STANDARD_NAME GSE5589_IL6_KO_VS_IL10_KO_LPS_AND_IL10_STIM_MACROPHAGE_180MIN_UP SYSTEMATIC_NAME M6668 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE5589_IL6_KO_VS_IL10_KO_LPS_AND_IL10_STIM_MACROPHAGE_180MIN_UP NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes up-regulated in bone marrow-derived macrophagesat 180 min of stimulation by IL10 [GeneID=3486] and LPS: IL6 [GeneID=3469] knockout versus IL10 [GeneID=3486] knockout. DESCRIPTION_FULL IL-10 or IL-6 stimulation of control 129xC57BL/6 murine bone marrow derived macrophages in the presence of LPS. We used microarrays to detail the global programme of gene expression changes in response to IL-6 or IL-10 stimulation in the presence of lipopolysaccharide. BMDMs were isolated from control, IL-6-/-, and IL-10-/- mice on a 129XBL/6 mixed background mice and differentiated in the presence of CSF-1 for 6-7 days. Cells were scraped and plated in 6 well plates at 2x10e6/well. Cells were washed with complete DMEM and rested for 1-2 hr before stimulation with combinations of IL-10 (10 ng/ml), IL-6 (2 ng/ml) or LPS (100 ng/ml) for 45 min or 180 mins. Complete biological replicates were performed. PMID 17114459 GEOID GSE5589 AUTHORS El Kasmi KC,Holst J,Coffre M,Mielke L,de Pauw A,Lhocine N,Smith AM,Rutschman R,Kaushal D,Shen Y,Suda T,Donnelly RP,Myers MG Jr,Alexander W,Vignali DA,Watowich SS,Ernst M,Hilton DJ,Murray PJ CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE5589_3018_200_UP FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ABHD14B,ADAP1,AGBL3,AGXT2L2,ALOX5AP,APAF1,ARHGAP18,ARHGAP19,ATG2B,ATL1,AZI1,B3GALNT1,BEND4,BLMH,BRD9,BST2,C11orf51,C12orf73,C1QC,C20orf177,C3orf58,C5orf42,C9orf95,CC2D1B,CCDC23,CCDC72,CCND3,CD180,CD1D,CD5L,CD99L2,CDC42EP3,CELF1,CEP19,CLEC4D,CNOT6,COBRA1,COMMD9,COPS7A,CPSF1,CRYZ,CSK,CYR61,DDX23,DGKZ,DHX32,DISP1,DSCR3,DTD1,EDC3,EIF4EBP2,EIF5A2,FAM107B,FAM125A,FAM189B,FAM3C,FAM63B,FBXW4,FLI1,FNIP2,GAB3,GALNT4,GAPVD1,GAS2L3,GDPD1,GLIS3,GLTP,GMIP,GNG12,GNPAT,GPR176,GPR34,GRAMD1A,H1F0,HELZ,HMGA2,HMOX2,HNRNPUL