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     See license terms at www.gsea-msigdb.org/gsea/license_terms_list. Please note that certain gene sets have special access terms.
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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="GSE5142_HTERT_TRANSDUCED_VS_CTRL_CD8_TCELL_LATE_PASSAGE_CLONE_DN" SYSTEMATIC_NAME="M6552" HISTORICAL_NAMES="" PMID="16951325" AUTHORS="Menzel O,Migliaccio M,Goldstein DR,Dahoun S,Delorenzi M,Rufer N" GEOID="GSE5142" EXACT_SOURCE="GSE5142_3573_200_DN" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="" CHIP="HUMAN_GENE_SYMBOL" CONTRIBUTOR="Jernej Godec" CONTRIBUTOR_ORG="Dana-Farber Cancer Institute" DESCRIPTION_BRIEF="Genes down-regulated in CD8 T cells: early passage clone over-expressing TERT [GeneID=7015] versus late passage control." DESCRIPTION_FULL="Using CD8+ T lymphocyte clones over-expressing telomerase weinvestigated the molecular mechanisms that regulate T cell proliferation. Transduction and subcloning procedures were performed on CD8 + naive T-cell clones isolated from two different healthy individuals aged between 30 to 35 years (HD1 and HD2). T-cell cloneswere transduced to express hTERT/GFP or GFP alone. HD2 was profiled on U133Plus 2.0 and submitted as a separate GEO series." TAGS="" MEMBERS="ABCC5,ABHD15,ABLIM2,ACAD10,ARID1A,ARRB1,ASCL3,ATP11C,BACH1,BAG5,BAHD1,BCDIN3D,BET1L,BRAT1,BTBD19,C10orf26,C10orf54,C16orf5,C17orf28,C17orf70,C7orf64,C8orf82,CABLES2,CAMK1D,CASC3,CCDC82,CD1D,CD97,CDC42SE2,CDS2,CELF1,CHM,CHMP1B,CPM,CRY2,CSGALNACT1,CSNK1E,CYP21A1P,CYP2D6,DAPK1,DEGS1,DENND2C,DGKD,DHRS13,DNAJB9,DNAJC6,ELAC1,ETS1,ETV3,FAM101B,FAM109A,FAM120AOS,FAM18B1,FAM49A,FAM63A,FLOT2,FOXO4,FPGT,FRAT2,FRMD6,FRMD8,FUK,GALNT2,GALNT9,GCLC,GLG1,GPR97,HIST1H1C,HIST1H2BL,HLCS,HSBP1,IER5,IL1RL2,IL6R,INO80,INPP5A,IRF6,ITPKB,KCTD10,KHNYN,KIAA0240,KIAA0930,KIAA1147,KIDINS220,KIF13B,KLF6,KLF7,KLHL21,KLHL8,KRAS,L3MBTL3,LAPTM4A,LATS2,LEF1,LEPROTL1,LETM2,LNPEP,MAN1C1,MAP3K1,MAP4K5,MARVELD1,MFGE8,MFSD6,MICALL1,MKRN1,MYO9A,NBEAL1,NCKAP5L,NDFIP2,NR3C1,NUMB,ODZ1,OTUD1,PAQR7,PATL2,PDCD6IP,PDE4DIP,PDE7A,PEX5,PHF23,PHF3,PIGP,PIK3C3,PIP4K2B,PITPNM1,PNPLA2,POLG,PRG4,PRKCZ,PTTG1,PTTG1IP,RABGGTA,RAMP1,RASSF2,RASSF3,RASSF8,RFX1,RFX