STANDARD_NAME GSE9988_LOW_LPS_VS_CTRL_TREATED_MONOCYTE_UP SYSTEMATIC_NAME M5867 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE9988_LOW_LPS_VS_CTRL_TREATED_MONOCYTE_UP NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes up-regulated in comparison of monocytes treated with 1 ng/ml LPS (TLR4 agonist) versus monocytes treated with control IgG. DESCRIPTION_FULL TREM-1 is an orphan immunoreceptor expressed on monocytes, macrophages, and neutrophils. TREM-1 associates with and signals via the adapter protein DAP12/TYROBP, which contains an immunoreceptor tyrosine-based activation motif (ITAM). TREM-1 activation by receptor cross-linking is pro-inflammatory, and can amplify cellular responses to Toll-like receptor (TLR) ligands such as bacterial lipopolysaccharide (LPS). To investigate the cellular consequences of TREM-1 activation, we have characterized global gene expression changes in human monocytes in response to TREM-1 cross-linking in comparison to and combined with LPS. Both TREM-1 activation and LPS up-regulate chemokines, cytokines, matrix metalloproteases, and PTGS/COX2, consistent with a core inflammatory response. However, other immunomodulatory factors are selectively induced, including SPP1 and CSF1 (i.e., M-CSF) by TREM-1 activation and IL-23 and CSF3 (i.e., G-CSF) by LPS. Additionally, cross-talk between TREM-1 activation and LPS occurs on multiple levels. While synergy in GM-CSF protein production is reflected in commensurate mRNA abundance, comparable synergy in IL-1b protein production is not. TREM-1 activation also attenuates the induction of some LPS target genes, including those that encode IL-12 cytokine family subunits. Whereas positive TREM-1 outputs are abolished by the PI3K inhibitor wortmannin, this attenuation is largely PI3K-independent. These experiments provide a detailed analysis of the cellular consequences of TREM-1 activation, and highlight some of the complexity in signal integration between ITAM- and TLR-mediated signaling. PMID 18292579 GEOID GSE9988 AUTHORS Dower K,Ellis DK,Saraf K,Jelinsky SA,Lin LL CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE9988_2044_200_UP FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ACSL1,ADAMDEC1,ADM,ANO5,AQP9,AREG,ARHGEF2,ARL5B,B3GNT2,BCL2A1,BIRC3,BTG2,BTG3,C11orf96,C12orf61,C13orf15,C22orf45,C6orf105,C9orf30,CASP5,CCDC59,CCL18,CCL20,CCL4,CCR7,CCRL2,CCRN4L,CD274,CD83,CDK1,CFLAR,CLCF1,CSF3,CSRNP1,CXCL1,CXCL2,CXCL3,CXCL5,CYB5D1,DCUN1D3,DDIT4,DDX5,DENND4A,DENND5A,DKFZp686L14188,DNAAF1,DNAJB4,DUSP1,DUSP2,DUSP5,DYRK3,E2F7,EDN1,EGR1,EGR3,EIF1B,ELL2,EREG,ERRFI1,ETS2,F3,F8,FLJ35776,FOSL1,FRMD7,G0S2,GADD45A,GADD45B,GBP1,GBP2,GCH1,GK,GK3P,GPR84,GRAMD1A,HAS1,HECW2,HES1,HIVEP2,HNRNPC,ICAM1,ID2,IER3,IL10,IL18,IL1A,IL1B,IL20,IL23A,IL2RA,IL36G,IL6,IL8,INHBA,IRG1,JUN,KIAA0247,LMOD1,LOC100134229,LOC100289049,LOC100302650,LOC100506229,LOC285628,LOC338758,LOC401588,LOC440934,LOC731424,LOC91548,MAFF,MAP3K4,MAP3K8,MEIR5,MESDC1,MFSD2A,MGC11082,MIR155HG,MMP7,MSH6,MST4,NAF1,NBN,NCRNA00299,NEDD4L,NFE2L2,NFKB1,NFKBIA,NFKBIZ,NLRP3,NR4A1,NR4A2,NR4A3,NUPL1,NXT2,OTUD1,PDE4B,PDSS1,PELI1,PFKFB3,PHLDA2,PIGA,PIM3,PLA1A,PLAUR,PLD1,PLEK,PLEKHF2,PLK3,PPP1R15A,PPP1R15B,PSMD5,PTGER4,PTGS2,PTP4A1,PTS,PTX3,RAB21,RAPGEF2,RBBP8,REL,RGS1,RHCG,RHOH,RIPK2,RND1,RPGR,RYBP,SAV1,SCN1B,SDC4,SELK,SERPINB8,SFMBT2,SGPP2,SIAH2,SOCS3,SOD2,ST20,STARD4,STARD8,STAT5A,TAOK3,TFRC,TIFA,TMEM194A,TMEM88,TNF,TNFAIP3,TNFAIP6,TNIP3,TP53BP2,TPD52,TRIP10,TSC22D2,TWISTNB,TXN,UBE2D1,USP12,WTAP,YRDC,ZC3H12A GENE_SYMBOLS ACSL1,ADAMDEC1,ADM,ANO5,AQP9,AREG,ARHGEF2,ARL5B,B3GNT2,BCL2A1,BIRC3,BTG2,BTG3,C11orf96,LINC01465,RGCC,ADORA2A-AS1,ADTRP,MSANTD3,CASP5,CCDC59,CCL18,CCL20,CCL4,CCR7,CCRL2,NOCT,CD274,CD83,CDK1,CFLAR,CLCF1,CSF3,CSRNP1,CXCL1,CXCL2,CXCL3,CXCL5,CYB5D1,DCUN1D3,DDIT4,DDX5,DENND4A,DENND5A,,DNAAF1,DNAJB4,DUSP1,DUSP2,DUSP5,DYRK3,E2F7,EDN1,EGR1,EGR3,EIF1B,ELL2,EREG,ERRFI1,ETS2,F3,F8,DLGAP1-AS1,FOSL1,FRMD7,G0S2,GADD45A,GADD45B,GBP1,GBP2,GCH1,GK,GK3,GPR84,GRAMD1A,HAS1,HECW2,HES1,HIVEP2,HNRNPC,ICAM1,ID2,IER3,IL10,IL18,IL1A,IL1B,IL20,IL23A,IL2RA,IL36G,IL6,CXCL8,INHBA,ACOD1,JUN,SUSD6,LMOD1,KDM7A-DT,,,LINC01093,MIR3142HG,ATP2B1-AS1,ZNF674-AS1,CT75,MIR3945HG,NEK2-DT,MAFF,MAP3K4,MAP3K8,SFR1,TLNRD1,MFSD2A,DLGAP1-AS2,MIR155HG,MMP7,MSH6,STK26,NAF1,NBN,LINC00299,NEDD4L,NFE2L2,NFKB1,NFKBIA,NFKBIZ,NLRP3,NR4A1,NR4A2,NR4A3,NUP58,NXT2,OTUD1,PDE4B,PDSS1,PELI1,PFKFB3,PHLDA2,PIGA,PIM3,PLA1A,PLAUR,PLD1,PLEK,PLEKHF2,PLK3,PPP1R15A,PPP1R15B,PSMD5,PTGER4,PTGS2,PTP4A1,PTS,PTX3,RAB21,RAPGEF2,RBBP8,REL,RGS1,RHCG,RHOH,RIPK2,RND1,RPGR,RYBP,SAV1,SCN1B,SDC4,SELENOK,SERPINB8,SFMBT2,SGPP2,SIAH2,SOCS3,SOD2,ST20,STARD4,STARD8,STAT5A,TAOK3,TFRC,TIFA,NEMP1,TMEM88,TNF,TNFAIP3,TNFAIP6,TNIP3,TP53BP2,TPD52,TRIP10,TSC22D2,POLR1F,TXN,UBE2D1,USP12,WTAP,YRDC,ZC3H12A FOUNDER_NAMES