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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="GSE46468_LUNG_INNATE_LYMPHOID_CELL_VS_SPLEEN_CD4_TCELL_UP" SYSTEMATIC_NAME="M8443" HISTORICAL_NAMES="" PMID="21946417" AUTHORS="Monticelli LA,Sonnenberg GF,Abt MC,Alenghat T,Ziegler CG,Doering TA,Angelosanto JM,Laidlaw BJ,Yang CY,Sathaliyawala T,Kubota M,Turner D,Diamond JM,Goldrath AW,Farber DL,Collman RG,Wherry EJ,Artis D" GEOID="GSE46468" EXACT_SOURCE="GSE46468_3662_200_UP" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="" CHIP="HUMAN_GENE_SYMBOL" CONTRIBUTOR="Jernej Godec" CONTRIBUTOR_ORG="Dana-Farber Cancer Institute" DESCRIPTION_BRIEF="Genes up-regulated in lung innate lymphoid cells versus spleen CD4 [GeneID=920] T cells." DESCRIPTION_FULL="Innate lymphoid cells (ILCs) are a recently recognized heterogenous group of immune cells that are critical in orchestrating immunity and inflammation in the intestine, but whether ILCs influence immune responses or tissue homeostasis at other mucosal sites remains poorly characterized. Here we identify a population of lung-resident ILCs in mice and humans that expressed the alloantigen Thy-1 (CD90), interleukin 2 (IL-2) receptor a-chain (CD25), IL-7 receptor a-chain (CD127) and the IL-33 receptor subunit T1-ST2. Notably, mouse ILCs accumulated in the lung after infection with influenza virus, and depletion of ILCs resulted in loss of airway epithelial integrity, diminished lung function and impaired airway remodeling. These defects were restored by administration of the lung ILC product amphiregulin. Collectively, our results demonstrate a critical role for lung ILCs in restoring airway epithelial integrity and tissue homeostasis after infection with influenza virus. As part of this study, we performed gene expression profiling to examine how the transcriptional signatures compared between murine naïve group 2 lung ILC and group 3 splenic LTi cell populations." TAGS="" MEMBERS="ACAP1,ACAT1,ACAT2,ADI1,AGAP3,AGK,AKR1B1,ANAPC5,ANKRA2,ANXA11,ANXA4,AP1G2,ARHGAP15,ARHGEF6,ARSK,ASAH1,ASL,ASPRV1,ATMIN,ATP6V1G1,ATP7B,B3GNT1,BBS1,C3orf71,C5orf53,C6orf57,C9orf130,CAMK4,CAPS,CASC5,CBFA2T2,CDK5RAP2,CDKN2D,CHD9,CHST14,CLOCK,CLYBL,CMC1,CMPK1,CNPY3,COBRA1,COMMD9,CPNE1,DCAF17,DHFR,DHFRL1,DNASE1L1,DPEP2,EFCAB4B,EIF2AK1,EMB,EXOC1,EXOC4,FAM116A,FAM134A,FAM160B1,FAM172A,FAM45A,FAM96A,FBXO9,FBXW4,FGD3,FLJ37453,FOXJ2,GDPD1,GPD1L,GSK3B,GTF2IRD2,GUSBP11,GYS1,HEATR5B,HECA,HEXA,HINFP