3,RGS2,RHEBL1,RHOB,RICTOR,RNF146,RNF167,RNF44,RNPEPL1,RPS6KA2,RRM2B,RSU1,RYBP,SAG,SBSN,SERTAD2,SETD3,SH3PXD2A,SHOC2,SLC25A35,SLC36A1,SMAD4,SMAD7,SMUG1,SPACA1,SPPL2A,STAT5B,STX17,TAGAP,TBC1D20,TBC1D30,TCF7,TCN2,TCTA,TEC,TES,THRA,TIRAP,TMEM204,TMEM42,TMEM43,TMEM8A,TNKS,TP53I13,TRIB3,TRIO,TSC22D3,TTC28,TTYH2,TUBB2A,UBE2J1,UGCG,USE1,VWCE,WIPF2,XYLT2,YPEL3,YY1,ZBTB2,ZHX2,ZMYM5,ZNF274,ZNF394" MEMBERS_SYMBOLIZED="ABCC5,ABHD15,ABLIM2,ACAD10,ADGRE5,ADGRG3,ARID1A,ARRB1,ASCL3,ATP11C,BACH1,BAG5,BAHD1,BCDIN3D,BET1L,BICRAL,BRAT1,BTBD19,C8orf82,CABLES2,CAMK1D,CASC3,CCDC82,CD1D,CDC42SE2,CDIP1,CDS2,CELF1,CHM,CHMP1B,CPM,CRY2,CSGALNACT1,CSNK1E,CYP21A1P,CYP2D6,CYRIA,DAPK1,DEGS1,DENND11,DENND2C,DGKD,DHRS13,DNAJB9,DNAJC6,ELAC1,ETS1,ETV3,FAAP100,FAM120AOS,FCSK,FLOT2,FOXO4,FPGT,FRAT2,FRMD6,FRMD8,GALNT2,GALNT9,GCLC,GLG1,H1-2,H2BC13,HID1,HLCS,HSBP1,IER5,IL1RL2,IL6R,INO80,INPP5A,IRF6,ITPKB,KCTD10,KHNYN,KIAA0930,KIDINS220,KIF13B,KLF6,KLF7,KLHL21,KLHL8,KRAS,L3MBTL3,LAPTM4A,LATS2,LEF1,LEPROTL1,LETM2,LNPEP,MAN1C1,MAP3K1,MAP4K5,MARVELD1,MFGE8,MFSD6,MICALL1,MINDY1,MKRN1,MYO9A,NBEAL1,NCKAP5L,NDFIP2,NR3C1,NUMB,OTUD1,PAQR7,PATL2,PDCD6IP,PDE4DIP,PDE7A,PEX5,PGAP6,PHETA1,PHF23,PHF3,PIGP,PIK3C3,PIP4K2B,PITPNM1,PNPLA2,POLG,PRG4,PRKCZ,PTTG1,PTTG1IP,RABGGTA,RAMP1,RASSF2,RASSF3,RASSF8,RBM48,RFLNB,RFX1,RFX3,RGS2,RHEBL1,RHOB,RICTOR,RNF146,RNF167,RNF44,RNPEPL1,RPS6KA2,RRM2B,RSU1,RYBP,SAG,SBSN,SERTAD2,SETD3,SH3PXD2A,SHOC2,SLC25A35,SLC36A1,SMAD4,SMAD7,SMUG1,SPACA1,SPPL2A,STAT5B,STX17,TAGAP,TBC1D20,TBC1D30,TCF7,TCN2,TCTA,TEC,TENM1,TES,THRA,TIRAP,TMEM204,TMEM42,TMEM43,TNKS,TP53I13,TRIB3,TRIO,TSC22D3,TTC28,TTYH2,TUBB2A,TVP23B,UBE2J1,UGCG,USE1,VSIR,VWCE,WBP1L,WIPF2,XYLT2,YPEL3,YY1,ZBTB2,ZHX2,ZMYM5,ZNF274,ZNF394" MEMBERS_EZID="10015,10057,10178,10216,10267,10658,10782,11183,1121,11228,114609,116236,117289,121268,122786,128637,1316,131616,1368,137994,1408,144233,144717,1454,147015,147179,149478,1565,158293,1590,1612,163259,164091,1831,197135,197258,206358,2113,2117,220001,220213,221927,222487,22794,22838,22882,22893,2319,23303,23313,23329,23331,23351,23401,23429,23469,23484,23506,23583,23608,253260,2590,26001,26136,26524,2729,2734,283349,283987,286410,2908,29965,3006,3141,3281,3570,359845,3632,3664,3707,374897,3845,388,399512,4012,408,4089,4092,414919,4