STANDARD_NAME	GSE46468_LUNG_INNATE_LYMPHOID_CELL_VS_SPLEEN_CD4_TCELL_UP
SYSTEMATIC_NAME	M8443
COLLECTION	C7:IMMUNESIGDB
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE46468_LUNG_INNATE_LYMPHOID_CELL_VS_SPLEEN_CD4_TCELL_UP
NAMESPACE	HUMAN_GENE_SYMBOL
DESCRIPTION_BRIEF	Genes up-regulated in lung innate lymphoid cells versus spleen CD4 [GeneID=920] T cells.
DESCRIPTION_FULL	Innate lymphoid cells (ILCs) are a recently recognized heterogenous group of immune cells that are critical in orchestrating immunity and inflammation in the intestine, but whether ILCs influence immune responses or tissue homeostasis at other mucosal sites remains poorly characterized. Here we identify a population of lung-resident ILCs in mice and humans that expressed the alloantigen Thy-1 (CD90), interleukin 2 (IL-2) receptor a-chain (CD25), IL-7 receptor a-chain (CD127) and the IL-33 receptor subunit T1-ST2. Notably, mouse ILCs accumulated in the lung after infection with influenza virus, and depletion of ILCs resulted in loss of airway epithelial integrity, diminished lung function and impaired airway remodeling. These defects were restored by administration of the lung ILC product amphiregulin. Collectively, our results demonstrate a critical role for lung ILCs in restoring airway epithelial integrity and tissue homeostasis after infection with influenza virus. As part of this study, we performed gene expression profiling to examine how the transcriptional signatures compared between murine naïve group 2 lung ILC and group 3 splenic LTi cell populations.
PMID	21946417
GEOID	GSE46468
AUTHORS	Monticelli LA,Sonnenberg GF,Abt MC,Alenghat T,Ziegler CG,Doering TA,Angelosanto JM,Laidlaw BJ,Yang CY,Sathaliyawala T,Kubota M,Turner D,Diamond JM,Goldrath AW,Farber DL,Collman RG,Wherry EJ,Artis D
CONTRIBUTOR	Jernej Godec
CONTRIBUTOR_ORG	Dana-Farber Cancer Institute
EXACT_SOURCE	GSE46468_3662_200_UP
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	ACAP1,ACAT1,ACAT2,ADI1,AGAP3,AGK,AKR1B1,ANAPC5,ANKRA2,ANXA11,ANXA4,AP1G2,ARHGAP15,ARHGEF6,ARSK,ASAH1,ASL,ASPRV1,ATMIN,ATP6V1G1,ATP7B,B3GNT1,BBS1,C3orf71,C5orf53,C6orf57,C9orf130,CAMK4,CAPS,CASC5,CBFA2T2,CDK5RAP2,CDKN2D,CHD9,CHST14,CLOCK,CLYBL,CMC1,CMPK1,CNPY3,COBRA1,COMMD9,CPNE1,DCAF17,DHFR,DHFRL1,DNASE1L1,DPEP2,EFCAB4B,EIF2AK1,EMB,EXOC1,EXOC4,FAM116A,FAM134A,FAM160B1,FAM172A,FAM45A,FAM96A,FBXO9,FBXW4,FGD3,FLJ37453,FOXJ2,GDPD1,GPD1L,GSK3B,GTF2IRD2,GUSBP11,GYS1,HEATR5B,HECA,HEXA,HINFP,HIST2H2BE,HIST3H2A,HSD17B11,HSDL2,HYLS1,IDH1,IDH2,ILK,INPP5D,IRAK4,ITIH4,KDELR1,KDM3B,KDM5A,KIAA0195,KIAA0319L,KIAA0391,KIAA0528,KIAA0586,KIAA1143,KIAA1530,KIAA1704,KIAA2013,KIF22,LIN7B,LIN9,LIX1L,LOC100129550,LOC100131754,LOC100288939,LOC100289420,LOC100294335,LOC100527964,LOC257396,LOC286272,LOC389831,MAP2K5,MAP2K6,MAP3K12,MARCH8,MARCH9,METTL23,MON2,MPND,MPP1,MRPL43,MYST2,NIN,NPRL3,NR1D2,OPN3,OSBPL7,PCBD2,PCCB,PIGY,PIGZ,PKN2,PNISR,PNRC1,PPARA,PPP1R12B,PURA,RABGAP1,RABGGTA,RAD52,RBM45,RFX7,RNPEPL1,RPS27L,RPS6KA1,SAC3D1,SAP30L,SDCBP2,SDHA,SH3BGRL,SIGIRR,SKA2,SLA2,SLC24A1,SLC25A20,SLC35A1,SLC35E2,SLC37A4,SLC7A6OS,SMAD2,SPG11,SPIN4,STMN3,SURF1,TAZ,TBC1D14,TBCK,TCF19,TGIF1,TM7SF2,TMEM101,TMEM129,TMEM179B,TMEM19,TMEM204,TPK1,TRERF1,TRIM46,TRMT1L,UBA7,UBR7,UCP2,VDAC3,VILL,VIPAR,VPS36,YIPF1,YPEL2,ZBP1,ZFAND1,ZKSCAN4,ZNF138,ZNF224,ZNF276,ZNF33A,ZNF398,ZNF449,ZNF500,ZNF518A,ZNF766,ZNF776
GENE_SYMBOLS	ACAP1,ACAT1,ACAT2,ADI1,AGAP3,AGK,AKR1B1,ANAPC5,ANKRA2,ANXA11,ANXA4,AP1G2,ARHGAP15,ARHGEF6,ARSK,ASAH1,ASL,ASPRV1,ATMIN,ATP6V1G1,ATP7B,B3GNT2,BBS1,ARIH2OS,IGIP,SDHAF4,ERCC6L2-AS1,CAMK4,CAPS,KNL1,CBFA2T2,CDK5RAP2,CDKN2D,CHD9,CHST14,CLOCK,CLYBL,CMC1,CMPK1,CNPY3,NELFB,COMMD9,CPNE1,DCAF17,DHFR,DHFR2,DNASE1L1,DPEP2,CRACR2A,EIF2AK1,EMB,EXOC1,EXOC4,DENND6A,RETREG2,FHIP2A,ARB2A,DENND10,CIAO2A,FBXO9,FBXW4,FGD3,SPEN-AS1,FOXJ2,GDPD1,GPD1L,GSK3B,GTF2IRD2,GUSBP11,GYS1,HEATR5B,HECA,HEXA,HINFP,H2BC21,H2AC25,HSD17B11,HSDL2,HYLS1,IDH1,IDH2,ILK,INPP5D,IRAK4,ITIH4,KDELR1,KDM3B,KDM5A,TMEM94,KIAA0319L,PRORP,C2CD5,KIAA0586,KIAA1143,UVSSA,GPALPP1,KIAA2013,KIF22,LIN7B,LIN9,LIX1L,LINC02035,,,,LRRC37A2,ACBD6,MOCS2-DT,,LOC389831,MAP2K5,MAP2K6,MAP3K12,MARCHF8,MARCHF9,METTL23,MON2,MPND,MPP1,MRPL43,KAT7,NIN,NPRL3,NR1D2,OPN3,OSBPL7,PCBD2,PCCB,PIGY,PIGZ,PKN2,PNISR,PNRC1,PPARA,PPP1R12B,PURA,RABGAP1,RABGGTA,RAD52,RBM45,RFX7,RNPEPL1,RPS27L,RPS6KA1,SAC3D1,SAP30L,SDCBP2,SDHA,SH3BGRL,SIGIRR,SKA2,SLA2,SLC24A1,SLC25A20,SLC35A1,SLC35E2A,SLC37A4,SLC7A6OS,SMAD2,SPG11,SPIN4,STMN3,SURF1,TAFAZZIN,TBC1D14,TBCK,TCF19,TGIF1,TM7SF2,TMEM101,TMEM129,TMEM179B,TMEM19,TMEM204,TPK1,TRERF1,TRIM46,TRMT1L,UBA7,UBR7,UCP2,VDAC3,VILL,VIPAS39,VPS36,YIPF1,YPEL2,ZBP1,ZFAND1,ZKSCAN4,ZNF138,ZNF224,ZNF276,ZNF33A,ZNF398,ZNF449,ZNF500,ZNF518A,ZNF766,ZNF776
FOUNDER_NAMES