STANDARD_NAME GSE46606_UNSTIM_VS_CD40L_IL2_IL5_3DAY_STIMULATED_IRF4HIGH_SORTED_BCELL_DN SYSTEMATIC_NAME M9832 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE46606_UNSTIM_VS_CD40L_IL2_IL5_3DAY_STIMULATED_IRF4HIGH_SORTED_BCELL_DN NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes down-regulated in at day 0 B cell IRF4-KO versus CD40L and IL-2 IL-4 IL-5 stimulated at day 3 B cell IRF4high. DESCRIPTION_FULL Temporal analysis of B cell activation in vitro using CD40L and IL-2/4/5 cytokines in wild type Irf4+/+ B cells or in mutant Irf4-/- B cells harboring a tet-inducible allele of Irf4. IRF4 expression was restored, or not, in the Irf4-/- background by culturing in the presence of low or high concentrations of doxycycline. The results provide insight in the role of IRF4 expression levels in coordinating different programs of B cell differentiation. PMID 23684984 GEOID GSE46606 AUTHORS Ochiai K,Maienschein-Cline M,Simonetti G,Chen J,Rosenthal R,Brink R,Chong AS,Klein U,Dinner AR,Singh H,Sciammas R CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE46606_3711_200_DN FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ACTL7A,ADAMTSL5,AEBP1,AFAP1L2,AGRP,AKR1D1,ALMS1,ALPPL2,AMY2A,AMZ2,ANKRD22,APCDD1,ARG2,ASB1,ASPM,BCL9,BNC2,BPGM,BRS3,C11orf16,C14orf39,C19orf43,C21orf63,C2orf28,C3orf22,CA13,CADPS2,CALN1,CBY3,CCDC153,CD1D,CD207,CD209,CDH11,CDH9,CFHR2,CLTB,CNBP,COL3A1,COX4NB,CRH,CRHBP,CRIPT,CRYZL1,CWH43,CXCL6,CXorf64,CYGB,CYP11B1,CYP4A11,DCST1,DEFB119,DLX1,DNAJC11,DPYS,EAF2,EHHADH,FAM46B,FAM71B,FAM90A13,FEZ1,FGF4,FGF7,FOXI1,FREM2,GABARAPL2,GABRA5,GIGYF2,GPR12,GPR137,GPRIN2,GREB1,GSTM2,GUCY2C,HBP1,HMX3,HOXC10,HSD17B11,IFNB1,IGDCC3,ILKAP,IYD,JAKMIP3,KBTBD3,KCNC2,KCNE3,KCNJ13,KCNJ16,KCNN3,KIAA1244,KLRC2,KRT10,KRTAP4-7,LAD1,LAPTM4A,LECT2,LEF1,LOC100128160,LRIT2,LRRIQ3,LRRTM1,M1,MAMDC2,MAPRE3,MEA1,MIXL1,MMS19,MNS1,MRPL46,MRPL49,MRPS24,MS4A1,MUC16,MYF6,MYH3,MYO1E,MYO3A,MYOD1,NGFR,NKAIN2,NOB1,NPFFR2,NPHP1,NRN1L,NSUN7,NUDT13,NYX,OR2T33,OXGR1,PCDH17,PDE6B,PDGFRL,PHEX,PIGB,PKDREJ,PKHD1,PLCZ1,PLEKHG5,PLXNA1,PM20D1,PMVK,POU2AF1,PPP1R14C,PRICKLE2,PRSS41,PRSS53,PSD,PSMD1,RAB36,RHBG,RPS9,SARS2,SCAI,SDPR,SELS,SFRP4,SIRT5,SLC15A1,SLC22A16,SLC25A3,SLC27A3,SLC2A12,SLC35F4,SLC6A19,SMARCE1,SOX2,SPAG1,SPATS1,SSR4,ST3GAL4,ST6GALNAC3,STARD13,SUPT4H1,SYCP2L,SYCP3,SYDE2,SYN3,SYT13,TCTN3,TFAP2D,TMCO2,TMEM158,TMEM159,TMEM17,TMEM180,TMEM184A,TMEM225,TNFRSF25,TNFSF9,TRAF4,UBE2U,UQCRFS1,VASH1,VAT1L,VIPR2,VSTM2B,VWA5B2,WDR73,ZNF248,ZNF560 GENE_SYMBOLS ACTL7A,ADAMTSL5,AEBP1,AFAP1L2,AGRP,AKR1D1,ALMS1,ALPG,AMY2A,AMZ2,ANKRD22,APCDD1,ARG2,ASB1,ASPM,BCL9,BNC2,BPGM,BRS3,C11orf16,C14orf39,TRIR,EVA1C,ATRAID,C3orf22,CA13,CADPS2,CALN1,CBY3,CCDC153,CD1D,CD207,CD209,CDH11,CDH9,CFHR2,CLTB,CNBP,COL3A1,EMC8,CRH,CRHBP,CRIPT,CRYZL1,CWH43,CXCL6,PRR32,CYGB,CYP11B1,CYP4A11,DCST1,DEFB119,DLX1,DNAJC11,DPYS,EAF2,EHHADH,TENT5B,GARIN3,FAM90A13P,FEZ1,FGF4,FGF7,FOXI1,FREM2,GABARAPL2,GABRA5,GIGYF2,GPR12,GPR137,GPRIN2,GREB1,GSTM2,GUCY2C,HBP1,HMX3,HOXC10,HSD17B11,IFNB1,IGDCC3,ILKAP,IYD,JAKMIP3,KBTBD3,KCNC2,KCNE3,KCNJ13,KCNJ16,KCNN3,ARFGEF3,KLRC2,KRT10,KRTAP4-7,LAD1,LAPTM4A,LECT2,LEF1,,LRIT2,LRRIQ3,LRRTM1,MRLN,MAMDC2,MAPRE3,MEA1,MIXL1,MMS19,MNS1,MRPL46,MRPL49,MRPS24,MS4A1,MUC16,MYF6,MYH3,MYO1E,MYO3A,MYOD1,NGFR,NKAIN2,NOB1,NPFFR2,NPHP1,NRN1L,NSUN7,NUDT13,NYX,OR2T33,OXGR1,PCDH17,PDE6B,PDGFRL,PHEX,PIGB,PKDREJ,PKHD1,PLCZ1,PLEKHG5,PLXNA1,PM20D1,PMVK,POU2AF1,PPP1R14C,PRICKLE2,PRSS41,PRSS53,PSD,PSMD1,RAB36,RHBG,RPS9,SARS2,SCAI,CAVIN2,SELENOS,SFRP4,SIRT5,SLC15A1,SLC22A16,SLC25A3,SLC27A3,SLC2A12,SLC35F4,SLC6A19,SMARCE1,SOX2,SPAG1,SPATS1,SSR4,ST3GAL4,ST6GALNAC3,STARD13,SUPT4H1,SYCP2L,SYCP3,SYDE2,SYN3,SYT13,TCTN3,TFAP2D,TMCO2,TMEM158,LDAF1,TMEM17,MFSD13A,TMEM184A,TMEM225,TNFRSF25,TNFSF9,TRAF4,UBE2U,UQCRFS1,VASH1,VAT1L,VIPR2,VSTM2B,VWA5B2,WDR73,ZNF248,ZNF560 FOUNDER_NAMES