,6576,661,6666,6675,6723,6908,6928,7064,7372,7465,7866,79072,79084,79135,7965,79697,80020,80144,80218,80380,8061,81034,81554,83743,83855,83871,84108,84275,84310,84549,8482,84916,8530,85365,8543,85463,85465,8607,87,8837,8884,8886,8891,8894,9047,9057,9136,92345,9334,9388,94120,9456,9532,955,960,9771,9816" MEMBERS_MAPPING="ABT1,ABT1,29777|ACTN1,ACTN1,87|ADM,ADM,133|AGFG1,AGFG1,3267|AGPAT5,AGPAT5,55326|AIMP2,AIMP2,7965|ALG2,ALG2,85365|ALOX15B,ALOX15B,247|AMZ1,AMZ1,155185|ANKRD13B,ANKRD13B,124930|APOO,APOO,79135|ARFRP1,ARFRP1,10139|ARL4C,ARL4C,10123|ATF3,ATF3,467|B4GALT5,B4GALT5,9334|BAG2,BAG2,9532|BATF,BATF,10538|BEX1,BEX1,55859|BTG3,BTG3,10950|C14orf1,ERG28,11161|C14orf169,RIOX1,79697|C14orf21,NOP9,161424|C17orf96,EPOP,100170841|C1orf51,CIART,148523|C3orf21,XXYLT1,152002|C4orf43,TMA16,55319|C7orf50,CHLSN,84310|C7orf68,HILPDA,29923|C9orf114,SPOUT1,51490|CACYBP,CACYBP,27101|CCDC137,CCDC137,339230|CCDC41,CEP83,51134|CCNB1IP1,CCNB1IP1,57820|CD44,CD44,960|CFLAR,CFLAR,8837|CHCHD4,CHCHD4,131474|CHRNA2,CHRNA2,1135|CHST11,CHST11,50515|CIRH1A,UTP4,84916|CITED2,CITED2,10370|CLEC12B,CLEC12B,387837|CST7,CST7,8530|CTPS,CTPS1,1503|DDX18,DDX18,8886|DDX31,DDX31,64794|DDX56,DDX56,54606|DNMT3B,DNMT3B,1789|DUSP4,DUSP4,1846|EGR2,EGR2,1959|EIF2B3,EIF2B3,8891|EIF2S2,EIF2S2,8894|EIF4A1,EIF4A1,1973|EIF4E,EIF4E,1977|ENTPD6,ENTPD6,955|EPT1,SELENOI,85465|ERH,ERH,2079|ERO1L,ERO1A,30001|ETF1,ETF1,2107|EXOSC2,EXOSC2,23404|FABP5,FABP5,2171|FASN,FASN,2194|FASTKD3,FASTKD3,79072|FOSL1,FOSL1,8061|FOXRED2,FOXRED2,80020|FRAS1,FRAS1,80144|FTSJ3,FTSJ3,117246|GFI1,GFI1,2672|GJC3,GJC3,349149|GLA,GLA,2717|GRHL1,GRHL1,29841|GRWD1,GRWD1,83743|GSPT1,GSPT1,2935|GTPBP4,GTPBP4,23560|HIC1,HIC1,3090|HMGA1,HMGA1,3159|HNF1B,HNF1B,6928|HOMER1,HOMER1,9456|HOXB1,HOXB1,3211|HPRT1,HPRT1,3251|HSPD1,HSPD1,3329|IDH3A,IDH3A,3419|IFRD2,IFRD2,7866|IL15RA,IL15RA,3601|IL28RA,IFNLR1,163702|IL2RA,IL2RA,3559|IL6,IL6,3569|IRF8,IRF8,3394|KCTD13,KCTD13,253980|KLF16,KLF16,83855|KTI12,KTI12,112970|LAG3,LAG3,3902|LAP3,LAP3,51056|LARS,LARS1,51520|LIPG,LIPG,9388|LMO4,LMO4,8543|LYAR,LYAR,55646|MAFG