,HIST2H2BE,HIST3H2A,HSD17B11,HSDL2,HYLS1,IDH1,IDH2,ILK,INPP5D,IRAK4,ITIH4,KDELR1,KDM3B,KDM5A,KIAA0195,KIAA0319L,KIAA0391,KIAA0528,KIAA0586,KIAA1143,KIAA1530,KIAA1704,KIAA2013,KIF22,LIN7B,LIN9,LIX1L,LOC100129550,LOC100131754,LOC100288939,LOC100289420,LOC100294335,LOC100527964,LOC257396,LOC286272,LOC389831,MAP2K5,MAP2K6,MAP3K12,MARCH8,MARCH9,METTL23,MON2,MPND,MPP1,MRPL43,MYST2,NIN,NPRL3,NR1D2,OPN3,OSBPL7,PCBD2,PCCB,PIGY,PIGZ,PKN2,PNISR,PNRC1,PPARA,PPP1R12B,PURA,RABGAP1,RABGGTA,RAD52,RBM45,RFX7,RNPEPL1,RPS27L,RPS6KA1,SAC3D1,SAP30L,SDCBP2,SDHA,SH3BGRL,SIGIRR,SKA2,SLA2,SLC24A1,SLC25A20,SLC35A1,SLC35E2,SLC37A4,SLC7A6OS,SMAD2,SPG11,SPIN4,STMN3,SURF1,TAZ,TBC1D14,TBCK,TCF19,TGIF1,TM7SF2,TMEM101,TMEM129,TMEM179B,TMEM19,TMEM204,TPK1,TRERF1,TRIM46,TRMT1L,UBA7,UBR7,UCP2,VDAC3,VILL,VIPAR,VPS36,YIPF1,YPEL2,ZBP1,ZFAND1,ZKSCAN4,ZNF138,ZNF224,ZNF276,ZNF33A,ZNF398,ZNF449,ZNF500,ZNF518A,ZNF766,ZNF776" MEMBERS_SYMBOLIZED="ACAP1,ACAT1,ACAT2,ACBD6,ADI1,AGAP3,AGK,AKR1B1,ANAPC5,ANKRA2,ANXA11,ANXA4,AP1G2,ARB2A,ARHGAP15,ARHGEF6,ARIH2OS,ARSK,ASAH1,ASL,ASPRV1,ATMIN,ATP6V1G1,ATP7B,B3GNT2,BBS1,C2CD5,CAMK4,CAPS,CBFA2T2,CDK5RAP2,CDKN2D,CHD9,CHST14,CIAO2A,CLOCK,CLYBL,CMC1,CMPK1,CNPY3,COMMD9,CPNE1,CRACR2A,DCAF17,DENND10,DENND6A,DHFR,DHFR2,DNASE1L1,DPEP2,EIF2AK1,EMB,ERCC6L2-AS1,EXOC1,EXOC4,FBXO9,FBXW4,FGD3,FHIP2A,FOXJ2,GDPD1,GPALPP1,GPD1L,GSK3B,GTF2IRD2,GUSBP11,GYS1,H2AC25,H2BC21,HEATR5B,HECA,HEXA,HINFP,HSD17B11,HSDL2,HYLS1,IDH1,IDH2,IGIP,ILK,INPP5D,IRAK4,ITIH4,KAT7,KDELR1,KDM3B,KDM5A,KIAA0319L,KIAA0586,KIAA1143,KIAA2013,KIF22,KNL1,LIN7B,LIN9,LINC02035,LIX1L,LOC389831,LRRC37A2,MAP2K5,MAP2K6,MAP3K12,MARCHF8,MARCHF9,METTL23,MOCS2-DT,MON2,MPND,MPP1,MRPL43,NELFB,NIN,NPRL3,NR1D2,OPN3,OSBPL7,PCBD2,PCCB,PIGY,PIGZ,PKN2,PNISR,PNRC1,PPARA,PPP1R12B,PRORP,PURA,RABGAP1,RABGGTA,RAD52,RBM45,RETREG2,RFX7,RNPEPL1,RPS27L,RPS6KA1,SAC3D1,SAP30L,SDCBP2,SDHA,SDHAF4,SH3BGRL,SIGIRR,SKA2,SLA2,SLC24A1,SLC25A20,SLC35A1,SLC35E2A,SLC37A4,SLC7A6OS,SMAD2,SPEN-AS1,SPG11,SPIN4,STMN3,SURF1,TAFAZZIN,TBC1D14,TBCK,TCF19,TGIF1,TM7SF2,TMEM101,TMEM129,TMEM179B,TMEM19,TMEM204,TMEM94,TPK1,TRERF1,TRIM46,TRMT1L,UBA7,UBR7,UCP2,UVSSA,VDAC3,VILL,VIPAS39,VPS36,YIPF1,YPEL2,ZBP1,ZFAND1,ZKSCAN4,ZNF138,ZNF224,ZNF276,ZNF33A,ZNF398,ZNF449,ZNF500,ZNF518A,ZNF766,ZNF776" MEMBERS_EZID="100128782,100129550,1032,10559,10678,10695,10945,10957,11143,113189,114881,116988,124512,128077,129831,133418,135154,139886,151516,152100,153642,171425,1719,1774,200895,201627,203523,219844,220972,23041,231,23171,23300,23596