STANDARD_NAME GSE7768_OVA_ALONE_VS_OVA_WITH_LPS_IMMUNIZED_MOUSE_WHOLE_SPLEEN_6H_UP SYSTEMATIC_NAME M6851 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE7768_OVA_ALONE_VS_OVA_WITH_LPS_IMMUNIZED_MOUSE_WHOLE_SPLEEN_6H_UP NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes up-regulated in spleens from mice immunized with ova peptides alone versus those immunized with LPS as adjuvant. DESCRIPTION_FULL An unresolved issue in immunology is the extent to which inflammatory effects are needed for robust T cell responses. In this study, mice were immunized by iv injection using either high toxicity lipopolysaccharide (LPS) or low toxicity monophosphoryl lipid A (MPL) as adjuvant. Six hours after iv immunization, whole spleens were harvested and gene expression was measured in unfractionated splenic populations of cells. The analysis indicated that the low toxicity adjuvanticity of MPL was associated with TLR4-mediated signaling that was biased to the TRIF branch of TLR4, while LPS generated balanced MyD88 and TRIF-associated outcomes. PMID 17569868 GEOID GSE7768 AUTHORS Mata-Haro V,Cekic C,Martin M,Chilton PM,Casella CR,Mitchell TC CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE7768_2696_200_UP FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS 1600002H07Rik,1700040I03Rik,2210018M11Rik,2310001H12Rik,2310035K24Rik,2410017P07Rik,2610008E11Rik,2610029I01Rik,2610507B11Rik,2810001A02Rik,3110052M02Rik,4632428N05Rik,4933407C03Rik,5730419I09Rik,6430527G18Rik,6720463M24Rik,A530017D24Rik,A830007P12Rik,ACER3,ADAMTS10,ADRBK1,AGA,AKAP7,ALMS1,AMACR,AP2A2,APOBEC1,ARHGAP25,ARHGEF7,ARL11,ARL4C,BAZ1B,BC037034,BC053749,BC068281,BHLHE41,BLOC1S2,BLOC1S3,BRIP1,BTBD19,BUB1B,C79407,CASP9,CCDC163,CCDC45,CD200R1,CD300LB,CDC25B,CDCA7,CEP68,CLIC1,CLIP2,CLN8,COMMD5,CROT,CTAGE5,CUL9,CYTH4,DCTN5,DEF6,E130306D19Rik,ELMO2,ELMOD2,ERCC5,ESCO2,FAM193B,FBXO21,FBXW7,FES,GAB3,GAN,GCC2,GCNT1,GM10759,GM13242,GM3338,GM6762,GMNN,GPR146,GPR155,GPR157,GPR77,GRN,GTF2I,GTL3,HDAC10,HELQ,HIST1H2AB,HPS3,HYLS1,ID1,IFFO2,IL21,IMP3,KBTBD7,KIFC3,LACTB2,LPAR5,LPAR6,LRMP,LRRC33,MAGEF1,MAP3K9,MDC1,METTL7A1,MIDN,MPV17,MSRB2,MTMR3,MTRF1L,MUM1,MYO1F,NCOA1,NCOA3,NDUFV3,NEDD9,NFAM1,NFATC1,NIT2,NKIRAS1,NLRP1C,NPAT,NT5DC3,OPLAH,OSBPL11,OSGIN1,PCMTD1,PDCD7,PDPK1,PEO1,PLEKHM1,PLK3,POLD3,POLG2,PPARGC1B,PPCDC,PPP1CC,PPP1R13B,PRAM1,PRKRA,PROKR1,PRR12,PSTK,R3HCC1,RAB3A,REV3L,RREB1,RUNX3,SCLT1,SEPT10,SEPT7,SLBP,SLC25A35,SLC35A1,SLC35A5,SMPD2,SMYD4,SNX2,SNX24,SNX8,SOCS6,STARD8,STARD9,TBC1D14,TBC1D2,TBL1XR1,TBXAS1,TDP2,TGFBRAP1,THBD,TIFAB,TIGD2,TMEM104,TMEM106A,TMEM126B,TMEM154,TMEM18,TMEM194B,TMEM218,TRMT12,TRP53INP1,TTC14,TUBGCP5,UMPS,UVRAG,VGLL4,VPS26A,WDR67,XPC,XRCC6,ZBTB38,ZBTB45,ZDHHC1,ZFAND2A,ZFP207,ZFP608,ZFP652,ZFP710,ZFP760,ZMYND8 GENE_SYMBOLS ,,,,,,,,,,,,,,,,,,ACER3,ADAMTS10,GRK2,AGA,AKAP7,ALMS1,AMACR,AP2A2,APOBEC1,ARHGAP25,ARHGEF7,ARL11,ARL4C,BAZ1B,TRAPPC14,PROSER3,WDCP,BHLHE41,BLOC1S2,BLOC1S3,BRIP1,BTBD19,BUB1B,MIS18BP1,CASP9,CCDC163,CEP95,CD200R1,CD300LB,CDC25B,CDCA7,CEP68,CLIC1,CLIP2,CLN8,COMMD5,CROT,MIA2,CUL9,CYTH4,DCTN5,DEF6,,ELMO2,ELMOD2,ERCC5,ESCO2,FAM193B,FBXO21,FBXW7,FES,GAB3,GAN,GCC2,GCNT1,,,,,GMNN,GPR146,GPR155,GPR157,C5AR2,GRN,GTF2I,CFAP20,HDAC10,HELQ,H2AC4,HPS3,HYLS1,ID1,IFFO2,IL21,IMP3,KBTBD7,KIFC3,LACTB2,LPAR5,LPAR6,IRAG2,NRROS,MAGEF1,MAP3K9,MDC1,,MIDN,MPV17,MSRB2,MTMR3,MTRF1L,IRF4,MYO1F,NCOA1,NCOA3,NDUFV3,NEDD9,NFAM1,NFATC1,NIT2,NKIRAS1,,NPAT,NT5DC3,OPLAH,OSBPL11,OSGIN1,PCMTD1,PDCD7,PDPK1,TWNK,PLEKHM1,PLK3,POLD3,POLG2,PPARGC1B,PPCDC,PPP1CC,PPP1R13B,PRAM1,PRKRA,PROKR1,PRR12,PSTK,R3HCC1,RAB3A,REV3L,RREB1,RUNX3,SCLT1,SEPTIN10,SEPTIN7,SLBP,SLC25A35,SLC35A1,SLC35A5,SMPD2,SMYD4,SNX2,SNX24,SNX8,SOCS6,STARD8,STARD9,TBC1D14,TBC1D2,TBL1XR1,TBXAS1,TDP2,TGFBRAP1,THBD,TIFAB,TIGD2,TMEM104,TMEM106A,TMEM126B,TMEM154,TMEM18,NEMP2,TMEM218,TRMT12,,TTC14,TUBGCP5,UMPS,UVRAG,VGLL4,VPS26A,TBC1D31,XPC,XRCC6,ZBTB38,ZBTB45,ZDHHC1,ZFAND2A,,,,,,ZMYND8 FOUNDER_NAMES