STANDARD_NAME	GSE46025_WT_VS_FOXO1_KO_KLRG1_LOW_CD8_EFFECTOR_TCELL_UP
SYSTEMATIC_NAME	M9873
COLLECTION	C7:IMMUNESIGDB
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE46025_WT_VS_FOXO1_KO_KLRG1_LOW_CD8_EFFECTOR_TCELL_UP
NAMESPACE	HUMAN_GENE_SYMBOL
DESCRIPTION_BRIEF	Genes up-regulated during acute viral infection in KLRG1 low [GeneID=10219] CD8 T cells: wildtype versus FOXO1 [GeneID=2308] knockout.
DESCRIPTION_FULL	The forkhead O transcription factors (FOXO) integrate a range of extracellular signals including growth factor signaling, inflammation, oxidative stress and nutrient availability, to substantially alter the program of gene expression and modulate cell survival, cell cycle progression, and many cell-type specific responses yet to be unraveled. Naive antigen-specific CD8+ T cells undergo a rapid expansion and arming of effector function within days of pathogen exposure, but in addition, by the peak of expansion, they form precursors to memory T cells capable of self-renewal and indefinite survival. We used microarrays to determine whether FOXO1 broadly affects effector and memory differentiation, and to what extent FOXO1 determines the program of memory T cell gene expression.
PMID	23712431
GEOID	GSE46025
AUTHORS	Hess Michelini R,Doedens AL,Goldrath AW,Hedrick SM
CONTRIBUTOR	Jernej Godec
CONTRIBUTOR_ORG	Dana-Farber Cancer Institute
EXACT_SOURCE	GSE46025_3672_200_UP
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	ACO2,ADAM23,ADAMTS3,AGPAT4,AKAP8L,APBB3,ARRB2,ARRDC2,ATP5D,AURKAIP1,BCOR,BSCL2,C18orf12,C2orf14,C2orf54,C2orf84,C4orf49,C6orf27,CA2,CALU,CASC3,CCDC9,CD2BP2,CDH12,CEP72,CEP85,CHST5,CISH,CLK3,CLPB,CMTM2,CN5H6.4,CNIH2,COMTD1,COX6A2,CRB1,CRK,CTSA,DDX56,DNAH17,DSG3,ECEL1,EDDM3B,EFHC2,EFHD2,EPCAM,ERP27,FAM110C,FAM150B,FAM38A,FAM43B,FAM47C,FBXO40,FHOD1,FLJ30838,FLJ37396,FLJ39051,FOXP2,FPR2,FPR3,FRRS1,GBP6,GEMIN5,GFOD2,GHRL,GLOD5,GLT25D1,GLYATL2,GNA15,GNPTG,GPATCH3,H6PD,HIF3A,HK1,HLA-E,HNRNPAB,HOXA4,HRH1,HSD3B1,IGF1,IP6K1,KIAA0090,KIAA1257,KLF7,KRT19P2,KRTAP4-1,LAMTOR1,LCAT,LOC100131170,LOC100286993,LOC256021,LOC283112,LOC285548,LOC286272,LOC340947,LOC400604,LSM2,LSR,LYL1,MAF1,MKRN7P,MMRN2,MOCS1,MPST,MS4A2,MT3,MYCNOS,NDUFB2,NNMT,NR2F2,NUDC,NUP210,OCM2,OR13C4,OR52K3P,OSGEP,OTOS,PDIA5,PDK4,PES1,PIGH,PIP5K1A,PKDREJ,PLCB3,PLCXD1,PLOD3,PMPCA,PRR14,PTGIS,PTOV1,PYCR1,RAC3,RAF1,RALY,RAMP1,RASGRF1,RCC2,REXO1L1,RGS10,RGS16,RNF182,RPL22,RPS19BP1,S1PR5,SELENBP1,SERPINF1,SH3BP2,SLC12A5,SLC14A1,SLC18A3,SLC1A2,SLC33A1,SLCO1B3,SLCO4A1,SLIT2,SPHK1,SRM,ST6GALNAC6,STX4,SULT1E1,TAB1,TAT,TBC1D14,TCTEX1D1,TEAD4,TES,TEX14,TGM2,THEMIS,THOC4,TLR4,TMEM120A,TMEM203,TMEM219,TNFRSF25,TNFSF14,TOX4,TPTE2P1,TRPM7,TTLL9,TUBA1B,TUBB3,TWIST2,TYK2,TYSND1,UCK2,ULK1,VASN,VTI1A,WDFY3,WDR59,WNT7B,WNT8A,YIF1A,YRDC,ZBTB1,ZCWPW2,ZDHHC18,ZNF558,ZNF598
GENE_SYMBOLS	ACO2,ADAM23,ADAMTS3,AGPAT4,AKAP8L,APBB3,ARRB2,ARRDC2,ATP5F1D,AURKAIP1,BCOR,BSCL2,ZBTB7C-AS2,CYP4F30P,MAB21L4,FAM228A,MGARP,VWA7,CA2,CALU,CASC3,CCDC9,CD2BP2,CDH12,CEP72,CEP85,CHST5,CISH,CLK3,CLPB,CMTM2,,CNIH2,COMTD1,COX6A2,CRB1,CRK,CTSA,DDX56,DNAH17,DSG3,ECEL1,EDDM3B,EFHC2,EFHD2,EPCAM,ERP27,FAM110C,ALKAL2,PIEZO1,FAM43B,FAM47C,FBXO40,FHOD1,LINC01122,CCDC162P,GSEC,FOXP2,FPR2,FPR3,FRRS1,GBP6,GEMIN5,GFOD2,GHRL,GLOD5,COLGALT1,GLYATL2,GNA15,GNPTG,GPATCH3,H6PD,HIF3A,HK1,HLA-E,HNRNPAB,HOXA4,HRH1,HSD3B1,IGF1,IP6K1,EMC1,CFAP92,KLF7,KRT19P2,KRTAP4-1,LAMTOR1,LCAT,,,LINC01619,,LINC01096,,EIF3LP3,TOB1-AS1,LSM2,LSR,LYL1,MAF1,MKRN7P,MMRN2,MOCS1,MPST,MS4A2,MT3,MYCNOS,NDUFB2,NNMT,NR2F2,NUDC,NUP210,OCM2,OR13C4,OR52K3P,OSGEP,OTOS,PDIA5,PDK4,PES1,PIGH,PIP5K1A,PKDREJ,PLCB3,PLCXD1,PLOD3,PMPCA,PRR14,PTGIS,PTOV1,PYCR1,RAC3,RAF1,RALY,RAMP1,RASGRF1,RCC2,REXO1L1P,RGS10,RGS16,RNF182,RPL22,RPS19BP1,S1PR5,SELENBP1,SERPINF1,SH3BP2,SLC12A5,SLC14A1,SLC18A3,SLC1A2,SLC33A1,SLCO1B3,SLCO4A1,SLIT2,SPHK1,SRM,ST6GALNAC6,STX4,SULT1E1,TAB1,TAT,TBC1D14,DYNLT5,TEAD4,TES,TEX14,TGM2,THEMIS,ALYREF,TLR4,TMEM120A,TMEM203,TMEM219,TNFRSF25,TNFSF14,TOX4,TPTE2P1,TRPM7,TTLL9,TUBA1B,TUBB3,TWIST2,TYK2,TYSND1,UCK2,ULK1,VASN,VTI1A,WDFY3,WDR59,WNT7B,WNT8A,YIF1A,YRDC,ZBTB1,ZCWPW2,ZDHHC18,ZNF558,ZNF598
FOUNDER_NAMES