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<!-- Copyright (c) 2004-2026 Broad Institute, Inc., Massachusetts Institute of Technology, and Regents of the University of California.  All rights reserved.
     See license terms at www.gsea-msigdb.org/gsea/license_terms_list. Please note that certain gene sets have special access terms.
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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="HALLMARK_G2M_CHECKPOINT" SYSTEMATIC_NAME="M5901" HISTORICAL_NAMES="" PMID="26771021" AUTHORS="Liberzon A,Birger C,Thorvaldsdóttir H,Ghandi M,Mesirov JP,Tamayo P" GEOID="" EXACT_SOURCE="" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="" CHIP="HUMAN_GENE_SYMBOL" CONTRIBUTOR="Arthur Liberzon" CONTRIBUTOR_ORG="MSigDB Team" DESCRIPTION_BRIEF="Genes involved in the G2/M checkpoint, as in progression through the cell division cycle." DESCRIPTION_FULL="" TAGS="" MEMBERS="ABL1,AMD1,ARID4A,ATF5,ATRX,AURKA,AURKB,BARD1,BCL3,BIRC5,BRCA2,BUB1,BUB3,CASC5,CASP8AP2,CBX1,CCNA2,CCNB2,CCND1,CCNF,CCNT1,CDC20,CDC25A,CDC25B,CDC27,CDC45,CDC6,CDC7,CDK1,CDK4,CDKN1B,CDKN2C,CDKN3,CENPA,CENPE,CENPF,CHAF1A,CHEK1,CHMP1A,CKS1B,CKS2,CTCF,CUL1,CUL3,CUL4A,CUL5,DBF4,DDX39A,DKC1,DMD,DR1,DTYMK,E2F1,E2F2,E2F3,E2F4,EFNA5,EGF,ESPL1,EWSR1,EXO1,EZH2,FANCC,FBXO5,FOXN3,G3BP1,GINS2,GSPT1,H2AFV,H2AFX,H2AFZ,HIF1A,HIRA,HIST1H2BK,HMGA1,HMGB3,HMGN2,HMMR,HN1,HNRNPD,HNRNPU,HOXC10,HSPA8,HUS1,ILF3,INCENP,KATNA1,KIF11,KIF15,KIF20B,KIF22,KIF23,KIF2C,KIF4A,KIF5B,KPNA2,KPNB1,LBR,LIG3,LMNB1,MAD2L1,MAPK14,MARCKS,MCM2,MCM3,MCM5,MCM6,MEIS1,MEIS2,MKI67,MNAT1,MT2A,MTF2,MYBL2,MYC,NASP,NCL,NDC80,NEK2,NOLC1,NOTCH2,NUMA1,NUP50,NUP98,NUSAP1,ODC1,ODF2,ORC5,ORC6,PAFAH1B1,PAPD7,PBK,PDS5B,PLK1,PLK4,PML,POLA2,POLE,POLQ,PRC1,PRIM2,PRMT5,PRPF4B,PTTG1,PTTG3P,PURA,RACGAP1,RAD21,RAD23B,RAD54L,RASAL2,RBL1,RBM14,RPA2,RPS6KA5,SAP30,SETD8,SFPQ,SLC12A2,SLC38A1,SLC7A1,SLC7A5,SMAD3,SMARCC1,SMC1A,SMC2,SMC4,SNRPD1,SQLE,SRSF1,SRSF10,SRSF2,SS18,STAG1,STIL,STMN1,SUV39H1,SYNCRIP,TACC3,TFDP1,TGFB1,TLE3,TMPO,TNPO2,TOP1,TOP2A,TPX2,TRA2B,TRAIP,TROAP,TTK,UBE2C,UBE2S,UCK2,UPF1,WHSC1,WRN,XPO1,YTHDC1,ZAK" MEMBERS_SYMBOLIZED="ABL1,AMD1,ARID4A,ATF5,ATRX,AURKA,AURKB,BARD1,BCL3,BIRC5,BRCA2,BUB1,BUB3,CASP8AP2,CBX1,CCNA2,CCNB2,CCND1,CCNF,CCNT1,CDC20,CDC25A,CDC25B,CDC27,CDC45,CDC6,CDC7,CDK1,CDK4,CDKN1B,CDKN2C,CDKN3,CENPA,CENPE,CENPF,CHAF1A,CHEK1,CHMP1A,CKS1B,CKS2,CTCF,CUL1,CUL3,CUL4A,CUL5,DBF4,DDX39A,DKC1,DMD,DR1,DTYMK,E2F1,E2F2,E2F3,E2F4,EFNA5,EGF,ESPL1,EWSR1,EXO1,EZH2,FANCC,FBXO5,FOXN3,G3BP1,GINS2,GSPT1,H2AX,H2AZ1,H2AZ2,H2BC12,HIF1A,HIRA,HMGA1,HMGB3,HMGN2,HMMR,HNRNPD,HNRNPU,HOXC10,HSPA8,HUS1,ILF3,INCENP,JPT1,KATNA1,KIF11,KIF15,KIF20B,KIF22,KIF23,KIF2C,KIF4A,KIF5B,KMT5A,KNL1,KPNA2,KPNB1,LBR,LIG3,LMNB1,MAD2L1,MAP3K20,MAPK14,MARCKS,MCM2,MCM3,MCM5,MCM6,MEIS1,MEIS2,MKI67,MNAT1,MT2A,MTF2,MYBL2,MYC,NASP,NCL,NDC80,NEK2,NOLC1,NOTCH2,NSD2,NUMA1,NUP50