,23637,2542,257396,25920,25957,25988,26048,26268,27010,27102,27111,284161,284309,286826,29099,2932,29901,2997,307,3073,311,3417,3418,348235,3611,3635,3700,374395,38,3835,387032,388403,389831,39,404636,4087,427,435,4354,4660,474170,492311,50853,50861,5096,51028,51065,51135,51170,51199,51433,51696,51727,51780,540,54432,54497,5465,55148,55256,55266,55425,55750,55755,55763,55809,55810,55843,5586,5607,5608,57082,57140,57456,57533,57541,57654,57700,57763,5813,582,5875,5893,5927,59307,60412,6195,6389,63894,64130,64174,6451,646450,6468,64864,6834,6901,6941,7050,7108,729614,7318,7351,7419,7581,7697,7767,7786,788,79137,79652,79685,79752,79932,80067,80128,80205,80208,80235,81030,8131,814,81627,828,8349,83989,84105,84138,84163,84174,84191,84263,84320,84336,84545,84766,84954,84992,8904,8906,89846,90231,90321,91316,9139,9187,92305,92815,92822,92979,93627,9459,9550,9575,9692,9744,9772,9786,9847,9849,9906,9975" MEMBERS_MAPPING="ACAP1,ACAP1,9744|ACAT1,ACAT1,38|ACAT2,ACAT2,39|ADI1,ADI1,55256|AGAP3,AGAP3,116988|AGK,AGK,55750|AKR1B1,AKR1B1,231|ANAPC5,ANAPC5,51433|ANKRA2,ANKRA2,57763|ANXA11,ANXA11,311|ANXA4,ANXA4,307|AP1G2,AP1G2,8906|ARHGAP15,ARHGAP15,55843|ARHGEF6,ARHGEF6,9459|ARSK,ARSK,153642|ASAH1,ASAH1,427|ASL,ASL,435|ASPRV1,ASPRV1,151516|ATMIN,ATMIN,23300|ATP6V1G1,ATP6V1G1,9550|ATP7B,ATP7B,540|B3GNT1,B3GNT2,10678|BBS1,BBS1,582|C3orf71,ARIH2OS,646450|C5orf53,IGIP,492311|C6orf57,SDHAF4,135154|C9orf130,ERCC6L2-AS1,100128782|CAMK4,CAMK4,814|CAPS,CAPS,828|CASC5,KNL1,57082|CBFA2T2,CBFA2T2,9139|CDK5RAP2,CDK5RAP2,55755|CDKN2D,CDKN2D,1032|CHD9,CHD9,80205|CHST14,CHST14,113189|CLOCK,CLOCK,9575|CLYBL,CLYBL,171425|CMC1,CMC1,152100|CMPK1,CMPK1,51727|CNPY3,CNPY3,10695|COBRA1,NELFB,25920|COMMD9,COMMD9,29099|CPNE1,CPNE1,8904|DCAF17,DCAF17,80067|DHFR,DHFR,1719|DHFRL1,DHFR2,200895|DNASE1L1,DNASE1L1,1774|DPEP2,DPEP2,64174|EFCAB4B,CRACR2A,84766|EIF2AK1,EIF2AK1,27102|EMB,EMB,133418|EXOC1,EXOC1,55763|EXOC4,EXOC4,60412|FAM116A,DENND6A,201627|FAM134A,RETREG2,79137|FAM160B1,FHIP2A,57700|FAM172A,ARB2A,83989|FAM45A,DENND10,404636|FAM96A,CIAO2A,84191|FBXO9,FBXO9,26268|FBXW4,FBXW4,6468|FGD3,FGD3,89846|FLJ37453,SPEN-AS1,729614|FOXJ2,FOXJ2,55810|GDPD1,GDPD1,284161|GPD1L,GPD1L,23171|GSK3B,GSK3B,2932|GTF2IRD2,GTF2IRD2,84163|GUSBP11,GUSBP11,91316|GYS1,GYS1,2997|HEATR5B,HEATR5B,54497|HECA,HECA,51696|HEXA,HEXA,3073|HINFP,HINFP,25988|HIST2H2BE,H2BC21,8349|HIST3H2A,H2AC25,92815|HSD17B11,HSD17B11,51170|HSDL2,HSDL2,84263|HYLS1,HYLS1,219844|IDH1,IDH1,3417|IDH2,IDH2,3418