STANDARD_NAME GSE5455_HEALTHY_VS_TUMOR_BEARING_MOUSE_SPLEEN_MONOCYTE_24H_INCUBATION_DN SYSTEMATIC_NAME M6578 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE5455_HEALTHY_VS_TUMOR_BEARING_MOUSE_SPLEEN_MONOCYTE_24H_INCUBATION_DN NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes down-regulated in ITGAM+ [GeneID=3684] cells (incubated for 24h in complete medium) from spleen: healthy versus tumor bearing mice. DESCRIPTION_FULL Active suppression of tumor-specific T lymphocytes can limit the immune-surveillance and immunotherapy efficacy. While tumor-recruited CD11b+ myeloid cells are known mediators of tumor-associated immune dysfunction, the true nature of these suppressive cells and the fine biochemical pathways governing their immunosuppressive activity remain elusive. Here we describe a population of circulating CD11b+/IL-4Rα+, inflammatory-type monocytes that is elicited by growing tumors and activated by IFN-γ released from T lymphocytes. CD11b+/IL-4Rα+ cells produce IL-13 and IFN-γ and integrate the downstream signals of these cytokines to trigger the molecular pathways suppressing antigen-activated CD8+ T lymphocytes. Analogous immunosuppressive circuits are active in CD11b+ cells present within the tumor microenvironment. These suppressor cells challenge the current idea that tumor-conditioned immunosuppressive monocytes/macrophages are alternatively activated. Moreover, our data show how the inflammatory response elicited by tumors has detrimental effects on the adaptive immune system and suggest novel approaches for the treatment of tumorinduced immune dysfunctions. PMID 17016559 GEOID GSE5455 AUTHORS Gallina G,Dolcetti L,Serafini P,De Santo C,Marigo I,Colombo MP,Basso G,Brombacher F,Borrello I,Zanovello P,Bicciato S,Bronte V CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE5455_2446_200_DN FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ABCB1,ACOT2,ACOT7,ADAM19,ANKRD6,ARHGAP26,ARHGAP31,ARID5B,ARMCX4,ASAP1,ASPN,AXL,B3GNT2,BAIAP3,BATF,BMP2K,BMP7,BTBD11,C10orf72,C3orf37,C3orf58,C9orf16,CACNA1D,CAPG,CARHSP1,CASP1,CASP4,CD200,CD79B,CD80,CD83,CDV3,CEP19,CHST11,CKS2,CNIH4,COBLL1,COMMD6,CORO2B,CSDA,CSK,CTLA4,CXCL13,CYB561,CYFIP1,DERA,DNAJC24,DPP4,DUS2L,DUSP4,DYNLT3,EBNA1BP2,EFHD2,EHD3,ELL2,ENDOD1,EPGN,EVI5,FAM109B,FAM111A,FAM129A,FAM164A,FAM164C,FAM188A,FAS,FBXO4,FHL2,GABARAPL1,GADD45B,GALNT14,GATA3,GFI1B,GFOD1,GLRX,GPM6B,GPR110,GRAMD1B,GRASP,GRHL1,H2AFZ,HAP1,HDGFRP3,HECTD2,HGSNAT,HMGN3,HOXB4,HRASLS5,ICOS,IFI27L2,IGLC7,IGLL1,IKZF2,IL12RB1,IL17RB,IL18,IL1R1,IL21,INPPL1,IRAK4,JARID2,KCNA3,KCNC2,KDELC2,KSR1,L3MBTL3,LBH,LCLAT1,LEO1,LGMN,LOC100506049,LRIT1,LSM6,LUZP1,MAGED1,MAP3K5,MAP3K8,MAPKAPK2,MCM9,MNS1,MPP2,MRE11A,MRPS6,MX2,MYB,NANOS1,NBN,NDC80,NKG7,NR2F6,NRP1,NUPR1,OAS1,PDCD1LG2,PKP4,PLA2G16,PLAC8,PLCL1,PLEKHB2,PLSCR1,PLXNC1,POLE3,POMP,PON3,PPP2R5C,PRDM5,PRG3,PTPN3,RAB19,RABEPK,RAPH1,RGL1,RIPK3,RNF149,RNF19A,RNF19B,RNF216,S100A4,SAMSN1,SAP30BP,SCNN1G,SLA,SLAMF6,SLC12A2,SLC12A8,SLC17A7,SLC22A15,SLC24A3,SLC41A1,SOX4,ST3GAL1,STAC,STK39,STX11,SYNGR2,SYP,SYPL1,TAF12,TMBIM1,TMEM38B,TNFRSF19,TNFRSF9,TNFSF11,TOX2,TRPS1,TRPV1,TTC39B,TUB,UBE2H,UBE2L3,VPS45,WDR55,WFIKKN2,WNT10A,ZBED5,ZC3H12A,ZC3H12D,ZNF125,ZNF518B,ZNRF1,ZSCAN2 GENE_SYMBOLS ABCB1,ACOT2,ACOT7,ADAM19,ANKRD6,ARHGAP26,ARHGAP31,ARID5B,ARMCX4,ASAP1,ASPN,AXL,B3GNT2,BAIAP3,BATF,BMP2K,BMP7,ABTB3,VSTM4,HMCES,DIPK2A,BBLN,CACNA1D,CAPG,CARHSP1,CASP1,CASP4,CD200,CD79B,CD80,CD83,CDV3,CEP19,CHST11,CKS2,CNIH4,COBLL1,COMMD6,CORO2B,YBX3,CSK,CTLA4,CXCL13,CYB561,CYFIP1,DERA,DNAJC24,DPP4,DUS2,DUSP4,DYNLT3,EBNA1BP2,EFHD2,EHD3,ELL2,ENDOD1,EPGN,EVI5,PHETA2,FAM111A,NIBAN1,ZC2HC1A,ZC2HC1C,MINDY3,FAS,FBXO4,FHL2,GABARAPL1,GADD45B,GALNT14,GATA3,GFI1B,GFOD1,GLRX,GPM6B,ADGRF1,GRAMD1B,TAMALIN,GRHL1,H2AZ1,HAP1,,HECTD2,HGSNAT,HMGN3,HOXB4,PLAAT5,ICOS,IFI27L2,IGLC7,IGLL1,IKZF2,IL12RB1,IL17RB,IL18,IL1R1,IL21,INPPL1,IRAK4,JARID2,KCNA3,KCNC2,POGLUT3,KSR1,L3MBTL3,LBH,LCLAT1,LEO1,LGMN,LRRC72,LRIT1,LSM6,LUZP1,MAGED1,MAP3K5,MAP3K8,MAPKAPK2,MCM9,MNS1,MPP2,MRE11,MRPS6,MX2,MYB,NANOS1,NBN,NDC80,NKG7,NR2F6,NRP1,NUPR1,OAS1,PDCD1LG2,PKP4,PLAAT3,PLAC8,PLCL1,PLEKHB2,PLSCR1,PLXNC1,POLE3,POMP,PON3,PPP2R5C,PRDM5,PRG3,PTPN3,RAB19,RABEPK,RAPH1,RGL1,RIPK3,RNF149,RNF19A,RNF19B,RNF216,S100A4,SAMSN1,SAP30BP,SCNN1G,SLA,SLAMF6,SLC12A2,SLC12A8,SLC17A7,SLC22A15,SLC24A3,SLC41A1,SOX4,ST3GAL1,STAC,STK39,STX11,SYNGR2,SYP,SYPL1,TAF12,TMBIM1,TMEM38B,TNFRSF19,TNFRSF9,TNFSF11,TOX2,TRPS1,TRPV1,TTC39B,TUB,UBE2H,UBE2L3,VPS45,WDR55,WFIKKN2,WNT10A,ZBED5,ZC3H12A,ZC3H12D,,ZNF518B,ZNRF1,ZSCAN2 FOUNDER_NAMES