,NUP98,NUSAP1,ODC1,ODF2,ORC5,ORC6,PAFAH1B1,PBK,PDS5B,PLK1,PLK4,PML,POLA2,POLE,POLQ,PRC1,PRIM2,PRMT5,PRP4K,PTTG1,PTTG3P,PURA,RACGAP1,RAD21,RAD23B,RAD54L,RASAL2,RBL1,RBM14,RPA2,RPS6KA5,SAP30,SFPQ,SLC12A2,SLC38A1,SLC7A1,SLC7A5,SMAD3,SMARCC1,SMC1A,SMC2,SMC4,SNRPD1,SQLE,SRSF1,SRSF10,SRSF2,SS18,STAG1,STIL,STMN1,SUV39H1,SYNCRIP,TACC3,TENT4A,TFDP1,TGFB1,TLE3,TMPO,TNPO2,TOP1,TOP2A,TPX2,TRA2B,TRAIP,TROAP,TTK,UBE2C,UBE2S,UCK2,UPF1,WRN,XPO1,YTHDC1" MEMBERS_EZID="10024,10036,10051,10146,1019,10212,1027,10274,10293,1031,1033,10403,10419,10432,10460,10492,1058,10592,1062,1063,10664,10721,10733,10762,10772,10926,10951,11004,11044,11065,11104,1111,1112,1163,1164,1432,1736,1756,1810,1841,1869,1870,1871,1874,1946,1950,2130,2146,2176,22809,22823,22974,23047,23594,23649,24137,25,262,26255,26271,27338,29127,2935,30000,3014,3015,3091,3149,3151,3159,3161,3184,3192,3226,3312,332,3364,3609,3619,3799,3832,3835,3837,3838,387893,3925,3930,3980,4001,4082,4085,4088,4171,4172,4174,4175,4211,4212,4288,4331,4502,4605,4609,4678,4691,4751,4853,4926,4928,4953,4957,5001,5048,51155,5119,51203,51659,51776,5347,5371,5426,546,5558,55872,56992,57082,580,5813,5885,5887,5926,5933,595,5976,602,6118,6421,6426,6427,6434,6491,6541,6558,6599,6632,6713,675,6760,6790,6839,699,7027,7040,7090,7112,7150,7153,7272,7290,7371,7468,7486,7514,8065,8140,81539,8243,8317,8318,8438,8451,8452,8454,85236,8819,8899,890,899,904,9055,9133,9156,91746,9184,9212,9221,9232,9252,94239,9462,9493,9585,9700,983,990,991,993,994,996,9994" MEMBERS_MAPPING="ABL1,ABL1,25|AMD1,AMD1,262|ARID4A,ARID4A,5926|ATF5,ATF5,22809|ATRX,ATRX,546|AURKA,AURKA,6790|AURKB,AURKB,9212|BARD1,BARD1,580|BCL3,BCL3,602|BIRC5,BIRC5,332|BRCA2,BRCA2,675|BUB1,BUB1,699|BUB3,BUB3,9184|CASC5,KNL1,57082|CASP8AP2,CASP8AP2,9994|CBX1,CBX1,10951|CCNA2,CCNA2,890|CCNB2,CCNB2,9133|CCND1,CCND1,595|CCNF,CCNF,899|CCNT1,CCNT1,904|CDC20,CDC20,991|CDC25A,CDC25A,993|CDC25B,CDC25B,994|CDC27,CDC27,996|CDC45,CDC45,8318|CDC6,CDC6,990|CDC7,CDC7,8317|CDK1,CDK1,983|CDK4,CDK4,1019|CDKN1B,CDKN1B,1027|CDKN2C,CDKN2C,1031|CDKN3,CDKN3,1033|CENPA,CENPA,1058|CENPE,CENPE,1062|CENPF,CENPF,1063|CHAF1A,CHAF1A,10036|CHEK1,CHEK1,1111|CHMP1A,CHMP1A,5119|CKS1B,CKS1B,1163|CKS2,CKS2,1164|CTCF,CTCF,10664|CUL1,CUL1,8454|CUL3,CUL3,8452|CUL4A,CUL4A,8451|CUL5,CUL5,8065|DBF4,DBF4,10926|DDX39A,DDX39A,10212|DKC1,DKC1,1736|DMD,DMD,1756|DR1,DR1,1810|DTYMK,DTYMK,1841|E2F1,E2F1,1869|E2F2,E2F2,1870|E2F3,E2F3,1871|E2F4,E2F4,1874|EFNA5,EFNA5,1946|EGF,EGF,1950|ESPL1,ESPL1,9700|EWSR1,EWSR1,2130|EXO1,EXO1,9156|EZH2,EZH2,2146|FANCC,FANCC,2176|FBXO5,FBXO5,26271|FOXN3,FOXN3,1112|G3BP1,G3BP1,10146|GINS2,GINS2,51659|GSPT1,GSPT1,2935|H2AFV,H2AZ2,94239|H2AFX,H2AX,3014|H2AFZ,H2AZ1,3015|HIF1A,HIF1A,3091|HIRA,HIRA,7290|HIST1H2BK,H2BC12,85236|HMGA1,HMGA1,3159|HMGB3,HMGB3,3149|HMGN2,HMGN2,3151|HMMR,HMMR,3161|HN1,JPT1,51155|HNRNPD,HNRNPD,3184|HNRNPU,HNRNPU,3192|HOXC10,HOXC10,3226|HSPA8,HSPA8,3312|HUS1,HUS1,3364|ILF3,ILF3,3609|INCENP,INCENP,3619|KATNA1,KATNA1,11104|KIF11,KIF11,3832|KIF15,KIF15,56992|KIF20B,KIF20B,9585|KIF22,KIF22,3835|KIF23,KIF23,9493|KIF2C,KIF2C,11004|KIF4A,KIF4A,24137|KIF5B,KIF5B,3799|KPNA2,KPNA2,3838|KPNB1,KPNB1,3837|LBR,LBR,3930|LIG3,LIG3,3980|LMNB1,LMNB1,4001|MAD2L1,MAD2L1,4085|MAPK14,MAPK14,1432|MARCKS,MARCKS,4082|MCM2,MCM2,4171|MCM3,MCM3,4172|MCM5,MCM5,4174|MCM6,MCM6,4175|MEIS1,MEIS1,4211|MEIS2,MEIS2,4212|MKI67,MKI67,4288|MNAT1,MNAT1,4331|MT2A,MT2A,4502|MTF2,MTF2,22823|MYBL2,MYBL2,4605|MYC,MYC,4609|NASP,NASP,4678|NCL,NCL,4691|NDC80,NDC80,10403|NEK2,NEK2,4751|NOLC1,NOLC1,9221|NOTCH2,NOTCH2,4853|NUMA1,NUMA1,4926|NUP50,NUP50,10762|NUP98,NUP98,4928|NUSAP1,NUSAP1,51203|ODC1,ODC1,4953|ODF2,ODF2,4957|ORC5,ORC5,5001|ORC6,ORC6,23594|PAFAH1B1,PAFAH1B1,5048|PAPD7,TENT4A,11044|PBK,PBK,55872|PDS5B,PDS5B,23047|PLK1,PLK1,5347|PLK4,PLK4,10733|PML,PML,5371|POLA2,POLA2,23649|POLE,POLE,5426|POLQ,POLQ,10721|PRC1,PRC1,9055|PRIM2,PRIM2,5558|PRMT5,PRMT5,10419|PRPF4B,PRP4K,8899|PTTG1,PTTG1,9232|PTTG3P,PTTG3P,26255|PURA,PURA,5813|RACGAP1,RACGAP1,29127|RAD21,RAD21,5885|RAD23B,RAD23B,5887|RAD54L,RAD54L,8438|RASAL2,RASAL2,9462|RBL1,RBL1,5933|RBM14,RBM14,10432|RPA2,RPA2,6118|RPS6KA5,RPS6KA5,9252|SAP30,SAP30,8819|SETD8,KMT5A,387893|SFPQ,SFPQ,6421|SLC12A2,SLC12A2,6558|SLC38A1,SLC38A1,81539|SLC7A1,SLC7A1,6541|SLC7A5,SLC7A5,8140|SMAD3,SMAD3,4088|SMARCC1,SMARCC1,6599|SMC1A,SMC1A,8243|SMC2,SMC2,10592|SMC4,SMC4,10051|SNRPD1,SNRPD1,6632|SQLE,SQLE,6713|SRSF1,SRSF1,6426|SRSF10,SRSF10,10772|SRSF2,SRSF2,6427|SS18,SS18,6760|STAG1,STAG1,10274|STIL,STIL,6491|STMN1,STMN1,3925|SUV39H1,SUV39H1,6839|SYNCRIP,SYNCRIP,10492|TACC3,TACC3,10460|TFDP1,TFDP1,7027|TGFB1,TGFB1,7040|TLE3,TLE3,7090|TMPO,TMPO,7112|TNPO2,TNPO2,30000|TOP1,TOP1,7150|TOP2A,TOP2A,7153|TPX2,TPX2,22974|TRA2B,TRA2B,6434|TRAIP,TRAIP,10293|TROAP,TROAP,10024|TTK,TTK,7272|UBE2C,UBE2C,11065|UBE2S,UBE2S,27338|UCK2,UCK2,7371|UPF1,UPF1,5976|WHSC1,NSD2,7468|WRN,WRN,7486|XPO1,XPO1,7514|YTHDC1,YTHDC1,91746|ZAK,MAP3K20,51776" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="PID_FANCONI_PATHWAY;M1|GNF2_CKS1B;M10065|E2F_Q4;M10115|KALMA_E2F1_TARGETS;M10142|REACTOME_INHIBITION_OF_REPLICATION_INITIATION_OF_DAMAGED_DNA_BY_RB1_E2F1;M1015|SA_G2_AND_M_PHASES;M10154|WU_APOPTOSIS_BY_CDKN1A_VIA_TP53;M10169|E2F_Q4_01;M102|HORIUCHI_WTAP_TARGETS_DN;M10279|GOMF_ENDONUCLEASE_ACTIVITY;M10284|GOMF_RNA_NUCLEASE_ACTIVITY;M10307|MODULE_451;M10327|KANG_DOXORUBICIN_RESISTANCE_UP;M1037|REACTOME_G1_S_SPECIFIC_TRANSCRIPTION;M1040|GNF2_CENPF;M10439|SEMBA_FHIT_TARGETS_DN;M10504|E2F4DP1_01;M10526|MEIOTIC_RECOMBINATION;M10539|BIOCARTA_ATM_PATHWAY;M10628|PAL_PRMT5_TARGETS_UP;M10688|GOMF_NUCLEASE_ACTIVITY;M10734|CROONQUIST_NRAS_SIGNALING_DN;M10739|INTERPHASE_OF_MITOTIC_CELL_CYCLE;M10740|LI_WILMS_TUMOR;M10773|REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT;M1080|M_PHASE_OF_MITOTIC_CELL_CYCLE;M10824|OHASHI_AURKB_TARGETS;M10867|AMUNDSON_GENOTOXIC_SIGNATURE;M10949|BIOCARTA_SRCRPTP_PATHWAY;M10994|GEORGES_CELL_CYCLE_MIR192_TARGETS;M11038|RIZ_ERYTHROID_DIFFERENTIATION_CCNE1;M11048|REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS;M11153|GNF2_H2AFX;M112|JOHANSSON_GLIOMAGENESIS_BY_PDGFB_UP;M1120|FRASOR_RESPONSE_TO_SERM_OR_FULVESTRANT_DN;M11250|MITSIADES_RESPONSE_TO_APLIDIN_DN;M11318|MODULE_308;M11526|XU_HGF_SIGNALING_NOT_VIA_AKT1_48HR_DN;M11536|CHANG_CYCLING_GENES;M11537|KAUFFMANN_DNA_REPAIR_GENES;M11563|KONG_E2F3_TARGETS;M1157|CROSBY_E2F4_TARGETS;M1158|GNF2_RRM2;M11613|MONTERO_THYROID_CANCER_POOR_SURVIVAL_UP;M11629|BAKER_HEMATOPOIESIS_STAT3_TARGETS;M1163|GOBP_CHROMOSOME_CONDENSATION;M11637|BAKER_HEMATOPOESIS_STAT5_TARGETS;M1165|KEGG_HOMOLOGOUS_RECOMBINATION;M11675|IWANAGA_E2F1_TARGETS_NOT_INDUCED_BY_SERUM;M1175|G1_S_TRANSITION_OF_MITOTIC_CELL_CYCLE;M1178|GNF2_RRM1;M11786|OHASHI_AURKA_TARGETS;M1180|SHEPARD_BMYB_MORPHOLINO_DN;M11840|HERNANDEZ_MITOTIC_ARREST_BY_DOCETAXEL_1_DN;M1187|GOLDRATH_ANTIGEN_RESPONSE;M11884|LI_WILMS_TUMOR_ANAPLASTIC_UP;M1215|GOCC_NUCLEAR_REPLICATION_FORK;M12171|G1_PHASE;M12184|GOBP_RNA_CATABOLIC_PROCESS;M12276|MUELLER_PLURINET;M123|OXFORD_RALA_OR_RALB_TARGETS_UP;M1235|REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND;M12363|E2F1DP1_01;M12402|M_PHASE;M12426|LI_WILMS_TUMOR_VS_FETAL_KIDNEY_2_UP;M1245|LY_AGING_MIDDLE_DN;M12457|YU_MYC_TARGETS_UP;M1249|E2F_Q3;M12497|GNF2_HMMR;M12521|E2F1DP2_01;M12555|GOMF_RNA_ENDONUCLEASE_ACTIVITY;M12611|MOLENAAR_TARGETS_OF_CCND1_AND_CDK4_DN;M12661|LE_EGR2_TARGETS_UP;M12804|GOBP_NEGATIVE_REGULATION_OF_CELL_CYCLE;M12829|GNF2_SMC4L1;M12856|GOMF_DNA_POLYMERASE_ACTIVITY;M12881|PID_PLK1_PATHWAY;M129|CHUANG_OXIDATIVE_STRESS_RESPONSE_DN;M12948|MATHEW_FANCONI_ANEMIA_GENES;M12972|GLINSKY_CANCER_DEATH_UP;M13007|BIOCARTA_PTC1_PATHWAY;M13022|GROSS_HYPOXIA_VIA_ELK3_UP;M1303|SMID_BREAST_CANCER_LUMINAL_A_DN;M13072|GROSS_HYPOXIA_VIA_HIF1A_UP;M1308|LI_WILMS_TUMOR_VS_FETAL_KIDNEY_1_DN;M13108|GROSS_HYPOXIA_VIA_ELK3_ONLY_DN;M1316|GOBP_REGULATION_OF_CELL_CYCLE;M13170|GROSS_HYPOXIA_VIA_ELK3_AND_HIF1A_DN;M1318|FOURNIER_ACINAR_DEVELOPMENT_LATE_DN;M13202|GNF2_RFC3;M13406|GOBP_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE;M13458|KEGG_MISMATCH_REPAIR;M13515|GNF2_CDC2;M13566|GOBP_DNA_DAMAGE_RESPONSE;M13636|JEON_SMAD6_TARGETS_DN;M13678|PYEON_CANCER_HEAD_AND_NECK_VS_CERVICAL_UP;M13736|MODULE_123;M13751|BOYAULT_LIVER_CANCER_SUBCLASS_G123_UP;M13831|GARCIA_TARGETS_OF_FLI1_AND_DAX1_DN;M13844|MORI_PRE_BI_LYMPHOCYTE_UP;M1395|GOBP_MITOTIC_CELL_CYCLE;M1396|PID_AURORA_B_PATHWAY;M14|BENPORATH_ES_CORE_NINE_CORRELATED;M14079|SLEBOS_HEAD_AND_NECK_CANCER_WITH_HPV_UP;M14132|PEART_HDAC_PROLIFERATION_CLUSTER_DN;M1421|GOBP_CELL_CYCLE_ARREST;M14297|GNF2_FEN1;M14325|FUJII_YBX1_TARGETS_DN;M14340|NEMETH_INFLAMMATORY_RESPONSE_LPS_DN;M1452|PETROVA_ENDOTHELIUM_LYMPHATIC_VS_BLOOD_UP;M1461|VANTVEER_BREAST_CANCER_POOR_PROGNOSIS;M14693|AFFAR_YY1_TARGETS_DN;M1471|REACTOME_RESOLUTION_OF_AP_SITES_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY;M14735|AMUNDSON_GAMMA_RADIATION_RESPONSE;M14767|REACTOME_EXTENSION_OF_TELOMERES;M14804|GOBP_SIGNAL_TRANSDUCTION_IN_RESPONSE_TO_DNA_DAMAGE;M14832|MODULE_98;M14843|E2F1_Q3;M1485|KAMMINGA_EZH2_TARGETS;M1486|BIOCARTA_P53_PATHWAY;M14863|GOBP_CELL_CYCLE_CHECKPOINT_SIGNALING;M14894|GREENBAUM_E2A_TARGETS_UP;M1490|LY_AGING_PREMATURE_DN;M1491|REACTOME_ABASIC_SUGAR_PHOSPHATE_REMOVAL_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY;M1494|PETROVA_PROX1_TARGETS_UP;M1495|BASAKI_YBX1_TARGETS_UP;M14985|REACTOME_FANCONI_ANEMIA_PATHWAY;M14990|MODULE_360;M15029|ZAMORA_NOS2_TARGETS_UP;M1507|SASAKI_ADULT_T_CELL_LEUKEMIA;M15171|SA_G1_AND_S_PHASES;M1529|PUJANA_BRCA_CENTERED_NETWORK;M15305|PUJANA_BREAST_CANCER_LIT_INT_NETWORK;M15356|MODULE_125;M15402|GOCC_CHROMOSOME;M15462|MODULE_397;M15502|NUNODA_RESPONSE_TO_DASATINIB_IMATINIB_UP;M15510|GOMF_EXONUCLEASE_ACTIVITY;M15530|REACTOME_DOUBLE_STRAND_BREAK_REPAIR;M15652|ROSTY_CERVICAL_CANCER_PROLIFERATION_CLUSTER;M15664|E2F_Q6_01;M15729|GNF2_CCNB2;M15766|BURTON_ADIPOGENESIS_3;M1577|BIDUS_METASTASIS_UP;M15866|BURTON_ADIPOGENESIS_PEAK_AT_24HR;M1591|VERNELL_RETINOBLASTOMA_PATHWAY_UP;M15969|SHEPARD_BMYB_TARGETS;M15973|KOBAYASHI_EGFR_SIGNALING_24HR_DN;M16010|CONCANNON_APOPTOSIS_BY_EPOXOMICIN_DN;M16108|GOBP_DNA_REPLICATION;M16148|MODULE_124;M16174|BERENJENO_TRANSFORMED_BY_RHOA_UP;M16189|GOMF_DNA_ENDONUCLEASE_ACTIVITY;M16353|GOBP_DNA_INTEGRITY_CHECKPOINT_SIGNALING;M16357|SIMBULAN_PARP1_TARGETS_DN;M1642|RIZ_ERYTHROID_DIFFERENTIATION;M16458|MANN_RESPONSE_TO_AMIFOSTINE_DN;M16463|HU_GENOTOXIC_DAMAGE_4HR;M1648|GOMF_SINGLE_STRANDED_DNA_BINDING;M16628|INDUCTION_OF_APOPTOSIS_BY_INTRACELLULAR_SIGNALS;M16635|BURTON_ADIPOGENESIS_PEAK_AT_16HR;M1681|KEGG_DNA_REPLICATION;M16853|RICKMAN_TUMOR_DIFFERENTIATED_MODERATELY_VS_POORLY_DN;M17006|GOBP_MEIOTIC_CELL_CYCLE;M17093|GOMF_CHROMATIN_BINDING;M17106|E2F_Q3_01;M17117|GNF2_CDC20;M17151|CHIARETTI_T_ALL_RELAPSE_PROGNOSIS;M17204|GNF2_PCNA;M17279|GOBP_NEGATIVE_REGULATION_OF_DNA_REPLICATION;M17293|FARMER_BREAST_CANCER_CLUSTER_2;M17333|GAVIN_FOXP3_TARGETS_CLUSTER_P6;M1735|MARSON_BOUND_BY_E2F4_UNSTIMULATED;M1744|GNF2_MCM4;M17594|PID_FOXM1_PATHWAY;M176|MODULE_198;M17658|GOBP_POSITIVE_REGULATION_OF_CELL_CYCLE;M17705|E2F1_Q3_01;M17736|BIOCARTA_CELLCYCLE_PATHWAY;M17770|GOBP_CELL_CYCLE_PROCESS;M17773|LINDGREN_BLADDER_CANCER_CLUSTER_1_DN;M17788|GOBP_DNA_METABOLIC_PROCESS;M17815|E2F_02;M17867|ZERBINI_RESPONSE_TO_SULINDAC_DN;M17956|ZHENG_GLIOBLASTOMA_PLASTICITY_UP;M1796|BIOCARTA_P27_PATHWAY;M17977|WILCOX_RESPONSE_TO_PROGESTERONE_UP;M18058|THUM_MIR21_TARGETS_HEART_DISEASE_DN;M18073|GOBP_DNA_TEMPLATED_DNA_REPLICATION;M