STANDARD_NAME GSE6259_FLT3L_INDUCED_33D1_POS_DC_VS_CD4_TCELL_UP SYSTEMATIC_NAME M6746 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE6259_FLT3L_INDUCED_33D1_POS_DC_VS_CD4_TCELL_UP NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes up-regulated in cells from Flt3L Melanom injected mice: 33D1+ versus CD4 [GeneID=920] T cells. DESCRIPTION_FULL Dendritic cells (DCs) process and present self and foreign antigens to induce tolerance or immunity. In vitro models suggest that induction of immunity is controlled by regulating the presentation of antigen, but little is known about how DCs control antigen presentation in vivo. To examine antigen processing and presentation in vivo we specifically targeted antigens to the two major subsets of DCs using chimeric monoclonal antibodies. Unlike CD8+ DCs that express the cell surface protein CD205, CD8- DCs, which are positive for the 33D1 antigen, are specialized for presentation on MHC class II. This difference in antigen processing is intrinsic to the DC subsets and associated with increased expression of proteins associated with MHC processing. PMID 17204652 GEOID GSE6259 AUTHORS Dudziak D,Kamphorst AO,Heidkamp GF,Buchholz VR,Trumpfheller C,Yamazaki S,Cheong C,Liu K,Lee HW,Park CG,Steinman RM,Nussenzweig MC CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE6259_2685_200_UP FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS 1810014F10Rik,2010110P09Rik,3222401L13Rik,4930511M11Rik,9030617O03Rik,ABCA9,ACOX1,ADAM10,ADAM15,ALOX5,AOAH,ATP6V0D2,BANK1,BLVRB,C1QTNF1,C1S,CALCRL,CCL12,CCL24,CCL7,CCL8,CD163,CD84,CDC42BPA,CFH,CLTC,CMAH,CMKLR1,COPZ2,CP,CSF3R,CTSA,CTSF,CX3CR1,CXCL13,D6WSU116E,DCLRE1C,DDX60,DMXL2,DPPA3,DPYSL3,DRAM2,DSE,DST,DUSP6,DUSP7,E130018O15Rik,ELF2,EPO,ETV1,ETV5,EYA4,FAM116A,FAM20C,FAM26F,FBLIM1,FBXL5,FCNA,FOLR2,GAB1,GALC,GAS7,GBGT1,GM10531,GM10790,GM10877,GM4787,GM4989,GNG7,GPR146,GPR75,GPX2,GPX3,HGSNAT,HK3,HOXA11,HPGD,HPGDS,HS1BP3,HS3ST3A1,IFI202B,IFI27L2B,IGF1,IGF1R,IGF2BP3,IL10RB,IL15,IMPACT,INSR,IRAK3,ITSN1,KCNJ10,KCNK13,KDELC2,KLK11,LAMC1,LAP3,LCP2,LGALS8,LGALS9,LIFR,LRP6,LRRC25,LRRC8A,LST1,LY86,LYVE1,MAF,MAMDC4,MAN1C1,MAPK8,MERTK,MFSD11,MGP,MMP2,MPP1,MS4A6C,MS4A8A,MTNR1B,MTUS1,NCF2,NLRC4,NPL,NUPR1,OCRL,OLFR1087,OLFR295,OLFR703,P2RX4,P2RX7,P2RY12,P2RY6,PARP14,PDGFC,PELI2,PHYHD1,PLA2G15,PLA2G2D,PLD3,PLEKHG5,PLOD1,PLXNA4,POU2F2,PRMT10,PRSS28,PSD3,PTGFRN,PTPLAD2,PTPRB,RALGPS2,RAPGEF5,RASGRP1,RIPK1,RNF185,ROCK2,SCAMP1,SEP15,SEPN1,SERINC3,SERPINA3N,SERPINF1,SGCE,SIGLECE,SLC11A1,SLC16A7,SLC1A3,SLC28A2,SLCO2B1,SLFN1,SNX27,SNX5,SNX6,SPATS2L,STAB1,TAAR4,TBK1,TEF,TEX12,TFPI,TIGD2,TLR1,TLR8,TM9SF4,TMEM141,TMEM37,TMEM59,TMEM9,TPP1,TPPP,TRP53TG5,TRPV4,TTYH2,UBE2Q2,VSIG4,WWP1,XPR1,ZDHHC11,ZFP691,ZFP704,ZFYVE20 GENE_SYMBOLS ,,,,,ABCA9,ACOX1,ADAM10,ADAM15,ALOX5,AOAH,ATP6V0D2,BANK1,BLVRB,C1QTNF1,C1S,CALCRL,,CCL24,CCL7,CCL8,CD163,CD84,CDC42BPA,CFH,CLTC,CMAHP,CMKLR1,COPZ2,CP,CSF3R,CTSA,CTSF,CX3CR1,CXCL13,,DCLRE1C,DDX60,DMXL2,DPPA3,DPYSL3,DRAM2,DSE,DST,DUSP6,DUSP7,,ELF2,EPO,ETV1,ETV5,EYA4,DENND6A,FAM20C,CALHM6,FBLIM1,FBXL5,,FOLR2,GAB1,GALC,GAS7,GBGT1,,,,,,GNG7,GPR146,GPR75,GPX2,GPX3,HGSNAT,HK3,HOXA11,HPGD,HPGDS,HS1BP3,HS3ST3A1,,,IGF1,IGF1R,IGF2BP3,IL10RB,IL15,IMPACT,INSR,IRAK3,ITSN1,KCNJ10,KCNK13,POGLUT3,KLK11,LAMC1,LAP3,LCP2,LGALS8,LGALS9,LIFR,LRP6,LRRC25,LRRC8A,LST1,LY86,LYVE1,MAF,MAMDC4,MAN1C1,MAPK8,MERTK,MFSD11,MGP,MMP2,MPP1,,,MTNR1B,MTUS1,NCF2,NLRC4,NPL,NUPR1,OCRL,,,,P2RX4,P2RX7,P2RY12,P2RY6,PARP14,PDGFC,PELI2,PHYHD1,PLA2G15,PLA2G2D,PLD3,PLEKHG5,PLOD1,PLXNA4,POU2F2,PRMT9,,PSD3,PTGFRN,HACD4,PTPRB,RALGPS2,RAPGEF5,RASGRP1,RIPK1,RNF185,ROCK2,SCAMP1,SELENOF,SELENON,SERINC3,,SERPINF1,SGCE,,SLC11A1,SLC16A7,SLC1A3,SLC28A2,SLCO2B1,,SNX27,SNX5,SNX6,SPATS2L,STAB1,,TBK1,TEF,TEX12,TFPI,TIGD2,TLR1,TLR8,TM9SF4,TMEM141,TMEM37,TMEM59,TMEM9,TPP1,TPPP,,TRPV4,TTYH2,UBE2Q2,VSIG4,WWP1,XPR1,ZDHHC11,,,RBSN FOUNDER_NAMES