STANDARD_NAME GSE7460_TREG_VS_TCONV_ACT_DN SYSTEMATIC_NAME M5691 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE7460_TREG_VS_TCONV_ACT_DN NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes down-regulated in comparsion of ActTreg versus ActCD4 (see Fig. 1 in the paper for details). DESCRIPTION_FULL The transcription factor Foxp3 is usually considered the master regulator for the CD4+CD25+ "Treg" lineage, which plays a key role in controlling immune and autoimmune responses, and is characterized by a unique transcriptional signature. We have performed a meta-analysis of this signature in Treg cells in several conditions to delineate the elements that can be ascribed to T cell activation, TGFbeta signaling, or Foxp3 itself. We find that these influences synergize to activate many of the signature’s components. Foxp3 and TGFbeta signaling have interconnected relationships, as Foxp3 is induced by TGFbeta while enhancing TGFbeta’s positive feedback loop. Much of the Treg signature cannot be ascribed to Foxp3, as it contains gene clusters that are co-regulated, but cannot be transactivated, by Foxp3. This suggests that the Treg lineage is specified at a higher level of regulation, upstream of Foxp3, which does control some of the lineage’s essential immunoregulatory attributes. PMID 18024188 GEOID GSE7460 AUTHORS Hill JA,Feuerer M,Tash K,Haxhinasto S,Perez J,Melamed R,Mathis D,Benoist C CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE7460_1333_200_DN FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ACP5,ACSS2,ADCY6,AEBP1,AGAP2,AGT,AIRE,AKT2,ALDH5A1,ALKBH3,AP2A1,APP,APPL2,ASPSCR1,AUH,B3GNT9,BCORL1,BEX1,BHLHE41,BTN1A1,C12orf51,C14orf38,C17orf59,C1orf201,C1orf21,C20orf195,C20orf54,C6orf145,C8orf37,C8orf41,CACNA1G,CAMK2G,CAPZA3,CATSPERG,CCDC25,CDYL2,CEP164,CLEC4E,CNGA1,CNST,COL15A1,COL17A1,CTAGE5,CTNND2,CYB5R1,CYSLTR1,DAP,DAPL1,DCP2,DHCR7,DIO1,DNAJB2,DPH5,DSE,EEF2,ELAVL3,EMB,EPHA6,EVI2A,EXOSC6,FAM105B,FBXO10,FCAMR,FPGS,FPR3,GDF2,GNB2L1,GPR35,GTF2I,GUCY2D,HOXC13,HOXD11,HPCAL1,HS3ST3B1,HSDL1,IL1RL2,IL4,IQCF5,ITGB3,ITK,KCNK1,KCTD21,KIAA0564,KIAA1033,KIAA1147,KIAA1797,KIF3A,KIFC3,KLHL25,LIX1,LOC100506540,LOC729275,LRMP,MAN1C1,MCART1,MCCC2,MCM3AP,MCOLN2,MCTP2,MERTK,METTL9,MFAP2,MGAT5B,MGLL,MIA2,MOBKL2B,MOSC1,MSX1,MTA1,MYO10,MZB1,NECAB3,NHEDC1,NIPA1,NME6,NPAS3,NTAN1,OGDH,OPN3,PACRG,PDE3B,PDXK,PGBD5,PIK3R5,PIM2,PLUNC,PLXNB3,PMFBP1,PMVK,POLRMT,PPOX,PRG3,PROX2,PRSS37,PRSS54,PTPN22,PXMP4,RASGRF2,RASL12,RBFA,RGS5,RHOBTB2,RNASE2,RNF150,RNF157,RNF208,RPLP0,RRP12,SCGN,SEC16A,SEC24C,SEPT6,SGK223,SH2D5,SHISA4,SIGLEC10,SIPA1L1,SLC16A7,SLC30A4,SLC30A7,SLC46A3,SLCO3A1,SLPI,SMAD6,SPEF1,SPHK2,SPOCK2,SPRN,SSPN,ST6GALNAC2,STRC,SUSD1,TBL1X,TDRD12,TECR,TEX9,TFR2,TGFBR2,THEMIS,TMEM121,TMEM170A,TMEM186,TMEM229B,TNFRSF1A,TNNT1,TRIM6,TSPAN5,TSPYL2,TTLL12,UGT3A2,UNC119B,USF2,VARS2,VPS26B,VWA3A,WDR96,WDSUB1,WSCD1,ZCWPW2,ZDHHC9 GENE_SYMBOLS ACP5,ACSS2,ADCY6,AEBP1,AGAP2,AGT,AIRE,AKT2,ALDH5A1,ALKBH3,AP2A1,APP,APPL2,ASPSCR1,AUH,B3GNT9,BCORL1,BEX1,BHLHE41,BTN1A1,HECTD4,CCDC175,BORCS6,STPG1,C1orf21,FNDC11,SLC52A3,PXDC1,CFAP418,TTI2,CACNA1G,CAMK2G,CAPZA3,CATSPERG,CCDC25,CDYL2,CEP164,CLEC4E,CNGA1,CNST,COL15A1,COL17A1,MIA2,CTNND2,CYB5R1,CYSLTR1,DAP,DAPL1,DCP2,DHCR7,DIO1,DNAJB2,DPH5,DSE,EEF2,ELAVL3,EMB,EPHA6,EVI2A,EXOSC6,OTULIN,FBXO10,FCAMR,FPGS,FPR3,GDF2,RACK1,GPR35,GTF2I,GUCY2D,HOXC13,HOXD11,HPCAL1,HS3ST3B1,HSDL1,IL1RL2,IL4,IQCF5,ITGB3,ITK,KCNK1,KCTD21,VWA8,WASHC4,DENND11,FOCAD,KIF3A,KIFC3,KLHL25,LIX1,MISFA,,IRAG2,MAN1C1,SLC25A51,MCCC2,MCM3AP,MCOLN2,MCTP2,MERTK,METTL9,MFAP2,MGAT5B,MGLL,MIA2,MOB3B,MTARC1,MSX1,MTA1,MYO10,MZB1,NECAB3,SLC9B1,NIPA1,NME6,NPAS3,NTAN1,OGDH,OPN3,PACRG,PDE3B,PDXK,PGBD5,PIK3R5,PIM2,BPIFA1,PLXNB3,PMFBP1,PMVK,POLRMT,PPOX,PRG3,PROX2,PRSS37,PRSS54,PTPN22,PXMP4,RASGRF2,RASL12,RBFA,RGS5,RHOBTB2,RNASE2,RNF150,RNF157,RNF208,RPLP0,RRP12,SCGN,SEC16A,SEC24C,SEPTIN6,,SH2D5,SHISA4,SIGLEC10,SIPA1L1,SLC16A7,SLC30A4,SLC30A7,SLC46A3,SLCO3A1,SLPI,SMAD6,SPEF1,SPHK2,SPOCK2,SPRN,SSPN,ST6GALNAC2,STRC,SUSD1,TBL1X,TDRD12,TECR,TEX9,TFR2,TGFBR2,THEMIS,TMEM121,TMEM170A,TMEM186,TMEM229B,TNFRSF1A,TNNT1,TRIM6,TSPAN5,TSPYL2,TTLL12,UGT3A2,UNC119B,USF2,VARS2,VPS26B,VWA3A,CFAP43,WDSUB1,WSCD1,ZCWPW2,ZDHHC9 FOUNDER_NAMES