18074|BIOCARTA_RB_PATHWAY;M18159|MATZUK_MEIOTIC_AND_DNA_REPAIR;M1819|GOBP_DNA_REPAIR;M18229|MODULE_320;M18242|MATZUK_SPERMATOCYTE;M1831|S_PHASE;M18369|BOYAULT_LIVER_CANCER_SUBCLASS_G3_UP;M18436|RAY_TUMORIGENESIS_BY_ERBB2_CDC25A_UP;M1844|GOBP_DNA_RECOMBINATION;M18489|CROONQUIST_IL6_DEPRIVATION_DN;M18506|GOMF_3_5_EXONUCLEASE_ACTIVITY;M18526|BHATI_G2M_ARREST_BY_2METHOXYESTRADIOL_UP;M18550|MANALO_HYPOXIA_DN;M18562|GOCC_NUCLEAR_CHROMOSOME;M18650|GOCC_CONDENSED_NUCLEAR_CHROMOSOME;M18735|LY_AGING_OLD_DN;M18789|PIONTEK_PKD1_TARGETS_DN;M1880|PUJANA_XPRSS_INT_NETWORK;M18811|VECCHI_GASTRIC_CANCER_EARLY_UP;M18855|XU_HGF_TARGETS_INDUCED_BY_AKT1_48HR_DN;M18912|MORI_IMMATURE_B_LYMPHOCYTE_DN;M18917|GRAHAM_CML_QUIESCENT_VS_NORMAL_QUIESCENT_UP;M18983|STEIN_ESRRA_TARGETS_RESPONSIVE_TO_ESTROGEN_DN;M19002|GOBP_REGULATION_OF_MITOTIC_CELL_CYCLE;M19030|RUIZ_TNC_TARGETS_DN;M19048|SGCGSSAAA_E2F1DP2_01;M1905|E2F_Q6;M19064|ZHANG_TLX_TARGETS_36HR_DN;M1913|ZHANG_TLX_TARGETS_60HR_DN;M1915|ZHANG_TLX_TARGETS_UP;M1917|WEST_ADRENOCORTICAL_TUMOR_UP;M1918|MODULE_325;M19221|MORI_LARGE_PRE_BII_LYMPHOCYTE_UP;M19287|E2F4DP2_01;M19298|REACTOME_DNA_STRAND_ELONGATION;M19312|REACTOME_G2_M_CHECKPOINTS;M19381|ISHIDA_E2F_TARGETS;M1945|WANG_CISPLATIN_RESPONSE_AND_XPC_UP;M19511|GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_TURQUOISE_DN;M19590|GOBP_CHROMOSOME_SEGREGATION;M19628|GOBP_NEGATIVE_REGULATION_OF_DNA_METABOLIC_PROCESS;M19816|FERREIRA_EWINGS_SARCOMA_UNSTABLE_VS_STABLE_UP;M19957|WEST_ADRENOCORTICAL_TUMOR_MARKERS_UP;M205|WHITFIELD_CELL_CYCLE_LITERATURE;M2066|WHITFIELD_CELL_CYCLE_G1_S;M2074|WHITFIELD_CELL_CYCLE_S;M2075|WHITFIELD_CELL_CYCLE_G2;M2076|WHITFIELD_CELL_CYCLE_G2_M;M2077|WHITFIELD_CELL_CYCLE_M_G1;M2078|WANG_METASTASIS_OF_BREAST_CANCER_ESR1_UP;M2082|BENPORATH_PROLIFERATION;M2114|WANG_RESPONSE_TO_GSK3_INHIBITOR_SB216763_DN;M2132|SHEPARD_CRASH_AND_BURN_MUTANT_DN;M2148|DUTERTRE_ESTRADIOL_RESPONSE_24HR_UP;M2156|REACTOME_BASE_EXCISION_REPAIR;M2158|PUJANA_BREAST_CANCER_WITH_BRCA1_MUTATED_UP;M2180|SONG_TARGETS_OF_IE86_CMV_PROTEIN;M2257|ZHU_SKIL_TARGETS_DN;M2275|DELPUECH_FOXO3_TARGETS_DN;M2314|DORMOY_ELAVL1_TARGETS;M2323|FEVR_CTNNB1_TARGETS_DN;M2343|GOBP_BASE_EXCISION_REPAIR;M2350|GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_UP;M2368|WANG_THOC1_TARGETS_UP;M2390|JUBAN_TARGETS_OF_SPI1_AND_FLI1_DN;M2394|PID_AURORA_A_PATHWAY;M242|NAKAMURA_CANCER_MICROENVIRONMENT_DN;M2427|KAUFFMANN_MELANOMA_RELAPSE_UP;M2431|LE_NEURONAL_DIFFERENTIATION_DN;M2441|MITOSIS;M2454|REICHERT_MITOSIS_LIN9_TARGETS;M2483|YU_BAP1_TARGETS;M2515|PID_BARD1_PATHWAY;M258|ZHOU_CELL_CYCLE_GENES_IN_IR_RESPONSE_2HR;M2604|ZHOU_CELL_CYCLE_GENES_IN_IR_RESPONSE_6HR;M2606|ZHOU_CELL_CYCLE_GENES_IN_IR_RESPONSE_24HR;M2608|E2F1_UP.V1_UP;M2632|GCNP_SHH_UP_EARLY.V1_UP;M2639|GCNP_SHH_UP_LATE.V1_UP;M2641|CSR_LATE_UP.V1_UP;M2660|YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