STANDARD_NAME GSE6674_UNSTIM_VS_PL2_3_STIM_BCELL_DN SYSTEMATIC_NAME M6923 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE6674_UNSTIM_VS_PL2_3_STIM_BCELL_DN NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes down-regulated in B lymphocytes: control versus PL2-3 (Chromatin IC). DESCRIPTION_FULL We have previously shown that rheumatoid factors (RF) produced by Fas-deficient autoimmune-prone mice typically bind autologous IgG2a with remarkably low affinity. Nevertheless, B cells representative of this RF population proliferate vigorously in response IgG2a/chromatin immune complexes through a mechanism dependent on the sequential engagement of the BCR and Toll-like receptor 9 (TLR9). To more precisely address the role of both receptors in this response, we analyzed the signaling pathways activated in AM14 B cells stimulated with these complexes. We found that the BCR not only serves to direct the chromatin complex to an internal compartment where it can engage TLR9 but also transmits a suboptimal signal that in combination with the signals emanating from TLR9 leads to NF-kappa-B activation and proliferation. Importantly, engagement of both receptors leads to the upregulation of a group of gene products, not induced by the BCR or TLR9 alone, that include IL-2. These data indicate that autoreactive B cells, stimulated by a combination of BCR and TLR9 ligands, acquire functional properties that may contribute to the activation of additional cells involved in the autoimmune disease process. PMID 18025183 GEOID GSE6674 AUTHORS Busconi L,Bauer JW,Tumang JR,Laws A,Perkins-Mesires K,Tabor AS,Lau C,Corley RB,Rothstein TL,Lund FE,Behrens TW,Marshak-Rothstein A CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE6674_3088_200_DN FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS 1700129C05Rik,1810046J19Rik,2010002M12Rik,2010002N04Rik,5730508B09Rik,6230427J02Rik,8430408G22Rik,9230113P08Rik,9430016H08Rik,ABCA1,ACAP2,ACOT10,ACSL4,ACVR1,ADAM17,ADM,ADPRH,AHI1,AIFM1,AIM1,ALCAM,ALKBH6,AMY1,ANKRD32,APOF,APP,ARFGAP3,ASF1A,BC017612,BCAP31,BCO2,BEST1,BLM,BTRC,CAB39L,CCDC138,CCL2,CCND1,CCNL1,CD34,CD70,CD82,CDO1,CENPJ,CHMP2A,CHSY3,CNN3,COPS4,CPM,CTSK,CYTSA,D8ERTD82E,DBNL,DDHD1,DEDD,DERL3,DNAJB1,DNASE1L3,DNMT1,DTNBP1,DYNC1I2,E330009J07Rik,ELMOD2,EMD,ETNK2,FAH,FAM115A,FAM26F,FAP,FAS,FBXO7,FEZ2,FGF23,FIBP,FLRT3,G530011O06Rik,GFI1,GGTA1,GIMAP9,GM10134,GM10474,GM12474,GNS,GOLPH3L,GPKOW,GSTM1,GTPBP4,H2-OA,H2AFY,HMGXB4,HMOX1,HNRNPH2,HOOK1,IER5,IL18,IL33,IL4,IL7R,INSL6,ITGA4,ITGB8,JAZF1,KAT5,KLC2,KLRI1,KPNA1,LCP1,LDHD,LIF,LOC675736,LRCH1,LRRK2,LUC7L3,LXN,MAN1A,MAPKAPK2,MBNL2,MDM2,METTL10,MIR10A,MIR142,MIR196A-1,MIR450B,MIRLET7E,MOCS1,MORC3,MTAP4,MTF2,NAGA,NAP1L4,NDUFS4,NLRP3,NOD1,NONO,NPHP1,NR1H3,ODC1,OLFR1288,OPLAH,P2RY14,PARP3,PDE4D,PDE6D,PGAM1,PGF,PHLPP2,PLCL2,PLK4,POLDIP3,PPP1R15B,PRKAB2,PRKRIP1,PSMD13,RAB1,RABGAP1L,RAMP3,RANBP2,RDH12,RHCG,RHOC,RILPL1,RNF214,SCARF1,SCO1,SEC23B,SERPINB6B,SGTB,SH3BP4,SIRT1,SMCHD1,SMURF1,ST3GAL3,STARD3,SURF4,SYT17,TBC1D2B,TCEA1,TCF4,TET1,TLR6,TMEM38B,TMEM39A,TMEM67,TOP1,TRIM34,TRIP11,TRP53I11,TSPAN33,TXNRD1,UBE2Z,USP12,USP15,USP37,UTP11L,VCAN,WDFY1,ZBTB12,ZBTB7A,ZCRB1,ZFP503 GENE_SYMBOLS ,,,,,,,,,ABCA1,ACAP2,,ACSL4,ACVR1,ADAM17,ADM,ADPRH,AHI1,AIFM1,CRYBG1,ALCAM,ALKBH6,AMY1A,SLF1,APOF,APP,ARFGAP3,ASF1A,SMCO4,BCAP31,BCO2,BEST1,BLM,BTRC,CAB39L,CCDC138,CCL2,CCND1,CCNL1,CD34,CD70,CD82,CDO1,CENPJ,CHMP2A,CHSY3,CNN3,COPS4,CPM,CTSK,SPECC1L,,DBNL,DDHD1,DEDD,DERL3,DNAJB1,DNASE1L3,DNMT1,DTNBP1,DYNC1I2,,ELMOD2,EMD,ETNK2,FAH,TCAF1,CALHM6,FAP,FAS,FBXO7,FEZ2,FGF23,FIBP,FLRT3,,GFI1,GGTA1,,,,,GNS,GOLPH3L,GPKOW,GSTM1,GTPBP4,,MACROH2A1,HMGXB4,HMOX1,HNRNPH2,HOOK1,IER5,IL18,IL33,IL4,IL7R,INSL6,ITGA4,ITGB8,JAZF1,KAT5,KLC2,,KPNA1,LCP1,LDHD,LIF,,LRCH1,LRRK2,LUC7L3,LXN,,MAPKAPK2,MBNL2,MDM2,EEF1AKMT2,MIR10A,MIR142,,MIR450B,MIRLET7E,MOCS1,MORC3,,MTF2,NAGA,NAP1L4,NDUFS4,NLRP3,NOD1,NONO,NPHP1,NR1H3,ODC1,,OPLAH,P2RY14,PARP3,PDE4D,PDE6D,PGAM1,PGF,PHLPP2,PLCL2,PLK4,POLDIP3,PPP1R15B,PRKAB2,PRKRIP1,PSMD13,RAB1A,RABGAP1L,RAMP3,RANBP2,RDH12,RHCG,RHOC,RILPL1,RNF214,SCARF1,SCO1,SEC23B,,SGTB,SH3BP4,SIRT1,SMCHD1,SMURF1,ST3GAL3,STARD3,SURF4,SYT17,TBC1D2B,TCEA1,TCF4,TET1,TLR6,TMEM38B,TMEM39A,TMEM67,TOP1,TRIM34,TRIP11,,TSPAN33,TXNRD1,UBE2Z,USP12,USP15,USP37,UTP11,VCAN,WDFY1,ZBTB12,ZBTB7A,ZCRB1, FOUNDER_NAMES