STANDARD_NAME GU_PDEF_TARGETS_DN SYSTEMATIC_NAME M10480 COLLECTION C2:CGP MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GU_PDEF_TARGETS_DN NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Integrin, VEGF, Wnt and TGFbeta signaling pathway genes down-regulated in PC-3 cells (prostate cancer) after knockdown of PDEF [GeneID=25803] by RNAi. DESCRIPTION_FULL The epithelium-specific Ets transcription factor, PDEF, plays a role in prostate and breast cancer, although its precise function has not been established. In prostate cancer, PDEF is involved in regulating prostate-specific antigen expression via interaction with the androgen receptor and NKX3.1, and down-regulation of PDEF by antiproliferative agents has been associated with reduced PDEF expression. We now report that reduced expression of PDEF leads to a morphologic change, increased migration and invasiveness in prostate cancer cells, reminiscent of transforming growth factor beta (TGFbeta) function and epithelial-to-mesenchymal transition. Indeed, inhibition of PDEF expression triggers a transcriptional program of genes involved in the TGFbeta pathway, migration, invasion, adhesion, and epithelial dedifferentiation. Our results establish PDEF as a critical regulator of genes involved in cell motility, invasion, and adhesion of prostate cancer cells. PMID 17483333 GEOID GSE6576 AUTHORS Gu X,Zerbini LF,Otu HH,Bhasin M,Yang Q,Joseph MG,Grall F,Onatunde T,Correa RG,Libermann TA CONTRIBUTOR Jessica Robertson CONTRIBUTOR_ORG MSigDB Team EXACT_SOURCE Table 1S FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS CDH1,CDH20,CDH3,EIF1AX,EIF2B2,EIF3S8,FOXA1,FOXC1,FOXO1A,FOXO3A,FZD10,FZD5,INHBB,ITGB4,ITGB6,ITGB8,K6HF,KRT18,KRT19,KRT3,KRT6A,KRT6B,KRT6C,KRT6E,KRT7,KRT8,KRTAP9-5,KRTAP9-9,KRTHA3A,KRTHA4,NKX2-5,PARVA,PIK3CB,PIK3R3,PIK3R4,PIK4CB,PIP5K2C,SMURF1,TCF1,TGFB2,THBS1,VEGFC GENE_SYMBOLS CDH1,CDH20,CDH3,EIF1AX,EIF2B2,EIF3C,FOXA1,FOXC1,FOXO1,FOXO3,FZD10,FZD5,INHBB,ITGB4,ITGB6,ITGB8,KRT75,KRT18,KRT19,KRT3,KRT6A,KRT6B,KRT6C,KRT6C,KRT7,KRT8,KRTAP9-9,KRTAP9-9,KRT33A,KRT34,NKX2-5,PARVA,PIK3CB,PIK3R3,PIK3R4,PI4KB,PIP4K2C,SMURF1,HNF1A,TGFB2,THBS1,VEGFC FOUNDER_NAMES