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     See license terms at www.gsea-msigdb.org/gsea/license_terms_list. Please note that certain gene sets have special access terms.
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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="GSE46025_WT_VS_FOXO1_KO_KLRG1_LOW_CD8_EFFECTOR_TCELL_UP" SYSTEMATIC_NAME="M9873" HISTORICAL_NAMES="" PMID="23712431" AUTHORS="Hess Michelini R,Doedens AL,Goldrath AW,Hedrick SM" GEOID="GSE46025" EXACT_SOURCE="GSE46025_3672_200_UP" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="" CHIP="HUMAN_GENE_SYMBOL" CONTRIBUTOR="Jernej Godec" CONTRIBUTOR_ORG="Dana-Farber Cancer Institute" DESCRIPTION_BRIEF="Genes up-regulated during acute viral infection in KLRG1 low [GeneID=10219] CD8 T cells: wildtype versus FOXO1 [GeneID=2308] knockout." DESCRIPTION_FULL="The forkhead O transcription factors (FOXO) integrate a range of extracellular signals including growth factor signaling, inflammation, oxidative stress and nutrient availability, to substantially alter the program of gene expression and modulate cell survival, cell cycle progression, and many cell-type specific responses yet to be unraveled. Naive antigen-specific CD8+ T cells undergo a rapid expansion and arming of effector function within days of pathogen exposure, but in addition, by the peak of expansion, they form precursors to memory T cells capable of self-renewal and indefinite survival. We used microarrays to determine whether FOXO1 broadly affects effector and memory differentiation, and to what extent FOXO1 determines the program of memory T cell gene expression." TAGS="" MEMBERS="ACO2,ADAM23,ADAMTS3,AGPAT4,AKAP8L,APBB3,ARRB2,ARRDC2,ATP5D,AURKAIP1,BCOR,BSCL2,C18orf12,C2orf14,C2orf54,C2orf84,C4orf49,C6orf27,CA2,CALU,CASC3,CCDC9,CD2BP2,CDH12,CEP72,CEP85,CHST5,CISH,CLK3,CLPB,CMTM2,CN5H6.4,CNIH2,COMTD1,COX6A2,CRB1,CRK,CTSA,DDX56,DNAH17,DSG3,ECEL1,EDDM3B,EFHC2,EFHD2,EPCAM,ERP27,FAM110C,FAM150B,FAM38A,FAM43B,FAM47C,FBXO40,FHOD1,FLJ30838,FLJ37396,FLJ39051,FOXP2,FPR2,FPR3,FRRS1,GBP6,GEMIN5,GFOD2,GHRL,GLOD5,GLT25D1,GLYATL2,GNA15,GNPTG,GPATCH3,H6PD,HIF3A,HK1,HLA-E,HNRNPAB,HOXA4,HRH1,HSD3B1,IGF1,IP6K1,KIAA0090,KIAA1257,KLF7,KRT19P2,KRTAP4-1,LAMTOR1,LCAT,LOC100131170,LOC100286993,LOC256021,LOC283112,LOC285548,LOC286272,LOC340947,LOC400604,LSM2,LSR,LYL1,MAF1,MKRN7P,MMRN2,MOCS1,MPST,MS4A2,MT3,MYCNOS,NDUFB2,NNMT,NR2F2,NUDC,NUP210,OCM2,OR13C4,OR52K3P,OSGEP,OTOS,PDIA5,PDK4,PES1,PIGH,PIP5K1A,PKDREJ,PLCB3,PLCXD1,PLOD3,PMPCA,PRR14,PTGIS,PTOV1,PYCR1,RAC3,RAF1,RALY,RAMP1,RASGRF1,RCC2,REXO1L1,RGS10,RGS16,RNF182,RPL22,RPS19BP1,S1PR5,SELENBP1,SERPINF1,SH3BP2,SLC12A5,SLC14A1,SLC18A3,SLC1A2,SLC33A1,SLCO1B3,SLCO4A1,SLIT2,SPHK1,SRM,ST6GALNAC6,STX4,SULT1E1,TAB1,TAT,TBC1D14,TCTEX1D1,TEAD4,TES,TEX14,TGM2,THEMIS,THOC4,TLR4,TMEM120A,TMEM203,TMEM219,TNFRSF25,TNFSF14,TOX4,TPTE2P1,TRPM7,TTLL9,TUBA1B,TUBB3,TWIST2,TYK2,TYSND1,UCK2,ULK1,VASN,VTI1A,WDFY3,WDR59,WNT7B,WNT8A,YIF1A,YRDC,ZBTB1,ZCWPW2,ZDHHC18,ZNF558,ZNF598" MEMBERS_SYMBOLIZED="ACO2,ADAM23,ADAMTS3,AGPAT4,AKAP8L,ALKAL2,ALYREF,APBB3,ARRB2,ARRDC2,ATP5F1D,AURKAIP1,BCOR,BSCL2,CA2,CALU,CASC3,CCDC162P,CCDC9,CD2BP2,CDH12,CEP72,CEP85,CFAP92,CHST5,CISH,CLK3,CLPB,CMTM2,CNIH2,COLGALT1,COMTD1,COX6A2,CRB1,CRK,CTSA,CYP4F30P,DDX56,DNAH17,DSG3,DYNLT5,ECEL1,EDDM3B,EFHC2,EFHD2,EIF3LP3,EMC1,EPCAM,ERP27,FAM110C,FAM228A,FAM43B,FAM47C,FBXO40,FHOD1,FOXP2,FPR2,FPR3,FRRS1,GBP6,GEMIN5,GFOD2,GHRL,GLOD5,GLYATL2,GNA15,GNPTG,GPATCH3,GSEC,H6PD,HIF3A,HK1,HLA-E,HNRNPAB,HOXA4,HRH1,HSD3B1,IGF1,IP6K1,KLF7,KRT19P2,KRTAP4-1,LAMTOR1,LCAT,LINC01096,LINC01122,LINC01619,LSM2,LSR,LYL1,MAB21L4,MAF1,MGARP,MKRN7P,MMRN2,MOCS1,MPST,MS4A2,MT3,MYCNOS,NDUFB2,NNMT,NR2F2,NUDC,NUP210,OCM2,OR13C4,OR52K3P,OSGEP,OTOS,PDIA5,PDK4,PES1,PIEZO1,PIGH,PIP5K1A,PKDREJ,PLCB3,PLCXD1,PLOD3,PMPCA,PRR14,PTGIS,PTOV1,PYCR1,RAC3,RAF1,RALY,RAMP1,RASGRF1,RCC2,REXO1L1P,RGS10,RGS16,RNF182,RPL22,RPS19BP1,S1PR5,SELENBP1,SERPINF1,SH3BP2,SLC12A5,SLC14A1,SLC18A3,SLC1A2,SLC33A1,SLCO1B3,SLCO4A1,SLIT2,SPHK1,SRM,ST6GALNAC6,STX4,SULT1E1,TAB1,TAT,TBC1D14,TEAD4,TES,TEX14,TGM2,THEMIS,TLR4,TMEM120A,TMEM203,TMEM219,TNFRSF25,TNFSF14,TOB1-AS1,TOX4,TPTE2P1,TRPM7,TTLL9,TUBA1B,TUBB3,TWIST2,TYK2,TYSND1,UCK2,ULK1,VASN,VTI1A,VWA7,WDFY3,WDR59,WNT7B,WNT8A,YIF1A,YRDC,ZBTB1,ZBTB7C-AS2,ZCWPW2,ZDHHC18,ZNF558,ZNF598" MEMBERS_EZID="100132708,1010,10189,101927285,10267,10307,10343,10376,10381,10408,10421,10454,10726,10897,10954,114990,1154,117581,118881,1198,121506,124446,1339,138804,1398,143187,146225,148156,150677,152098,160313,163351,163933,164395,1830,200132,219743,219970,2206,221262,221687,22794,22890,22913,23001,23065,23203,23225,23418,23481,23563,2358,2359,254263,254958,256021,25929,26093,26136,26580