STANDARD_NAME GUTIERREZ_WALDENSTROEMS_MACROGLOBULINEMIA_2 SYSTEMATIC_NAME M17096 COLLECTION C2:CGP MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GUTIERREZ_WALDENSTROEMS_MACROGLOBULINEMIA_2 NAMESPACE AFFY_HG_U133 DESCRIPTION_BRIEF Genes exclusively up-regulated in B lymphocytes from WM (Waldenstroem's macroglobulinemia) but with a similar expression profile in MM (macroglobulinemia) and normal cells. DESCRIPTION_FULL The tumoral clone of Waldenström's macroglobulinemia (WM) shows a wide morphological heterogeneity, which ranges from B lymphocytes (BL) to plasma cells (PC). By means of genome-wide expression profiling we have been able to identify genes exclusively deregulated in BL and PC from WM, but with a similar expression pattern in their corresponding cell counterparts from chronic lymphocytic leukemia (CLL) and multiple myeloma (MM), as well as normal individuals. The differentially expressed genes have important functions in B-cell differentiation and oncogenesis. Thus, two of the genes downregulated in WM-BL were IL4R, which plays a relevant role in CLL B-cell survival, and BACH2, which participates in the development of class-switched PC. Interestingly, one of the upregulated genes in WM-BL was IL6. A set of four genes was able to discriminate clonal BL from WM and CLL: LEF1 (WNT/beta-catenin pathway), MARCKS, ATXN1 and FMOD. We also found deregulation of genes involved in plasma cell differentiation such as PAX5, which was overexpressed in WM-PC, and IRF4 and BLIMP1, which were underexpressed. In addition, three of the target genes activated by PAX5 - CD79, BLNK and SYK - were upregulated in WM-PC. In summary, these results indicate that both PC and BL from WM are genetically different from the MM and CLL cell counterpart. PMID 17252022 GEOID GSE6691 AUTHORS Gutiérrez NC,Ocio EM,de Las Rivas J,Maiso P,Delgado M,Fermiñán E,Arcos MJ,Sánchez ML,Hernández JM,San Miguel JF CONTRIBUTOR Arthur Liberzon CONTRIBUTOR_ORG MSigDB Team EXACT_SOURCE Table 4 FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS 200934_at,204798_at,205419_at,205624_at,206111_at,206207_at,207540_s_at,208306_x_at,210254_at,211991_s_at,214938_x_at,217148_x_at,217478_s_at GENE_SYMBOLS DEK,MYB,GPR183,CPA3,RNASE2,CLC,SYK,HLA-DRB1,MS4A3,HLA-DPA1,HMGB1,IGLV2-14,HLA-DMA FOUNDER_NAMES