STANDARD_NAME GSE5542_UNTREATED_VS_IFNG_TREATED_EPITHELIAL_CELLS_24H_UP SYSTEMATIC_NAME M6522 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE5542_UNTREATED_VS_IFNG_TREATED_EPITHELIAL_CELLS_24H_UP NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes up-regulated in epithelial cells (24h): untreated versus IFNG [GeneID=3458]. DESCRIPTION_FULL Type I and type II interferons (IFNs) bind to different cell surface receptors but activate overlapping signal transduction pathways. We examined the effects of a type I IFN (IFN-acon1) and a type II iFN (IFN-g1b) on gene experession in A549 cells and demonstrate that there is a common set of genes modulated by both IFNs as well as a set of gene specifically regulated by each, reflecting the activation of different signaling pathways. In particualr, IFN-g induced many more genes of the signaling pathways, apoptosis, and cytokine interactions than did IFN-a. Even with genes induced by both IFNs there were distinctive quantitativive differences in expression. IFN-g1b plays a major role in the induction and regulation of the complement pathway. Previous work has shown a synergistic antivral and antiproliferative effect of type I and type II IFNs in cell culture and in the treament of tumors in mice. We demonstrate that a majority of genes showed and additive effect of IFN-acon1 and IFN-g1b, but a subset of gene is synergistically induced; these incluce ISG10, MX2, OAS2, and other genes known to be involved in the antiviral response, TRAIL (TNFSF10) and caspases involved in apoptosis and chemokine genes RANTES, CXCL10, and CXCL11. Greater than additive transcription of some of these genes in the presence of both IFNs was confirmed by real-time kinetic RT-PCR. Elevated induction of many of these genes may be sufficient to explain the synergistic antiviral and antitumor effects of this combination of IFNS in vivo. PMID 16800785 GEOID GSE5542 AUTHORS Sanda C,Weitzel P,Tsukahara T,Schaley J,Edenberg HJ,Stephens MA,McClintick JN,Blatt LM,Li L,Brodsky L,Taylor MW CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE5542_3332_200_UP FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ABR,ACADVL,ACE,ACOT9,ACTN4,AHNAK,AIM2,AKIRIN2,ALCAM,ANXA2,APOBEC3D,APOBEC3F,APOBEC3G,ARF3,ARHGAP31,ARHGAP35,ARHGEF12,ARID5B,ARL6IP1,ATP6V0B,ATXN1,AUTS2,BATF,BICD1,C17orf66,CACNB1,CACNB2,CACNB3,CALHM2,CAMTA1,CAPN2,CCR4,CD99,CDHR3,CEP97,CHN1,CHST11,CLDND1,CLIC1,CNOT6L,CRIM1,CYB561,DLG3,DNAJC1,DUSP10,DUSP2,EIF3A,EMB,ENTPD1,EPS15,EZR,F2R,FADS3,FAM46C,FAS,FLJ34503,FLVCR2,FOSL2,FTH1,FUCA2,FYN,GABARAPL1,GALM,GBF1,GGA2,GIT2,GLB1,GPR137C,GPR183,GRAMD4,GTDC1,GZMK,HECTD3,HYOU1,IL12RB1,IL12RB2,IL18RAP,IL2RB,IQGAP1,ITGB1,ITPR3,ITPRIPL1,JOSD1,KATNAL1,KIAA0247,KIF1C,KIF21A,KLRD1,KSR1,LLGL2,LOC146880,LOC283174,LPGAT1,LRIG1,LRP8,LUZP1,LYAR,MAP2K3,MAP3K1,MAPKAPK2,MBOAT1,MC3R,MICAL3,MIR21,MIR24-2,MPDZ,MPZL3,MVD,MXD4,MYBL1,MYO1C,MYO1F,NFATC2,NIPA1,NIPAL2,NLRP3,NPFFR2,OASL,ODF2,OGDH,OPTN,OR9A4,PDE1B,PDXK,PDZD11,PHACTR2,PI4K2A,PIEZO1,PLCB3,PLEKHD1,PLXND1,PNPLA6,PPP2R5C,PPP4R1,PTPRM,PYHIN1,RAPGEF1,RB1,RBMS3,RCBTB2,RDH10,RFTN1,RGAG4,RGS2,RHBDF2,RUNDC2C,RXRA,SAV1,SEC14L1,SEPT8,SESN3,SH2B3,SH2D2A,SH3BGRL3,SH3TC1,SKCG-1,SLAMF1,SLC1A4,SLCO3A1,SLFN11,SLFN12L,SNTB2,SNX33,SPC25,SRGN,ST8SIA1,STAT5B,STOM,SURF4,SV2A,SYNE1,SYT11,SYTL3,TBX21,TCIRG1,TGFBR3,THBS1,TIGIT,TNFRSF1B,TNIP3,TOLLIP,TOM1,TOX,TP53INP1,TRANK1,TSEN54,TSHR,TSPAN18,TTYH2,UCK2,ULK1,UST,VCP,WEE1,WSB2,ZC3H12A,ZEB2,ZNF335,ZNF487P,ZRSR1 GENE_SYMBOLS ABR,ACADVL,ACE,ACOT9,ACTN4,AHNAK,AIM2,AKIRIN2,ALCAM,ANXA2,APOBEC3D,APOBEC3F,APOBEC3G,ARF3,ARHGAP31,ARHGAP35,ARHGEF12,ARID5B,ARL6IP1,ATP6V0B,ATXN1,AUTS2,BATF,BICD1,HEATR9,CACNB1,CACNB2,CACNB3,CALHM2,CAMTA1,CAPN2,CCR4,CD99,CDHR3,CEP97,CHN1,CHST11,CLDND1,CLIC1,CNOT6L,CRIM1,CYB561,DLG3,DNAJC1,DUSP10,DUSP2,EIF3A,EMB,ENTPD1,EPS15,EZR,F2R,FADS3,TENT5C,FAS,LINC02880,FLVCR2,FOSL2,FTH1,FUCA2,FYN,GABARAPL1,GALM,GBF1,GGA2,GIT2,GLB1,GPR137C,GPR183,GRAMD4,GTDC1,GZMK,HECTD3,HYOU1,IL12RB1,IL12RB2,IL18RAP,IL2RB,IQGAP1,ITGB1,ITPR3,ITPRIPL1,JOSD1,KATNAL1,SUSD6,KIF1C,KIF21A,KLRD1,KSR1,LLGL2,,IGSF9B,LPGAT1,LRIG1,LRP8,LUZP1,LYAR,MAP2K3,MAP3K1,MAPKAPK2,MBOAT1,MC3R,MICAL3,MIR21,MIR24-2,MPDZ,MPZL3,MVD,MXD4,MYBL1,MYO1C,MYO1F,NFATC2,NIPA1,NIPAL2,NLRP3,NPFFR2,OASL,ODF2,OGDH,OPTN,OR9A4,PDE1B,PDXK,PDZD11,PHACTR2,PI4K2A,PIEZO1,PLCB3,PLEKHD1,PLXND1,PNPLA6,PPP2R5C,PPP4R1,PTPRM,PYHIN1,RAPGEF1,RB1,RBMS3,RCBTB2,RDH10,RFTN1,RTL5,RGS2,RHBDF2,SNX29P2,RXRA,SAV1,SEC14L1,SEPTIN8,SESN3,SH2B3,SH2D2A,SH3BGRL3,SH3TC1,,SLAMF1,SLC1A4,SLCO3A1,SLFN11,SLFN12L,SNTB2,SNX33,SPC25,SRGN,ST8SIA1,STAT5B,STOM,SURF4,SV2A,SYNE1,SYT11,SYTL3,TBX21,TCIRG1,TGFBR3,THBS1,TIGIT,TNFRSF1B,TNIP3,TOLLIP,TOM1,TOX,TP53INP1,TRANK1,TSEN54,TSHR,TSPAN18,TTYH2,UCK2,ULK1,UST,VCP,WEE1,WSB2,ZC3H12A,ZEB2,ZNF335,ZNF487,ZRSR2P1 FOUNDER_NAMES