STANDARD_NAME GSE9509_10MIN_VS_30MIN_LPS_STIM_IL10_KO_MACROPHAGE_UP SYSTEMATIC_NAME M6904 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE9509_10MIN_VS_30MIN_LPS_STIM_IL10_KO_MACROPHAGE_UP NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes up-regulated in macrophages with IL10 [GeneID=3586] knockout treated by LPS: 10 min versus 30 min. DESCRIPTION_FULL IL-10 regulates anti-inflammatory signaling via the activation of STAT3, which in turn controls the induction of a gene expression program whose products execute inhibitory effects on pro-inflammatory mediator production. Here we show that IL-10 induces the expression of an ETS family transcriptional repressor, ETV3 and a helicase family co-repressor, SBNO2 (Strawberry notch homolog 2) in mouse and human macrophages. IL-10-mediated induction of ETV3 and SBNO2 expression was dependent upon both STAT3, and co-stimulus through the TLR pathway. We also observed that ETV3 expression was strongly induced by the STAT3 pathway induced by IL-10 but not STAT3 signaling activated by IL-6, which cannot activate the anti-inflammatory signaling pathway. ETV3 and SBNO2 specifically repressed NF-kB-mediated transcription and can physically interact. Collectively our data suggest that ETV3 and SBNO2 are components of the pathways that contribute to the downstream anti-inflammatory effects of IL-10. We compared expression profiles of macrophages isolated from IL-10 -/- mice. Macrophages were treated with either LPS or LPS plus IL-10. Treatment times were 10, 20 and 30 minutes. PMID 18025162 GEOID GSE9509 AUTHORS El Kasmi KC,Smith AM,Williams L,Neale G,Panopoulos AD,Watowich SS,Häcker H,Foxwell BM,Murray PJ CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE9509_3055_200_UP FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ACAP1,ACOT7,AIG1,AK2,ALCAM,ALDH18A1,ALKBH2,AMICA1,ANKRD27,ANXA2,ANXA2P2,ANXA5,APEX1,APLP2,ARHGEF40,ARPC2,ASAH1,ATP5O,AVPI1,BACE1,BIVM,BNIP3,C11orf10,C11orf74,C12orf44,C12orf75,C14orf1,C14orf2,C19orf2,C1orf151,C1orf162,C1orf96,C20orf24,C4orf52,C9orf43,CANX,CASP1,CD84,CD93,CDC123,CDC45,CECR1,CECR6,CFL1,CLDN10,CNNM2,COMMD8,CORO1C,COTL1,COX6A1,CPA3,CSF1R,CST3,CTSA,CTSG,DAD1,DCXR,DDX46,DOCK5,DYM,DYNLRB1,EBNA1BP2,EEF1B2,EEF1E1,EIF2S2,EIF5A,ELF4,ERO1L,ETHE1,EXOSC7,FAS,FCER1G,FGFR2,GGCX,GLIPR2,GNPTG,GOLGA8H,GRN,GXYLT2,HADH,HENMT1,HERPUD1,HEXB,HOPX,HSBP1,HSD17B12,IFI27L1,IL13RA1,IMPA2,ITGB7,JAM2,KCNK17,KIAA1797,KIAA1804,KLF11,KRTCAP2,LAMTOR2,LAP3,LAPTM4B,LIPA,LOC100129250,LRPAP1,LSP1,MAN2B1,MAPKAPK3,METTL10,METTL7A,MKKS,MRPL20,MRPL27,MRPL48,MRPS23,MRPS33,NAP1L3,NCOR2,NDUFA12,NDUFB5,NGFRAP1,NPC2,NUCB2,NUP210,OST4,P2RY2,PALLD,PARK7,PGRMC1,PIGK,PIGY,PLAGL1,PLAUR,PNP,POLR2K,PPA1,PRAM1,PRDX4,PRKAR2B,PRR14,PRTFDC1,PSMB1,PTPN7,PTPRS,PYGL,QARS,RAB11FIP1,RAB32,RAN,RBPMS,RIN3,RNF135,RPL22,RPN2,RPS8,S100A6,S100B,SAMHD1,SAMSN1,SBNO1,SCRN1,SDHB,SEC11C,SELK,SEMA4A,SEMA4C,SFXN3,SIGLEC5,SIRPA,SLA2,SLC22A15,SLC2A4RG,SLC35F2,SNX5,SPATS2L,SPCS1,SPINT2,SPIRE1,STARD3NL,STEAP3,SUCLG1,TBCB,THEM4,TIMM50,TLE3,TM2D2,TMED2,TMEM159,TNFAIP2,TNFSF13,TNRC18,TOP1MT,TPP1,TREM1,TSTD1,TXNL4A,TYROBP,UGCG,USMG5,VPS29,WAPAL,ZNF511,ZYX GENE_SYMBOLS ACAP1,ACOT7,AIG1,AK2,ALCAM,ALDH18A1,ALKBH2,JAML,ANKRD27,ANXA2,ANXA2P2,ANXA5,APEX1,APLP2,ARHGEF40,ARPC2,ASAH1,ATP5PO,AVPI1,BACE1,BIVM,BNIP3,TMEM258,IFTAP,ATG101,C12orf75,ERG28,ATP5MJ,URI1,MICOS10,C1orf162,CCSAP,RAB5IF,SMIM20,C9orf43,CANX,CASP1,CD84,CD93,CDC123,CDC45,ADA2,TMEM121B,CFL1,CLDN10,CNNM2,COMMD8,CORO1C,COTL1,COX6A1,CPA3,CSF1R,CST3,CTSA,CTSG,DAD1,DCXR,DDX46,DOCK5,DYM,DYNLRB1,EBNA1BP2,EEF1B2,EEF1E1,EIF2S2,EIF5A,ELF4,ERO1A,ETHE1,EXOSC7,FAS,FCER1G,FGFR2,GGCX,GLIPR2,GNPTG,GOLGA8H,GRN,GXYLT2,HADH,HENMT1,HERPUD1,HEXB,HOPX,HSBP1,HSD17B12,IFI27L1,IL13RA1,IMPA2,ITGB7,JAM2,KCNK17,FOCAD,MAP3K21,KLF11,KRTCAP2,LAMTOR2,LAP3,LAPTM4B,LIPA,SMIM27,LRPAP1,LSP1,MAN2B1,MAPKAPK3,EEF1AKMT2,METTL7A,MKKS,MRPL20,MRPL27,MRPL48,MRPS23,MRPS33,NAP1L3,NCOR2,NDUFA12,NDUFB5,BEX3,NPC2,NUCB2,NUP210,OST4,P2RY2,PALLD,PARK7,PGRMC1,PIGK,PIGY,PLAGL1,PLAUR,PNP,POLR2K,PPA1,PRAM1,PRDX4,PRKAR2B,PRR14,PRTFDC1,PSMB1,PTPN7,PTPRS,PYGL,EPRS1,RAB11FIP1,RAB32,RAN,RBPMS,RIN3,RNF135,RPL22,RPN2,RPS8,S100A6,S100B,SAMHD1,SAMSN1,SBNO1,SCRN1,SDHB,SEC11C,SELENOK,SEMA4A,SEMA4C,SFXN3,SIGLEC5,SIRPA,SLA2,SLC22A15,SLC2A4RG,SLC35F2,SNX5,SPATS2L,SPCS1,SPINT2,SPIRE1,STARD3NL,STEAP3,SUCLG1,TBCB,THEM4,TIMM50,TLE3,TM2D2,TMED2,LDAF1,TNFAIP2,TNFSF13,TNRC18,TOP1MT,TPP1,TREM1,TSTD1,TXNL4A,TYROBP,UGCG,ATP5MK,VPS29,WAPL,ZNF511,ZYX FOUNDER_NAMES