STANDARD_NAME GSE5679_RARA_AGONIST_AM580_VS_AM580_AND_ROSIGLITAZONE_TREATED_DC_DN SYSTEMATIC_NAME M6570 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE5679_RARA_AGONIST_AM580_VS_AM580_AND_ROSIGLITAZONE_TREATED_DC_DN NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes down-regulated in monocyte-derived dendritic cells: AM580 [PubChem=2126] versus rosiglitazone and AM580 [PubChem=77999;2126]. DESCRIPTION_FULL Our data indicated that activation of the PPARg nuclear receptor induces a retinoid response in human dendritic cells. In order to assess the contribution of retinoid signaling to the PPARg response we decided to use a combination of pharmacological activators and inhibitors of these pathways. Cells were treated with the synthetic PPARg ligand rosiglitazone (RSG), or with RSG along with the RARa antagonist (AGN193109) to block RARa mediated gene expression, or the RARa specific agonists (AM580) alone. This design allows one to determine if retinoid signaling is a downstream event of PPARg activation and what portion of PPARg regulated genes are regulated via induced retinoid signaling. PMID 16982809 GEOID GSE5679 AUTHORS Szatmari I,Pap A,Rühl R,Ma JX,Illarionov PA,Besra GS,Rajnavolgyi E,Dezso B,Nagy L CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE5679_3393_200_DN FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ACP5,ACSBG1,ADAM8,ADCY6,ADD1,ADPGK,AKT3,ANXA1,APBB1IP,ARHGAP9,ARHGEF1,ARHGEF18,ARMC10,ARMC7,ARV1,ASS1,ATP1B3,ATP8B4,B4GALNT1,BEND6,BST2,C10orf107,C14orf159,C17orf28,C21orf91,C22orf36,C8orf42,C9orf3,C9orf9,CACNB3,CAPG,CCR2,CD226,CD5,CD96,CD97,CFLAR,CISH,CORO2A,CPM,CRY1,DCTN6,DDX19B,DENND5A,DOCK10,DPH5,DUSP22,DYRK2,ENTPD1,FAM102B,FAM46A,FAM53B,FAM69A,FAM78A,FCGRT,FLOT1,FLT3LG,FOSL2,FRMD6,FXYD7,GALNT10,GBA2,GCOM1,GGT1,GOLM1,GPR34,GPR97,GRAP,GRASP,GZMB,HAAO,HBEGF,HOPX,HVCN1,IFIT1,IFITM2,IFITM3,IFNAR1,IGFBP4,IKZF4,IL18,IL2RA,IL7R,IMP3,IRAK3,IRF4,ITGA4,ITGA6,ITGB3,ITGB7,IZUMO4,KIAA1949,KIF1B,KLF2,KLRD1,KLRK1,L1CAM,LAIR1,LBP,LFNG,LMNA,LRP4,LRRC8A,MAPKAPK3,MATN2,MED7,MEIR5,MINA,MRPS5,MTSS1,MX2,MYO1G,NCF1,NDOR1,NDRG1,NEB,NHSL2,NKG7,NOD1,NUPR1,ORAI2,OSM,OTUD5,PDE8A,PDLIM4,PEX11G,PGLYRP2,PHYHD1,PIK3R1,PIK3R5,PITPNC1,PLA2G10,PLAC8,PPM1J,PQLC1,PRDX6,QPCT,QTRT1,RAE1,RAP1GAP2,RAPGEF6,RASA3,RASGRP2,RBM38,RCBTB2,RCN3,RELL2,RGS14,RHOBTB2,RPL4,RRAD,RRAS2,S1PR1,S1PR4,SBK1,SERPINI1,SFN,SGMS1,SH3BP1,SHARPIN,SHD,SHE,SIDT1,SIKE1,SIT1,SLC17A9,SLC29A2,SLFN5,SOCS2,SPON1,ST3GAL6,ST8SIA6,STK10,STK38,STMN2,STX1A,SURF2,SYTL1,SYTL2,TACC2,TBX21,TECPR1,TES,TKTL1,TMEM5,TMEM64,TMEM71,TMPRSS13,TNFRSF25,TNFSF4,TPST2,TRAF3IP3,TXNIP,UBXN11,USP3,USP48,UST,ZNF259,ZNF274,ZNF652 GENE_SYMBOLS ACP5,ACSBG1,ADAM8,ADCY6,ADD1,ADPGK,AKT3,ANXA1,APBB1IP,ARHGAP9,ARHGEF1,ARHGEF18,ARMC10,ARMC7,ARV1,ASS1,ATP1B3,ATP8B4,B4GALNT1,BEND6,BST2,CABCOCO1,DGLUCY,HID1,C21orf91,LRRC75B,TDRP,AOPEP,SPACA9,CACNB3,CAPG,CCR2,CD226,CD5,CD96,ADGRE5,CFLAR,CISH,CORO2A,CPM,CRY1,DCTN6,DDX19B,DENND5A,DOCK10,DPH5,DUSP22,DYRK2,ENTPD1,EEIG2,TENT5A,FAM53B,DIPK1A,FAM78A,FCGRT,FLOT1,FLT3LG,FOSL2,FRMD6,FXYD7,GALNT10,GBA2,GCOM1,GGT1,GOLM1,GPR34,ADGRG3,GRAP,TAMALIN,GZMB,HAAO,HBEGF,HOPX,HVCN1,IFIT1,IFITM2,IFITM3,IFNAR1,IGFBP4,IKZF4,IL18,IL2RA,IL7R,IMP3,IRAK3,IRF4,ITGA4,ITGA6,ITGB3,ITGB7,IZUMO4,PPP1R18,KIF1B,KLF2,KLRD1,KLRK1,L1CAM,LAIR1,LBP,LFNG,LMNA,LRP4,LRRC8A,MAPKAPK3,MATN2,MED7,SFR1,RIOX2,MRPS5,MTSS1,MX2,MYO1G,NCF1,NDOR1,NDRG1,NEB,NHSL2,NKG7,NOD1,NUPR1,ORAI2,OSM,OTUD5,PDE8A,PDLIM4,PEX11G,PGLYRP2,PHYHD1,PIK3R1,PIK3R5,PITPNC1,PLA2G10,PLAC8,PPM1J,SLC66A2,PRDX6,QPCT,QTRT1,RAE1,RAP1GAP2,RAPGEF6,RASA3,RASGRP2,RBM38,RCBTB2,RCN3,RELL2,RGS14,RHOBTB2,RPL4,RRAD,RRAS2,S1PR1,S1PR4,SBK1,SERPINI1,SFN,SGMS1,SH3BP1,SHARPIN,SHD,SHE,SIDT1,SIKE1,SIT1,SLC17A9,SLC29A2,SLFN5,SOCS2,SPON1,ST3GAL6,ST8SIA6,STK10,STK38,STMN2,STX1A,SURF2,SYTL1,SYTL2,TACC2,TBX21,TECPR1,TES,TKTL1,RXYLT1,TMEM64,TMEM71,TMPRSS13,TNFRSF25,TNFSF4,TPST2,TRAF3IP3,TXNIP,UBXN11,USP3,USP48,UST,ZPR1,ZNF274,ZNF652 FOUNDER_NAMES