STANDARD_NAME	HAHTOLA_MYCOSIS_FUNGOIDES_DN
SYSTEMATIC_NAME	M12073
COLLECTION	C2:CGP
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/HAHTOLA_MYCOSIS_FUNGOIDES_DN
NAMESPACE	AFFY_HG_U133
DESCRIPTION_BRIEF	Genes down-regulated in monocytes isolated from peripheral blood samples of patients with mucosis fungoides compared to those from normal healthy donors.
DESCRIPTION_FULL	PURPOSE: Increased production of Th2 cytokines characterizes Sezary syndrome, the leukemic form of cutaneous T-cell lymphomas (CTCL). To identify the molecular background and to study whether shared by the most common CTCL subtype, mycosis fungoides, we analyzed the gene expression profiles in both subtypes. EXPERIMENTAL DESIGN: Freshly isolated cells from 30 samples, representing skin, blood, and enriched CD4(+) cell populations of mycosis fungoides and Sezary syndrome, were analyzed with Affymetrix (Santa Clara, CA) oligonucleotide microarrays, quantitative PCR, or immunohistochemistry. The gene expression profiles were combined with findings of comparative genomic hybridization of the same samples to identify chromosomal changes affecting the aberrant gene expression. RESULTS: We identified a set of Th1-specific genes [e.g., TBX21 (T-bet), NKG7, and SCYA5 (RANTES)] to be down-regulated in Sezary syndrome as well as in a proportion of mycosis fungoides samples. In both Sezary syndrome and mycosis fungoides blood samples, the S100P and LIR9 gene expression was up-regulated. In lesional skin, IL7R and CD52 were up-regulated. Integration of comparative genomic hybridization and transcriptomic data identified chromosome arms 1q, 3p, 3q, 4q, 12q, 16p, and 16q as likely targets for new CTCL-associated gene aberrations. CONCLUSIONS: Our findings revealed several new genes involved in CTCL pathogenesis and potential therapeutic targets. Down-regulation of a set of genes involved in Th1 polarization, including the major Th1-polarizing factor, TBX21, was for the first time associated with CTCL. In addition, a plausible explanation for the proliferative response of CTCL cells to locally produced interleukin-7 was revealed.
PMID	16914566
GEOID	
AUTHORS	Hahtola S,Tuomela S,Elo L,Häkkinen T,Karenko L,Nedoszytko B,Heikkilä H,Saarialho-Kere U,Roszkiewicz J,Aittokallio T,Lahesmaa R,Ranki A
CONTRIBUTOR	Arthur Liberzon
CONTRIBUTOR_ORG	MSigDB Team
EXACT_SOURCE	Table 6S: M =< -1
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	200962_at,201369_s_at,204192_at,205039_s_at,205883_at,206099_at,206445_s_at,207840_at,208727_s_at,208852_s_at,209138_x_at,209616_s_at,211654_x_at,212592_at,212998_x_at,213746_s_at,215121_x_at,217022_s_at,221756_at
GENE_SYMBOLS	RPL31,ZFP36L2,CD37,IKZF1,ZBTB16,PRKCH,PRMT1,CD160,CDC42,CANX,IGLC2,CES1,HLA-DQB1,JCHAIN,HLA-DQB1,FLNA,IGLC2,IGHA1,PIK3IP1
FOUNDER_NAMES