STANDARD_NAME GSE43955_1H_VS_20H_ACT_CD4_TCELL_WITH_TGFB_IL6_DN SYSTEMATIC_NAME M9677 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE43955_1H_VS_20H_ACT_CD4_TCELL_WITH_TGFB_IL6_DN NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes down-regulated in CD4 [GeneID=920] T helper cells Th17 treated with TGFB1 and IL6 [GeneID=7040;3569]: 1h versus 20h. DESCRIPTION_FULL Despite their enormous importance, the molecular circuits that control the differentiation of Th17 cells remain largely unknown. Recent studies have reconstructed regulatory networks in mammalian cells, but have focused on short-term responses and relied on perturbation approaches that cannot be applied to primary T cells. Here, we develop a systematic strategy – combining transcriptional profiling at high temporal resolution, novel computational algorithms, and innovative nanowire-based tools for performing gene perturbations in primary T cells – to derive and experimentally validate a temporal model of the dynamic regulatory network that controls Th17 differentiation. The network is arranged into two self-reinforcing and mutually antagonistic modules that either suppress or promote Th17 differentiation. The two modules contain 12 novel regulators with no previous implication in Th17 differentiation, which may be essential to maintain the appropriate balance of Th17 and other CD4+ T cell subsets. Overall, our study identifies and validates 39 regulatory factors that are embedded within a comprehensive temporal network and identifies novel drug targets and organizational principles for the differentiation of Th17 cells. PMID 23467089 GEOID GSE43955 AUTHORS Yosef N,Shalek AK,Gaublomme JT,Jin H,Lee Y,Awasthi A,Wu C,Karwacz K,Xiao S,Jorgolli M,Gennert D,Satija R,Shakya A,Lu DY,Trombetta JJ,Pillai MR,Ratcliffe PJ,Coleman ML,Bix M,Tantin D,Park H,Kuchroo VK,Regev A CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE43955_2433_200_DN FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ABCA2,ABCD3,ACP5,ACRV1,ACTR3,ADAM28,ADORA2B,AEBP1,AGAP1,AGFG1,AOC3,APBB2,APOC1,APOC2,ATXN2,AZI1,AZIN1,B2M,B4GALT6,BASP1,BIRC3,C11orf51,C19orf12,C3AR1,C3orf78,C5orf15,C5orf32,CACNA2D1,CASP4,CCR7,CCT6A,CD59,CD5L,CD8A,CDK14,CDKN1C,CDKN2A,CETN1,CFB,CHRNB2,CISH,CLIC4,CLPTM1L,CNN3,COL10A1,COL1A2,COL5A2,COPA,CPNE3,CR2,CSF1,CSF2RB,CSF3,CTSE,CTSK,CTSS,CXCL9,CYTIP,DCN,DDIT3,DDR2,DDX3Y,DERL2,DHRS7,DNTT,ECM1,ELL2,EPB41L4B,EPHA4,EPHA6,FBN1,FCRLA,FEM1A,FERMT2,FGFR1,FHL1,FIP1L1,FLNB,FOLR2,FRMD6,FRRS1,FZD9,GABRR1,GJA1,GLRX,GNA13,GNAI2,GPC4,GPR37,GTF3C1,HEPH,HGSNAT,HIC1,HK2,HNF4A,HOXA4,HOXB9,HS3ST1,HTR1F,IFNAR1,IGFBP1,IKZF2,IL10,IL1A,IRF7,IRF8,ISG20,ITM2B,KCNH1,KCNS2,KDELR3,KIF1C,KLF12,KLHL7,LPL,LY6E,LY86,MARK1,MDFI,MET,MGP,MX1,MX2,MYH7,MYO10,NAV1,NCK2,NDN,NEDD1,NEDD4,NEDD4L,NELF,NFKBIZ,NNMT,NR2F1,NRP1,NUPR1,OLR1,ORM1,OSBPL5,OSMR,OSTalpha,PAM,PCDHA10,PCSK2,PDE1A,PDRG1,PGLYRP1,PHLDA1,PLAC8,PLAC9,PLIN2,PLS3,PPARG,PPP1R3C,PRDM1,PTGS2,PTPRR,PTTG1,RAD51,RHD,RNF19B,RPGR,RPL14,S100A6,SASH1,SCAMP1,SCOC,SEMA3C,SERPINB2,SERPINE2,SGIP1,SIAE,SIM1,SIT1,SLC30A4,SNAI2,SNHG6,SRY,TAF9,TAGLN,TFDP1,TGDS,TIMP3,TMEM176B,TMEM66,TNC,TNPO3,TRAF3,TSR1,TUBB,TWIST1,UGDH,UIMC1,VCL,WDR1,WRN,WWTR1,ZFR,ZNF638 GENE_SYMBOLS ABCA2,ABCD3,ACP5,ACRV1,ACTR3,ADAM28,ADORA2B,AEBP1,AGAP1,AGFG1,AOC3,APBB2,APOC1,APOC2,ATXN2,CEP131,AZIN1,B2M,B4GALT6,BASP1,BIRC3,ANAPC15,C19orf12,C3AR1,UQCC5,C5orf15,CYSTM1,CACNA2D1,CASP4,CCR7,CCT6A,CD59,CD5L,CD8A,CDK14,CDKN1C,CDKN2A,CETN1,CFB,CHRNB2,CISH,CLIC4,CLPTM1L,CNN3,COL10A1,COL1A2,COL5A2,COPA,CPNE3,CR2,CSF1,CSF2RB,CSF3,CTSE,CTSK,CTSS,CXCL9,CYTIP,DCN,DDIT3,DDR2,DDX3Y,DERL2,DHRS7,DNTT,ECM1,ELL2,EPB41L4B,EPHA4,EPHA6,FBN1,FCRLA,FEM1A,FERMT2,FGFR1,FHL1,FIP1L1,FLNB,FOLR2,FRMD6,FRRS1,FZD9,GABRR1,GJA1,GLRX,GNA13,GNAI2,GPC4,GPR37,GTF3C1,HEPH,HGSNAT,HIC1,HK2,HNF4A,HOXA4,HOXB9,HS3ST1,HTR1F,IFNAR1,IGFBP1,IKZF2,IL10,IL1A,IRF7,IRF8,ISG20,ITM2B,KCNH1,KCNS2,KDELR3,KIF1C,KLF12,KLHL7,LPL,LY6E,LY86,MARK1,MDFI,MET,MGP,MX1,MX2,MYH7,MYO10,NAV1,NCK2,NDN,NEDD1,NEDD4,NEDD4L,NSMF,NFKBIZ,NNMT,NR2F1,NRP1,NUPR1,OLR1,ORM1,OSBPL5,OSMR,SLC51A,PAM,PCDHA10,PCSK2,PDE1A,PDRG1,PGLYRP1,PHLDA1,PLAC8,PLAC9,PLIN2,PLS3,PPARG,PPP1R3C,PRDM1,PTGS2,PTPRR,PTTG1,RAD51,RHD,RNF19B,RPGR,RPL14,S100A6,SASH1,SCAMP1,SCOC,SEMA3C,SERPINB2,SERPINE2,SGIP1,SIAE,SIM1,SIT1,SLC30A4,SNAI2,SNHG6,SRY,TAF9,TAGLN,TFDP1,TGDS,TIMP3,TMEM176B,SARAF,TNC,TNPO3,TRAF3,TSR1,TUBB,TWIST1,UGDH,UIMC1,VCL,WDR1,WRN,WWTR1,ZFR,ZNF638 FOUNDER_NAMES