189,4214,4240,4303,4649,50484,50614,51030,51176,51227,51272,51278,51465,5150,5289,5428,54602,54617,54838,54842,55014,55520,55790,55793,55850,5590,56676,56990,571,57104,57118,57132,57134,57140,57189,57498,57563,57621,57701,57761,5830,5875,58986,5989,5991,5997,6196,6251,6295,64115,64132,65065,6777,6932,6948,6988,7006,7067,7204,7280,7357,7528,754,79142,79188,79652,79780,80233,8036,80724,81553,81833,81847,81928,8289,8340,83719,83742,83786,83892,8396,84060,84124,84193,84448,84456,84888,8527,85377,8560,8609,8650,8658,8760,8790,8808,90313,912,9205,9232,94015,9529,9600,9644,9659,9741,976,9770,9792,9829,9903" MEMBERS_MAPPING="ABCC5,ABCC5,10057|ABHD15,ABHD15,116236|ABLIM2,ABLIM2,84448|ACAD10,ACAD10,80724|ARID1A,ARID1A,8289|ARRB1,ARRB1,408|ASCL3,ASCL3,56676|ATP11C,ATP11C,286410|BACH1,BACH1,571|BAG5,BAG5,9529|BAHD1,BAHD1,22893|BCDIN3D,BCDIN3D,144233|BET1L,BET1L,51272|BRAT1,BRAT1,221927|BTBD19,BTBD19,149478|C10orf26,WBP1L,54838|C10orf54,VSIR,64115|C16orf5,CDIP1,29965|C17orf28,HID1,283987|C17orf70,FAAP100,80233|C7orf64,RBM48,84060|C8orf82,C8orf82,414919|CABLES2,CABLES2,81928|CAMK1D,CAMK1D,57118|CASC3,CASC3,22794|CCDC82,CCDC82,79780|CD1D,CD1D,912|CD97,ADGRE5,976|CDC42SE2,CDC42SE2,56990|CDS2,CDS2,8760|CELF1,CELF1,10658|CHM,CHM,1121|CHMP1B,CHMP1B,57132|CPM,CPM,1368|CRY2,CRY2,1408|CSGALNACT1,CSGALNACT1,55790|CSNK1E,CSNK1E,1454|CYP21A1P,CYP21A1P,1590|CYP2D6,CYP2D6,1565|DAPK1,DAPK1,1612|DEGS1,DEGS1,8560|DENND2C,DENND2C,163259|DGKD,DGKD,8527|DHRS13,DHRS13,147015|DNAJB9,DNAJB9,4189|DNAJC6,DNAJC6,9829|ELAC1,ELAC1,55520|ETS1,ETS1,2113|ETV3,ETV3,2117|FAM101B,RFLNB,359845|FAM109A,PHETA1,144717|FAM120AOS,FAM120AOS,158293|FAM18B1,TVP23B,51030|FAM49A,CYRIA,81553|FAM63A,MINDY1,55793|FLOT2,FLOT2,2319|FOXO4,FOXO4,4303|FPGT,FPGT,8790|FRAT2,FRAT2,23401|FRMD6,FRMD6,122786|FRMD8,FRMD8,83786|FUK,FCSK,197258|GALNT2,GALNT2,2590|GALNT9,GALNT9,50614|GCLC,GCLC,2729|GLG1,GLG1,2734|GPR97,ADGRG3,222487|HIST1H1C,H1-2,3006|HIST1H2BL,H2BC13,8340|HLCS,HLCS,3141|HSBP1,HSBP1,3281|IER5,IER5,51278|IL1RL2,IL1RL2,8808|IL6R,IL6R,3570|INO80,INO80,54617|INPP5A,INPP5A,3632|IRF6,IRF6,3664|ITPKB,ITPKB,3707|KCTD10,KCTD10,83892|KHNYN,KHNYN,23351|KIAA0240,BICRAL,23506|KIAA0930,KIAA0930,23313|KIAA1147,DENND11,57189|KIDINS220,KIDINS220,57498|KIF13B,KIF13B,23303|KLF