STANDARD_NAME GSE8921_UNSTIM_VS_TLR1_2_STIM_MONOCYTE_3H_UP SYSTEMATIC_NAME M6412 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE8921_UNSTIM_VS_TLR1_2_STIM_MONOCYTE_3H_UP NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes up-regulated in monocytes (3h): untreated versus M. tuberculosis 19 kDa lipopeptide. DESCRIPTION_FULL In innate immune responses, activation of Toll-like receptors (TLRs) triggers direct antimicrobial activity against intracellular bacteria, which in murine, but not human, monocytes and macrophages is mediated principally by nitric oxide. We report here that TLR activation of human macrophages up-regulated expression of the vitamin D receptor and the vitamin D-1-hydroxylase genes, leading to induction of the antimicrobial peptide cathelicidin and killing of intracellular Mycobacterium tuberculosis. We also observed that sera from African-American individuals, known to have increased susceptibility to tuberculosis, had low 25-hydroxyvitamin D and were inefficient in supporting cathelicidin messenger RNA induction. These data support a link between TLRs and vitamin D-mediated innate immunity and suggest that differences in ability of human populations to produce vitamin D may contribute to susceptibility to microbial infection. PMID 16497887 GEOID GSE8921 AUTHORS Liu PT,Stenger S,Li H,Wenzel L,Tan BH,Krutzik SR,Ochoa MT,Schauber J,Wu K,Meinken C,Kamen DL,Wagner M,Bals R,Steinmeyer A,Zügel U,Gallo RL,Eisenberg D,Hewison M,Hollis BW,Adams JS,Bloom BR,Modlin RL CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE8921_3125_200_UP FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ABLIM3,ADAMTS6,AGR3,ALDH4A1,ANKRD17,ANKRD44,ARL6IP1,ATP13A4,ATP1A2,ATP8A1,B3GAT2,BCKDHB,BMI1,BTG3,BUB3,C12orf75,C14orf156,C14orf80,C16orf74,C17orf104,C1orf123,C1orf196,C3orf37,C4orf27,C7orf23,CACNA1G,CBX5,CCDC158,CCDC164,CCND2,CD300LB,CD96,CD97,CDC20,CDC45,CDSN,CENPE,CENPK,CHAF1B,CHCHD10,CKAP2L,CLCNKB,CLDN16,CLRN3,CNIH4,CNTN4,CNTNAP1,COQ6,CUL2,DCLK2,DDX51,DDX56,DHFR,DIS3,DNMT1,DTYMK,DUSP12,DUT,EFCAB1,EFHA1,EIF3I,EIF3L,ELF5,ENO3,EPB41L4A,EPHX1,ERAP1,ERCC6L,FAM110C,FAM111A,FAM204A,FAM82A2,FASTKD5,FLYWCH2,FUT9,GEMIN6,GFI1B,GLE1,GRASP,GTF3C5,HAUS3,HBG2,HCAR1,HDAC1,HELLS,HNRNPA3,HNRNPAB,HS6ST3,HSD11B1,HSPBP1,IFI44L,IFIH1,IFITM2,IFNG,IMPA1,INPP1,IQCA1,KDR,KIF2C,KIFC1,LAP3,LCN9,LGALS7,LGALS9B,LIN28B,LIPF,LOC100128160,LOC401097,LOC81691,LPIN2,LRPPRC,LTV1,LYAR,MBNL1,MELK,MEMO1,MLLT1,MRPL39,MTFP1,MTM1,MYCBP2,MYL4,MYO1E,MZB1,NANS,NCAPD2,NCAPG,NDUFS7,NEK2,NEK8,NINJ1,NMI,NOP10,NOP16,NPM3,NPTX1,NR1H4,NUP155,NUP160,NUP43,NUP85,O3FAR1,OIP5,OOEP,OPCML,PARP8,PDE7A,PDSS2,PDZRN3,PENK,PLA2G4F,POLE4,PRSS36,PUS10,PYCARD,RAB11FIP4,RAB3IP,RAD51AP1,RAD54B,RAD54L,RBBP7,RECQL4,RESP18,RPS6KL1,RTEL1,SAMD9L,SAT2,SCIN,SET,SETDB2,SLC23A3,SLC25A3,SLC35C2,SLC39A3,SLC43A1,SLC43A3,SLC9A5,SMARCB1,SRFBP1,STBD1,STC1,SYTL4,TBC1D4,TBC1D7,TGIF2,TIMM8B,TK1,TMCC3,TMEM39A,TNFSF10,USP39,VRK2,VWA3B,WDHD1,WDR76,WNT9B,YWHAB,ZCRB1,ZEB2,ZZZ3 GENE_SYMBOLS ABLIM3,ADAMTS6,AGR3,ALDH4A1,ANKRD17,ANKRD44,ARL6IP1,ATP13A4,ATP1A2,ATP8A1,B3GAT2,BCKDHB,BMI1,BTG3,BUB3,C12orf75,SLIRP,TEDC1,C16orf74,MEIOC,CZIB,KAZN,HMCES,HPF1,TMEM243,CACNA1G,CBX5,CCDC158,DRC1,CCND2,CD300LB,CD96,ADGRE5,CDC20,CDC45,CDSN,CENPE,CENPK,CHAF1B,CHCHD10,CKAP2L,CLCNKB,CLDN16,CLRN3,CNIH4,CNTN4,CNTNAP1,COQ6,CUL2,DCLK2,DDX51,DDX56,DHFR,DIS3,DNMT1,DTYMK,DUSP12,DUT,CLXN,MICU2,EIF3I,EIF3L,ELF5,ENO3,EPB41L4A,EPHX1,ERAP1,ERCC6L,FAM110C,FAM111A,FAM204A,RMDN3,FASTKD5,FLYWCH2,FUT9,GEMIN6,GFI1B,GLE1,TAMALIN,GTF3C5,HAUS3,HBG2,HCAR1,HDAC1,HELLS,HNRNPA3,HNRNPAB,HS6ST3,HSD11B1,HSPBP1,IFI44L,IFIH1,IFITM2,IFNG,IMPA1,INPP1,IQCA1,KDR,KIF2C,KIFC1,LAP3,LCN9,LGALS7,LGALS9B,LIN28B,LIPF,,C3orf80,REXO5,LPIN2,LRPPRC,LTV1,LYAR,MBNL1,MELK,MEMO1,MLLT1,MRPL39,MTFP1,MTM1,MYCBP2,MYL4,MYO1E,MZB1,NANS,NCAPD2,NCAPG,NDUFS7,NEK2,NEK8,NINJ1,NMI,NOP10,NOP16,NPM3,NPTX1,NR1H4,NUP155,NUP160,NUP43,NUP85,FFAR4,OIP5,OOEP,OPCML,PARP8,PDE7A,PDSS2,PDZRN3,PENK,PLA2G4F,POLE4,PRSS36,PUS10,PYCARD,RAB11FIP4,RAB3IP,RAD51AP1,RAD54B,RAD54L,RBBP7,RECQL4,RESP18,RPS6KL1,RTEL1,SAMD9L,SAT2,SCIN,SET,SETDB2,SLC23A3,SLC25A3,SLC35C2,SLC39A3,SLC43A1,SLC43A3,SLC9A5,SMARCB1,SRFBP1,STBD1,STC1,SYTL4,TBC1D4,TBC1D7,TGIF2,TIMM8B,TK1,TMCC3,TMEM39A,TNFSF10,USP39,VRK2,VWA3B,WDHD1,WDR76,WNT9B,YWHAB,ZCRB1,ZEB2,ZZZ3 FOUNDER_NAMES