STANDARD_NAME GSE9509_LPS_VS_LPS_AND_IL10_STIM_IL10_KO_MACROPHAGE_20MIN_UP SYSTEMATIC_NAME M6899 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE9509_LPS_VS_LPS_AND_IL10_STIM_IL10_KO_MACROPHAGE_20MIN_UP NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes up-regulated in macrophages with IL10 [GeneID=3586] knockout in response to 20 min treatment by: LPS versus LPS and IL10 [GeneID=3586]. DESCRIPTION_FULL IL-10 regulates anti-inflammatory signaling via the activation of STAT3, which in turn controls the induction of a gene expression program whose products execute inhibitory effects on pro-inflammatory mediator production. Here we show that IL-10 induces the expression of an ETS family transcriptional repressor, ETV3 and a helicase family co-repressor, SBNO2 (Strawberry notch homolog 2) in mouse and human macrophages. IL-10-mediated induction of ETV3 and SBNO2 expression was dependent upon both STAT3, and co-stimulus through the TLR pathway. We also observed that ETV3 expression was strongly induced by the STAT3 pathway induced by IL-10 but not STAT3 signaling activated by IL-6, which cannot activate the anti-inflammatory signaling pathway. ETV3 and SBNO2 specifically repressed NF-kB-mediated transcription and can physically interact. Collectively our data suggest that ETV3 and SBNO2 are components of the pathways that contribute to the downstream anti-inflammatory effects of IL-10. We compared expression profiles of macrophages isolated from IL-10 -/- mice. Macrophages were treated with either LPS or LPS plus IL-10. Treatment times were 10, 20 and 30 minutes. PMID 18025162 GEOID GSE9509 AUTHORS El Kasmi KC,Smith AM,Williams L,Neale G,Panopoulos AD,Watowich SS,Häcker H,Foxwell BM,Murray PJ CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE9509_3053_200_UP FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ABCB1,ABLIM1,ACACB,ACOX2,ACRBP,ADAM8,ADAMTSL4,AKR1C2,ALDH1A1,ANGPT1,ARHGAP22,ARHGAP36,ARHGEF40,ARMCX1,ARNTL2,ARSD,ATP7B,ATP9A,ATXN7L1,BACE2,BCORL1,BIRC3,C10orf93,C15orf17,C1orf150,C1orf216,C1QL1,C1RL,C20orf108,C21orf49,C22orf33,C2orf18,C3,C8orf42,C9orf103,C9orf125,CALN1,CAMLG,CCDC87,CD7,CDC14B,CFH,CHRM3,CNKSR1,CNST,COL5A1,CRHBP,CTDSPL,CTGF,DAPK1,DDN,DIRC2,DNAH10,EEF2,EFNB2,EHD2,EHD3,ELOVL7,EPHB4,ERG,FAM117A,FAM19A2,FAM65C,FGD5,FITM2,FKBP9,FN3K,FOXO1,GALNS,GAS1,GATAD1,GBP4,GFI1B,GIPC2,GLB1L,GLS2,GMPR,GP1BA,GPR126,GPR146,GTPBP5,GUCY1B3,HEMGN,HIST2H2BE,HMGA2,HOXB3,HSD17B11,HTR1F,IFITM3,IGKV4-1,IGSF10,IGSF9,IKZF2,IL12RB2,INHA,IP6K3,ITGA2B,JPH4,KAZALD1,KIAA0748,KLKB1,KSR1,LIMCH1,LOC100129361,LOC100131096,LOC100271722,LOC100507240,LOC283861,LOC284475,LOC388588,LOC441204,LOC646762,LOC728789,LOC729810,LOXL1,LPCAT2,LRP4,LRP6,LTBR,MALL,MAPRE3,MCL1,MECOM,MLLT3,MPL,MYCT1,NEAT1,NFATC2,NFIA,NFKBIZ,NMU,NOTCH4,NPR3,NRIP1,PAX5,PBX1,PDZD2,PEAR1,PKD2,PLOD2,PLSCR4,PLXDC2,PNMA1,PPFIBP1,PPP1R9A,PRKCH,PRKG2,PROS1,PRSS36,psiTPTE22,PTRF,RAB13,RAB27B,RAB37,RABGAP1,RBPMS,RHOB,RIN2,RNF150,ROBO4,RSAD2,RXRB,SAA3P,SAV1,SESN3,SIRT4,SKAP1,SLC2A10,SLC35D2,SLC8A3,SMARCA2,SNHG12,SNRK,SOCS2,SPRY4,SPTLC2,ST6GAL2,STARD9,STEAP1B,STON2,STX17,SYCP2,TAL1,TBC1D25,TCTEX1D1,TMEM140,TMEM64,TNRC18,TRIM39,TSPAN6,TTC7B,VPS8,WWTR1,ZNF282,ZNF385D,ZNF501,ZNF521,ZNF692,ZNF768,ZNF862 GENE_SYMBOLS ABCB1,ABLIM1,ACACB,ACOX2,ACRBP,ADAM8,ADAMTSL4,AKR1C2,ALDH1A1,ANGPT1,ARHGAP22,ARHGAP36,ARHGEF40,ARMCX1,BMAL2,ARSD,ATP7B,ATP9A,ATXN7L1,BACE2,BCORL1,BIRC3,CFAP46,FAM219B,C1QL1,C1RL,GCSAML,C1orf216,FAM210B,C21orf62-AS1,TEX33,SLC35F6,C3,TDRP,IDNK,PGAP4,CALN1,CAMLG,CCDC87,CD7,CDC14B,CFH,CHRM3,CNKSR1,CNST,COL5A1,CRHBP,CTDSPL,CCN2,DAPK1,DDN,SLC49A4,DNAH10,EEF2,EFNB2,EHD2,EHD3,ELOVL7,EPHB4,ERG,FAM117A,TAFA2,RIPOR3,FGD5,FITM2,FKBP9,FN3K,FOXO1,GALNS,GAS1,GATAD1,GBP4,GFI1B,GIPC2,GLB1L,GLS2,GMPR,GP1BA,ADGRG6,GPR146,MTG2,GUCY1B1,HEMGN,H2BC21,HMGA2,HOXB3,HSD17B11,HTR1F,IFITM3,IGKV4-1,IGSF10,IGSF9,IKZF2,IL12RB2,INHA,IP6K3,ITGA2B,JPH4,KAZALD1,TESPA1,KLKB1,KSR1,LIMCH1,SMIM10L1,TMC6,LINC00899,VWA8-AS1,,,SMIM1,LINC02981,,,,LOXL1,LPCAT2,LRP4,LRP6,LTBR,MALL,MAPRE3,MCL1,MECOM,MLLT3,MPL,MYCT1,NEAT1,NFATC2,NFIA,NFKBIZ,NMU,NOTCH4,NPR3,NRIP1,PAX5,PBX1,PDZD2,PEAR1,PKD2,PLOD2,PLSCR4,PLXDC2,PNMA1,PPFIBP1,PPP1R9A,PRKCH,PRKG2,PROS1,PRSS36,CAVIN1,RAB13,RAB27B,RAB37,RABGAP1,RBPMS,RHOB,RIN2,RNF150,ROBO4,RSAD2,RXRB,SAA3P,SAV1,SESN3,SIRT4,SKAP1,SLC2A10,SLC35D2,SLC8A3,SMARCA2,SNHG12,SNRK,SOCS2,SPRY4,SPTLC2,ST6GAL2,STARD9,STEAP1B,STON2,STX17,SYCP2,TAL1,TBC1D25,DYNLT5,TMEM140,TMEM64,TNRC18,TRIM39,TSPAN6,TTC7B,VPS8,WWTR1,ZNF282,ZNF385D,ZNF501,ZNF521,ZNF692,ZNF768,ZNF862,TPTEP1 FOUNDER_NAMES