,26993,27106,2769,28231,28234,285016,285548,29109,30815,3098,3133,3182,3201,3269,3283,340947,3479,387357,390035,391059,392465,3931,399972,400604,4066,4072,409,4337,4357,442444,4504,4708,4837,4951,50,513,51599,5166,51725,51738,5176,5283,5331,53635,53637,54606,5476,54822,54880,54998,55004,55344,55644,55722,55920,56155,56895,5740,57468,57501,57533,57819,5831,5881,5894,5923,6001,6004,6146,63906,64184,642273,64344,6452,646405,64793,6506,653140,6563,6572,6723,6783,6810,6898,7004,7026,7052,7099,7297,7371,7477,7478,760,7686,78994,79180,79693,79709,79726,79812,79919,80258,80737,813,81570,81577,83862,8394,8408,84232,84243,84322,84572,84709,85285,8609,8632,8718,8740,8745,8877,8985,8991,90850,91582,9197,9353,93986,94107,9427,9508,9563,9780,9807,9878" MEMBERS_MAPPING="ACO2,ACO2,50|ADAM23,ADAM23,8745|ADAMTS3,ADAMTS3,9508|AGPAT4,AGPAT4,56895|AKAP8L,AKAP8L,26993|APBB3,APBB3,10307|ARRB2,ARRB2,409|ARRDC2,ARRDC2,27106|ATP5D,ATP5F1D,513|AURKAIP1,AURKAIP1,54998|BCOR,BCOR,54880|BSCL2,BSCL2,26580|C18orf12,ZBTB7C-AS2,84322|C2orf14,CYP4F30P,100132708|C2orf54,MAB21L4,79919|C2orf84,FAM228A,653140|C4orf49,MGARP,84709|C6orf27,VWA7,80737|CA2,CA2,760|CALU,CALU,813|CASC3,CASC3,22794|CCDC9,CCDC9,26093|CD2BP2,CD2BP2,10421|CDH12,CDH12,1010|CEP72,CEP72,55722|CEP85,CEP85,64793|CHST5,CHST5,23563|CISH,CISH,1154|CLK3,CLK3,1198|CLPB,CLPB,81570|CMTM2,CMTM2,146225|CN5H6.4,null,null|CNIH2,CNIH2,254263|COMTD1,COMTD1,118881|COX6A2,COX6A2,1339|CRB1,CRB1,23418|CRK,CRK,1398|CTSA,CTSA,5476|DDX56,DDX56,54606|DNAH17,DNAH17,8632|DSG3,DSG3,1830|ECEL1,ECEL1,9427|EDDM3B,EDDM3B,64184|EFHC2,EFHC2,80258|EFHD2,EFHD2,79180|EPCAM,EPCAM,4072|ERP27,ERP27,121506|FAM110C,FAM110C,642273|FAM150B,ALKAL2,285016|FAM38A,PIEZO1,9780|FAM43B,FAM43B,163933|FAM47C,FAM47C,442444|FBXO40,FBXO40,51725|FHOD1,FHOD1,29109|FLJ30838,LINC01122,101927285|FLJ37396,CCDC162P,221262|FLJ39051,GSEC,399972|FOXP2,FOXP2,93986|FPR2,FPR2,2358|FPR3,FPR3,2359|FRRS1,FRRS1,391059|GBP6,GBP6,163351|GEMIN5,GEMIN5,25929|GFOD2,GFOD2,81577|GHRL,GHRL,51738|GLOD5,GLOD5,392465|GLT25D1,COLGALT1,79709|GLYATL2,GLYATL2,219970|GNA15,GNA15,2769|GNPTG,GNPTG,84572|GPATCH3,GPATCH3,63906|H6PD,H6PD,9563|HIF3A,HIF3A,64344|HK1,HK1,3098|HLA-E,HLA-E,3133|HNRNPAB,HNRNPAB,3182|HOXA4,HOXA4,3201|HRH1,HRH1,3269|HSD3B1,HSD3B1,3283|IGF1,IGF1,3479|IP6K1,IP6K1,9807|KIAA0090,EMC1,23065|KIAA1257,CFAP92,57501|KLF7,KLF7,