_15;M2687|NAKAYAMA_SOFT_TISSUE_TUMORS_PCA2_UP;M2761|PID_RB_1PATHWAY;M279|RB_DN.V1_UP;M2800|RB_P107_DN.V1_UP;M2802|RB_P130_DN.V1_UP;M2805|RPS14_DN.V1_DN;M2812|NUCLEAR_CHROMOSOME_PART;M2823|BLUM_RESPONSE_TO_SALIRASIB_DN;M2879|MARKEY_RB1_CHRONIC_LOF_UP;M2895|MEIOSIS_I;M2985|CHROMOSOMAL_PART;M3006|E2F1_Q6_01;M3037|CHEMNITZ_RESPONSE_TO_PROSTAGLANDIN_E2_UP;M3045|GRAHAM_CML_DIVIDING_VS_NORMAL_QUIESCENT_UP;M3155|GOBP_DOUBLE_STRAND_BREAK_REPAIR;M3162|CHIANG_LIVER_CANCER_SUBCLASS_PROLIFERATION_UP;M3268|MARKS_HDAC_TARGETS_DN;M3362|KTGGYRSGAA_UNKNOWN;M3383|GOBP_DNA_REPLICATION_INITIATION;M3528|GNF2_CKS2;M3537|GOMF_DNA_DIRECTED_DNA_POLYMERASE_ACTIVITY;M355|MODULE_303;M3615|REACTOME_UNWINDING_OF_DNA;M3656|GOMF_DNA_NUCLEASE_ACTIVITY;M3657|SA_REG_CASCADE_OF_CYCLIN_EXPR;M3686|SOTIRIOU_BREAST_CANCER_GRADE_1_VS_3_UP;M3766|PID_E2F_PATHWAY;M40|FOURNIER_ACINAR_DEVELOPMENT_LATE_2;M4077|MODULE_197;M4092|E2F_03;M4220|SARRIO_EPITHELIAL_MESENCHYMAL_TRANSITION_UP;M4288|DOUBLE_STRANDED_DNA_BINDING;M4356|BOYAULT_LIVER_CANCER_SUBCLASS_G23_UP;M4448|EGUCHI_CELL_CYCLE_RB1_TARGETS;M4455|REN_BOUND_BY_E2F;M4493|GOCC_CONDENSED_CHROMOSOME;M451|MODULE_252;M4550|GNF2_TTK;M4598|PID_ATR_PATHWAY;M46|KORKOLA_TERATOMA;M4623|GOCC_CHROMOSOME_CENTROMERIC_REGION;M4721|CAIRO_HEPATOBLASTOMA_CLASSES_UP;M4772|RRCCGTTA_UNKNOWN;M4778|NUCLEAR_CHROMATIN;M4807|ZHAN_MULTIPLE_MYELOMA_PR_UP;M4888|VANTVEER_BREAST_CANCER_METASTASIS_UP;M500|E2F1_Q4;M5000|CHANG_CORE_SERUM_RESPONSE_UP;M5042|GRAHAM_NORMAL_QUIESCENT_VS_NORMAL_DIVIDING_DN;M5198|INTERPHASE;M5226|GNF2_CENPE;M5265|GOMF_NUCLEOTIDYLTRANSFERASE_ACTIVITY;M5310|REACTOME_G0_AND_EARLY_G1;M532|GOBP_SISTER_CHROMATID_SEGREGATION;M536|REACTOME_RESOLUTION_OF_AP_SITES_VIA_THE_MULTIPLE_NUCLEOTIDE_PATCH_REPLACEMENT_PATHWAY;M541|GNF2_RFC4;M5444|GOMF_HYDROLASE_ACTIVITY_HYDROLYZING_N_GLYCOSYL_COMPOUNDS;M5449|MODULE_403;M5464|MODULE_54;M5468|KEGG_BASE_EXCISION_REPAIR;M5500|HOFFMANN_LARGE_TO_SMALL_PRE_BII_LYMPHOCYTE_UP;M5588|MODULE_315;M5597|GOCC_CHROMATIN;M5728|REACTOME_E2F_ENABLED_INHIBITION_OF_PRE_REPLICATION_COMPLEX_FORMATION;M5756|E2F1DP1RB_01;M5768|REACTOME_ASSOCIATION_OF_LICENSING_FACTORS_WITH_THE_PRE_REPLICATIVE_COMPLEX;M580|MODULE_57;M582|GOBP_MITOTIC_SISTER_CHROMATID_SEGREGATION;M5962|BIOCARTA_SKP2E2F_PATHWAY;M6031|S_PHASE_OF_MITOTIC_CELL_CYCLE;M6105|G1_PHASE_OF_MITOTIC_CELL_CYCLE;M6116|GNF2_MKI67;M6132|TANG_SENESCENCE_TP53_TARGETS_DN;M6171|LIANG_SILENCED_BY_METHYLATION_DN;M6302|WU_APOPTOSIS_BY_CDKN1A_NOT_VIA_TP53;M6312|MODULE_158;M6330|KUMAMOTO_RESPONSE_TO_NUTLIN_3A_DN;M6379|NUCLEOLAR_PART;M6380|WINNEPENNINCKX_MELANOMA_METASTASIS_UP;M6387|GOBP_REGULATION_OF_MITOTIC_NUCLEAR_DIVISION;M642|MODULE_337;M6448|ODONNELL_TFRC_TARGETS_DN;M6451|BIOCARTA_G1_PATHWAY;M648|GNF2_ESPL1;M664|GOBP_RESPONSE_TO_ENDOGENOUS_STIMULUS;M6658|BIOCARTA_MCM_PATHWAY;M6682|REACTOME_E2F_MEDIATED_REGULATION_OF_DNA_REPLICATION;M6768|SCIBETTA_KDM5B_TARGETS_DN;M6787|REICHERT_G1S_REGULATORS_AS_PI3K_TARGETS;M679|ODONNELL_TARGETS_OF_MYC_AND_TFRC_DN;M6792|NADERI_BREAST_CANCER_PROGNOSIS_UP;M6862|MISSIAGLIA_REGULATED_BY_METHYLATION_DN;M6866|GNF2_SMC2L1;M6962|WONG_EMBRYONIC_STEM_CELL_CORE;M7079|MARKEY_RB1_ACUTE_LOF_DN;M7094|GOBP_REGULATION_OF_DNA_METABOLIC_PROCESS;M7262|FURUKAWA_DUSP6_TARGETS_PCI35_DN;M7339|LEE_EARLY_T_LYMPHOCYTE_UP;M7357|GNF2_CCNA2;M7419|REACTOME_PROCESSIVE_SYNTHESIS_ON_THE_LAGGING_STRAND;M744|DNA_DAMAGE_CHECKPOINT;M7533|REACTOME_G1_PHASE;M7591|BOHN_PRIMARY_IMMUNODEFICIENCY_SYNDROM_UP;M7603|GNF2_BUB1;M7629|REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS;M767|PYEON_HPV_POSITIVE_TUMORS_UP;M7738|REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX;M780|WHITEFORD_PEDIATRIC_CANCER_MARKERS;M7854|MODULE_485;M7862|REACTOME_POLYMERASE_SWITCHING;M787|REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY;M788|KEGG_CELL_CYCLE;M7963|PENG_GLUCOSE_DEPRIVATION_DN;M7970|REACTOME_CYCLIN_A_B1_B2_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION;M808|CELL_CYCLE_PHASE;M8083|BENPORATH_CYCLING_GENES;M8156|GOCC_REPLICATION_FORK;M8237|REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER;M827|GNF2_BUB1B;M8304|GOMF_ENDONUCLEASE_ACTIVITY_ACTIVE_WITH_EITHER_RIBO_OR_DEOXYRIBONUCLEIC_ACIDS_AND_PRODUCING_5_PHOSPHOMONOESTERS;M8317|RHODES_UNDIFFERENTIATED_CANCER;M8365|GOBP_DNA_DAMAGE_RESPONSE_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR;M8378|PID_ATM_PATHWAY;M84|SHEDDEN_LUNG_CANCER_POOR_SURVIVAL_A6;M8520|LINDGREN_BLADDER_CANCER_CLUSTER_3_UP;M854|BIOCARTA_G2_PATHWAY;M8560|GOBP_REGULATION_OF_DNA_REPLICATION;M8566|GOBP_MITOTIC_CELL_CYCLE_CHECKPOINT_SIGNALING;M8627|STRUCTURE_SPECIFIC_DNA_BINDING;M8837|E2F1_Q4_01;M8998|E2F1_Q6;M9279|KAUFFMANN_DNA_REPLICATION_GENES;M9372|FINETTI_BREAST_CANCER_KINOME_RED;M9389|SCIAN_CELL_CYCLE_TARGETS_OF_TP53_AND_TP73_DN;M9402|GOCC_KINETOCHORE;M9421|REACTOME_LAGGING_STRAND_SYNTHESIS;M9461|MODULE_372;M9465|MODULE_244;M949|PUJANA_BRCA2_PCC_NETWORK;M9516|OLSSON_E2F3_TARGETS_DN;M952|WAKASUGI_HAVE_ZNF143_BINDING_SITES;M9575|GOBP_CELL_CYCLE;M9669|STEIN_ESR1_TARGETS;M9678|GOMF_DAMAGED_DNA_BINDING;M968|REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX;M9694|BIOCARTA_ATRBRCA_PATHWAY;M9703|MMS_MOUSE_LYMPH_HIGH_4HRS_UP;M972|VANTVEER_BREAST_CANCER_METASTASIS_DN;M9826|HONRADO_BREAST_CANCER_BRCA1_VS_BRCA2;M9940|E2F_01;M9995" REFINEMENT_DATASETS="GSE19510,DMSO vs 1 uM BPDE WI-38 (fibroblasts)|GSE20928,calactin vs untreated K562 (chronic myelogenous leukemia)|GSE26922,6-8h (M phase) vs 0-2h (S phase) HeLa (cervical carcinoma)|GSE6410,untreated vs cisplatin A549 (non small cell carcinoma)" VALIDATION_DATASETS="GSE30240,untreated vs ionized radiation both at 3-6h HepG2 (hepatocellular carcinoma)" CATEGORY_CODE="H" ORGANISM="Homo sapiens" SUB_CATEGORY_CODE=""/>
</MSIGDB>