1,HOXA3,HSPA2,HSPB1,ICA1,IGKC,ING1,KDSR,KIFAP3,KLHL8,KPNA3,LAGE3,LAMA3,LASS5,LIFR,LOXL3,LPCAT2,LRG1,LRSAM1,LSP1,LTC4S,MADD,MAF,MAN1C1,MAP1LC3B,MAP1S,MAP3K5,MBD1,MFNG,MLEC,MPST,MRPL11,MRPS21,MRPS33,MS4A6A,MSRB2,MYL6,NDUFA1,NDUFA3,NEK3,NFXL1,NGDN,NGLY1,NKIRAS2,NOD1,OCEL1,P2RY13,PAK2,PBXIP1,PCBP4,PDP2,PECR,PF4,PKIB,POSTN,PPP1R13B,PRKAR2B,PRPS2,PTEN,PTK2B,PTPN6,RAB34,RAC1,RAC3,RALBP1,RAPGEF6,RAPH1,RAPSN,RASSF2,RFNG,RNASE4,RNF14,RNF19A,RNPEPL1,RPL11,RPP21,RTEL1,RUNDC3B,S1PR1,SASH1,SC5DL,SCAP,SCARB1,SEMA4D,SEPW1,SERHL2,SGCB,SH3BP5L,SH3D19,SIAE,SKIL,SLC9A9,SLFN13,SMAGP,SOD1,STARD9,STK38,SUCLG2,SUSD3,SYNGR1,TBC1D14,TLR3,TMEM18,TNC,TNRC6A,TRAF3IP3,TRIM32,TRIOBP,TSC22D4,TTYH3,TUBB2B,ULK2,UQCR11,USP22,VAMP3,VAV3,WHSC2,WWP1,YWHAH,ZC4H2,ZNF229,ZNF658,ZZEF1 GENE_SYMBOLS ABHD14B,ADAP1,AGBL3,PHYKPL,ALOX5AP,APAF1,ARHGAP18,ARHGAP19,ATG2B,ATL1,CEP131,B3GALNT1,BEND4,BLMH,BRD9,BST2,ANAPC15,UQCC6,C1QC,FAM217B,DIPK2A,CPLANE1,NMRK1,CC2D1B,SVBP,TMA7,CCND3,CD180,CD1D,CD5L,CD99L2,CDC42EP3,CELF1,CEP19,CLEC4D,CNOT6,NELFB,COMMD9,COPS7A,CPSF1,CRYZ,CSK,CCN1,DDX23,DGKZ,DHX32,DISP1,VPS26C,DTD1,EDC3,EIF4EBP2,EIF5A2,FAM107B,MVB12A,ENTREP3,FAM3C,MINDY2,FBXW4,FLI1,FNIP2,GAB3,GALNT4,GAPVD1,GAS2L3,GDPD1,GLIS3,GLTP,GMIP,GNG12,GNPAT,GPR176,GPR34,GRAMD1A,H1-0,HELZ,HMGA2,HMOX2,HNRNPUL1,HOXA3,HSPA2,HSPB1,ICA1,IGKC,ING1,KDSR,KIFAP3,KLHL8,KPNA3,LAGE3,LAMA3,CERS5,LIFR,LOXL3,LPCAT2,LRG1,LRSAM1,LSP1,LTC4S,MADD,MAF,MAN1C1,MAP1LC3B,MAP1S,MAP3K5,MBD1,MFNG,MLEC,MPST,MRPL11,MRPS21,MRPS33,MS4A6A,MSRB2,MYL6,NDUFA1,NDUFA3,NEK3,NFXL1,NGDN,NGLY1,NKIRAS2,NOD1,OCEL1,P2RY13,PAK2,PBXIP1,PCBP4,PDP2,PECR,PF4,PKIB,POSTN,PPP1R13B,PRKAR2B,PRPS2,PTEN,PTK2B,PTPN6,RAB34,RAC1,RAC3,RALBP1,RAPGEF6,RAPH1,RAPSN,RASSF2,RFNG,RNASE4,RNF14,RNF19A,RNPEPL1,RPL11,RPP21,RTEL1,RUNDC3B,S1PR1,SASH1,SC5D,SCAP,SCARB1,SEMA4D,SELENOW,SERHL2,SGCB,SH3BP5L,SH3D19,SIAE,SKIL,SLC9A9,SLFN13,SMAGP,SOD1,STARD9,STK38,SUCLG2,SUSD3,SYNGR1,TBC1D14,TLR3,TMEM18,TNC,TNRC6A,TRAF3IP3,TRIM32,TRIOBP,TSC22D4,TTYH3,TUBB2B,ULK2,UQCR11,USP22,VAMP3,VAV3,NELFA,WWP1,YWHAH,ZC4H2,ZNF229,ZNF658,ZZEF1 FOUNDER_NAMES