8609|KRT19P2,KRT19P2,160313|KRTAP4-1,KRTAP4-1,85285|LAMTOR1,LAMTOR1,55004|LCAT,LCAT,3931|LOC100131170,null,null|LOC100286993,null,null|LOC256021,LINC01619,256021|LOC283112,null,null|LOC285548,LINC01096,285548|LOC286272,null,null|LOC340947,EIF3LP3,340947|LOC400604,TOB1-AS1,400604|LSM2,LSM2,57819|LSR,LSR,51599|LYL1,LYL1,4066|MAF1,MAF1,84232|MKRN7P,MKRN7P,7686|MMRN2,MMRN2,79812|MOCS1,MOCS1,4337|MPST,MPST,4357|MS4A2,MS4A2,2206|MT3,MT3,4504|MYCNOS,MYCNOS,10408|NDUFB2,NDUFB2,4708|NNMT,NNMT,4837|NR2F2,NR2F2,7026|NUDC,NUDC,10726|NUP210,NUP210,23225|OCM2,OCM2,4951|OR13C4,OR13C4,138804|OR52K3P,OR52K3P,390035|OSGEP,OSGEP,55644|OTOS,OTOS,150677|PDIA5,PDIA5,10954|PDK4,PDK4,5166|PES1,PES1,23481|PIGH,PIGH,5283|PIP5K1A,PIP5K1A,8394|PKDREJ,PKDREJ,10343|PLCB3,PLCB3,5331|PLCXD1,PLCXD1,55344|PLOD3,PLOD3,8985|PMPCA,PMPCA,23203|PRR14,PRR14,78994|PTGIS,PTGIS,5740|PTOV1,PTOV1,53635|PYCR1,PYCR1,5831|RAC3,RAC3,5881|RAF1,RAF1,5894|RALY,RALY,22913|RAMP1,RAMP1,10267|RASGRF1,RASGRF1,5923|RCC2,RCC2,55920|REXO1L1,REXO1L1P,254958|RGS10,RGS10,6001|RGS16,RGS16,6004|RNF182,RNF182,221687|RPL22,RPL22,6146|RPS19BP1,RPS19BP1,91582|S1PR5,S1PR5,53637|SELENBP1,SELENBP1,8991|SERPINF1,SERPINF1,5176|SH3BP2,SH3BP2,6452|SLC12A5,SLC12A5,57468|SLC14A1,SLC14A1,6563|SLC18A3,SLC18A3,6572|SLC1A2,SLC1A2,6506|SLC33A1,SLC33A1,9197|SLCO1B3,SLCO1B3,28234|SLCO4A1,SLCO4A1,28231|SLIT2,SLIT2,9353|SPHK1,SPHK1,8877|SRM,SRM,6723|ST6GALNAC6,ST6GALNAC6,30815|STX4,STX4,6810|SULT1E1,SULT1E1,6783|TAB1,TAB1,10454|TAT,TAT,6898|TBC1D14,TBC1D14,57533|TCTEX1D1,DYNLT5,200132|TEAD4,TEAD4,7004|TES,TES,26136|TEX14,TEX14,56155|TGM2,TGM2,7052|THEMIS,THEMIS,387357|THOC4,ALYREF,10189|TLR4,TLR4,7099|TMEM120A,TMEM120A,83862|TMEM203,TMEM203,94107|TMEM219,TMEM219,124446|TNFRSF25,TNFRSF25,8718|TNFSF14,TNFSF14,8740|TOX4,TOX4,9878|TPTE2P1,TPTE2P1,646405|TRPM7,TRPM7,54822|TTLL9,TTLL9,164395|TUBA1B,TUBA1B,10376|TUBB3,TUBB3,10381|TWIST2,TWIST2,117581|TYK2,TYK2,7297|TYSND1,TYSND1,219743|UCK2,UCK2,7371|ULK1,ULK1,8408|VASN,VASN,114990|VTI1A,VTI1A,143187|WDFY3,WDFY3,23001|WDR59,WDR59,79726|WNT7B,WNT7B,7477|WNT8A,WNT8A,7478|YIF1A,YIF1A,10897|YRDC,YRDC,79693|ZBTB1,ZBTB1,22890|ZCWPW2,ZCWPW2,152098|ZDHHC18,ZDHHC18,84243|ZNF558,ZNF558,148156|ZNF598,ZNF598,90850" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="C7" ORGANISM="Mus musculus" SUB_CATEGORY_CODE="IMMUNESIGDB"/>
</MSIGDB>
