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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="HALLMARK_APICAL_SURFACE" SYSTEMATIC_NAME="M5916" HISTORICAL_NAMES="" PMID="26771021" AUTHORS="Liberzon A,Birger C,Thorvaldsdóttir H,Ghandi M,Mesirov JP,Tamayo P" GEOID="" EXACT_SOURCE="" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="" CHIP="HUMAN_GENE_SYMBOL" CONTRIBUTOR="Arthur Liberzon" CONTRIBUTOR_ORG="MSigDB Team" DESCRIPTION_BRIEF="Genes encoding proteins over-represented on the apical surface of epithelial cells, e.g., important for cell polarity (apical area)." DESCRIPTION_FULL="" TAGS="" MEMBERS="ADAM10,ADIPOR2,AFAP1L2,AIM1,AKAP7,APP,ATP6V0A4,ATP8B1,B4GALT1,BRCA1,CD160,CROCC,CX3CL1,DCBLD2,EFNA5,EPHB4,FLOT2,GAS1,GATA3,GHRL,GSTM3,HSPB1,IL2RB,IL2RG,LYN,LYPD3,MAL,MDGA1,NCOA6,NTNG1,PCSK9,PKHD1,PLAUR,RHCG,RTN4RL1,SCUBE1,SHROOM2,SLC22A12,SLC2A4,SLC34A3,SRPX,SULF2,THY1,TMEM8B" MEMBERS_SYMBOLIZED="ADAM10,ADIPOR2,AFAP1L2,AKAP7,APP,ATP6V0A4,ATP8B1,B4GALT1,BRCA1,CD160,CROCC,CRYBG1,CX3CL1,DCBLD2,EFNA5,EPHB4,FLOT2,GAS1,GATA3,GHRL,GSTM3,HSPB1,IL2RB,IL2RG,LYN,LYPD3,MAL,MDGA1,NCOA6,NTNG1,PCSK9,PKHD1,PLAUR,RHCG,RTN4RL1,SCUBE1,SHROOM2,SLC22A12,SLC2A4,SLC34A3,SRPX,SULF2,THY1,TMEM8B" MEMBERS_EZID="102,11126,116085,131566,142680,146760,1946,202,2050,22854,23054,2319,255738,2619,2625,266727,2683,27076,2947,3315,351,3560,3561,357,4067,4118,50617,51458,51738,51754,5205,5314,5329,55959,6376,6517,672,7070,79602,80274,8406,84632,9465,9696" MEMBERS_MAPPING="ADAM10,ADAM10,102|ADIPOR2,ADIPOR2,79602|AFAP1L2,AFAP1L2,84632|AIM1,CRYBG1,202|AKAP7,AKAP7,9465|APP,APP,351|ATP6V0A4,ATP6V0A4,50617|ATP8B1,ATP8B1,5205|B4GALT1,B4GALT1,2683|BRCA1,BRCA1,672|CD160,CD160,11126|CROCC,CROCC,9696|CX3CL1,CX3CL1,6376|DCBLD2,DCBLD2,131566|EFNA5,EFNA5,1946|EPHB4,EPHB4,2050|FLOT2,FLOT2,2319|GAS1,GAS1,2619|GATA3,GATA3,2625|GHRL,GHRL,51738|GSTM3,GSTM3,2947|HSPB1,HSPB1,3315|IL2RB,IL2RB,3560|IL2RG,IL2RG,3561|LYN,LYN,4067|LYPD3,LYPD3,27076|MAL,MAL,4118|MDGA1,MDGA1,266727|NCOA6,NCOA6,23054|NTNG1,NTNG1,22854|PCSK9,PCSK9,255738|PKHD1,PKHD1,5314|PLAUR,PLAUR,5329|RHCG,RHCG,51458|RTN4RL1,RTN4RL1,146760|SCUBE1,SCUBE1,80274|SHROOM2,SHROOM2,357|SLC22A12,SLC22A12,116085|SLC2A4,SLC2A4,6517|SLC34A3,SLC34A3,142680|SRPX,SRPX,8406|SULF2,SULF2,55959|THY1,THY1,7070|TMEM8B,TMEM8B,51754" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="GOCC_CELL_SURFACE;M11182|GOMF_KINASE_ACTIVATOR_ACTIVITY;M12088|GOCC_ANCHORED_COMPONENT_OF_MEMBRANE;M1242|GOBP_RESPONSE_TO_STEROID_HORMONE;M13901|GOBP_RESPONSE_TO_HORMONE;M13987|GOCC_APICAL_PLASMA_MEMBRANE;M1446|GOCC_APICAL_PART_OF_CELL;M17164|GOCC_BRUSH_BORDER;M19093|GOCC_EXTERNAL_SIDE_OF_PLASMA_MEMBRANE;M2251|CELL_PROJECTION_PART;M3065|GOCC_ANCHORED_COMPONENT_OF_PLASMA_MEMBRANE;M6036|chr6q;M6155" REFINEMENT_DATASETS="GSE19299,RB WT vs KO MC3T3 (osteoblasts)|GSE32217,EGF vs vehicle 100% confluence normal epidermal keratinocytes|GSE38628,CaCl2 12-48h vs 0-3h normal epidermal keratinocytes|GSE5264,mucociliary differentiation time course days 0-4 vs days 14-28 bronchial epithelial cells" VALIDATION_DATASETS="GSE15768,GRHL3 WT vs KO E18.5 bladder|GSE20257,non-smokers vs smokers with COPD airway epithelium" CATEGORY_CODE="H" ORGANISM="Homo sapiens" SUB_CATEGORY_CODE=""/>
</MSIGDB>
