STANDARD_NAME	GSE7460_CTRL_VS_TGFB_TREATED_ACT_FOXP3_MUT_TCONV_DN
SYSTEMATIC_NAME	M5699
COLLECTION	C7:IMMUNESIGDB
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE7460_CTRL_VS_TGFB_TREATED_ACT_FOXP3_MUT_TCONV_DN
NAMESPACE	HUMAN_GENE_SYMBOL
DESCRIPTION_BRIEF	Genes down-regulated in comparsion of sfActCD4 versus sfActCD4TGF (see Fig. 1 in the paper for details).
DESCRIPTION_FULL	The transcription factor Foxp3 is usually considered the master regulator for the CD4+CD25+ "Treg" lineage, which plays a key role in controlling immune and autoimmune responses, and is characterized by a unique transcriptional signature. We have performed a meta-analysis of this signature in Treg cells in several conditions to delineate the elements that can be ascribed to T cell activation, TGFbeta signaling, or Foxp3 itself. We find that these influences synergize to activate many of the signature’s components. Foxp3 and TGFbeta signaling have interconnected relationships, as Foxp3 is induced by TGFbeta while enhancing TGFbeta’s positive feedback loop. Much of the Treg signature cannot be ascribed to Foxp3, as it contains gene clusters that are co-regulated, but cannot be transactivated, by Foxp3. This suggests that the Treg lineage is specified at a higher level of regulation, upstream of Foxp3, which does control some of the lineage’s essential immunoregulatory attributes.
PMID	18024188
GEOID	GSE7460
AUTHORS	Hill JA,Feuerer M,Tash K,Haxhinasto S,Perez J,Melamed R,Mathis D,Benoist C
CONTRIBUTOR	Jernej Godec
CONTRIBUTOR_ORG	Dana-Farber Cancer Institute
EXACT_SOURCE	GSE7460_1337_200_DN
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	ABHD15,ACPP,ADCY5,AFF3,AGFG1,AHR,AKT3,ANKRD34B,ANKRD50,APCS,APEH,APLNR,ARID5A,ARMC7,ART1,ART4,ATP6V1D,B3GNT8,BATF2,BCAS3,BCMO1,C18orf1,C1orf100,C1orf21,C5orf62,C7orf43,CABLES1,CAPG,CBX8,CC2D1A,CD38,CD8A,CD8B,CDH1,CES1,CHD1,CIB1,CLIC6,CLK3,CLNK,COL4A1,COMMD7,CPD,CTSC,CTSW,CXorf23,CYGB,CYP1B1,DAPK2,DDI1,DENND4A,DEXI,DIAPH2,DNAJC9,DNMT3B,DNTTIP1,EFCAB6,EGFR,ENDOU,EPHA8,F2RL1,FAM3C,FAM5C,FAM78A,FES,FGD1,FHAD1,FHL3,FOXM1,FZD10,GABARAPL1,GAL3ST4,GAPVD1,GGN,GPR155,GPR18,GPR68,GPRIN3,GRIA4,GRM7,HMGB4,HNRPLL,HOXA10,IGF2AS,IGFLR1,IL17B,IL1B,IQCC,IQCE,IRF3,IRF8,ISM1,ITGAE,JOSD2,JPH3,KANK1,KBTBD7,KCTD11,KDM1A,KIAA1467,KIT,KLRD1,KLRK1,LCA5L,LFNG,LHX8,LITAF,LMX1B,LPAR1,LPAR3,LRRC2,LRRC66,LSM1,LTK,MAP7D1,MB21D2,MED10,MMP11,MPZL2,MTUS1,NANP,NCF1,NEK6,NFKBIE,NKD2,NMT2,NPAS4,NR4A3,NRARP,NSUN4,NT5E,NT5M,PANK4,PDCD1,PMEPA1,PPP1R16B,PRDX6,PRKCZ,PTAFR,PTPN11,QPRT,RAB20,RAI1,RASGRP2,RCAN3,RDH10,RG9MTD2,RHOC,RIN2,RNASE6,RNF149,RPA1,RUNX2,SCMH1,SELV,SEPT12,SERPINH1,SFTPC,SKIL,SLC15A1,SLC22A1,SLC35B2,SLC39A4,SMPD5,SMYD3,SNAI3,SNHG11,SNORD89,SNTG1,SNX17,SPATA2L,SPOCK3,SPSB1,STK38L,STRA8,SUSD3,TAGAP,TDRD1,THAP1,THY1,TINF2,TMCC3,TMEM2,TNFSF10,TNFSF8,TONSL,TRIO,TRPC4AP,TTC39B,TTLL4,UGT8,UNC5A,VPS25,WEE1,ZDHHC23,ZDHHC8,ZNF238,ZNF354A,ZNF644,ZNF706
GENE_SYMBOLS	ABHD15,ACP3,ADCY5,AFF3,AGFG1,AHR,AKT3,ANKRD34B,ANKRD50,APCS,APEH,APLNR,ARID5A,ARMC7,ART1,ART4,ATP6V1D,B3GNT8,BATF2,BCAS3,BCO1,LDLRAD4,SPMIP3,C1orf21,SMIM3,TRAPPC14,CABLES1,CAPG,CBX8,CC2D1A,CD38,CD8A,CD8B,CDH1,CES1,CHD1,CIB1,CLIC6,CLK3,CLNK,COL4A1,COMMD7,CPD,CTSC,CTSW,BCLAF3,CYGB,CYP1B1,DAPK2,DDI1,DENND4A,DEXI,DIAPH2,DNAJC9,DNMT3B,DNTTIP1,EFCAB6,EGFR,ENDOU,EPHA8,F2RL1,FAM3C,BRINP3,FAM78A,FES,FGD1,FHAD1,FHL3,FOXM1,FZD10,GABARAPL1,GAL3ST4,GAPVD1,GGN,GPR155,GPR18,GPR68,GPRIN3,GRIA4,GRM7,HMGB4,HNRNPLL,HOXA10,IGF2-AS,IGFLR1,IL17B,IL1B,IQCC,IQCE,IRF3,IRF8,ISM1,ITGAE,JOSD2,JPH3,KANK1,KBTBD7,KCTD11,KDM1A,FAM234B,KIT,KLRD1,KLRK1,LCA5L,LFNG,LHX8,LITAF,LMX1B,LPAR1,LPAR3,LRRC2,LRRC66,LSM1,LTK,MAP7D1,MB21D2,MED10,MMP11,MPZL2,MTUS1,NANP,NCF1,NEK6,NFKBIE,NKD2,NMT2,NPAS4,NR4A3,NRARP,NSUN4,NT5E,NT5M,PANK4,PDCD1,PMEPA1,PPP1R16B,PRDX6,PRKCZ,PTAFR,PTPN11,QPRT,RAB20,RAI1,RASGRP2,RCAN3,RDH10,TRMT10A,RHOC,RIN2,RNASE6,RNF149,RPA1,RUNX2,SCMH1,SELENOV,SEPTIN12,SERPINH1,SFTPC,SKIL,SLC15A1,SLC22A1,SLC35B2,SLC39A4,SMPD5,SMYD3,SNAI3,SNHG11,SNORD89,SNTG1,SNX17,SPATA2L,SPOCK3,SPSB1,STK38L,STRA8,SUSD3,TAGAP,TDRD1,THAP1,THY1,TINF2,TMCC3,CEMIP2,TNFSF10,TNFSF8,TONSL,TRIO,TRPC4AP,TTC39B,TTLL4,UGT8,UNC5A,VPS25,WEE1,ZDHHC23,ZDHHC8,ZBTB18,ZNF354A,ZNF644,ZNF706
FOUNDER_NAMES