STANDARD_NAME	GSE7509_DC_VS_MONOCYTE_WITH_FCGRIIB_STIM_DN
SYSTEMATIC_NAME	M6835
COLLECTION	C7:IMMUNESIGDB
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE7509_DC_VS_MONOCYTE_WITH_FCGRIIB_STIM_DN
NAMESPACE	HUMAN_GENE_SYMBOL
DESCRIPTION_BRIEF	Genes down-regulated in response to anti-FcgRIIB: dendritic cells versus monocytes.
DESCRIPTION_FULL	The ability of dendritic cells (DCs) to activate immunity is linked to their maturation status. In prior studies we have shown that selective antibody-mediated blockade of inhibitory FcgRIIB receptor on human DCs in the presence of activating immunoglobulin (Ig) ligands leads to DC maturation and enhanced immunity to antibody-coated tumor cells. Here we show that Fcg receptor (FcgR) mediated activation of human monocytes and monocyte-derived DCs is associated with a distinct gene expression pattern, including several inflammation associated chemokines as well as type 1 interferon (IFN) response genes including the activation of signal transducer and activator of transcription 1 (STAT1).
PMID	17502666
GEOID	GSE7509
AUTHORS	Dhodapkar KM,Banerjee D,Connolly J,Kukreja A,Matayeva E,Veri MC,Ravetch JV,Steinman RM,Dhodapkar MV
CONTRIBUTOR	Jernej Godec
CONTRIBUTOR_ORG	Dana-Farber Cancer Institute
EXACT_SOURCE	GSE7509_3408_200_DN
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	ABL2,ABTB2,ACSL1,ADAR,ADM,ADPRH,AKR1C4,AMD1,ANKS1A,APOBEC3G,ARAP2,ARF6,ARHGAP25,ARID5A,ASCL2,ATF3,ATF6,ATG12,AXL,B4GALT5,BAK1,BARD1,BAZ1A,BIRC2,BMPR2,BRCA2,BST2,C1orf38,C22orf28,C2orf27A,CACNA1A,CASP10,CCL13,CCL2,CCL7,CCL8,CCR1,CD2AP,CD86,CDK17,CEACAM1,CGGBP1,CHSY1,CKAP4,CLDND1,CNTN1,CSTF3,CTNS,CXCL11,CXCL9,DACH1,DHX15,DHX34,DIO3,DNAJA1,DRAP1,DUSP6,DYNLT1,EED,EIF4G3,ELF4,ENPP2,ETV6,EVPL,FAM190B,FAS,FBXO7,FPR2,FTSJD2,FUT4,FZD2,GCA,GRIK2,GTF2B,H3F3B,HCK,HEG1,HIRA,HIVEP2,IFI35,IFI44,IFI44L,IFIT1,IFIT2,IFIT3,IFITM1,IFITM3,IGF2BP3,IL6,IL7,IRF7,IRF9,ISG15,ISG20,KBTBD2,KIAA0226,KIAA0754,KIAA1109,KRT76,LAG3,LAMP3,LCP2,LGALS9,LIG4,LILRB1,LMNB1,LMO2,LOC100131510,LRRC42,LYN,MACF1,MALT1,MEIS3P1,MFN1,MTMR6,MX1,MX2,MYL12A,MYO1B,N4BP1,NAMPT,NAPA,NASP,NDRG2,NRIP1,NUP62,OAS1,OAS2,OASL,P2RY6,PAPD7,PLN,PLSCR1,PPFIBP1,PPP2R2A,PPP3CC,PPP4R1,PSMA4,PTPN2,PVRL2,RAB14,RABGAP1L,RALB,RASGRF1,RBBP6,RBCK1,RBM34,RBMS1,RBPJ,RERE,RGL1,RIF1,RIN2,RIPK1,RNF144A,RNF19B,RSAD2,S100G,SASH1,SBNO2,SERPINB1,SETD1B,SFT2D2,SLC10A1,SLC31A2,SMAD3,SOCS1,SP100,SP110,SRGAP2,SRSF4,SSB,SSTR2,ST3GAL5,STAT2,STBD1,STK17B,STRN,TDRD7,TGM1,TLK2,TMEM110,TNFRSF1A,TOP1,TOP1P2,TOR1B,TRAFD1,TRIM14,TRIM21,TRIM25,TRIM38,TWF1,UBE2S,USPL1,XAF1,XIAP,ZC3HAV1,ZFP36,ZNF200,ZNF207
GENE_SYMBOLS	ABL2,ABTB2,ACSL1,ADAR,ADM,ADPRH,AKR1C4,AMD1,ANKS1A,APOBEC3G,ARAP2,ARF6,ARHGAP25,ARID5A,ASCL2,ATF3,ATF6,ATG12,AXL,B4GALT5,BAK1,BARD1,BAZ1A,BIRC2,BMPR2,BRCA2,BST2,THEMIS2,RTCB,LINC03124,CACNA1A,CASP10,CCL13,CCL2,CCL7,CCL8,CCR1,CD2AP,CD86,CDK17,CEACAM1,CGGBP1,CHSY1,CKAP4,CLDND1,CNTN1,CSTF3,CTNS,CXCL11,CXCL9,DACH1,DHX15,DHX34,DIO3,DNAJA1,DRAP1,DUSP6,DYNLT1,EED,EIF4G3,ELF4,ENPP2,ETV6,EVPL,CCSER2,FAS,FBXO7,FPR2,CMTR1,FUT4,FZD2,GCA,GRIK2,GTF2B,H3-3B,HCK,HEG1,HIRA,HIVEP2,IFI35,IFI44,IFI44L,IFIT1,IFIT2,IFIT3,IFITM1,IFITM3,IGF2BP3,IL6,IL7,IRF7,IRF9,ISG15,ISG20,KBTBD2,RUBCN,MACF1,BLTP1,KRT76,LAG3,LAMP3,LCP2,LGALS9,LIG4,LILRB1,LMNB1,LMO2,,LRRC42,LYN,MACF1,MALT1,MEIS3P1,MFN1,MTMR6,MX1,MX2,MYL12A,MYO1B,N4BP1,NAMPT,NAPA,NASP,NDRG2,NRIP1,NUP62,OAS1,OAS2,OASL,P2RY6,TENT4A,PLN,PLSCR1,PPFIBP1,PPP2R2A,PPP3CC,PPP4R1,PSMA4,PTPN2,NECTIN2,RAB14,RABGAP1L,RALB,RASGRF1,RBBP6,RBCK1,RBM34,RBMS1,RBPJ,RERE,RGL1,RIF1,RIN2,RIPK1,RNF144A,RNF19B,RSAD2,S100G,SASH1,SBNO2,SERPINB1,SETD1B,SFT2D2,SLC10A1,SLC31A2,SMAD3,SOCS1,SP100,SP110,SRGAP2,SRSF4,SSB,SSTR2,ST3GAL5,STAT2,STBD1,STK17B,STRN,TDRD7,TGM1,TLK2,STIMATE,TNFRSF1A,TOP1,,TOR1B,TRAFD1,TRIM14,TRIM21,TRIM25,TRIM38,TWF1,UBE2S,USPL1,XAF1,XIAP,ZC3HAV1,ZFP36,ZNF200,ZNF207
FOUNDER_NAMES