STANDARD_NAME GUO_HEX_TARGETS_UP SYSTEMATIC_NAME M1436 COLLECTION C2:CGP MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GUO_HEX_TARGETS_UP NAMESPACE MOUSE_SEQ_ACCESSION DESCRIPTION_BRIEF Genes up-regulated in day 6 embryoid bodies derived from embryonic stem cells (ES) with HEX [GeneID=3087] knockout. DESCRIPTION_FULL The first hematopoietic and endothelial progenitors are derived from a common embryonic precursor termed the hemangioblast. The genetic cascades that regulate the differentiation of the hemangioblast to hematopoietic and endothelial cells are largely unknown. In general, much of embryonic development is coordinately regulated by temporal and spatial expression of transcription factors, such as the Homeobox (Hox) gene family. We and others isolated a divergent homeobox gene termed Hex (or Prh) that is preferentially expressed in hematopoietic and endothelial cells. Using in vitro Hex-/- embryonic stem (ES) cell differentiation, in vivo yolk sac hematopoietic progenitor assays, and chimeric mouse analysis, we found that Hex is required for differentiation of the hemangioblast to definitive embryonic hematopoietic progenitors and to a lesser extent endothelial cells. Therefore, Hex is a novel regulator of hemangioblast differentiation to hematopoietic and endothelial cells. PMID 12791650 GEOID AUTHORS Guo Y,Chan R,Ramsey H,Li W,Xie X,Shelley WC,Martinez-Barbera JP,Bort B,Zaret K,Yoder M,Hromas R CONTRIBUTOR Kevin Vogelsang CONTRIBUTOR_ORG MSigDB Team EXACT_SOURCE Table 2 FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS AA189677,AA268823,AA600647,AA711516,AA733868,AA759910,AA795284,AA795486,AA981581,AB020886,AB024538,AF022432,AF039021,AF041472,AF056187,AF069953,AI042802,AI449034,AI503821,AI551087,AI642417,AI645050,AI838398,AI839004,AI843739,AI848050,AI848841,AI851048,AI852838,AI853712,AI854614,AJ001166,AJ002366,AJ002730,AJ243608,AV171460,AV276058,AV299153,AW046038,AW046101,AW048233,AW048581,AW061234,AW107922,AW121323,AW121328,AW121960,AW122897,AW123115,AW123697,AW125031,AW209098,AW212708,AW260482,C79248,C80249,D10011,D26046,D50086,D76440,D83966,L47480,M19380,M87802,M95200,M97590,S78454,U02098,U05252,U06944,U13837,U14941,U22325,U36778,U82122,U85614,U88567,U92437,U92885,X16672,X60136,X65138,X68363,X70764,X71978,X73230,X75285,X78989,X80171,X83569,X84037,X96639,Y15910 GENE_SYMBOLS LUC7L2,CD59,RRAGD,SRSF7,CD2BP2,ENY2,WDR26,AGFG1,,AKAP12,ISLR,,PCM1,ATXN2,IGF1R,GNG3,SLC6A6,REST,PCGF2,,,,CIC,ELOVL6,TBL1X,,,,,KLF7,SPG21,ABCD4,,KDM6A,MAGEL2,AKAP8,,DHX36,WWTR1,WWC2,ERF,ENPP5,LIFR,SOX11,URM1,TBX3,BPNT2,FZD4,RTN1,CD99,CMTM6,IQGAP1,ZNF322,NAA15,,,GRIK5,ZFHX3,NRP1,NDN,PTPN13,BMP4,CALM3,HOXD1,VEGFA,PTPN1,MTF2,PURA,SATB1,,ATP6V1A,EFNA2,FGD1,STIL,UBE3A,SMARCC1,SFRP2,PTEN,EFNA3,,SP1,EPHA4,POU2F1,MARK2,AKTIP,ARSA,FBLN2,TES,PGF,NNAT,GLG1,EXT1,DIAPH2 FOUNDER_NAMES