STANDARD_NAME GSE6259_33D1_POS_VS_DEC205_POS_SPLENIC_DC_DN SYSTEMATIC_NAME M6731 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE6259_33D1_POS_VS_DEC205_POS_SPLENIC_DC_DN NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes down-regulated in spleen dendritic cells from healthy mice: 33D1+ versus DEC205+ subpopulations. DESCRIPTION_FULL Dendritic cells (DCs) process and present self and foreign antigens to induce tolerance or immunity. In vitro models suggest that induction of immunity is controlled by regulating the presentation of antigen, but little is known about how DCs control antigen presentation in vivo. To examine antigen processing and presentation in vivo we specifically targeted antigens to the two major subsets of DCs using chimeric monoclonal antibodies. Unlike CD8+ DCs that express the cell surface protein CD205, CD8- DCs, which are positive for the 33D1 antigen, are specialized for presentation on MHC class II. This difference in antigen processing is intrinsic to the DC subsets and associated with increased expression of proteins associated with MHC processing. PMID 17204652 GEOID GSE6259 AUTHORS Dudziak D,Kamphorst AO,Heidkamp GF,Buchholz VR,Trumpfheller C,Yamazaki S,Cheong C,Liu K,Lee HW,Park CG,Steinman RM,Nussenzweig MC CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE6259_2680_200_DN FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ABCG2,ADAP1,ADCY9,AHRR,AIFM1,ALCAM,ANKRD27,AREG,ARL3,ARL4C,ARRDC4,ATP11A,AUTS2,BAG3,BMPR1A,BTG2,C10orf88,C11orf24,C13orf31,C16orf72,C16orf91,C18orf1,C19orf10,C1orf150,C5orf62,CA8,CABLES1,CABP7,CCNJL,CCR7,CD109,CD48,CDK15,CEBPA,CEP19,CHN2,CHRDL1,CLCN4,CLN5,CMTM3,CTSZ,CXXC5,CYP1A1,CYP1B1,DAG1,DDIT4,DDX1,DKK2,DOK2,DPY19L3,DSCR4,EEPD1,EGR1,ELAC1,EPB41L3,ERGIC3,ERLIN2,EXTL2,FAM102A,FAM171A1,FBXL12,FCER1G,FUCA1,FUT7,FZD7,GAD1,GALNT2,GLCCI1,GPD2,GPR146,GPR68,GPX1,GTF2IRD1,GUCY2C,HAS3,HEG1,HERC2,HIPK2,HIST1H2AC,HJURP,HMGCL,HS6ST1,HSD17B10,IFITM3,IGFBP4,IL1RN,IL7R,INPP1,INTS9,IRF2BPL,JUB,KATNB1,KCNH5,KHNYN,KIF26A,KIT,KRCC1,L3MBTL3,LOC100216546,LOC100527964,LOC346887,LOC646484,LOC647979,LPXN,LRIG2,LRP5,MAD1L1,MAD2L2,MAF,MAPK6,MBTPS2,MFAP1,MFSD1,MOBKL2A,MOGAT2,MR1,MRPL36,MTSS1,NCOA3,NCRNA00275,NEK6,NGLY1,NOL9,NYNRIN,PACSIN2,PDE4A,PEMT,PHLDA3,PIGT,PITPNA,PLIN2,POLR3D,PPIF,PROM1,PRSS23,PSMB2,PTCH1,PTPRJ,PXMP4,RAB30,RAB33A,RAB38,RAD51C,RARS,RFESD,RFTN1,RGL1,RGS10,RHOBTB3,RHOU,RNF144A,RNFT2,RPS3,RSAD2,SARS,SECTM1,SEMA4A,SEPHS2,SETDB2,SH3PXD2A,SH3RF1,SIPA1L2,SLC17A5,SLC1A4,SLC22A1,SLC22A4,SLC43A3,SLC45A4,SOS1,SPATS2L,SPNS2,SPRY4,SPRYD7,SQRDL,SSH1,STOM,STON1,SYNJ2,TACC1,TBC1D14,TBC1D8,TIPARP,TMEM42,TMEM51,TNS3,TSC22D3,TTC39C,TUBB2A,TUBB2B,VDR,WASF3,XYLT1,YIPF6,ZBED1,ZMIZ1,ZNF264,ZNF295,ZNF704,ZSCAN12,ZSCAN5A GENE_SYMBOLS ABCG2,ADAP1,ADCY9,AHRR,AIFM1,ALCAM,ANKRD27,AREG,ARL3,ARL4C,ARRDC4,ATP11A,AUTS2,BAG3,BMPR1A,BTG2,C10orf88,C11orf24,LACC1,HAPSTR1,UQCC4,LDLRAD4,MYDGF,GCSAML,SMIM3,CA8,CABLES1,CABP7,CCNJL,CCR7,CD109,CD48,CDK15,CEBPA,CEP19,CHN2,CHRDL1,CLCN4,CLN5,CMTM3,CTSZ,CXXC5,CYP1A1,CYP1B1,DAG1,DDIT4,DDX1,DKK2,DOK2,DPY19L3,DSCR4,EEPD1,EGR1,ELAC1,EPB41L3,ERGIC3,ERLIN2,EXTL2,EEIG1,FAM171A1,FBXL12,FCER1G,FUCA1,FUT7,FZD7,GAD1,GALNT2,GLCCI1,GPD2,GPR146,GPR68,GPX1,GTF2IRD1,GUCY2C,HAS3,HEG1,HERC2,HIPK2,H2AC6,HJURP,HMGCL,HS6ST1,HSD17B10,IFITM3,IGFBP4,IL1RN,IL7R,INPP1,INTS9,IRF2BPL,AJUBA,KATNB1,KCNH5,KHNYN,KIF26A,KIT,KRCC1,L3MBTL3,LINC01004,,,,NORAD,LPXN,LRIG2,LRP5,MAD1L1,MAD2L2,MAF,MAPK6,MBTPS2,MFAP1,MFSD1,MOB3A,MOGAT2,MR1,MRPL36,MTSS1,NCOA3,ZFAS1,NEK6,NGLY1,NOL9,NYNRIN,PACSIN2,PDE4A,PEMT,PHLDA3,PIGT,PITPNA,PLIN2,POLR3D,PPIF,PROM1,PRSS23,PSMB2,PTCH1,PTPRJ,PXMP4,RAB30,RAB33A,RAB38,RAD51C,RARS1,RFESD,RFTN1,RGL1,RGS10,RHOBTB3,RHOU,RNF144A,RNFT2,RPS3,RSAD2,SARS1,SECTM1,SEMA4A,SEPHS2,SETDB2,SH3PXD2A,SH3RF1,SIPA1L2,SLC17A5,SLC1A4,SLC22A1,SLC22A4,SLC43A3,SLC45A4,SOS1,SPATS2L,SPNS2,SPRY4,SPRYD7,SQOR,SSH1,STOM,STON1,SYNJ2,TACC1,TBC1D14,TBC1D8,TIPARP,TMEM42,TMEM51,TNS3,TSC22D3,TTC39C,TUBB2A,TUBB2B,VDR,WASF3,XYLT1,YIPF6,ZBED1,ZMIZ1,ZNF264,ZBTB21,ZNF704,ZSCAN12,ZSCAN5A FOUNDER_NAMES