|ILK,ILK,3611|INPP5D,INPP5D,3635|IRAK4,IRAK4,51135|ITIH4,ITIH4,3700|KDELR1,KDELR1,10945|KDM3B,KDM3B,51780|KDM5A,KDM5A,5927|KIAA0195,TMEM94,9772|KIAA0319L,KIAA0319L,79932|KIAA0391,PRORP,9692|KIAA0528,C2CD5,9847|KIAA0586,KIAA0586,9786|KIAA1143,KIAA1143,57456|KIAA1530,UVSSA,57654|KIAA1704,GPALPP1,55425|KIAA2013,KIAA2013,90231|KIF22,KIF22,3835|LIN7B,LIN7B,64130|LIN9,LIN9,286826|LIX1L,LIX1L,128077|LOC100129550,LINC02035,100129550|LOC100131754,null,null|LOC100288939,null,null|LOC100289420,null,null|LOC100294335,LRRC37A2,474170|LOC100527964,ACBD6,84320|LOC257396,MOCS2-DT,257396|LOC286272,null,null|LOC389831,LOC389831,389831|MAP2K5,MAP2K5,5607|MAP2K6,MAP2K6,5608|MAP3K12,MAP3K12,7786|MARCH8,MARCHF8,220972|MARCH9,MARCHF9,92979|METTL23,METTL23,124512|MON2,MON2,23041|MPND,MPND,84954|MPP1,MPP1,4354|MRPL43,MRPL43,84545|MYST2,KAT7,11143|NIN,NIN,51199|NPRL3,NPRL3,8131|NR1D2,NR1D2,9975|OPN3,OPN3,23596|OSBPL7,OSBPL7,114881|PCBD2,PCBD2,84105|PCCB,PCCB,5096|PIGY,PIGY,84992|PIGZ,PIGZ,80235|PKN2,PKN2,5586|PNISR,PNISR,25957|PNRC1,PNRC1,10957|PPARA,PPARA,5465|PPP1R12B,PPP1R12B,4660|PURA,PURA,5813|RABGAP1,RABGAP1,23637|RABGGTA,RABGGTA,5875|RAD52,RAD52,5893|RBM45,RBM45,129831|RFX7,RFX7,64864|RNPEPL1,RNPEPL1,57140|RPS27L,RPS27L,51065|RPS6KA1,RPS6KA1,6195|SAC3D1,SAC3D1,29901|SAP30L,SAP30L,79685|SDCBP2,SDCBP2,27111|SDHA,SDHA,6389|SH3BGRL,SH3BGRL,6451|SIGIRR,SIGIRR,59307|SKA2,SKA2,348235|SLA2,SLA2,84174|SLC24A1,SLC24A1,9187|SLC25A20,SLC25A20,788|SLC35A1,SLC35A1,10559|SLC35E2,SLC35E2A,9906|SLC37A4,SLC37A4,2542|SLC7A6OS,SLC7A6OS,84138|SMAD2,SMAD2,4087|SPG11,SPG11,80208|SPIN4,SPIN4,139886|STMN3,STMN3,50861|SURF1,SURF1,6834|TAZ,TAFAZZIN,6901|TBC1D14,TBC1D14,57533|TBCK,TBCK,93627|TCF19,TCF19,6941|TGIF1,TGIF1,7050|TM7SF2,TM7SF2,7108|TMEM101,TMEM101,84336|TMEM129,TMEM129,92305|TMEM179B,TMEM179B,374395|TMEM19,TMEM19,55266|TMEM204,TMEM204,79652|TPK1,TPK1,27010|TRERF1,TRERF1,55809|TRIM46,TRIM46,80128|TRMT1L,TRMT1L,81627|UBA7,UBA7,7318|UBR7,UBR7,55148|UCP2,UCP2,7351|VDAC3,VDAC3,7419|VILL,VILL,50853|VIPAR,VIPAS39,63894|VPS36,VPS36,51028|YIPF1,YIPF1,54432|YPEL2,YPEL2,388403|ZBP1,ZBP1,81030|ZFAND1,ZFAND1,79752|ZKSCAN4,ZKSCAN4,387032|ZNF138,ZNF138,7697|ZNF224,ZNF224,7767|ZNF276,ZNF276,92822|ZNF33A,ZNF33A,7581|ZNF398,ZNF398,57541|ZNF449,ZNF449,203523|ZNF500,ZNF500,26048|ZNF518A,ZNF518A,9849|ZNF766,ZNF766,90321|ZNF776,ZNF776,284309" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="C7" ORGANISM="Mus musculus" SUB_CATEGORY_CODE="IMMUNESIGDB"/>
</MSIGDB>