6,KLF6,1316|KLF7,KLF7,8609|KLHL21,KLHL21,9903|KLHL8,KLHL8,57563|KRAS,KRAS,3845|L3MBTL3,L3MBTL3,84456|LAPTM4A,LAPTM4A,9741|LATS2,LATS2,26524|LEF1,LEF1,51176|LEPROTL1,LEPROTL1,23484|LETM2,LETM2,137994|LNPEP,LNPEP,4012|MAN1C1,MAN1C1,57134|MAP3K1,MAP3K1,4214|MAP4K5,MAP4K5,11183|MARVELD1,MARVELD1,83742|MFGE8,MFGE8,4240|MFSD6,MFSD6,54842|MICALL1,MICALL1,85377|MKRN1,MKRN1,23608|MYO9A,MYO9A,4649|NBEAL1,NBEAL1,65065|NCKAP5L,NCKAP5L,57701|NDFIP2,NDFIP2,54602|NR3C1,NR3C1,2908|NUMB,NUMB,8650|ODZ1,TENM1,10178|OTUD1,OTUD1,220213|PAQR7,PAQR7,164091|PATL2,PATL2,197135|PDCD6IP,PDCD6IP,10015|PDE4DIP,PDE4DIP,9659|PDE7A,PDE7A,5150|PEX5,PEX5,5830|PHF23,PHF23,79142|PHF3,PHF3,23469|PIGP,PIGP,51227|PIK3C3,PIK3C3,5289|PIP4K2B,PIP4K2B,8396|PITPNM1,PITPNM1,9600|PNPLA2,PNPLA2,57104|POLG,POLG,5428|PRG4,PRG4,10216|PRKCZ,PRKCZ,5590|PTTG1,PTTG1,9232|PTTG1IP,PTTG1IP,754|RABGGTA,RABGGTA,5875|RAMP1,RAMP1,10267|RASSF2,RASSF2,9770|RASSF3,RASSF3,283349|RASSF8,RASSF8,11228|RFX1,RFX1,5989|RFX3,RFX3,5991|RGS2,RGS2,5997|RHEBL1,RHEBL1,121268|RHOB,RHOB,388|RICTOR,RICTOR,253260|RNF146,RNF146,81847|RNF167,RNF167,26001|RNF44,RNF44,22838|RNPEPL1,RNPEPL1,57140|RPS6KA2,RPS6KA2,6196|RRM2B,RRM2B,50484|RSU1,RSU1,6251|RYBP,RYBP,23429|SAG,SAG,6295|SBSN,SBSN,374897|SERTAD2,SERTAD2,9792|SETD3,SETD3,84193|SH3PXD2A,SH3PXD2A,9644|SHOC2,SHOC2,8036|SLC25A35,SLC25A35,399512|SLC36A1,SLC36A1,206358|SMAD4,SMAD4,4089|SMAD7,SMAD7,4092|SMUG1,SMUG1,23583|SPACA1,SPACA1,81833|SPPL2A,SPPL2A,84888|STAT5B,STAT5B,6777|STX17,STX17,55014|TAGAP,TAGAP,117289|TBC1D20,TBC1D20,128637|TBC1D30,TBC1D30,23329|TCF7,TCF7,6932|TCN2,TCN2,6948|TCTA,TCTA,6988|TEC,TEC,7006|TES,TES,26136|THRA,THRA,7067|TIRAP,TIRAP,114609|TMEM204,TMEM204,79652|TMEM42,TMEM42,131616|TMEM43,TMEM43,79188|TMEM8A,PGAP6,58986|TNKS,TNKS,8658|TP53I13,TP53I13,90313|TRIB3,TRIB3,57761|TRIO,TRIO,7204|TSC22D3,TSC22D3,1831|TTC28,TTC28,23331|TTYH2,TTYH2,94015|TUBB2A,TUBB2A,7280|UBE2J1,UBE2J1,51465|UGCG,UGCG,7357|USE1,USE1,55850|VWCE,VWCE,220001|WIPF2,WIPF2,147179|XYLT2,XYLT2,64132|YPEL3,YPEL3,83719|YY1,YY1,7528|ZBTB2,ZBTB2,57621|ZHX2,ZHX2,22882|ZMYM5,ZMYM5,9205|ZNF274,ZNF274,10782|ZNF394,ZNF394,84124" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="C7" ORGANISM="Homo sapiens" SUB_CATEGORY_CODE="IMMUNESIGDB"/>
</MSIGDB>