,MAFG,4097|MAK16,MAK16,84549|MAN1A2,MAN1A2,10905|MAT2A,MAT2A,4144|MIOS,MIOS,54468|MRPL50,MRPL50,54534|MRTO4,MRTO4,51154|MTRR,MTRR,4552|MYO1E,MYO1E,4643|NAA50,NAA50,80218|NAF1,NAF1,92345|NBN,NBN,4683|NFKBIB,NFKBIB,4793|NLE1,NLE1,54475|NOC3L,NOC3L,64318|NOL11,NOL11,25926|NOP16,NOP16,51491|NUDT5,NUDT5,11164|NUP205,NUP205,23165|NUS1,NUS1,116150|ODC1,ODC1,4953|ORC2,ORC2,4999|PCGF6,PCGF6,84108|PDCD1LG2,PDCD1LG2,80380|PDGFC,PDGFC,56034|PELP1,PELP1,27043|PITRM1,PITRM1,10531|PLK3,PLK3,1263|PLXND1,PLXND1,23129|PMP22,PMP22,5376|POLR3D,POLR3D,661|PPAT,PPAT,5471|PPP5C,PPP5C,5536|PRDM4,PRDM4,11108|PREP,PREP,5550|PRPS1,PRPS1,5631|PSMD8,PSMD8,5714|PTAR1,PTAR1,375743|PUS10,PUS10,150962|RAB20,RAB20,55647|RAB34,RAB34,83871|RAP1B,RAP1B,5908|RAPGEF5,RAPGEF5,9771|RBM15B,RBM15B,29890|RBPMS2,RBPMS2,348093|RCC1,RCC1,1104|RCL1,RCL1,10171|RCN1,RCN1,5954|RHBDL3,RHBDL3,162494|RPS6KA2,RPS6KA2,6196|RRP9,RRP9,9136|RSL24D1,RSL24D1,51187|RUVBL1,RUVBL1,8607|RUVBL2,RUVBL2,10856|RWDD4,RWDD4,201965|SCN1A,SCN1A,6323|SEMA7A,SEMA7A,8482|SERPINB9,SERPINB9,5272|SH2D2A,SH2D2A,9047|SLC15A3,SLC15A3,51296|SLC16A1,SLC16A1,6566|SLC19A2,SLC19A2,10560|SLC25A1,SLC25A1,6576|SLC25A32,SLC25A32,81034|SLC25A33,SLC25A33,84275|SLC39A14,SLC39A14,23516|SLC39A6,SLC39A6,25800|SLC5A6,SLC5A6,8884|SLC7A1,SLC7A1,6541|SLC7A6,SLC7A6,9057|SLC9A5,SLC9A5,6553|SOX12,SOX12,6666|SOX21,SOX21,11166|SPRYD7,SPRYD7,57213|SRFBP1,SRFBP1,153443|SRM,SRM,6723|ST6GALNAC4,ST6GALNAC4,27090|SYTL3,SYTL3,94120|TBP,TBP,6908|THOP1,THOP1,7064|TIMM44,TIMM44,10469|TIMM8A,TIMM8A,1678|TLCD1,TLCD1,116238|TMEM150A,TMEM150A,129303|TMEM189,PEDS1,387521|TMEM20,SLC35G1,159371|TRIB1,TRIB1,10221|TRMT6,TRMT6,51605|TRNAU1AP,TRNAU1AP,54952|UAP1,UAP1,6675|UBXN2A,UBXN2A,165324|UMPS,UMPS,7372|URB2,URB2,9816|USP36,USP36,57602|UTP6,UTP6,55813|WBSCR16,RCC1L,81554|WDR18,WDR18,57418|WDR43,WDR43,23160|WDR55,WDR55,54853|WDR77,WDR77,79084|WEE1,WEE1,7465|XCL1,XCL1,6375|ZC3H12C,ZC3H12C,85463|ZMYND19,ZMYND19,116225" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="C7" ORGANISM="Mus musculus" SUB_CATEGORY_CODE="IMMUNESIGDB"/>
</MSIGDB>
